Clinical trials: Neural Degeneration
Retinitis Pigmentosa
CNS10-NPC for the Treatment of RP
The investigator is examining the safety of transplanting cells into the subretinal space of patients with Retinitis Pigmentosa (RP).
- Trial name
- NCT04284293
- Testing
- CNS10-NPC implantation
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Cedars-Sinai Medical Center
Amyotrophic Lateral Sclerosis
The Effect of Memantine on Functional Outcomes and Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis (ALS)
The purpose of the study is to investigate the effects of memantine in ALS patients using functional outcome measures.
- Trial name
- NCT00409721
- Testing
- Memantine
- Where
- 2 sites in Canada
- Volunteers
- 42 people
- Sponsor
- University of Alberta
Amphetamine Addiction, Pharmacotherapy
Dextromethorphan, Memantine Monotherapy, or Combined Use of Dextromethorphan and Memantine in Amphetamine Addiction
The investigators will conducted a randomized double-blind placebo-controlled study to investigate the treatment outcomes of add-on low dose dextromethorphan (DM), memantine (MM), or dextromethorphan and memantine combination…
- Trial name
- NCT04687566
- Testing
- Dextromethorphan, Memantine, Dextromethorphan and memantine
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Cheng-Kung University Hospital
Diabetic Retinopathy, Neurodegeneration
Retinal Neurodegenerative and Vascular Changes in Diabetic Patients
Using Optical Coherence Tomography and ImageJ software the investigators will analyze retinal and choroidal vascular changes and their impact on retinal layers among patients with diabetes without retinopathy and patients with…
- Trial name
- NCT04637217
- Testing
- Optical Coherence Tomography
- Where
- Romania
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Neurodevelopmental Disorders, Autism Spectrum Disorder
Patterns of Neurodevelopmental Disorders
The purpose of this study is to systematically evaluate the results of medical investigations to identify symptom and biological patterns and common etiologies of neurodevelopmental disorders.
- Conditions
- Neurodevelopmental Disorders, Autism Spectrum Disorder, Pediatric Autoimmune Neuropsychiatric Disorder Associated With Streptococcal Infection, Pediatric Acute-Onset Neuropsychiatric Syndrome
- Trial name
- NCT06213090
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Richard Frye
Parkinson's Disease (PD), Alzheimer's Disease (AD)
Quantification of Hsp90 in the Human Brain
This study tests the radiolabeled molecule ("tracer"), [¹¹C]HSP990, using positron emission tomography (PET) imaging to assess whether it can be used to measure levels of Heat Shock Protein 90 (Hsp90).
- Conditions
- Parkinson's Disease (PD), Alzheimer's Disease (AD), Amyotrophic Lateral Sclerosis (ALS)
- Trial name
- NCT07380204
- Testing
- [11C]HSP990 PET dosimetry, [11C]HSP990 PET test-retest, [11C]HSP990 simplified scan protocol
- Where
- Belgium
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Retinal Neuropathy, Neurodegeneration
Retinal Neurodegeneration In Type 2 Diabetes Mellitus Detected by Optical Coherence Tomography
Evaluation of retinal neurodegeneration in patients with type 2 diabetes mellitus (DM2) without diabetic retinopathy or with mild non proliferative diabetic retinopathy
- Trial name
- NCT04808804
- Testing
- Optical Coherence Tomography (OCT)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Parkinson's, Parkinson Disease
Longitudinal Investigation of I2BS in PD
In this study, the researchers aim to find a biomarker of PD. Using imaging scans called Positron Emission tomography (PET), Single Photon Emission Computed Tomography (SPECT), and Magnetic Resonance Imaging (MRI).
- Conditions
- Parkinson's, Parkinson Disease, Parkinson's Disease, Neurodegenerative Diseases
- Trial name
- FOX_2 (NCT05516719)
- Testing
- Positron Emission Tomography (PET) scan using BU99008 tracer, FP-CIT Single-photon Emission Computed Tomography (SPECT) scan, Magnetic Resonance Imaging (MRI) Scan
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Amyotrophic Lateral Sclerosis
Exploring Nasal Drop Therapy With Small Extracellular Vesicles for ALS
This is a multicenter, randomized, double-blind, placebo-controlled, dose-escalation trial. The goal of this clinical trial is to evaluate the safety and preliminary efficacy of nasal drop exosomes derived from human umbilical…
- Trial name
- de-ALS (NCT06598202)
- Testing
- exosomes derived from human umbilical cord blood mesenchymal stem cells for nasal drop
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Xuanwu Hospital, Beijing
Neurodegeneration, General Anesthesia
Neurodegeneration in Newborns After Anesthetics
The purpose of the study is to quantify biomarkers of neural damage in neonates exposed to varying levels of volatile anesthetic in utero.
