Clinical trials: Neural Stress Response
Traumatic Brain Injury, Stroke
Neural Dynamics and Connectivity in Response Inhibition and Traumatic Brain Injury
Background: Previous research has shown that certain parts of the brain are involved in voluntarily stopping an ongoing motor response (movement); however, it is not known whether this same network is also involved in suppressing…
- Conditions
- Traumatic Brain Injury, Stroke, Headache, PTSD
- Trial name
- NCT01194661
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
PTSD
Efficacy and Neural Mediators of Response to Trauma Management Therapy for PTSD
Social difficulties are serious and frequent complicating factors in the treatment of post-traumatic stress disorder (PTSD). To better understand how treatment of post-traumatic stress disorder impacts neural mechanisms of social…
- Trial name
- NCT03449576
- Testing
- Trauma Management Therapy, Exposure Therapy with Psychotherapy group
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- VA Office of Research and Development
Healthy, Stress, Psychological
Neural Indications of Stress-Induced Mental Overload
The aim of the current research is to characterize the complex interaction between stress and cognitive workload. Furthermore, the investigators aim to create a functional magnetic resonance imaging (fMRI) inspired…
- Trial name
- NCT03585205
- Where
- Israel
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Alcohol Abuse, Craving
Using Neurofeedback to Understand the Relationship Between Stress and Alcohol Consumption
In this research project, the aim is to discover the role specific brain networks play in the relationship between stress reactions and the desire for alcohol and alcohol consumption.
- Conditions
- Alcohol Abuse, Craving, Psychosocial Stressor, Neural Stress Response
- Trial name
- NeuStress (NCT06247306)
- Testing
- ScanSTRESS fMRI-paradigm (Streit et al., 2014), real-time fMRI neurofeedback
- Where
- Germany
- Volunteers
- 102 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Resistance Exercise Pressor and Neural Responses in Older Women
Blood Pressure Reactivity After Resistance Exercise in Older Women
The purpose of this study is to determine and compare the effects of two sessions of resistance exercise in blood pressure reactivity to a mental stress test in older hypertensive women.
- Trial name
- NCT03002714
- Testing
- Exercise
- Volunteers
- 10 people
- Sponsor
- University of Brasilia
Impulsive Aggression, Posttraumatic Stress Disorder
Pilot Trial of Neural Correlates of Response to Treatment of PTSD-Associated Impulsive Aggression
The purpose of this study is to identify changes in brain functioning which are related to reduced frequency and/or intensity of impulsive aggressive actions after treatment of PTSD-related impulsive aggression with either…
- Trial name
- NCT00333931
- Testing
- Phenytoin, Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Michael E. DeBakey VA Medical Center
Post Traumatic Stress Disorder, Traumatic Brain Injury
Cannabidiol as a Treatment for PTSD and PTSD Comorbid With TBI
This will be a randomized placebo controlled study to test the efficacy of cannabidiol (CBD) as a treatment for symptoms of post-traumatic stress disorder (PTSD).
- Trial name
- NCT04550377
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- NYU Langone Health
Cardiovascular Disease
Beta-Blocker Influences on Inflammatory and Neural Responses to Stress
The purpose of this study is to map the neural and molecular mechanisms underlying psychological stress-induced changes in inflammation which could reveal new targets for intervention to reduce the risk of cardiovascular disease.
- Trial name
- NCT06263452
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Alcohol Use Disorder, Stress Reaction
Psychobiology of Stress and Alcohol Craving
In this feasibility study the investigators are using a setup of stress-related body sensors including established as well as innovative sensor-based measures to identify predictor profiles for alcohol-related behavioral and…
- Conditions
- Alcohol Use Disorder, Stress Reaction, Social Stress, Craving
- Trial name
- NCT03810950
- Testing
- Trier Social Stress Test, Reading Newspaper, Barlab-Exposure
- Where
- Germany
- Volunteers
- 11 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Blood Pressure, Stress, Physiological
Cardiovascular Reactivity to Physical Stress
It is well-accepted that an exaggerated blood pressure (BP) response to physical stress has a prognostic value, indicating a higher cardiovascular risk (e.g., sudden cardiac death, myocardial infarction, future hypertension, and…
- Trial name
- REACT (NCT06319001)
- Testing
- Low-volume high intensity exercise, Combined intermittent sauna and cold water bath (sauna+cold bath).
- Where
- Norway
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Western Norway University of Applied Sciences
Stress, Anxiety
Minerals and Botanicals for Acute Stress
The objective of this acute intervention study is to examine the potential of minerals combined with botanicals to demonstrate unique and synergistic effects on oscillatory brain activity, cognitive performance, and stress…
- Trial name
- NCT03262376
- Testing
- Minerals + Vitamins, Botanical A, Botanical B
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Generalized Anxiety Disorder
MBSR Mechanisms in GAD
The purpose of this study is to understand the neural mechanisms that drive response to MBSR compared to stress education in patients with generalized anxiety disorder (GAD), and to examine the degree to which sex differences in…
- Trial name
- NCT05064813
- Testing
- Mindfulness Based Stress Reduction MBSR Intervention, Stress Education Control Condition (SE)
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- NYU Langone Health