Clinical trials: Neurocognitive Decline
Brain Metastases, Neurocognitive Deficit
MRI Biomarkers for Radiation-Induced Neurocognitive Decline Following SRS of Newly Diagnosed Brain Mets
Brain metastases are a source of much morbidity and mortality in adults with primary solid malignant tumors. With improvements in systemic therapy that prolong survival but have limited central nervous system penetration…
- Conditions
- Brain Metastases, Neurocognitive Deficit, White Matter Alterations, Radiation Exposure
- Trial name
- NCT04073966
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Chronic Kidney Diseases, Cognitive Decline
Curcumin and Vascular and Cognitive Function in Patients With Chronic Kidney Disease
The proposed research is clinical study evaluating the therapeutic benefits of curcumin on vascular function in patients with chronic kidney disease (CKD).
- Trial name
- NCT03223883
- Testing
- Curcumin
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Diana Jalal
Postoperative Cognitive Dysfunction
Effects of Brain Beta-Amyloid on Postoperative Cognition
Postoperative cognitive decline (POCD) affects up to 50% of non-cardiac surgical patients greater than or equal to 65 years of age.
- Trial name
- NCT01606488
- Testing
- Florbetapir F 18 (18F-AV-45), no intervention
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of California, San Francisco
Cognitive Dysfunction ( MMSE < 24 )
Effects of tDCS on Cognitive Function in Older Adults With Subjective Cognitive Decline: Randomized Sham-Controlled Trial
This randomized, double-blind, sham-controlled clinical trial evaluates the effects of transcranial direct current stimulation (tDCS) using the Sooma Oy device on cognitive function in older adults with Subjective Cognitive…
- Trial name
- TDCSCOGSCDTRIA (NCT07531888)
- Testing
- Transcranial Direct Current Stimulation
- Where
- Mexico
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidad Autónoma del Estado de Hidalgo
Dementia, Neurocognitive Disorders
Effect of Individual Reminiscence Therapy in the Elderly People With Neurocognitive Disorders
This research aims to evaluate the ability of individual reminiscence therapy (RT), using a simple reminiscence format, to improve the overall cognitive function, memory, emotional status and quality of life (QoL) of older adults…
- Conditions
- Dementia, Neurocognitive Disorders, Cognitive Impairment, Cognitive Dysfunction
- Trial name
- NCT04658394
- Testing
- Reminiscence therapy
- Where
- 13 sites in Portugal
- Volunteers
- 122 people
- Sponsor
- Rsocialform - Geriatria, Lda
Mild Cognitive Impairment, Alzheimer Disease
The Effects of Intermittent Theta Burst Stimulation in MCI and Early AD
Transcranial magnetic stimulation (TMS) is a noninvasive brain stimulation technique that is increasingly used for a growing number of research and clinical applications.Typically, this transient magnetic field is focally applied…
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Cognitive Decline
- Trial name
- NCT04555941
- Testing
- intermittent theta burst stimulation
- Where
- Taiwan
- Volunteers
- 54 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Mild Cognitive Impairment, Older Adults
engAGE: Managing cognitivE decliNe throuGh Theatre Therapy, Artificial Intelligence and Social Robots drivEn Interventions
The objectives of the engAGE project are to counteract and slow down cognitive decline progression, to enhance the intrinsic capacity of the users, and to support the wellbeing of older persons with mild cognitive impairment…
- Trial name
- engAGE (NCT06302686)
- Testing
- engAGE system, Group practicing with only the support of a booklet
- Where
- 3 sites in Italy, Norway and 1 more
- Volunteers
- 78 people
- Sponsor
- Istituto Nazionale di Ricovero e Cura per Anziani
Postoperative Cognitive Dysfunction
Evaluation of the Ketogenic Diet to Improve Post Operative Cognitive Decline in Cardiac Surgery
Postoperative cognitive decline (POCD) is a significant neurological problem that commonly follows coronary artery bypass grafting surgery (CABG) in elderly patients.
- Trial name
- NCT06480708
- Testing
- Ketogenic diet, Control diet
- Where
- United States
- Sponsor
- University of Missouri-Columbia
Dementia in Nursing Home
Impact of Systematic Tracking of Dementia Cases on the Rate of Hospitalization in Emergency Care Units
Introduction: Epidemiological data show that in France only half of patients with Alzheimer disease are currently diagnosed in the general population.
- Trial name
- IDEM (NCT01569997)
- Testing
- MultiDisciplinary Team Meetings (MDTM)
- Where
- 90 sites in France
- Volunteers
- 1,428 people
- Sponsor
- University Hospital, Toulouse
Gait Disorders, Neurologic
Gait Disorders in Patients With Cognitive Decline
The prevalence of neurodegenerative diseases will increase over the next decades driven by ageing population. It seems important to develop reliable, replicable and accessible diagnostic tools.
- Trial name
- NCT03399591
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Covid19, Corona Virus Infection
Safety, Tolerability and Pharmacokinetics of Inhaled Nanoparticle Formulation of Remdesivir (GS-5734) and NA-831
The clinical study is designed to evaluate the safety, tolerability and pharmacokinetics of inhaled nanoparticle nanoparticle formulation of Remdesivir (GS-5734) alone and in combination with NA-831 in 48 healthy volunteers.
