Clinical trials: Neuritis
Optic Neuritis
Defining the Functional and Neuro-Protective Potential of ACTHAR in Acute Optic Neuritis
The goal of the study is to determine the earliest structural changes in the optic nerve during the acute event and during the twelve months of recovery following Acthar treatment.
- Trial name
- ACHTAR (NCT01987167)
- Testing
- ACTHAR
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Neuro-Ophthalmologic Associates, PC
Optic Neuritis
Initial Clinical Presentation of Inflammatory Optic Neuritis Associated or Not With Autoantibodies Anti-Myelin-oligodendrocyte-glycoprotein
In eight ophthalmic units, the investigator will include all inflammatory optic neuritis (ON) during acute phase and rank them in two groups: 1/ ON with autoantibodies anti-myelin-oligodendrocyte-glycoprotein (ON MOG+) 2/ ON…
- Trial name
- MOG (NCT03345537)
- Testing
- Non interventional study
- Where
- 8 sites in France
- Volunteers
- 103 people
- Sponsor
- Nantes University Hospital
Gynecologic Cancer, Neuropathy;Peripheral
The Effect of Low Frequency Soundwave Stimulation on Chemotherapy Induced Peripheral Neuropathy
The goal of this clinical trial is to assess the efficacy of SensoniQ® Treatment Station in preventing or reducing chemotherapy induced peripheral neuropathy symptoms (CIPNS) in patients receiving frontline carboplatin and…
- Trial name
- NCT05980169
- Testing
- SensoniQ Treatment Station
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Augusta University
Neuromyelitis Optica Spectrum Disorder
Efficacy and Safety Study of Ravulizumab IV in Pediatric Participants With NMOSD
The primary purpose of this study is to evaluate the safety and efficacy of ravulizumab in pediatric participants with Neuromyelitis Optica Spectrum Disorder (NMOSD).
- Trial name
- NCT05346354
- Testing
- Ravulizumab
- Where
- 16 sites in United States, Canada and 5 more
- Volunteers
- 12 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Acute Unilateral Vestibular Deafferentiation
Unravelling Risk Factors for Chronic Dizziness in Patients After an Acute Unilateral Vestibular Deafferentiation.
In many patients with an acute unilateral vestibular deafferentiation (uVD) syndrome symptoms are expected to resolve spontaneously because of central compensation.
- Trial name
- Activation (NCT04979598)
- Testing
- Home exercise program
- Where
- Belgium
- Volunteers
- 103 people
- Sponsor
- Universiteit Antwerpen
Neuromyelitis Optica, Neuromyelitis Optica Spectrum Disorder
Safety and Efficacy of Daratumumab in Patients With Anti-Aquaporin 4 Antibody Positive Neuromyelitis Optica Spectrum Disorders
The objectives of this time-to-event study are to assess the efficacy and safety of Daratumumab as compared with placebo in participants with neuromyelitis optica spectrum disorder (NMOSD) who are anti-aquaporin-4 (AQP4)…
- Conditions
- Neuromyelitis Optica, Neuromyelitis Optica Spectrum Disorder, NMO Spectrum Disorder
- Trial name
- DAWN (NCT05403138)
- Testing
- Daratumumab
- Where
- China
- Volunteers
- 135 people
- Sponsor
- Tianjin Medical University General Hospital
Neuralgic Amyotrophy, Neuralgic Amyotrophy, Hereditary
Neuralgic Amyotrophy: Central Reorganization and Rehabilitation After Peripheral Dysfunction
This study evaluates the effect of a specific, multidisciplinary and personalized rehabilitation program compared to usual care, on motor control and functional disability in patients with neuralgic amyotrophy.
- Conditions
- Neuralgic Amyotrophy, Neuralgic Amyotrophy, Hereditary, Parsonage Turner Syndrome, Brachial Neuritis
- Trial name
- NA-CONTROL (NCT03441347)
- Testing
- Specific rehabilitation program, Usual Care
- Where
- Netherlands
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Neuromyelitis Optica Spectrum Disorder (NMOSD)
Impact of a Structured Wellness Behavioral Intervention on Quality of Life in NMOSD
This project aims to study whether a structured wellness program intervention can improve quality of life among people living with Neuromyelitis Optica Spectrum Disorder (NMOSD).
- Trial name
- NMOSD (NCT06780709)
- Testing
- Wellness Program and Behavioral Counseling
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Neuromyelitis Optica Spectrum Disorder
Treatment of Relapsed and/or Refractory AQP4-IgG Seropositive NMOSD by Tandem CAR T Cells Targeting CD19 and CD20
CAR-T therapy was proposed and has been recently used for cancer treatment. It has been hailed for its promising remission rates after early stage clinical trials for acute lymphoblastic leukemia.
