Clinical trials: Neurocognitive Development
Neurocognitive Disorders
Evaluating the Long-term Neurocognitive Effects of Preconceptional Exposure to Iodinated Contrast on the Offspring
Iodinated contrast is commonly used in hysterosalpingography (HSG), a diagnostic tool in fertility work-up. This study aims to investigate the safety of contrast media used during HSG by evaluating the long-term effects on the…
- Trial name
- Neuro-H2Oil (NCT05168228)
- Testing
- Oil- versus waterbased contrast in hysterosalpingography (HSG)
- Where
- Netherlands
- Volunteers
- 64 people
- Sponsor
- Amsterdam UMC, location VUmc
Autism Spectrum Disorder
Neurocognitive and Psychosocial Outcome of Youths With Autism Spectrum Disorder
Autism spectrum disorders (ASD) is a common childhood-onset, multi-factorial, highly heritable, clinically and genetically heterogeneous, neurodevelopmental disorder.
- Trial name
- NCT02233348
- Where
- Taiwan
- Volunteers
- 523 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD)
Digital Solutions for Predicting the Biological Mechanisms of Alzheimer's Disease Through the Analysis of Risk Factors
Population ageing is one of the main factors responsible for the global increase in the prevalence of dementia. Recent evidence suggests that modifiable risk factors, such as cardiovascular disease and lifestyle, may increase the…
- Trial name
- PrevAl (NCT07731191)
- Testing
- Digital solution for the prediction of the biological mechanisms of Alzheimer's disease through the analysis of risk factors
- Where
- 2 sites in Italy
- Volunteers
- 240 people
- Sponsor
- IRCCS Centro San Giovanni di Dio Fatebenefratelli
Working Memory, Inhibitory Control
BID WM Digital Intervention in Aging
The goal of this clinical trial is to learn if engaging with an digital intervention may improve cognitive function. The main questions it aims to answer are: 1.
- Conditions
- Working Memory, Inhibitory Control, Mild Cognitive Impairment (MCI), Aging
- Trial name
- NCT06918704
- Testing
- Coherence, Worder
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Gut Microbiome, Neurocognitive Correlates of Eating Habits
Early Avocado Exposure on Development and the Gut Microbiome in American Hispanic Infants
The goal of this clinical trial is to learn if daily avocado intake can improve growth and brain and gut health in infants. The main questions it aims to answer are: Does daily eating of avocados change which microbes live in the…
- Conditions
- Gut Microbiome, Neurocognitive Correlates of Eating Habits, Infant Growth
- Trial name
- Guac & Grow (NCT06876935)
- Testing
- Daily avocado
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Central Auditory Processing Disorder
The Effectiveness of Computerized Auditory Training Programme on Children With Auditory Processing Disorder
The current study aimed to examine the effectiveness of a Computer-based auditory training (CBAT) intervention for children with Central Auditory Processing Disorder (CAPD) by comparing the changes in auditory processing (AP) and…
- Trial name
- CBAT (NCT02111343)
- Testing
- Computer-based auditory training (CBAT)
- Where
- Singapore
- Volunteers
- 39 people
- Sponsor
- National University Health System, Singapore
Cognitive Impairment, Coginitive Assessment
A Modified Test of Goal-directed Behaviour: a Feasibility Study
Cognitive assessment plays an important part in decision making in acute neurological settings, partly because difficulties with cognitive skills such as attention, memory and executive functioning (which includes planning and…
- Trial name
- NCT07484048
- Testing
- Five cognitive tasks
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gloucestershire Hospitals NHS Foundation Trust
Stroke, Ischemic, Cognitive Decline
Post-stroke Immunological Changes in Young Stroke Patients
In the present study, the investigators aim to elucidate the role of T-cells on cognitive decline in younger stroke patients, using repeated cognitive testing, brain imaging, and immunological analyses in the first 6 month after…
- Trial name
- NCT03725137
- Testing
- Analysis of T-lymphocytes
- Volunteers
- 77 people
- Sponsor
- University Medicine Greifswald
Alzheimer Disease
Socially Assistive Robots for Interaction With Older Adults With Dementia
A 12-month pilot study will be comprised of two groups of people diagnosed with mild Alzheimer's disease and related dementia for a total of 80 senior subjects.
- Trial name
- NCT04384978
- Testing
- Play Serious Games with a Social Robot (Ryan), Play Solitary Games Without a Social Robot
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- DreamFace Technologies, LLC
Postoperative Delirium
The Relationship Between Zonulin and Interleukin-8 Levels and Postoperative Delirium Development
The relationship between zonulin and interleukin-8 levels and postoperative delirium development in patients who had femur fracture surgery under regional anesthesia
- Trial name
- ZolDel (NCT04875182)
- Testing
- Evaluation of Delirium development
- Where
- Turkey (Türkiye)
- Volunteers
- 73 people
- Sponsor
- Dr. Gokhan Vural
Bardet Biedl Syndrome (BBS), Bardet Biedl Syndrome
Real-World Effects of MC4R Agonist Therapy in BBS and Severe Genetic Obesity
Bardet-Biedl syndrome (BBS) and other rare disorders associated with impairment of the melanocortin-4 receptor (MC4R) pathway are characterized by severe early-onset obesity, hyperphagia, and substantial morbidity.
