Clinical trials: Neurocognitive Disorders, Mild
Hip Fractures, Mild Cognitive Impairment
Reducing Fall Risk Post Hip Fracture in Mild Cognitive Impairment
Hip fracture is recognized as one of the most serious consequences of osteoporosis, less than half regain pre-fracture independence. 95% of all hip fractures in older adults are due to falls.
- Trial name
- NCT04748354
- Testing
- Otago Exercise Program, Usual Care
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of British Columbia
Dementia, Alzheimer Disease
A Study to Evaluate the Efficacy and Safety of Galantamine in Patients With Mild Cognitive Impairment
The purpose of this study is to evaluate the efficacy and safety of galantamine treatment in patients with mild cognitive impairment.
- Trial name
- NCT00236574
- Testing
- Galantamine hydrobromide
- Volunteers
- 974 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Mild Cognitive Impairment (MCI), Dementia (Diagnosis)
Loneliness as Risk Factor for Dementia
This study aims to determine whether loneliness is associated with a higher incidence of dementia in older adults with a prior diagnosis of mild cognitive impairment after 12 months of follow-up.
- Conditions
- Mild Cognitive Impairment (MCI), Dementia (Diagnosis), Loneliness
- Trial name
- SOLETE (NCT07211945)
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Consorci Sanitari de l'Alt Penedès i Garraf
Parkinson Disease, COVID-19
Effect of Remote Cognitive Intervention in Patients With Parkinson's Disease During the COVID-19 Pandemic
Retrospective study to evaluate the effect of a remote cognitive-rehabilitative intervention during the Covid outbreak in subjects with Parkinson's disease.
- Conditions
- Parkinson Disease, COVID-19, Mild Cognitive Impairment
- Trial name
- TELEPARK (NCT05476302)
- Testing
- Cognitive digital treatment
- Where
- Italy
- Volunteers
- 18 people
- Sponsor
- Istituto Nazionale di Ricovero e Cura per Anziani
Alzheimer's Disease, Mild Cognitive Impairment
Wisconsin Brain Donor Program
The Wisconsin Brain Donor Program (WBDP) stores brain and other tissues/samples (e.g. blood and CSF) from deceased individuals who have participated in longitudinal research studies, as well as other select participants.
- Trial name
- WBDP (NCT00585572)
- Where
- United States
- Volunteers
- 9,999 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Mild Cognitive Impairment
Plasticity Using Stimulation and Habit: A Pilot Open-label rTMS Study for MCI
The goal of this pilot study is to determine whether a high-dose form of non-invasive brain stimulation is a promising and safe treatment for Mild Cognitive Impairment (MCI).
- Trial name
- PUSH-Pilot (NCT04503096)
- Testing
- High-dose accelerated rTMS
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Medical University of South Carolina
Cognitive Impairment, Stroke
Hypoalbuminemia in Mild Acute Stroke and Cognitive Impariment Post-stroke
This registration enrolled patients with acute ischemic stroke within 72 hours after stroke ictus. Patients was identified as first-ever stroke based on past medical histrory.
- Conditions
- Cognitive Impairment, Stroke, Albumin; Double
- Trial name
- NCT04135872
- Testing
- strengthened nuitritional treatment
- Where
- China
- Volunteers
- 435 people
- Sponsor
- Dongguan People's Hospital
Type 2 Diabetes Mellitus, Mild Cognitive Impairment
DEMAND - Multifactorial Study to Reduce Dementia in People With Type 2 Diabetes
In the DEMAND pilot study, we will recruit and randomize 80 participants at two study sites (Umeå and Uppsala) for a one-year intervention.
- Trial name
- DEMAND (NCT03877783)
- Testing
- mediterranean diet, individualized fitness program, recommended modified pharmacological treatment
- Where
- Sweden
- Volunteers
- 10 people
- Sponsor
- Umeå University
Alzheimer Disease
NMDA Enhancer for the Treatment of Mild Alzheimer's Disease
NMDA neurotransmission plays an important role in learning and memory. NMDA receptors (NMDAR) were found to decrease in the frontal lobe and hippocampus of Alzheimer's disease (AD).
- Trial name
- NCT03752463
- Testing
- DAOI-A group, DAOI-B group, DAOI-C group
- Where
- Taiwan
- Volunteers
- 154 people
- Sponsor
- Chang Gung Memorial Hospital
Lewy Body Disease, Dementia
MIBG in Aging and Neurologic Disorders
The purpose of the study is to investigate the use of a special radioactive drug called 123I-MIBG and myocardial MIBG scintigraphy.