- Trial name
- NCT03605238
- Testing
- Corticosteroids & tanCART19/20
- Where
- China
- Sponsor
- Chinese PLA General Hospital
AIRE Deficiency
Analysis of the Role of AIRE in Autoimmune Neurological Diseases Associated With Autoantibodies
Studying genetic predisposition in autoimmune neurological diseases could help improve diagnostic accuracy and offer new treatment possibilities
- Trial name
- NAD-AIRE (NCT06941584)
- Testing
- Test for AQP4, AChR, LGI1, and CASPR2 autoantibodies using cell-based assay, AIRE single gene sequencing, Molecular typing of HLA class I and II alleles
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Neuromyelitis Optica Spectrum Disorders, Pain
Efficacy of Electroacupuncture in NMOSD Patients With Pain: Study Protocol
Abstract Background Neuropathic pain is a common complication in neuromyelitis optica spectrum disorder (NMOSD), which seriously affects the quality of life of NMOSD patients, with no satisfactory treatment.
- Trial name
- NCT05871658
- Testing
- electroacupuncture
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Yuanqi Zhao,MD
Neuropathy;Peripheral, Chemotherapy-induced Peripheral Neuropathy
Voxx Human Performance Technology Socks for Chemotherapy-Induced Peripheral Neuropathy
This is a double blind, randomized, crossover pilot study of Voxx Human Performance Technology Socks versus placebo socks for the treatment of chemotherapy-induced peripheral neuropathy in patients with cancer.
- Conditions
- Neuropathy;Peripheral, Chemotherapy-induced Peripheral Neuropathy, Neuropathy
- Trial name
- NCT04403802
- Testing
- Voxx Human Performance Technology Socks
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- Arash Asher, MD
Neuromyelitis Optica Spectrum Disorder
Long-term, Open-label, Safety Study of Inebilizumab in Neuromyelitis Optica Spectrum Disorder (NMOSD)
The purpose of this study is to understand the effects of long-term treatment with inebilizumab on circulating levels of immunoglobulins, B-cell counts, and other safety measures, and to further monitor repletion of immunoglobins…
- Trial name
- N-MOmentum LT (NCT06180278)
- Testing
- Blood tests, Inebilizumab
- Where
- 11 sites in United States, China and 5 more
- Volunteers
- 32 people
- Sponsor
- Amgen
Cervicobrachial Neuralgia, Myofascial Pain Syndromes
Study to Evaluate the Efficacy of Botulinum Toxin Serotype A Injections for Cervicobrachial Myofascial Syndrome
Several studies have previously examined the use of botulinum toxin serotype A for myofascial pain of the neck and shoulders (cervicobrachial syndrome). These studies have suffered from: 1.
- Trial name
- NCT00241215
- Testing
- Botulinum toxin serotype A
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- University of California, Los Angeles
Optic Neuritis
OCS-05 in Patients With Optic Neuritis
To evaluate the safety and tolerability of OCS-05 compared to placebo in patients with optic neuritis receiving the standard of care
- Trial name
- ACUITY (NCT04762017)
- Testing
- OCS-05 +SoC (corticosteroid) IV administration
- Where
- 4 sites in France
- Volunteers
- 36 people
- Sponsor
- Oculis
Devic's Syndrome, Devic's Neuromyelitis Optica
Autologous Mesenchymal Stem Cells for the Treatment of Neuromyelitis Optica Spectrum Disorders
Neuromyelitis optica (NMO) is a demyelinating and degenerative disorder of the central nervous system affecting vision and brain and spinal cord function which leads to accumulating disability with a 5 year-mortality of…
- Conditions
- Devic's Syndrome, Devic's Neuromyelitis Optica, Devic Syndrome, Devic's Disease
- Trial name
- NCT02249676
- Testing
- Autologous mesenchymal stem cells
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Tianjin Medical University General Hospital
Neuropathy, Neuropathy;Peripheral
Clinical Efficacy of the Erchonia EVRL for Providing Temporary Relief of Idiopathic Peripheral Neuropathy Foot Pain
The purpose of this clinical study is to determine the effectiveness of the Erchonia® EVRL™, manufactured by Erchonia Corporation (the Company), in providing prescription home use application for temporary relief of idiopathic…
- Trial name
- NCT06912646
- Testing
- Erchonia® EVRL™
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Erchonia Corporation
Neuromyelitis Optica Spectrum Disorders
A Clinical Research Study of Inebilizumab in Neuromyelitis Optica Spectrum Disorders
To assess the efficacy and safety of Inebilizumab in Chinese adult patients with neuromyelitis optica spectrum disorders.
- Trial name
- NCT06212245
- Testing
- Inebilizumab
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Hansoh BioMedical R&D Company
Optic Neuritis
Adjunctive Gypenosides for Acute Optic Neuritis
This pilot randomized, double-blind, placebo-controlled trial evaluated whether short-course adjunctive gypenosides, added to standard corticosteroid treatment, may preserve retinal structural outcomes in adults with acute optic…
- Trial name
- NCT02976766
- Testing
- Gypenosides
- Where
- China
- Volunteers
- 10 people
- Sponsor
- First Affiliated Hospital of Guangxi Medical University
Multiple Sclerosis
A Trial of Neuroprotection With ACTH in Acute Optic Neuritis
We hypothesize that the novel melanocortin-mediated anti-inflammatory effects of ACTH will reduce axonal loss following ON by limiting inflammatory optic nerve injury.
- Trial name
- ACTHAR (NCT01838174)
- Testing
- ACTHAR Gel (ACTH), IV methylprednisolone (steroids)
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- University of Colorado, Denver