Clinical trials: Neurocognitive Deficit
Risk Reduction Behavior, Sexual Behavior
HIV Prevention With Adolescents: Neurocognitive Deficits and Treatment Response
This research is examining how genetic and brain factors play a role in adolescents' health risk behavior as well as studying behaviors that young people engage in that may place them at risk for contracting a sexually…
- Conditions
- Risk Reduction Behavior, Sexual Behavior, Health Behavior, Drinking Behavior
- Trial name
- SHARP (NCT01169922)
- Testing
- SEXUAL RISK REDUCTION + ALCOHOL RISK REDUCTION, INFORMATION-ONLY SEXUAL RISK REDUCTION
- Where
- 4 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of New Mexico
Autistic Disorders Spectrum, Adhd
Studies of Brain and Body Interaction
The goal of this study is to characterize biophysiolgoical signals as a comprehensive profile of the nervous systems in order to understand interactions between the brain and body, while an individual performs naturalistic…
- Conditions
- Autistic Disorders Spectrum, Adhd, Asperger Syndrome, Alzheimer Disease
- Trial name
- NCT03672266
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Rutgers University
Parkinson's Disease
Cognitive Impairment in Parkinson's Disease Categorised in Accordance to Motor Symptoms
Background: Approximately 40% of patients with Parkinson's disease (PD) have cognitive impairments. There is a lack of consensus as to the extent to which psychiatric symptoms, depression, age at disease onset, disease duration…
- Trial name
- NCT00476372
- Where
- Denmark
- Volunteers
- 107 people
- Sponsor
- University of Aarhus
Parkinson's Disease, Gait Disorders, Neurologic
Study of Methylphenidate to Treat Gait Disorders And Attention Deficit In Parkinson's Disease (PARKGAIT-II)
Therapeutic management of gait disorders in very advanced Parkinson's disease (PD) patients can sometimes be disappointing, since dopaminergic drug treatments and subthalamic nucleus (STN) stimulation are more effective for…
- Conditions
- Parkinson's Disease, Gait Disorders, Neurologic, Dementia
- Trial name
- PARKGAIT-II (NCT00914095)
- Testing
- methylphenidate
- Where
- France
- Volunteers
- 69 people
- Sponsor
- University Hospital, Lille
Alzheimer Disease
Long-term Follow-up of Cognitive and Functional Evolutions of Persons With Isolated Cognitive Complaints or Mild Cognitive Deficits
Dementia is a clinical syndrome that is the result of distinct underlying pathologies including Alzheimer's disease (AD). Despite more than two decades of research on prevention and treatment of dementia and aging-related…
- Trial name
- Memento-Plus (NCT04111211)
- Where
- 26 sites in France
- Volunteers
- 1,028 people
- Sponsor
- University Hospital, Bordeaux
Cognitive Deficit in Schizophrenia
Efficacy and Mechanisms of TUS on Cognitive Deficits in Schizophrenia: Based on the Hippocampal-Prefrontal Circuit
Cognitive deficit is a core symptom of schizophrenia related to poorer functional outcome. Prior studies indicated that abnormalities in the hippocampus-prefrontal circuit and glutamate/GABA imbalances may lead to cognitive…
- Trial name
- NCT06904092
- Testing
- Transcranial ultrasound stimulation
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Shanghai Mental Health Center
Cognition Disorder, Attention Deficit Disorder
Dopamine Receptor Imaging to Predict Response to Stimulant Therapy in Chronic TBI
Deficits in memory, attention, cognitive, and executive functions are the most common disabilities after traumatic brain injury (TBI).
- Conditions
- Cognition Disorder, Attention Deficit Disorder, Traumatic Brain Injury
- Trial name
- DAPET-TBI (NCT02225106)
- Testing
- Methylphenidate
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Pennsylvania
Cognitive Deficits, Cognitive Ability, General
Childhood Anesthesia and Cognitive Function
The purpose of this study is to determine whether pediatric anesthesia is associated with long-term hippocampal dysfunction
- Trial name
- UCSF-Anes-01 (NCT01359215)
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Coronary Artery Bypass Grafting
Complement Activation and Central Nervous System Injury After Coronary Artery Surgery
The impact of the postoperative inflammatory response on the central nervous system after cardiac surgery is uncertain. The goal of this study was to evaluate the role of complement activation on cellular brain injury and…
- Trial name
- NCT00188006
- Testing
- heparin-coated cardiopulmonary bypass
- Sponsor
- University Hospital, Angers
Cognitive Deficits, Mild
Microbiome-Targeted Enhancement of Neurocognition With Probiotics-Riboflavin Combination
This randomized, double-blind, placebo-controlled trial will evaluate whether 12 weeks of supplementation with the probiotic Lactobacillus rhamnosus GG combined with colon-delivered riboflavin will improve cognitive performance…
- Trial name
- MENTOR (NCT07410052)
- Testing
- Experimental 1, Experimental 2
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Center for Health Sciences, Serbia
Neurodevelopmental Disorders, Attention Deficit Hyperactivity Disorder
Validity of Neurocognitive Assessment Methods in Childhood ADHD
The aim of the study is to examine the prospective validity of neurocognitive functions and emotional factors in schoolchildren with ADHD and a control group of typically developing schoolchildren at baseline and after three…
- Trial name
- NCT04201509
- Where
- Sweden
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Region Skane
Psychiatric Disorders, Depression - Major Depressive Disorder
Implementing Action-Based Cognitive Remediation for Transdiagnostic Cognitive Difficulties in a Tertiary Mental Health Hospital
Psychiatric conditions are each defined by different set of symptoms, however, they often share common characteristics such as impairments in cognitive and social functioning.
