Clinical trials: Neurobiological
Sickle Cell Disease, Pain
Integrative Medicine in Pain Management in Sickle Cell Disease, 2.0
The proposed research is to determine the clinical efficacy and neurobiological mechanisms of acupuncture analgesia in patients with sickle cell disease.
- Conditions
- Sickle Cell Disease, Pain, Acupuncture, Quantitative Sensory Testing
- Trial name
- NCT06725550
- Testing
- needling acupuncture, laser acupuncture
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Anhedonia, Depression
A Neurobiological Model of Anhedonia
The purpose of this research study is to better understand anhedonia in Major Depressive Disorder by investigating the reward-related neural and inflammatory correlates.
- Trial name
- NCT05629520
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Alexithymia
Neurobiological, Neuropsychological,Linguistic and Gestural Processes and Phenomena in Individuals With Alexithymia
The syndrome of extremely restricted emotional competence, alexithymia, was originally conceptualized in psychoanalytic research and is now empirically and experimentally studied in clinical psychology and psychological medicine…
- Trial name
- ALEX (NCT00830752)
- Where
- Germany
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Drug Use
Neurobiological Substrate of Social Context on Cognitive Control in Drug Users
The aim of the present project is to reveal, using Functional Magnetic Resonance Imaging (fMRI) in drug users, a specific modulation of brain structures and circuits involved in cognitive control (and especially those of…
- Trial name
- STNdrugaddict (NCT03508362)
- Testing
- Functional Magnetic Resonance Imaging (fRMI)
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Autism Spectrum Disorder, Autism
Sensory Habituation in Autism Spectrum Disorders
Autism spectrum disorder (ASD) is one of the most common developmental disabilities and often people with ASD have sensory processing disorders.
- Conditions
- Autism Spectrum Disorder, Autism, Sensory Processing Disorder, Sensory Over-Responsivity
- Trial name
- ASD_VR_RE (NCT06247176)
- Testing
- Sensory Habituation Protocol
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Alcohol Use Disorder, Early Trauma Complications
Neurobiological Responses in Alcoholism and Early Trauma
Alcohol use disorder (AUD) accompanied by early trauma presents clinical challenges, including elevated rates of comorbid emotional symptoms and relapse.
- Trial name
- NCT04128228
- Testing
- 8-week outpatient treatment
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Yale University
Depression - Major Depressive Disorder, Irritability
Teen Vulnerability to Irritability: Brain and Estrogen Changes
Purpose: Risk of severe psychopathology increases dramatically during adolescence, especially for females. Changes in ovarian steroids across the menstrual cycle produce windows of vulnerability to mood disturbances, particularly…
- Trial name
- TeenVIBE (NCT07544966)
- Testing
- Kurvelo
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Schizophrenia, Schizoaffective Disorder
Cognitive Behavioral Social Skills Training in Early Onset Psychosis
Cognitive-behavioral therapy (CBT) and social skills training (SST) are recommended psychological interventions to improve symptomatology and functional recovery in psychosis.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Psychosis NOS
- Trial name
- NCT03261557
- Testing
- CBT + SST, Psychoeducation, habits and healthy lifestyle
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Adjustment Disorder With Work Inhibition
Neurobiological Effects of Work-related Adjustment Disorder
INTRODUCTION: Stress is one of the greatest burdens of our society and often imply impairments in cognitive and emotional functions.
- Trial name
- NeuroWAD (NCT03334045)
- Testing
- PET/MR scans
- Where
- Denmark
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Aging, Anxiety
Neurobiological Mechanisms of Aging and Stress on Prospective Navigation
Two hallmarks of both healthy aging and age-related disease are 1) memory and navigational deficits, particularly in orienting towards goal locations and planning how to navigate to them, and 2) increased susceptibility to stress…
- Conditions
- Aging, Anxiety, Memory Impairment
- Trial name
- NCT03896529
- Testing
- Anticipatory psychological stress
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Georgia Institute of Technology
Schizophrenia
Oxytocin and Social Decision Making in Schizophrenia
schizophrenia patients and healthy volunteers will be included. Subjects who meet the inclusion and exclusion criteria for the study will be recruited.
