Clinical trials: Neurocognitive Decline
Mild Cognitive Impairment, Alzheimer Disease (AD)
Microbiome in Aging of Gut and Brain
The Microbiome in Aging Gut and Brain (MiaGB) Study is an observational study designed to examine whether differences in the microorganisms living in the gut and mouth are associated with cognitive health and cognitive decline.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease (AD), Dementia
- Trial name
- MiaGB (NCT07799402)
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Alzheimer Disease, Cognitive Decline
Cognitive Decline and Alzheimer's Disease in the Dallas Lifespan Brain Study
The investigators will conduct tau positron emission tomography (PET) scans on 125 adults using the radiopharmaceutical Flortaucipir F18 ([18F]AV-1451).
- Trial name
- NCT04080544
- Testing
- [18F]AV-1451, Positron Emission Tomography
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Neil M Rofsky, MD, MHA
Delirium in Old Age, Cognitive Decline
Informant Questionaire on Cognitive Decline in the Elderly (IQCODE) and Delirium in Geriatric Patients
To investigate the usefulness of the Informant Questionaire on Cognitive Decline in the Elderly (IQCODE) to predict delirium in elderly patients admitted to Emergency Department (ED) with geriatric assessment and transferred to…
- Trial name
- Delirium (NCT03175276)
- Where
- Denmark
- Volunteers
- 315 people
- Sponsor
- Aarhus University Hospital
Cognitive Decline, Aging
Multiple Joint, Structural Barbell Resistance Exercise Improves Information Processing Speed
This study investigated the effect of acute multiple joint, structural barbell resistance exercise on information processing speed and conflict-related neural activity in older adults via a crossover, sham control, randomized…
- Trial name
- NCT04534374
- Testing
- Resistance exercise
- Where
- Taiwan
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- National Taiwan Normal University
Delirium, Cognitive Impairment
Redesigning the Surgical Pathway (PROMoTE)
Cognitive complications, that is problems with thinking and memory, are incredibly common after surgery, occurring in 10-50% of all older surgical patients.
- Conditions
- Delirium, Cognitive Impairment, Perioperative/Postoperative Complications, Cognitive Dysfunction
- Trial name
- PROMoTE (NCT05114876)
- Testing
- Multicomponent delirium-risk prevention bundle
- Where
- Canada
- Volunteers
- 260 people
- Sponsor
- Sunnybrook Health Sciences Centre
Alzheimer's Disease(AD), Mild Cognitive Impairment (MCI)
InRAD Observational Study
The goal of this international observational study is to evaluate long-term disease outcomes and treatment safety in people with Alzheimer's disease (PwAD), by collecting real-world data from routine clinical practice across…
- Conditions
- Alzheimer's Disease(AD), Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD), Non-Alzheimer Degenerative Dementia
- Trial name
- InRAD (NCT07213700)
- Testing
- None, this is a non-interventional observational study
- Where
- 23 sites in Australia, Austria and 15 more
- Volunteers
- 50,000 people
- Sponsor
- Stichting International Registry for Alzheimer's Disease and other Dementias Foundation
Dementia, Dementia Alzheimers
On Site Sensors Monitoring Impacts of Cognitive Decline on ADLs
The purpose of this research is to compare the effectiveness of a continuous monitoring system to assess Activities of Daily Living (ADLs) over time compared to the traditional assessments used by medical professionals as…
- Trial name
- NCT04871698
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- National Institute on Aging (NIA)
Aging, Cognitive Decline
Social and Cognitive Online Training: the SCOT Project
Social isolation and reduced involvement in cognitive activities are associated with repercussions on cognitive well-being and health status in elderly adults.
- Trial name
- SCOT (NCT05023187)
- Testing
- SCOT, CON
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Università degli Studi di Trento
Subjective Cognitive Decline (SCD), Alzheimer's Disease
Art of Memory for Cognitive Enhancement in the Monza Brain Health Service
The goal of this pilot interventional clinical trial (non-drug study) is to learn whether memory techniques (mnemonics) can improve cognitive performance in adults over 50 years old with subjective cognitive decline who are…
- Conditions
- Subjective Cognitive Decline (SCD), Alzheimer's Disease, Cognitive Enhancement
- Trial name
- MEMO (NCT07479914)
- Testing
- Art of memory classes, General information on art of memory
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- University of Milano Bicocca
Cognitive Impairment, Cognitive Decline
Music Therapy for Older Adults With Cognitive Decline Living in Care Homes
This research aims to investigate whether the use of music-improvisation therapy for older adult participants can lead to improvements in cognitive ability levels, especially in attentional functions.
