Clinical trials: Neuralgia Peripheral
Pain, Intractable, Facial Pain
CONCEPT: Crossover Efficacy Pain Trial in Motor Cortex Stimulation for Intractable Neuropathic Pain
The CONCEPT study has been designed to evaluate the safety and the efficacy of Motor Cortex Stimulation (MCS) with a new cortical lead (circular lead, eight electrodes, Medtronic Inc, Minneapolis, USA) in the treatment of…
- Trial name
- NCT00122915
- Testing
- Cortical lead, 8 electrodes (Model 2976) with Synergy neurostimulator
- Where
- 11 sites in Austria, Belgium and 2 more
- Volunteers
- 104 people
- Sponsor
- MedtronicNeuro
Pain, Peripheral Neuropathy
Effects of Neurofeedback on Neural Function, Neuromodulation, and Chemotherapy-Induced Neuropathic Pain
The goal of this study is to learn if using a non-invasive therapy called "neurofeedback training" can help teach patients ways to modify their own brain waves to decrease the perception of pain and improve quality of life.
- Trial name
- NCT01278225
- Testing
- EEG biofeedback (BF) Group, Wait-List Control (WLC) Group, Follow UP Questionnaires
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- M.D. Anderson Cancer Center
Diabetic Peripheral Neuropathic Pain
Evaluation of the Long-term Safety and Effectiveness of Suzetrigine (SUZ) in Participants With Painful Diabetic Peripheral Neuropathy (DPN)
The purpose of this study is to evaluate the long-term safety and tolerability of SUZ and long-term effectiveness of SUZ in treating pain associated with DPN.
- Trial name
- NCT06696443
- Testing
- Suzetrigine
- Where
- 65 sites in United States
- Volunteers
- 455 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Neuropathic Pain
Identifying Biomarkers and Changes in Cerebrospinal Fluid Collected Pre and Post Spinal Cord Stimulation in Subjects Suffering From Chronic Refractory Pain Conditions
This is a single center exploratory study in subjects suffering from chronic refractory pain to identify cellular, molecular and protein biomarkers within cerebrospinal fluid (CSF).
- Trial name
- CSF-STIM (NCT03986255)
- Testing
- Lumbar Puncture
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Diabetic Peripheral Neuropathic Pain (DPNP)
Randomized, Double-blind, Placebo-controlled, Multicenter Phase IIb Clinical Trial of Spray YJ001 for the Treatment of Diabetic Peripheral Neuropathic Pain
The goal of this clinical trial is to learn if YJ001 Spray can treat diabetic patients with Diabetic Peripheral Neuropathic Pain(DPNP).
- Trial name
- NCT07858344
- Testing
- YJ001 spray simulator, YJ001 Spray 240 mg/day, YJ001 Spray 480 mg/day
- Where
- China
- Volunteers
- 196 people
- Sponsor
- Zhejiang Yuejia Pharmaceuticals Co., Ltd.
Low Back Pain, Failed Back Surgery Syndrome
Subcutaneous Stimulation as Add on Therapy to SCS toTreat Low Back Pain in FBSS
Aim of the study Failed back surgery syndrome (FBSS) is a clinical entity consisting of chronic leg and /or back pain due to radicular nerve damage.
- Conditions
- Low Back Pain, Failed Back Surgery Syndrome, Neuropathic Pain
- Trial name
- SubQ (NCT01776749)
- Testing
- SubQ
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- SubQ
Lung Cancer
Sensory Mapping and Thermal Thresholds After Thoracic Surgery
The study will investigate topography of sensory changes late after lung cancer surgery
- Trial name
- NCT01274858
- Where
- 2 sites in Denmark
- Volunteers
- 12 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Meralgia Paresthetica
Effects of Lateral Femoral Cutaneous Nerve Mobilization With and Without Muscle Energy Techniques in Pregnant Females
The rationale of this study is to provide empirical evidence regarding the efficacy and safety of neural mobilization in pregnant women with meralgia paresthetica.
- Trial name
- NCT06751147
- Testing
- Group A, Experimental Group B
- Where
- 2 sites in Pakistan
- Volunteers
- 48 people
- Sponsor
- Riphah International University
Inflammatory Bowel Diseases, Neuropathic Pain
GI Medical Cannabis Study on IBD
Create a registry that will described the natural history and landscape of medical cannabis product use in patients with chronic abdominal pain or inflammatory bowel disease.
