Clinical trials: Neuro-Degenerative Diseases
Neuro-Degenerative Disease
3D Printers for Autonomy in the Care of Inpatients in Continuing and Rehabilitation Care
Patients hospitalized in Continuing and Rehabilitation Care Units (CRCU) are for the most part elderly people suffering from neurodegenerative diseases, requiring individual, personalized rehabilitation care.
- Trial name
- AUTARI-3D (NCT07087574)
- Testing
- adapted cutlery handle printed with 3D printer
- Where
- 2 sites in France
- Volunteers
- 75 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
PTSD, Alzheimer Disease
First-In-Human (FIH), Single Ascending Dose (SAD) Study of FluoroEthylNorMemantine (FENM)
The goal of this First-In-Human (FIH) trial is to learn about safety and PharmacoKinetics (PK) in healthy adult volunteers. The main questions it aims to answer are: What is the safety of single ascending doses of the…
- Conditions
- PTSD, Alzheimer Disease, Brain Diseases, Neuro-Degenerative Disease
- Trial name
- NCT05921929
- Testing
- Fluoroethylnormemantine (FENM)
- Where
- Belgium
- Volunteers
- healthy volunteers welcome
- Sponsor
- ReST Therapeutics
Cardiovascular Diseases, Neuro-Degenerative Disease
Neuromed- Integrated Health Life Platform and Biobank
This project aims to create a digital platform for personal, clinical, diagnostic and environmental data collection, management and analysis of patients with cardiovascular and neurological disease or cancer admitted to the…
- Conditions
- Cardiovascular Diseases, Neuro-Degenerative Disease, Cancer, Pregnancy
- Trial name
- PLATONE (NCT03279991)
- Where
- Italy
- Volunteers
- 4,000 people
- Sponsor
- Neuromed IRCCS
Parkinson Disease, Neuro-Degenerative Disease
Self-Management Behaviors of Arabs and Jews With Parkinson's Disease and Their Associations With Health Outcomes
The study will examine the reciprocal relationships between the community, healthcare system, and personal determinants of self-management behaviors in persons with Parkinson's disease and their association with the performance…
- Conditions
- Parkinson Disease, Neuro-Degenerative Disease, Movement Disorders
- Trial name
- NCT05209698
- Where
- Israel
- Volunteers
- 2,500 people
- Sponsor
- University of Haifa
Aging, Cognitive Decline
Blood Flow Restriction and High-intense Resistance Training in Aging: Interactions Between Neuroplasticity and Muscle
BRAIN-M is a randomized controlled trial designed to examine the effects of a single bout or 12 weeks of blood-flow restriction training or high-intensity resistance training on cognitive function, brain health, muscular…
- Conditions
- Aging, Cognitive Decline, Sarcopenia, Frailty
- Trial name
- BRAIN-M (NCT05744167)
- Testing
- BFRT, MDRT
- Where
- Lithuania
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lithuanian Sports University
Neuro-Degenerative Disease
Carbon-11 Butanol: Whole Body Radiochemical and Radiation Safety
This will be a Phase 1, open label, imaging study of radiochemical and radiation safety in healthy volunteers. Using positron emission tomography (PET) and in-line computed tomography (CT), the whole body (WB) biokinetics of…
- Trial name
- [11C]Butanol (NCT04050800)
- Testing
- Carbon 11 Butanol
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Neuro-Degenerative Disease, Parkinson Disease
Tocotrienols in Parkinson's Disease (PD)
A study using Parkinson's disease animal model, transgenic fruit flies, demonstrated the potential of using tocotrienols (HOV-12020) as a therapeutic agent for delaying Parkinsonian motor dysfunctions.
- Trial name
- NCT04491383
- Testing
- Tocovid Suprabio (HOV-12020)
- Where
- 2 sites in Singapore
- Volunteers
- 100 people
- Sponsor
- National Neuroscience Institute
Alzheimer's Disease, Mild Cognitive Impairment
Retinal Imaging in Neurodegenerative Disease
This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the…
- Conditions
- Alzheimer's Disease, Mild Cognitive Impairment, Parkinson's Disease, Multiple Sclerosis
- Trial name
- NCT03233646
- Testing
- Retinal and Choroidal Imaging
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Aging, Immunology
Peri-operative Inflammaging in the Elderly After Surgery
The population older than 80 years will significantly increase in the near future. Older patients' cognitive and physical status is known to deteriorate after surgery, leading to a high 30-day mortality due to post-operative…
- Conditions
- Aging, Immunology, Postoperative Complications, Surgery
- Trial name
- POPIMAGE (NCT05368896)
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- University of Bonn
Peripheral Neuropathy, Neuro-Degenerative Disease
A Prospective Natural History and Outcome Measure Discovery Study of Charcot-Marie-Tooth Disease, Type 4J
This is a multicenter, longitudinal, prospective observational natural history study of subjects with a molecularly confirmed diagnosis of CMT4J.
- Conditions
- Peripheral Neuropathy, Neuro-Degenerative Disease, Neuromuscular Diseases
- Trial name
- CMT4J (NCT06151600)
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Elpida Therapeutics SPC
Friedreich Ataxia
Neurology Measures in FA Children
The purpose of this study is to identify ways to follow progression of Friedreich's Ataxia (FA) and be able to measure changes over time in children with FA.