- Trial name
- NCT05856604
- Testing
- Music Therapy, Storytelling
- Where
- United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Middlesex University
Healthy
Diet and the Aging Brain
We investigate whether a change in diet could provide positive effects on general brain functions in healthy elderly people.
- Trial name
- NCT00463255
- Testing
- diet
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital Muenster
Cognitive Decline
CURATE.AI COR-Tx Trial for Post Brain Radiotherapy Patients
Cognitive deficit is common in patients who have undergone whole brain or partial brain radiotherapy. To counteract intellectual deterioration, the conventional strategies includes drug- based treatments such as donezepil and…
- Trial name
- NCT04848935
- Testing
- CURATE.AI
- Where
- 2 sites in Singapore
- Volunteers
- 15 people
- Sponsor
- National University Hospital, Singapore
Cognitive Decline
TRIAD - Tracking Risk in Integrated Alzheimer's Diagnostics.
The study is based on the hypothesis that the integration of biological, psychological, and social factors, according to the biopsychosocial paradigm, allows for more accurate identification of the different stages of the…
- Trial name
- TRIAD (NCT07399418)
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Dementia, Postoperative Delirium (POD)
Prediction and Prevention of Postoperative Mortality and Morbidity
This study will contribute to creating a prospective and automated preoperative risk assessment algorithm for predicting 30-day mortality, major adverse cardiac and cerebrovascular events (MACCE), and postoperative neurocognitive…
- Conditions
- Dementia, Postoperative Delirium (POD), Postoperative Neurocognitive Disorder, Major Adverse Cardiac and Cerebrovascular Events
- Trial name
- NCT06042413
- Testing
- Personalized CPC Prehabilitation, Cognitive Training, Meditation
- Where
- 5 sites in United States
- Volunteers
- 1,200 people
- Sponsor
- University of Pittsburgh
Frail Elderly Syndrome, Cognitive Impairment
Taiwan Health Promotion Intervention Study for Elders
Objectives: 1-year multidomain health promotion on prevention of physical and cognitive decline for community-living older people.
- Conditions
- Frail Elderly Syndrome, Cognitive Impairment, Cognitive Decline
- Trial name
- THISCE (NCT03056768)
- Testing
- Multidomain intervention, Active control
- Volunteers
- 1,080 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Subjective Cognitive Decline (SCD)
An Open Label Trial Evaluating the Efficacy of Lacticaseibacillus Paracasei PS23 on Cognition
This open label study aims to evaluate whether the consumption of probiotics can improve symptoms and overall quality of life in individuals experiencing cognitive decline symptoms, as well as to evaluate the effects of…
- Trial name
- NCT07168824
- Testing
- Lacticaseibacillus paracasei
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Chi-Chang Huang
Alzheimer's Disease (AD), Dementia
δ in Dementia Clinical Trials
The goal of this clinical trial is to demonstrate potential improvements in clinical trial methods relating to dementia and cognitive decline.
- Conditions
- Alzheimer's Disease (AD), Dementia, Cognitive Decline, Mild Cognitivie Impairment (MCI)
- Trial name
- δND (NCT05592678)
- Testing
- Donepezil
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Huntington Disease
TEsting METformin Against Cognitive Decline in HD
Multicenter, randomized, double-blind, placebo-controlled, parallel group study to assess the efficacy and safety of metformin treatment at a dose of 1700 mg / day in adults with Huntington's disease.
- Trial name
- TEMET (NCT04826692)
- Testing
- Metformin
- Where
- 9 sites in Spain
- Volunteers
- 60 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Cognitively Normal Older Adults, Hypertension
Impact of Intensive Treatment of SBP on Brain Perfusion, Amyloid, and Tau (IPAT Study)
The purpose of this study is to determine if intensive lowering of systolic blood pressure (SBP), using FDA approved medications (antihypertensive), reduces Alzheimer's Disease pathology (i.e., excessive brain amyloid and tau…
- Conditions
- Cognitively Normal Older Adults, Hypertension, Subjective Cognitive Decline, Family History of Dementia
- Trial name
- IPAT (NCT05331144)
- Testing
- Angiotensin II Receptor Blockers (ARBs, losartan) and Calcium Channel Blockers (CCB, amlodipine), PCP
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Rong Zhang
Brain Metastases, Neurocognitive Deficit
MRI Biomarkers for Radiation-Induced Neurocognitive Decline Following SRS of Newly Diagnosed Brain Mets
Brain metastases are a source of much morbidity and mortality in adults with primary solid malignant tumors. With improvements in systemic therapy that prolong survival but have limited central nervous system penetration…
- Conditions
- Brain Metastases, Neurocognitive Deficit, White Matter Alterations, Radiation Exposure
- Trial name
- NCT04073966
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center