- Trial name
- GIMEDCAN (NCT03886532)
- Testing
- Medical Marijuana
- Sponsor
- Children's Hospital of Philadelphia
Diabetes Mellitus, Type 2, Neuropathic Pain
Effect of a Combined Exercise Program on Neuropathic Pain and Perceived Quality of Life in Type 2 Diabetes
Therapeutic exercise is one of the therapies used as a treatment for diabetic neuropathy, which is a complication of diabetes. In order to reduce pain and improve the perception of quality of life, a combined therapeutic exercise…
- Conditions
- Diabetes Mellitus, Type 2, Neuropathic Pain, Neuropathy, Diabetic
- Trial name
- NCT05703152
- Testing
- Combined Exercise
- Where
- Mexico
- Volunteers
- 12 people
- Sponsor
- Maria Gabriela Aké Palomo
Chronic Pain, Pediatric Disorder
PET/MRI in the Diagnosis of Pediatric Chronic Pain
[18F]FTC-146 is a sigma-1 receptor detector and is an experimental radiotracer. Several studies have implicated involvement of sigma-1 receptors in generation and perpetuation of chronic pain conditions, while others are…
- Conditions
- Chronic Pain, Pediatric Disorder, Neuropathic Pain, Nociceptive Pain
- Trial name
- NCT04435821
- Testing
- [18F]FTC-146
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Stanford University
Postherpetic Neuralgia, Healthy Age/Gender Matched Volunteers
Evaluation of Five Selected Markers in Skin Biopsies of Patients With Postherpetic Neuralgia and Healthy Controls
Postherpetic Neuralgia is a painful nerve condition that can occur when nerve fibers are damaged following an outbreak of shingles.
- Trial name
- STTR (NCT01379716)
- Testing
- skin biopsy
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Albany Medical College
Pain, Irritability
Implementation of the Pain and Irritability of Unknown Origin (PIUO) Pathway in Community Pediatric Practices
The Pain and Irritability of Unknown Origin (PIUO) Pathway is a clinical pathway that was developed to evaluate and manage unexplained pain and irritability for children with severe neurological impairments (SNI) who cannot…
- Conditions
- Pain, Irritability, Neuropathic Pain
- Trial name
- NCT06869928
- Testing
- PIUO Pathway
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
Diabetic Peripheral Neuropathy
Laser Therapy for Diabetic Peripheral Neuropathic Pain
The proposed study is a randomized, double-blinded clinical trial to evaluate the efficacy of a course of laser therapy on peripheral neuropathic pain in persons with diabetes.
- Trial name
- NCT02328911
- Testing
- Laser treatment
- Where
- United States
- Sponsor
- University of Miami
Sciatica, Lumbar Radiculopathy
Brain Mechanisms Supporting Cannabis-induced Pain Relief
Chronic low back pain is a common and disabling condition that affects millions of people in the United States. Many people with chronic low back pain do not get enough relief from current treatments.
- Conditions
- Sciatica, Lumbar Radiculopathy, Lower Back Pain, Degenerative Disc Disease
- Trial name
- NCT04982965
- Testing
- Active Cannabis
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Neuralgia
Towards Individualized Deep Brain Stimulation Treatment of Chronic Neuropathic Pain
Chronic neuropathic pain affects millions of individuals worldwide. It causes marked reduction of health, utility and quality of life and represents a considerable economic burden to society due to loss of work capacity and large…
- Trial name
- DBSforPain (NCT01899170)
- Testing
- Deep brain stimulation, Cervel Neurotech, Multi-coil TMS, 11C-Carfentanil
- Where
- Denmark
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Spinal Cord Injuries, Neuropathic Pain
Cingulotomy for Refractory Neuropathic Pain Following Spinal Cord Injury (CRNP-SCI)
Neuropathic pain is very common following a spinal cord injury, estimated to affect 43% of patients after 6 months. A proportion of these patients do not respond to treatment and there remains an unmet need to treat people with…
- Trial name
- CRNP-SCI (NCT05084170)
- Testing
- Bilateral anterior cingulotomy
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- St George's, University of London
Neuropathic Pain
Intravenous Immunoglobulin (IVIG) for Resistant Neuropathic Pain
This project addresses a vexing problem that has alluded the best efforts of the medical/scientific community: treatment of resistant neuropathic pain.
- Trial name
- NCT00850005
- Testing
- Intravenous immunoglobulin, Normal Saline
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of Calgary
Neuropathic Pain
Psychotherapy for Ketamine's Enhanced Durability in Chronic Neuropathic Pain: A Randomized Controlled Pilot Trial
The purpose of the study is to investigate new therapies to alleviate pain on neuropathic chronic pain. At this time, the main purpose is to complete a feasibility or pilot study with 30 participants suffering from neuropathic…
- Trial name
- PSYKED-NP (NCT05639322)
- Testing
- Ketamine Hydrochloride, Cognitive Behavioral Therapy, Ketamine + Cognitive Behavioral Therapy
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
Painful Diabetic Neuropathy (PDN), Diabetic Neuropathy, Distal Symmetric Polyneuropathy (Manifestation)
Thai PainPREDICT Validation Study
Painful diabetic neuropathy (PDN) is one of the most common and disabling complications of diabetes mellitus, substantially affecting quality of life, daily functioning, and health system burden.
- Conditions
- Painful Diabetic Neuropathy (PDN), Diabetic Neuropathy, Distal Symmetric Polyneuropathy (Manifestation), Type 1 Diabetes Mellitus (T1DM), Type 2 Diabetes Mellitus (T2DM)
- Trial name
- PainPREDICT-Th (NCT07195045)
- Testing
- Thai PainPREDICT Questionnaire and Mobile Application
- Where
- Thailand
- Volunteers
- 277 people
- Sponsor
- Chulalongkorn University
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