- Conditions
- Covid19, Corona Virus Infection, Severe Acute Respiratory Syndrome, Severe Acute Respiratory Infection
- Trial name
- NEUROSIVIR (NCT04480333)
- Testing
- Drug: NA-831 - 0.10 mg/kg, Drug: NA-831 - 0.20 mg/kg, Drug: GS-5734 - 1.00 mg/kg
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Biomed Industries, Inc.
Mild Cognitive Impairment (MCI), Dementia
An Insole and Ankle Device for Monitoring Cognitive Decline in Individuals at Risk for Alzheimer's Disease and/or Alzheimer's Disease Related Dementias (AD/ADRD)
This study tests an innovative system and service for collecting objective, consistent, and in-community gait parameters suitable for use as AD/ADRD biomarkers.
- Trial name
- NCT07127133
- Testing
- Insole and ankle device
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- HealthPartners Institute
Breast Cancer, Cognitive Decline
Cognitive Stimulation and Chemobrain. An Innovative Intervention for Cancer Survivors
The present study aims to establish a non-pharmacological alternative in alleviating cognitive deterioration derived from undergoing chemotherapy treatment.
- Trial name
- NCT05409248
- Testing
- Personalized cognitive stimulation
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Universidad Antonio de Nebrija
Glucose Metabolism Disorders (Including Diabetes Mellitus), Cognitive Decline
Glucose Variability and Cognition in Prediabetes
This study examines the association of variability in glucose values over a 10-day period with cognitive function and AD risk markers among individuals with prediabetes, aged 50 or older.
- Conditions
- Glucose Metabolism Disorders (Including Diabetes Mellitus), Cognitive Decline, PreDiabetes, Aging
- Trial name
- NCT04201600
- Testing
- Continuous Glucose Monitoring System (CGMS)
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Epilepsy, Cognitive Decline
Influence of Non-invasive Neurostimulation (Transcutaneous Vagus Nerve Stimulation) on 1. the Noradrenergic Release in the Brain and 2. a Neuropsychological Memory Task
The goal of this study is to investigate the influence of transcutaneous vagus nerve stimulation 1. on the noradrenergic system in the brain and 2. on memory, in healthy volunteers.
- Trial name
- NCT02409069
- Testing
- Transcutaneous vagus nerve stimulation (Nemos®, Cerbomed GmbH)
- Where
- Belgium
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Cognitive Decline, Mild Cognitive Impairment
PRedicting the EVolution of SubjectIvE Cognitive Decline to Alzheimer's Disease With Machine Learning
Alzheimer's disease (AD) has a presymptomatic course which can last from several years to decades. Identification of subjects at an early stage is crucial for therapeutic intervention and possible prevention of cognitive decline.
- Conditions
- Cognitive Decline, Mild Cognitive Impairment, Alzheimer Disease
- Trial name
- PREVIEW (NCT05569083)
- Testing
- Genetic analysis of APOE and BDNF genes., EEG recording, CSF collection and AD biomarker measurement
- Where
- 4 sites in Italy
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Breast Cancer, Locally Advanced Breast Cancer
Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline During Chemotherapy in Breast Cancer
This randomized, placebo-controlled trial aims to assess the feasibility, acceptability, and preliminary efficacy of memantine and the University of Carolina (UNC)'s Get Real \& Heel cancer exercise program (MEM+EX) in addressing…
- Conditions
- Breast Cancer, Locally Advanced Breast Cancer, Cognitive Impairment, Cognitive Decline
- Trial name
- NCT06727773
- Testing
- Memantine, Exercise Intervention, Exercise Control
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Mild Cognitive Impairment, Mild Dementia
Assessing Cognitive Decline at Home
Neuropsychiatric symptoms (NPS) refer to a range of mental and emotional issues that can be observed through how patients move, perform daily tasks, and express feelings on their faces.
- Conditions
- Mild Cognitive Impairment, Mild Dementia, Dementia Alzheimers, Dementia
- Trial name
- NCT06704971
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Stanford University
Cognitive Impairment, Cognitive Decline
Personalized Virtual Reality Naturalistic Scenarios in Cognitive Impairment
The goal of this feasibility study is to investigate the feasibility of a personalized naturalistic Virtual Reality scenario by assessing motion-sickness effects, engagement, pleasantness, and emotions felt considering a sample…
- Conditions
- Cognitive Impairment, Cognitive Decline, Cognitive Deterioration, Anxiety State
- Trial name
- NCT05863065
- Testing
- Exposure to a Virtual Reality scenarios
- Where
- 2 sites in Italy
- Volunteers
- 23 people
- Sponsor
- University of Padova
Cognitive Decline
Cognitive Training and Social Interaction Effects on Cognitive Performance of Older Adults
Aging is associated with a decline in almost all aspects of cognitive functions, particularly memory. Recent research suggests that combining cognitive training with ongoing social interaction may aid in improving cognitive…
- Trial name
- NCT05016336
- Testing
- Social interaction combined with cognitive training based on mnemonic strategies., Social interaction group
- Where
- Israel
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Bar-Ilan University, Israel