Clinical trials: Neurocognitive Decline
Chronic Rhinosinusitis, Sleep Disorders
Sleep Disturbance and Daytime Fatigue as Predictors of Cognitive Decline and Functional Decline in Chronic Rhinosinusitis
FOCUS-CRS is a cross-sectional observational study examining the relationship between sleep disturbance, daytime fatigue, and cognitive and functional health in patients with chronic rhinosinusitis (CRS).
- Conditions
- Chronic Rhinosinusitis, Sleep Disorders, Fatigue, Cognitive Dysfunction
- Trial name
- SNOOZE-CRS (NCT07242040)
- Testing
- Self-Reported Questionnaires for Sleep, Fatigue, and Quality of Life
- Where
- Egypt
- Volunteers
- 134 people
- Sponsor
- Sinai University
Postoperative Delirium, Elderly Patient
Diagnosis, Incidence and Consequences of PACU-Delirium
This study aims to 1. determine sensitivity and specificity of the Confusion Assessment Method for Postanesthesia Care Unit (CAM-PACU) 2.
- Conditions
- Postoperative Delirium, Elderly Patient, Cognitive Decline
- Trial name
- PADE-DIC (NCT04978870)
- Where
- Germany
- Volunteers
- 450 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Cognitive Impairment, Alzheimer Disease
The SINgapore GERiatric Intervention Study to Reduce Cognitive Decline and Physical Frailty (SINGER) Study
A study in Finland found that a multidomain intervention of physical activity, nutritional guidance, cognitive training, social activities and management of vascular risk factors slowed cognitive decline in healthy older adults…
- Conditions
- Cognitive Impairment, Alzheimer Disease, Vascular Cognitive Impairment, Dementia
- Trial name
- SINGER (NCT05007353)
- Testing
- Structured Lifestyle Intervention, Self-Guided Intervention
- Where
- 3 sites in Singapore
- Volunteers
- 1,212 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Cerebral Small Vessel Disease, Stroke
Neurophysiological and Behavioral Study of the Cognitive Deficits Associated With Cerebral Small Vessel Disease in the SHIVA Cohort. SHIVA-CogNeurophys
Cerebral small vessel disease (cSVD) is characterized by an alteration of the structure and function of small penetrating brain arteries.
- Conditions
- Cerebral Small Vessel Disease, Stroke, Cognitive Complaint
- Trial name
- SHIVA-CogNeuro (NCT07068620)
- Testing
- Home-based cognitive training
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Bordeaux
Subjective Cognitive Decline, Alzheimer Dementia
Davos Alzheimer's Collaborative Healthcare System Preparedness to Increase Cognitive Assessment Rates for Older Adults
In this study the investigators explore a pragmatic strategy to increase cognitive screening rates in the community. The investigators will compare the monetary value of different combinations of SCD questionnaires, digital…
- Trial name
- NCT06191952
- Testing
- Cognigram, Subjective cognitive decline questionnaire (SCD-Q), blood-based biomarkers
- Where
- Germany
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Bilateral Salpingo-oophorectomy
Sleep in Women With Bilateral Salpingo-Oophorectomy
The purpose of this research study is the compare objective and subjective sleep characteristics in women who have undergone removal of both ovaries (bilateral salpingo-oophorectomy) before natural menopause compared to women who…
- Trial name
- NCT04565158
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Memory Disorders in Old Age
Improving Working Memory in Older Adults
The research program will evaluate the theoretical claim that age-related memory and cognitive decline in humans result from the inefficient orchestration of rhythmic activity within large-scale cortical networks.
- Trial name
- NCT04362696
- Testing
- High definition transcranial electrical current stimulation
- Where
- United States
- Volunteers
- 964 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Cognitive Decline, Cognitive Impairment
Effects of Cognitive Intervention on Cognition, Mobility and Brain Electrocortical Activity
Within this project the investigators tested the effectiveness of 2-month of computerized cognitive training (CCT) on CogniFit online platform on 77 older adults, which were randomly divided into intervention and control group.
- Conditions
- Cognitive Decline, Cognitive Impairment, Aging, Motor Coordination or Function
- Trial name
- GIBKOP (NCT03860441)
- Testing
- Computerized cognitive training
- Where
- Slovenia
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Science and Research Centre Koper
Alzheimer Disease (AD)
Tributyrin Treatment in Mild Alzheimer Disease: Assessment of Butyrate Effects Via the Gut-Brain
The goal of this clinical trial is to learn if tributyrin can help prevent or mitigate cognitive decline in individuals with mild Alzheimer's disease (AD).
- Trial name
- TRIM-GUT (NCT06797817)
- Testing
- tributyrin
- Where
- Spain
- Volunteers
- 156 people
- Sponsor
- Universidad de Almeria
Alzheimer Disease, Mild Cognitive Impairment
Longitudinal Study for the Characterization of the Phases of Subjective Perception of Cognitive Decline and Mild Cognitive Impairment of Alzheimer's Disease.