- Conditions
- Psychiatric Disorders, Depression - Major Depressive Disorder, Schizophrenia and Other Psychotic Disorders, Anxiety and Mood Disorders
- Trial name
- NCT07506070
- Testing
- Action-Based Cognitive Remediation
- Volunteers
- 160 people
- Sponsor
- The Royal Ottawa Mental Health Centre
Attention Deficit Hyperactivity Disorder
Sleep Dysfunction and Neurocognitive Outcomes in Adolescent ADHD
This study seeks to characterize sleep physiology in adolescents with and without Attention deficit hyperactivity disorder (ADHD) and its relationship to differential neurocognitive and clinical outcomes within these groups.
- Trial name
- NCT02897362
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Duke University
Schizophrenia, Schizoaffective Disorder
Cognitive Remediation Therapy Within a Secure Forensic Setting
This clinical trial tests the feasibility, effectiveness and patient satisfaction with cognitive remediation therapy for patients diagnosed with schizophrenia or schizoaffective disorder within a forensic hospital.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Cognitive Deficits
- Trial name
- NCT02360813
- Testing
- Cognitive Remediation Therapy, Treatment as usual
- Where
- Ireland
- Volunteers
- 65 people
- Sponsor
- Central Mental Hospital
Schizophrenia
Randomized Clinical Trial of Intensive Computer-based Cognitive Remediation in Recent-onset Schizophrenia
The purpose of this study is to test a new computerized training program as well as to find out whether the computer training might help people who have schizophrenia.
- Trial name
- TARA (NCT01773239)
- Testing
- TARA computer-based exercises
- Where
- 2 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Posit Science Corporation
Cognitive Deficit
Effect of Vortioxetine on Cognitive Symptoms in Patients With Schizophrenia
Research goals: 1. Examination of the relationship between the use of vortioxetine and cognitive efficacy in patients with schizophrenia. 2.
- Trial name
- NCT04456777
- Testing
- Vortioxetine
- Where
- Croatia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Alen Greš
Cognition Disorders, Cognitive Deficits
Smart Autonomous Neuro-Rehabilitation System
Cognitive rehabilitation is defined as a systematic functionally oriented intervention of therapeutic cognitive activities based on the assessment and understanding of patient's brain behavior deficits.
- Trial name
- SANaR (NCT02816008)
- Testing
- Cognitive rehabilitation training with RGS in the clinic, Passive/conventional cognitive training at home.
- Volunteers
- 59 people
- Sponsor
- Universitat Pompeu Fabra
Auditory Perceptual Disorder, Language Delay
Hereditary Deficits in Auditory Processing Leading to Language Impairment
Some children with certain language disorders may not properly process the sounds they hear, resulting in language impairments. The purpose of this study is to determine if deficits in auditory temporal processing the way the…
- Conditions
- Auditory Perceptual Disorder, Language Delay, Language Disorder
- Trial name
- NCT00004570
- Where
- United States
- Volunteers
- 875 people
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
HIV-1-infection, HIV Associated Neurocognitive Disorder
HIV-1 Infected Adult Subjects With HIV-associated Neurocognitive Disorders Despite Effective Antiretroviral Therapy
Prospective study in HIV-1 infected adult subjects with HIV-associated neurocognitive disorders despite effective antiretroviral therapy in plasma for more than one year, analyzing the evolution of cognitive disorders and markers…
- Trial name
- NCT04266002
- Testing
- Validation of Charter score for the CNS diffusion of antiretroviral drugs
- Where
- 12 sites in France
- Volunteers
- 31 people
- Sponsor
- Hôpital Franco-Britannique-Fondation Cognacq-Jay
Pediatric Retinoblastoma, Retinoblastoma
Determining Whether Multiple Anesthesia Exposures Affect Cognitive Function for Retinoblastoma Patients
The purpose of this study is to see if there is a difference between the development of the brain (neurodevelopment) in children who have been treated for retinoblastoma with multiple anesthetic exposures, compared with brain…
- Trial name
- NCT03546387
- Testing
- Wechsler Intelligence Scale for Children, Fifth Edition (WISC-V), California Verbal Learning Test, Children's Version, Beery Developmental Test of Visual Motor Integration, 6th edition
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Memorial Sloan Kettering Cancer Center