- Trial name
- NCT03418740
- Where
- 3 sites in United States
- Volunteers
- 108 people
- Sponsor
- Children's Hospital of Philadelphia
Multiple Sclerosis, Gait Disorders, Neurologic
Walking and Thinking - Brain Activity During Complex Walking in People With Multiple Sclerosis
Every-day life means being part of a complex environment and performing complex tasks that usually involve a combination of motor and cognitive skills.
- Conditions
- Multiple Sclerosis, Gait Disorders, Neurologic, Neuro-Degenerative Disease, Aging
- Trial name
- NCT05787704
- Testing
- No intervention
- Where
- Sweden
- Volunteers
- 41 people
- Sponsor
- Karolinska Institutet
Dementia Frontal, Dementia Alzheimers
Optimization and Harmonization of Advanced MRI Sequences
Development of a shared multimodal MRI protocol for the definition and quantification of imaging biomarkers in AD, DLB, FDT dementias, especially white matter alterations.
- Conditions
- Dementia Frontal, Dementia Alzheimers, Lewy Body Variant of Alzheimer Disease, Neuro-Degenerative Disease
- Trial name
- NCT06217237
- Testing
- AD FDT DBL GROUP
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Cancer, Pregnancy Related
Distribution of Biospecimens From Biorepositories/Biobanks for Research Use
This protocol seeks to assist biorepositories/biobanks in distributing their stored specimens and data to researchers that will actually utilize them to advance medicine and technology.
- Conditions
- Cancer, Pregnancy Related, Gastro-Intestinal Disorder, Cardio-Respiratory Distress
- Trial name
- NCT03884400
- Testing
- Specimens obtained from surgical, phlebotomy or other non-invasive procedure
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- iSpecimen Inc
Diabetes, Endocrine System Diseases
Evaluating Innovations in Transition From Pediatric to Adult Care - The Transition Navigator Trial
The Transition Navigator Trial (TNT) is a pragmatic randomized controlled trial evaluating the effectiveness of usual care plus a patient navigator service versus usual care plus newsletters and other educational materials, to…
- Conditions
- Diabetes, Endocrine System Diseases, Gastro-Intestinal Disorder, Neuro-Degenerative Disease
- Trial name
- TNT (NCT03342495)
- Testing
- Patient Navigator, Usual Care
- Where
- 3 sites in Canada
- Volunteers
- 337 people
- Sponsor
- University of Calgary
Cancer, Cardiac Disease
A Culturally-Based Palliative Care Tele-consult Program for Rural Southern Elders
Rural patients with life-limiting illness are at very high risk of not receiving appropriate care due to a lack of health professionals, long distances to treatment centers, and limited palliative care (PC) clinical expertise.
- Conditions
- Cancer, Cardiac Disease, Pulmonary Disease, Neuro-Degenerative Disease
- Trial name
- NCT03767517
- Testing
- Active Intervention, Usual Care
- Where
- 4 sites in United States
- Volunteers
- 209 people
- Sponsor
- University of Alabama at Birmingham
Stroke, Aging
Walking and Thinking - Brain Activity During Complex Walking in Stroke
Everyday life requires individuals to function in complex environments and perform tasks that involve the integration of motor and cognitive abilities.
- Conditions
- Stroke, Aging, Neuro-Degenerative Disease, Gait Impairment in Stroke Patients
- Trial name
- NCT07624630
- Testing
- No Interventions
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Karolinska Institutet
Swallowing Disorder, Dysphagia
Cross Cultural Validation of the Italian Version of the Clinical Assessment of Dysphagia in Neurodegeneration
The English version of the "Clinical Assessment of Dysphagia in Neurodegeneration" (CADN), represents a rapid and valid clinical assessment tool for dysphagia in neurodegenerative population.
- Conditions
- Swallowing Disorder, Dysphagia, Neuro-Degenerative Disease
- Trial name
- NCT05733494
- Testing
- Administration of Clinical Assessment of Dysphagia in Neurodegeneration (CADN)
- Where
- Italy
- Volunteers
- 101 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Alzheimer Disease, Neurodegenerative Diseases
Smell, Voice and Nasal Swabs as Markers for Neuro-degenerative Disorders
Degenerative dementias including Alzheimer's Disease (AD), Parkinson's Disease with Dementia (PDD), Dementia with Lewy Bodies (DLB), Frontotemporal Dementias (FTLD), Corticobasal Degeneration (CBD) and Progressive Supranuclear…
- Trial name
- NCT03299062
- Testing
- Cytology and Immunohistochemistry
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Arkansas
Friedreich Ataxia, Neuro-Degenerative Disease
FA Clinical Outcome Measures
This multicenter natural history study aims to expand the network of clinical research centers in FA, and to provide a framework for facilitating therapeutic interventions.
- Trial name
- FA-COMS (NCT03090789)
- Where
- 14 sites in United States, Australia and 3 more
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Friedreich's Ataxia Research Alliance