Clinical trials: Neurocognitive Decline
Heart Failure, Congestive
Heart Failure, Functional and Cognitive Decline, and Psychiatric Symptoms in Nursing Home Patients
Heart failure is very common in the elderly, in whom it may lead to functional and intellectual problems. Functional problems include loss in the ability to perform basic tasks of daily living such as bathing or dressing.
- Trial name
- NCT00182065
- Where
- Canada
- Volunteers
- 586 people
- Sponsor
- McMaster University
Frail Elderly Syndrome, Mood
FOCUS Guidelines and Adherence to Physical Activity in Ageing Women.
The study aimed at assessing whether the guidelines from the European project FOCUS had an effect on adherence to a physical activity program in older women.
- Conditions
- Frail Elderly Syndrome, Mood, Quality of Life, Cognitive Decline
- Trial name
- NCT03981965
- Testing
- Physical activity
- Where
- Spain
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Dementia
Treatment With Namenda in Women at Risk for Cognitive Decline
This research aims to explore the effectiveness of memantine (Namenda) in treating post-menopausal women between the ages of 50 and 65, who are at risk for cognitive decline.
- Trial name
- NCT00242632
- Testing
- Namenda
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Stanford University
Mild Cognitive Impairment
Dietary Supplement for the Prevention of Cognitive Decline in a Very Elderly Population.
The purpose of this study is to determine whether an omega-3 fatty acid supplementation is effective in the prevention of progressive cognitive decline in elderly people aged 75 years or older.
- Trial name
- NCT01817101
- Testing
- Omega-3 fatty acid supplementation
- Where
- 3 sites in Spain
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Cerebral Amyloid Angiopathy, CAA - Cerebral Amyloid Angiopathy
Effect of the Mediterranean Diet in Patients Affected by CADASIL and Cerebral Amyloid Angiopathy.
The study is divided into two phases: Phase 1 (observational) and Phase 2 (dietary intervention). The goal of Phase 1 is to assess the nutritional status and dietary habits of two cohorts of patients with CADASIL and CAA.
- Trial name
- DIETETICA (NCT06933212)
- Testing
- Mediterranean Diet with Extra Virgin Olive Oil, Mediterranean Diet with Walnuts, Low-Fat Control Diet
- Where
- Italy
- Volunteers
- 86 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Aging, Cognitive Decline
Fortifying Healthy Behaviors, Optimizing Medical Therapies and Enhancing Cognitive Function in Older Adults-pilot Study
The purpose of this research study is to explore ways to improve motor, cognitive and immune functions for aging adults using multiple techniques like lifestyle changes and risk factor management, as well as medications and…
- Conditions
- Aging, Cognitive Decline, Older Adults, Cardiovascular
- Trial name
- FOES (NCT07000734)
- Testing
- Risk managment, Dasatinib, Quercetin (dietary supplement)
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Washington University School of Medicine
Dementia, Alzheimer Disease
The Music, Sleep and Dementia Study
The specific aims of this studyare to examine the 1) feasibility; 2) acceptability; and 3) preliminary efficacy of a tailored music intervention in home-dwelling older adults with dementia suffering from sleep disruption.
- Conditions
- Dementia, Alzheimer Disease, Circadian Rhythm Disorders, Circadian Rhythm Sleep Disorder
- Trial name
- NCT04157244
- Testing
- Tailored music listening intervention
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Cancer, Prostate Cancer
Physicians' Health Study II
The use of vitamin E, vitamin C, beta carotene, and/or multivitamins may keep cancer, cardiovascular disease, eye diseases, or cognitive decline from occurring.
- Conditions
- Cancer, Prostate Cancer, Colorectal Cancer, Cardiovascular Disease
- Trial name
- PHS II (NCT00270647)
- Testing
- Vitamin E, Vitamin C, Multivitamin
- Volunteers
- 14,641 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Cerebral Small Vessel Diseases
Clinical Observation for the Therapeutic Effect of mNGF on Cognitive Decline in Cerebral Small Vessel Disease
This study was a multicenter, prospective, randomized controlled trial. In this study, 510 patients with cognitive impairment of cerebral small vessel disease who met the inclusion criteria are randomly included in multiple…
- Trial name
- NCT04041349
- Testing
- mouse nerve growth factor
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zhujiang Hospital
Cognitive Decline, Aging
Zinde Zihin Program to Reduce Alzheimer's Disease Risk in Adults Aged 65 and Older
This study aims to evaluate the feasibility and implementation of the Zinde Zihin ("Fit Mind") multidomain lifestyle program for older adults aged 65 years and older living in public nursing homes.
- Conditions
- Cognitive Decline, Aging, Alzheimer Disease
- Trial name
- ZZ-MIND (NCT07244848)
- Testing
- Zinde Zihin (Fit Mind) Multidomain Lifestyle Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Burdur Mehmet Akif Ersoy University
Physical Function, Cognitive Decline
Face-to-face vs Online Physical Exercise in Seniors Living in Nursing Homes (ExerMOT-NH)
The benefits of multicomponent physical exercise (MPE) in the mental and physical health of older adults are widely accepted. However, during Covid19 pandemic, some face-to-face programs for physical exercise were canceled.
- Conditions
- Physical Function, Cognitive Decline, Psychological Well-Being
- Trial name
- ExerMOT-NH (NCT06352749)
- Testing
- Advice to increase physical activity and reduce sedentary behavior, Online Physical Exercise, Face-to-Face Exercise
- Where
- 4 sites in Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of the Basque Country (UPV/EHU)
Neoplasm, Colorectal, Cognitive Impairment
Cognitive Impairment in Colorectal Cancer Patients Receiving Cytotoxic Chemotherapy
The purpose of this research study is to see how the brain changes in patients receiving chemotherapy (cytotoxic drug) treatment for colon or rectal cancer at Parkview Cancer Institute.
- Conditions
- Neoplasm, Colorectal, Cognitive Impairment, Cognitive Dysfunction, Cognitive Change
- Trial name
- Chemo Brain (NCT05014399)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Joseph McCollom
Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD)
LETHE-AT: a Personalized Multidomain Lifestyle Intervention for Individuals at Increased Risk of Memory Impairment.
The goal of this clinical trial is to learn whether a hybrid multidomain lifestyle program can prevent cognitive decline and reduce dementia risk in community-dwelling adults in mid- to late life who are at increased risk of…
- Trial name
- LETHE-AT (NCT07376135)
- Testing
- A tailored hybrid multidomain lifestyle intervention group, Self-guided multimodal lifestyle advice group
- Where
- 3 sites in Austria
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Anesthesia, General, Recovery Period, Anesthesia
Recovery From General Anesthesia
General anesthesia allows people to have surgery without experiencing the procedure or pain. To remain unconscious, the depth of sleep must be monitored.
- Trial name
- NCT00165971
- Testing
- BIS monitoring
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Emory University
Cognitive Decline
Vitamin B12 Supplement to Prevent Cognitive Decline
Background: Older diabetic people are at greater risk of cognitive decline than non-diabetic people. Vitamin B12 deficiency in older people is associated with cognitive impairment and Alzheimer's disease.
- Trial name
- NCT02457507
- Testing
- Vitamin B12
- Where
- China
- Volunteers
- 271 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Chronic Kidney Diseases, Dementia
BRINK (BRain In Kidney Disease) Memory Study 2.0
In this study, the investigators will be looking at results of tests of memory and thinking and daily activities in a group of people without known chronic kidney disease (CKD) , and a group of CKD patients, and follow the…
- Conditions
- Chronic Kidney Diseases, Dementia, Dementia, Vascular, Stroke
- Trial name
- BRINK (NCT04975464)
- Where
- 2 sites in United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Anne Murray
Alzheimer Disease
Application of TMS Coupled With VR for Slowing the Rate of Cognitive Decline in Patients With Alzheimer's Disease
This is a randomized sham control study to evaluate how repetitive Transcranial Magnetic Stimulation (rTMS), interactive cognitive training, or the combination of rTMS and cognitive training reduce the cognitive decline of…
- Trial name
- TMS_AD (NCT04440891)
- Testing
- TMS stimulation with X-Torp task, TMS-Stimulation with MindMotion Go
- Where
- United States
- Sponsor
- Ali Rezai
Stroke, Cognitive Decline
Brain Activation Pattern Caused by Immersive Virtual Reality Pathfinding Task in Stroke Patients: an FNIRS Study
This is an fNIRS study performed to investigate Brain Activation Pattern Caused by Immersive Virtual Reality Pathfinding Task in Stroke Patients.
- Trial name
- NCT06703320
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Dingqun Bai
Alzheimer Disease
Comparative Efficacy, Safety, and Tolerability of Rivastigmine 10 and 15 cm^2 Patch in Patients With Alzheimer's Disease (AD) Showing Cognitive Decline
The purpose of this study was to support the optimal use of rivastigmine patch in long-term treatment of Alzheimer's Disease in patients demonstrating functional and cognitive decline at the target maintenance dose of…
- Trial name
- NCT00506415
- Testing
- Rivastigmine 5 cm^2, Rivastigmine 10 cm^2, Rivastigmine 15 cm^2
- Where
- 145 sites in United States, Canada and 5 more
- Volunteers
- 1,584 people
- Sponsor
- Novartis Pharmaceuticals
Postoperative Cognitive Dysfunction
Modafinil to Prevent Postoperative Cognitive Decline
Postoperative cognitive dysfunction is a well-recognized complication of surgery. The aim of the study is to investigate whether cognitive dysfunction is reduced by the use of modafinil as shown by neurocognitive testing.The…
- Trial name
- NCT03914118
- Testing
- Preoperative modafinil + postoperative modafinil
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- The Cooper Health System