- Trial name
- NCT04176835
- Testing
- Oxytocin nasal spray
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health and Neuro Sciences, India
Major Depressive Disorder
Stress Dynamics and Familial Risk for Depression in Female Adolescents
Stress and a parental history of major depressive disorder (MDD) are among the strongest risk factors for future development of MDD.
- Trial name
- NCT06816329
- Testing
- Computer Task Manipulation
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Long COVID
Neurobiological Underpinnings of Neuropsychological Consequences in Long COVID
Objectives: To describe the standardized evaluation of the psychological and cognitive function of long COVID patients and their evolution, to compare immunological and HPA-axis related biomarkers between long COVID patients and…
- Trial name
- Cov-N-Psy (NCT06279936)
- Testing
- Neuropsychological battery, Surveys and symptom severity questionnaires, Blood withdrawal
- Where
- Belgium
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Cannabis Dependence, Cannabis Withdrawal
Clinical and Neurobiological Effects of Cannabis Dependence in Young Adults
The purpose of this study is to find out more about cognitive functioning in people who are cannabis dependent, relative to people who do not use cannabis, and how their brains process information after one month of not using…
- Trial name
- SCCAN (NCT00656487)
- Testing
- rimonabant
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- The Scripps Research Institute
Autism Spectrum Disorder (ASD)
Non-Helium Magnetoencephalography in Autism Spectrum Disorder
The goal of this observational study is to learn how brain activity in children with autism spectrum disorder (ASD) differs from typical developing children using magnetoencephalography (MEG).
- Trial name
- NCT07064967
- Testing
- Magnetoencephalography
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Guangzhou Women and Children's Medical Center
Unrecognized Condition
Deep Diaphragmatic Breathing: Neurobiological and Anti-inflammatory Effects
The exposure to acute and\or chronic stress can produce an activation of sympathetic nervous system (SNS), leading to an increased level of cortisol and pro-inflammatory cytokines.
- Trial name
- NCT04102813
- Testing
- Functional Therapy
- Where
- Italy
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo
Fibromyalgia
Neurophysiology of Fibromyalgia
Fibromyalgia is a syndrome associated with fatigue and chronic pain, leading to significant physical limitations and impaired quality of life.
- Trial name
- NCT06006130
- Testing
- Active Controlled Pulse Parameter Transcranial Magnetic Stimulation (cTMS)
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- McMaster University
Aging, Cognitive Function 1, Social
Effects of Physical and Cognitive Training in Neuroplasticity, Health and Cognition. Movement Project
The MoveMent project applies non-pharmacological strategies - physical exercise and cognitive training - that have been shown to be effective in promoting active and healthy aging.
- Trial name
- NCT03123900
- Testing
- Physical exercise, Cognitive training, Combined training
- Where
- Spain
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Barcelona
Mild Cognitive Impairment
Study of Neurobiological Predictors of Response to Non-invasive Neurostimulation and Genetic Susceptibility to Dementia in Patients With Amnestic Mild Cognitive Impairment
Transcranial Direct Current Stimulation is a non-invasive neuromodulatory technique that results in the clinical improvement of patients with Mild Cognitive Impairment, a prodromal condition for the onset of dementia.
- Trial name
- NCT04943003
- Testing
- Transcranial Direct Current Stimulation (tDCS)
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Suellen Marinho Andrade
Major Depressive Disorder 1, Major Depressive Disorder
The Neurobiological Fundaments of Depression and Its Relief Through Neurostimulation Treatments
The study will apply state of the art radiology through advanced magnetic resonance imaging (MRI) techniques to investigate structural and functional brain effects of electroconvulsive therapy (ECT) and repetitive transcranial…
- Conditions
- Major Depressive Disorder 1, Major Depressive Disorder, Healthy
- Trial name
- FundECT (NCT05135897)
- Testing
- Electroconvulsive therapy, rTMS
- Where
- Norway
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital