Clinical trials: Neurocognitive Decline
Cognitive Decline, Alzheimer Disease
Tau Pet Imaging in the Aging Brain Cohort Dedicated to Diversity Study
We will conduct a Tau PET scan in cognitively normal older adults, enrolled in the Aging Brain Cohort Dedicated to Diversity Study (ABCD2-Tau) study at the University of Pennsylvania's Penn Memory Center/Alzheimer's Disease Core…
- Trial name
- ABCD2-TAU (NCT05393388)
- Testing
- [18F]AV-1451
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Cognitive Decline, Cardiovascular Diseases
Cardiovascular Disease Cohort
The Cardiovascular Disease Cohort study is a prospective cohort study among cardiovascular disease patients enrolled in the Affiliated Hospital of Hangzhou Normal University.
- Trial name
- NCT05309824
- Where
- China
- Sponsor
- Westlake University
Alzheimer Disease, Cognitive Impairment
Multi-Center Study of Sensory Stimulation to Improve Brain Function
The Overture Study is a randomized, controlled, single-blind multi-center clinical trial using the GammaSense Stimulation system to study safety, tolerability, and efficacy in people with mild to moderate cognitive impairment.
- Conditions
- Alzheimer Disease, Cognitive Impairment, Mild Cognitive Impairment, Dementia Alzheimers
- Trial name
- Overture (NCT03556280)
- Testing
- GammaSense Stimulation System (Active Settings)
- Where
- 5 sites in United States
- Volunteers
- 60 people
- Sponsor
- Cognito Therapeutics, Inc.
Cognitive Dysfunction, Cognitive Decline
Broccoli Sprout Extract for Cognitive Function
This clinical trial aims to determine whether broccoli sprout extract improves cognitive function in adults with mild cognitive impairment and to assess its safety.
- Trial name
- NCT07334366
- Testing
- Broccoli sprout extract (BSE)
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Pusan National University Yangsan Hospital
Aging, Arterial Stiffness
Inorganic Nitrate Supplementation on Cerebrovascular Aging and Arterial Stiffness Study
This study investigates the effect of dietary inorganic nitrate supplementation on 1) large elastic artery stiffness and hemodynamics and 2) cerebrovascular function in middle-aged and older adults.
- Conditions
- Aging, Arterial Stiffness, Endothelial Dysfunction, Hypertension
- Trial name
- INCA (NCT03617302)
- Testing
- Experimental: Nitrate-containing
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Gary L. Pierce, PhD
Alzheimer's Type Dementia, Cognitive Decline
The Effectiveness of Global Postural Reeducation on Alzheimer Disease Patients
This research study is developed on an experimental design with randomized controlled intervention were participated 135 subjects with AD including 45 of the control group.
- Conditions
- Alzheimer's Type Dementia, Cognitive Decline, Postural; Strain
- Trial name
- GPR (NCT03732053)
- Testing
- GPR Intervention Research group
- Volunteers
- 135 people
- Sponsor
- Universidad Católica San Antonio de Murcia
Healthy
Effects of Vitamin D3 Supplementation on Cognitive Function in Community Dwelling Older Adults
Ireland is predicted to have the highest older adult population growth of any European Union country. A substantial economic and social challenge of this projected growth is the increased incidence of cognitive impairment and the…
- Trial name
- NCT02804841
- Testing
- Cholecalciferol -Vitamin D3
- Where
- Ireland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Dublin, Trinity College
Risk Behavior, Cognitive Decline
Intervention on Modifiable Lifestyle Risk Factors for Dementia Prevention
The overarching aim is to develop and deploy a multidomain intervention delivered on a mobile application to help older adults reduce their risk for dementia by improving a set of modifiable lifestyle risk factors associated with…
- Trial name
- NCT04616794
- Testing
- Cognitive Engagement Group, Physical Activity Group, Diet Group
- Where
- Canada
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- LuciLab
Alzheimer Disease
A Donanemab (LY3002813) Study in Participants With Preclinical Alzheimer's Disease (TRAILBLAZER-ALZ 3)
The main purpose of this study is to evaluate the safety and efficacy of donanemab in participants with preclinical Alzheimer's Disease (AD) over up to 332 weeks.
- Trial name
- NCT05026866
- Testing
- Donanemab
- Where
- 216 sites in United States, Japan and 1 more
- Volunteers
- 2,996 people
- Sponsor
- Eli Lilly and Company
Parkinson's Disease, PD
iPACES v3 MCI NIA Protocol Copied for iPACES v4 PD NINDS
The primary purpose of this study is to attempt to replicate and extend promising pilot findings regarding the cognitive benefits of in-home neuro-exergaming with iPACES (interactive Physical and Cognitive Exercise System v3) for…
- Conditions
- Parkinson's Disease, PD, Mild Cognitive Impairment, MCI
- Trial name
- iPACES-PD (NCT05810454)
- Testing
- iPACES (interactive Physical and Cognitive Exercise System), PACE (Physical and Cognitive Exercise)
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- iPACES LLC
Cognitive Decline
Effectiveness of Reminiscence Therapy Versus Cognitive Stimulation in Older Adults With Cognitive Decline
Although data suggest that non-pharmacologic therapies such as Reminiscence Therapy (RT) and Cognitive Stimulation (CS) can potentially maintain or reverse this trend, cognitive impairment can be a precursor to neurodegenerative…
- Trial name
- TRvsCS (NCT05187572)
- Testing
- Group intervention
- Where
- Portugal
- Volunteers
- 106 people
- Sponsor
- Paulo Costa
Asymptomatic Intracranial Stenosis, Cognitive Impairment
Cognitive Decline and Underlying Mechanisms in Asymptomatic Intracranial Artery Stenosis Patients
The purpose of this study is to explore the mechanism of cognitive impairment in patients with asymptomatic intracranial atherosclerotic stenosis(ICAS),and to examine the natural history and the pathogenesis of asymptomatic ICAS.
- Conditions
- Asymptomatic Intracranial Stenosis, Cognitive Impairment, Cerebrovascular Event
- Trial name
- NCT05504330
- Testing
- Aspirin Tablet, Clopidogrel Bisulfate Tablets and Atorvastatin
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Anhui Medical University
Cognitive Dysfunction, Cognition Disorders
Multiple Interventions to Prevent Cognitive Decline
The investigators aim to test the feasibility of a pragmatic non-pharmacological strategy, that may prevent cognitive decline in patients with mild cognitive impairment.
- Conditions
- Cognitive Dysfunction, Cognition Disorders, Memory Disorders
- Trial name
- MIND (NCT04079075)
- Testing
- Cognitive training, Physical activity, Nutrition education
- Where
- Portugal
- Volunteers
- 50 people
- Sponsor
- Universidade do Porto
Dementia, Mild Cognitive Impairment (MCI)
Comprehensive Assessment of Neurodegeneration and Dementia
This is a longitudinal observational study recruiting individuals between the ages of 50 and 90 with different types of dementia as well as a comparison group without cognitive deficits.
- Conditions
- Dementia, Mild Cognitive Impairment (MCI), Subjective Cognitive Impairment, Parkinson's Disease (PD)
- Trial name
- COMPASS-ND (NCT03402919)
- Where
- 19 sites in Canada
- Volunteers
- 1,573 people, healthy volunteers welcome
- Sponsor
- McGill University
Meningioma, Skull Base Meningioma
Cognitive Status After Removal of Skull Base Meningioma
The purpose of this prospectively enrolling trial is to assess long-term cognitive outcomes of patients undergoing surgery for resection of a meningioma associated with the frontal and temporal lobes.
- Conditions
- Meningioma, Skull Base Meningioma, Frontal Meningioma, Temporal Meningioma
- Trial name
- NCT04635657
- Testing
- Long-term Cognitive testing
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Ohio State University
Functional Ability, Cognitive Decline
Caregiver Training: Evidence of Its Effectiveness for Cognitive and Functional Improvement in Older Adults
Due to demographic changes that have resulted in an aging population, the role of caregiver of an older adult has become very important in recent years.
- Conditions
- Functional Ability, Cognitive Decline, Older Adults, Healthy Aging
- Trial name
- NCT04490070
- Testing
- Cognitive Stimulation
- Where
- 10 sites in Spain
- Volunteers
- 160 people
- Sponsor
- Universidad de Granada
Rheumatoid Arthritis, Pain
Effect of Antiinflammatory Treatment Versus Hand Training on Neuropsychiatric Comorbidity in RA-patients
The purpose of this study is to investigate how RA affect the brain structures in RA-patients and if anti-inflammatory treatment that target TNF-α or JAK OR physical training of hands has positive impact on neuropsychiatric…
- Conditions
- Rheumatoid Arthritis, Pain, Fatigue, Cognitive Decline
- Trial name
- NeuMRA (NCT04378621)
- Testing
- TNF-α inhibitor OR JAK inhibitor, Hand training
- Where
- Sweden
- Volunteers
- 212 people
- Sponsor
- Vastra Gotaland Region
Mild Cognitive Impairment
Investigating the Efficacy of Ergothioneine to Delay Cognitive Decline (Pilot)
With the growing burden of dementia (including Alzheimer's disease), and the lack of efficacious therapies, there is an urgent need to identify new therapeutics.
- Trial name
- NCT03641404
- Testing
- L-ergothioneine
- Where
- Singapore
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Cognitive Dysfunction
Fluoxetine Prevention Trial
Many cancer survivors are experiencing problems with memory and other cognitive abilities following cancer treatment. Little is known concerning the contributions of potentially preventive therapies on cognitive function, but…
- Trial name
- NCT01615055
- Testing
- Fluoxetine
- Where
- 2 sites in United States
- Sponsor
- University of California, Los Angeles
Traumatic Brain Injury, Cognitive Decline
Cognitive and Vascular Functioning Following TBI
This observational study will examine the association of chronic traumatic cerebrovascular injury and cardiovascular risk factors with TBI-related cognitive impairment and vascular dementia.
- Conditions
- Traumatic Brain Injury, Cognitive Decline, Vascular Dementia
- Trial name
- NCT06034509
- Testing
- No intervention. This is an observational study.
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Walter Reed National Military Medical Center