Alzheimer's disease (AD) is the leading cause of dementia and its prevalence is estimated to exceed 100 million affects by 2050, becoming the main public health problem worldwide.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Subjective Cognitive Decline
- Trial name
- NCT03851523
- Testing
- No intervention
- Where
- Spain
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
Cognitive Decline
Exercise Adherence and Cognitive Decline
The purpose of this study is to conduct a small-scale test of a goals-based program to help people to exercise more and learn what people like or don't like about the procedures.
- Trial name
- MOVE (NCT06769022)
- Testing
- Goal Setting and Exercise Intensity Intervention
- Where
- 3 sites in United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Type 2 Diabetes, Subjective Cognitive Decline
China Diabetes Cognitive Dysfunction Early Diagnosis and Intervention Study (China-DECODE Study)
Type 2 diabetes (T2D) and dementia are both diseases with increasing incidence and prevalence globally, leading to substantial economic burdens for families and society.
- Conditions
- Type 2 Diabetes, Subjective Cognitive Decline, Mild Cognitive Impairment, Dementia
- Trial name
- NCT06650969
- Testing
- Naturalistic observation
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Aging, Elderly
Successful Aging and Age-related Decline
Recent studies have shown promising cognitive and physical interventions aimed at slowing down ageing-related declines in quality of life, but they lack strong ecological validity (brief durations, unrealistic goals, no…
- Conditions
- Aging, Elderly, Cognitive Decline, Physical Decline
- Trial name
- MyAgeWell (NCT06376656)
- Testing
- Cognitive stimulation, Physical activity
- Where
- Malaysia
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Sunway University
Vestibular Function Disorder, Cognitive Decline
The Effect of Computerized Vestibular Function Assessment and Training System Combined With Cognitive/Motor Dual-task
This study aims to investigate the effect of computerized vestibular function assessment and interactive training system, combined with cognitive/motor dual-task for the elderly with dizziness.
- Conditions
- Vestibular Function Disorder, Cognitive Decline, Dizziness, Vestibular Abnormality
- Trial name
- NCT05990023
- Testing
- Traditional vestibule rehabilitation training, Dual-task vestibule rehabilitation training
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Dementia
Effects of Snoezelen Multisensory Therapy on Older Adults With Dementia
This randomized, controlled, longitudinal clinical trial investigates the effects of Snoezelen Multisensory Therapy (SMT) as an adjunct to standard therapy (ST) in older adults with dementia.
- Trial name
- SMT (NCT07657208)
- Testing
- Snoezelen Multisensory Therapy, Standard Therapy
- Where
- Slovenia
- Volunteers
- 63 people
- Sponsor
- University of Primorska
Frail Elderly Syndrome, Cognitive Impairment
Taiwan Health Promotion Intervention Study for Elders
Objectives: 1-year multidomain health promotion on prevention of physical and cognitive decline for community-living older people.
- Conditions
- Frail Elderly Syndrome, Cognitive Impairment, Cognitive Decline
- Trial name
- THISCE (NCT03056768)
- Testing
- Multidomain intervention, Active control
- Volunteers
- 1,080 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Alzheimer Disease
A Donanemab (LY3002813) Study in Participants With Preclinical Alzheimer's Disease (TRAILBLAZER-ALZ 3)
The main purpose of this study is to evaluate the safety and efficacy of donanemab in participants with preclinical Alzheimer's Disease (AD) over up to 332 weeks.
- Trial name
- NCT05026866
- Testing
- Donanemab
- Where
- 216 sites in United States, Japan and 1 more
- Volunteers
- 2,996 people
- Sponsor
- Eli Lilly and Company
Postoperative Cognitive Dysfunction, Coronary Artery Disease
Neuroinflammation in Cognitive Decline Post-cardiac Surgery
Major cardiovascular surgery is associated with postoperative cognitive decline (POCD), with a deterioration in memory, attention and speed of information processing.
- Conditions
- Postoperative Cognitive Dysfunction, Coronary Artery Disease, Pathophysiology
- Trial name
- FOCUS (NCT04520802)
- Testing
- 18F-DPA-714 PET/CT neuroimaging
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Radboud University Medical Center
Upper Extremity Dysfunction, Dementia
Upper Limb Reeducation Across Life Span
Program Ready2E.A.T. was developed to be tested in the upper limb reeducation on population at risk, such as: Children with dysfunction Cognitive impaired elderly Dementia people
- Conditions
- Upper Extremity Dysfunction, Dementia, Cerebral Palsy, Cognitive Decline
- Trial name
- ULReed (NCT03997591)
- Testing
- Ready2E.A.T. PROGRAM
- Where
- Portugal
- Volunteers
- 15 people
- Sponsor
- Instituto Politécnico de Leiria
Cognitive Decline, Cardiovascular Diseases
Cardiovascular Disease Cohort
The Cardiovascular Disease Cohort study is a prospective cohort study among cardiovascular disease patients enrolled in the Affiliated Hospital of Hangzhou Normal University.
- Trial name
- NCT05309824
- Where
- China
- Sponsor
- Westlake University