- Trial name
- NCT03064607
- Testing
- Fluid collection
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Pennsylvania
Friedreich Ataxia
Early and Longitudinal Assessment of Neurodegeneration in the Brain and Spinal Cord in Friedreich's Ataxia
Friedreich's ataxia is characterized by progressive alterations in the function of the cerebellum accompanied by an atrophy of the spinal cord.
- Trial name
- NCT01776164
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Diabetic Retinopathy, Glaucoma
AI for the Detection of Retinal Disease and Glaucoma in Patients With Diabetes Mellitus in Primary Care
Background: Diabetic retinopathy (DR) is one of the most important causes of blindness worldwide, especially in developed countries.
- Conditions
- Diabetic Retinopathy, Glaucoma, Age-Related Macular Degeneration, Choroidal Nevus
- Trial name
- NCT04132401
- Testing
- algorithm
- Where
- Spain
- Volunteers
- 902 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Mild Cognitive Impairment, Hypertension
Hypertension, Brain Clearance, and Markers of Neurodegeneration
The purpose of this research study is to measure cerebrospinal fluid (CSF) clearance in subjects with and without high blood pressure.
- Trial name
- NCT05785871
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Prodromal Alzheimer's Disease, Mild Cognitive Impairment
Brain Iron Toxicity and Neurodegeneration - A 7T MRI Study
A longitudinal observational neuroimaging study of individuals with Early Onset Alzheimer's disease during the prodromal phase, and matched control group - Ultrahigh Field MRI study at 7T
- Trial name
- BITaN (NCT04992975)
- Testing
- MRI at 7T
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Parkinson's Disease, Mild Cognitive Impairment
Auditory Sleep Stimulation or Sham in People With Parkinson Disease Mild Cognitive Impairment During Cognitive Training
People with Parkinson's disease are at higher risk of cognitive decline, and current treatments cannot fully prevent this. This study explores non-drug ways to support brain function.
- Trial name
- PDCogTSleep (NCT07441915)
- Testing
- Phase-Targeted Auditory Stimulation (PTAS), Digital Cognitive Training (CogT)
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University of Zurich
Elderly, Alzheimer Disease
Effects of 3-Month Melatonin Treatment on Regional Cerebellar Structure and Blood Biomarkers in Alzheimer's Disease Spectrum
The goal of this clinical trial is to explore and verify the preventive effects of melatonin on the progression of Alzheimer's disease.
- Conditions
- Elderly, Alzheimer Disease, Melatonin, Cognitive Decline
- Trial name
- NCT06756828
- Testing
- Melatonin, Cognitive behavioral therapy group for insomnia
- Volunteers
- 40 people
- Sponsor
- Saint Vincent's Hospital, Korea
Brain Injuries, Traumatic, Demyelinating Disorder
Exploring the Utility of [18F]3F4AP for Demyelination Imaging in Controls, Neurodegeneration and Traumatic Brian Injury
The overall objective is to obtain an initial assessment of the value of using [18F]3F4AP for imaging demyelinating diseases such as traumatic brain injury (TBI), neurodegenerative diseases such as mild cognitive impairment (MCI)…
- Conditions
- Brain Injuries, Traumatic, Demyelinating Disorder, Alzheimer Disease
- Trial name
- NCT04710550
- Testing
- F18-3F4AP
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Parkinsons Disease (PD), Healthy Elderly Volunteers
MK-0947 PN-002: An Open-label Study to Evaluate Brain α-synuclein Deposition Using Positron Emission Tomography (PET) and [¹⁸F]MK-0947 in Participants With Parkinson's Disease (PD)
This is a single-center, open-label clinical study designed to evaluate alpha-synuclein (ASYN) deposition in the brain of participants with Parkinson's disease (PD), as compared with healthy elderly (HE) participants.
- Trial name
- NCT07880379
- Testing
- [¹⁸F]MK-0947
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- XingImaging, LLC
Pantothenate Kinase-Associated Neurodegeneration
Efficacy and Safety Study of Fosmetpantotenate (RE-024) in PKAN Participants
This study investigated whether fosmetpantotenate (RE-024), a phosphopantothenate replacement therapy, was safe and effective in treating participants with PKAN.
- Trial name
- PKAN (NCT03041116)
- Testing
- Fosmetpantotenate
- Where
- 20 sites in United States, Canada and 7 more
- Volunteers
- 84 people
- Sponsor
- Travere Therapeutics, Inc.
Sporadic Dystonia, Dystonia, Familial
Imaging Neuromelanin and Iron in Dystonia/Parkinsonism
To generate pilot data to investigate the potential to use in vivo iron- and neuromelanin-quantification as imaging tools for the diagnostic evaluation of movement disorders with predominant dystonia / parkinsonism.
- Conditions
- Sporadic Dystonia, Dystonia, Familial, Parkinson Disease, Juvenile, Neurodegeneration With Brain Iron Accumulation 5
- Trial name
- NCT03572114
- Testing
- 3Tesla MRI, Burke-Fahn-Marsden Dystonia Rating scale, MDS-United Parkinsons Disease Rating Scale, Part III
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University College, London