- Conditions
- Lewy Body Disease, Dementia, Parkinsonism, Mild Cognitive Impairment
- Trial name
- NCT05514106
- Testing
- meta-iodobenzylguanidine (MIBG) (123I), 123I-MIBG scintigraphy
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Mild Cognitive Impairment, Mild Alzheimer Disease
Effects of Nicotinamide Riboside on Bioenergetics and Oxidative Stress in Mild Cognitive Impairment/Alzheimer's Dementia
The primary aim of this study is to investigate the effects of exogenously administered nicotinamide riboside (NR) on brain energy metabolism, oxidative stress, and cognitive function in individuals with mild cognitive impairment…
- Trial name
- NCT04430517
- Testing
- Nicotinamide riboside
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Mclean Hospital
Alzheimer Disease
Allogeneic Adipose Tissue Derived-stem Cells in Alzheimer Disease
A3D is a phase I/II clinical trial. The primary objective is to evaluate the safety of allogeneic adipose tissue derived-stem cells (AdMSC) administered by intravenous (IV) route in mild to moderate Alzheimer disease (AD) using a…
- Trial name
- A3D (NCT07367815)
- Testing
- CellREADY® drug product IV dose of 50 millions, CellREADY® drug product IV dose of 100 millions, cerebral RMI
- Where
- France
- Volunteers
- 9 people
- Sponsor
- University Hospital, Toulouse
Alzheimer Disease, Late Onset
The Predictive Factors of Good Clinical Response to Cholinesterase Inhibitors in Alzheimer Disease and Mixed Dementia
Background and objectives: The aims of this naturalistic study were: to analyze factors which could be predictive of good response to cholinesterase inhibitors (ChEI), such as: age, sex, schooling, mild (CDR 1) or moderate…
- Trial name
- NCT02187276
- Testing
- cholinesterase inhibitors
- Volunteers
- 129 people
- Sponsor
- Federal University of Minas Gerais
Mild Cognitive Impairment (MCI), Alzheimer's Disease (AD)
Alzheimer's Disease Neuroimaging Initiative 3
Since its launch in 2004, the overarching aim of the Alzheimer's Disease Neuroimaging Initiative (ADNI) has been realized in informing the design of therapeutic trials in AD.
- Trial name
- ADNI3 (NCT02854033)
- Where
- 59 sites in United States, Canada
- Volunteers
- 1,141 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Cognitive Dysfunction
Guilingji Capsule for Mild-to-moderate Cognitive Impairment
This study is aiming to evaluate the efficacy and safety of Guilingji capsule in older adults with mild-to-moderate cognitive impairment who diagnosed as the kidney and marrow deficiency pattern in TCM.
- Trial name
- NCT03647384
- Testing
- Gulingji capsules, Ginko Biloba Extract tablet
- Where
- China
- Volunteers
- 348 people
- Sponsor
- Xiyuan Hospital of China Academy of Chinese Medical Sciences
Parkinson's Disease
Telemedicine Intervention to Improve Cognitive Function
This project is investigating whether a home-based exercise program will reduce cognitive decline in patients with Parkinson's disease.
- Trial name
- NCT02248649
- Testing
- Structured physical activity, Health education
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- VA Office of Research and Development
Stroke, Mild Cognitive Impairment
Telerehabilitation of Balance Clinical and Economic Decision Support System
This study follows the successfully completed HOLOBalance project which was funded by the EU Horizon 2020 scheme. TheHOLOBalance platform delivers exercises demonstrated via a hologram of the physiotherapist and corrected in real…
- Conditions
- Stroke, Mild Cognitive Impairment, Vestibular Diseases, Long Covid19
- Trial name
- TeleRehab DSS (NCT06534164)
- Testing
- Full/High Tech Telerehabilitation decision support system, Basic/Low Tech Telerehabilitation decision support system, OTAGO Home exercise program
- Where
- 5 sites in Germany, Greece and 3 more
- Volunteers
- 460 people
- Sponsor
- University College, London
Vascular Dementia
Efficacy and Safety of Tianzhi Granule in Mild to Moderate Vascular Dementia
This ongoing study aimed to evaluate the efficacy and safety of Tianzhi granule in mild to moderate vascular dementia in a more reasonable design.
- Trial name
- NCT02453932
- Where
- China
- Volunteers
- 543 people
- Sponsor
- Dongzhimen Hospital, Beijing
Cognitive Dysfunction, Mild Cognitive Impairment
Speed of Processing (SoP) Training Plus α-tACS
The current proposal aims to assess if the combination of Speed of Processing (SoP) training with alpha tACS (α-tACS) is able to increase brain speed of processing as assessed by the Useful Field of View (UFOV) when comparing to…
- Conditions
- Cognitive Dysfunction, Mild Cognitive Impairment, tACS, Cognitive Training
- Trial name
- aMCIUp (NCT05198726)
- Testing
- alpha tACS, Speed of Processing Training
- Where
- Portugal
- Volunteers
- 40 people
- Sponsor
- Portucalense University
Cancer, Cognitive Impairment
Cancer and Mild Cognitive Impairment Dyadic Intervention
The purpose of this study is to see whether programs that include both a patient and their spouse or a patient and family caregiver (known as a dyad) are helpful for families in which one member of the dyad has cancer and mild…
- Trial name
- NCT05144516
- Testing
- Behavioral: COPE +
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Duke University