- Conditions
- Bardet Biedl Syndrome (BBS), Bardet Biedl Syndrome, Bardet-Biedl Syndrome (BBS), Alstrom Syndrome
- Trial name
- REAL-MC4 (NCT07674290)
- Testing
- Setmelanotide
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Tom Hühne
Autism Spectrum Disorder
Impact of Early Interventions on Neurocognitive Profile of Children With Autism Spectrum Disorder
The Early start Denver model (Rogers, 2010; Dawson, 2010) is a developmental and behavioral model that aim to enhance socio-comunicative abilities and also global development of children with Autism spectrum disorder (ASD).
- Trial name
- IDEAEYE (NCT03254264)
- Testing
- Early Start Denver Model, 'as-usual' intervention
- Where
- France
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Hôpital le Vinatier
Mild Cognitive Impairment
Intervention Effect of Yizhi Baduanjin on Patients With Mild Cognitive Impairment
With mild cognitive impairment (MCI) as the research object, the intervention effect of Yizhi Baduanjin on mild cognitive impairment was evaluated by using the Montreal Cognitive Assessment (MoCA) scale, human-computer…
- Trial name
- NCT05899777
- Testing
- Yizhi Baduanjin
- Volunteers
- 100 people
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Attention-deficit/Hyperactivity Disorder
Attention-deficit/Hyperactivity Disorder Translational Center for Identifying Biomarkers
The purpose of this study was to identify genetic, brain morphologic, and environmental biomarkers that contribute to the pathophysiology of attention-deficit/hyperactivity disorder (ADHD).
- Trial name
- NCT02623114
- Testing
- methylphenidate, atomoxetine
- Where
- South Korea
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Seoul National University Childrens Hospital
Huntington's Disease
Safety and Tolerability Study of Phenylbutyrate in Huntington's Disease (PHEND-HD)
The purpose of this study is to evaluate the safety, tolerability and clinical impact of 15-grams daily of sodium phenylbutyrate (phenylbutyrate) in Huntington's disease and to lay the groundwork for possible subsequent trials…
- Trial name
- NCT00212316
- Testing
- sodium phenylbutyrate
- Where
- 8 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of Rochester
Obesity, Healthy Aging
Sukalmena InAge: Nutritional-culinary Programme to Promote Adherence to a Healthy Dietary Pattern.
Currently, one of the main health challenges of public health is to improve the quality of life of people with chronic non-communicable diseases, through new strategies that promote healthy eating habits and lifestyles.
- Conditions
- Obesity, Healthy Aging, Cognitive Impairment
- Trial name
- Sukalmena (NCT04908163)
- Testing
- Mediterranean diet-based nutritional education intervention, Mediterranean diet-based culinary intervention
- Where
- Spain
- Volunteers
- 56 people
- Sponsor
- Basque Culinary Center Fundazioa
Huntington Disease
Development of the Virtual Unified Huntington's Disease Rating Scale
The Huntington Study Group currently holds the registered trademark for the Unified Huntington's Disease Rating Scale. The UHDRS® is a research tool which has been developed by the HSG to provide a uniform assessment of the…
- Trial name
- vUHDRS (NCT05748288)
- Where
- 17 sites in United States
- Volunteers
- 60 people
- Sponsor
- Huntington Study Group
Gestational Diabetes Mellitus in Pregnancy, Cognitive Impairment
Gestational Diabetes Mother-infant Cohort
The bi-directional dynamic cohort study is to learn about the effects of prenatal exposure to high blood glucose levels and postnatal nurturing environment factors on delayed language development in children.
- Conditions
- Gestational Diabetes Mellitus in Pregnancy, Cognitive Impairment, Cohort Study
- Trial name
- NCT06021691
- Testing
- Acquired nurturing environment
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Gansu Provincial Maternal and Child Health Care Hospital
TBI (Traumatic Brain Injury), Concussion, Brain
Growth Hormone Replacement Therapy for Retried Professional Football Players
This is a randomized, double-blind, placebo-controlled, parallel-group trial with an open-label extension to evaluate the efficacy of growth hormone (GH) on cognitive functions of retired professional football players with growth…
- Conditions
- TBI (Traumatic Brain Injury), Concussion, Brain, Sport Injury, Anterior Pituitary Hyposecretion Syndrome
- Trial name
- NCT04121780
- Testing
- Growth Hormone
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Center for Neurological Studies
Alzheimer Disease and Related Dementias, Cognition
Home-Based Brain Stimulation for Motoric Cognitive Risk Syndrome
The objective of this study is to determine the effects of a 6-month, home-based personalized transcranial direct current stimulation (tDCS) intervention targeting the left dorsolateral prefrontal cortex on cognitive function…
- Conditions
- Alzheimer Disease and Related Dementias, Cognition, Mobility Disability
- Trial name
- TDCS4MCR (NCT06821568)
- Testing
- Personalized Transcranial Direct Current Stimulation (tDCS)
- Where
- 2 sites in United States, Israel
- Volunteers
- 128 people
- Sponsor
- Hebrew SeniorLife