Clinical trials: Neurocognitive Dysfunction, open to volunteers
Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease
Longitudinal Profiling of Plasma-Derived Glial Extracellular Vesicles in Alzheimer's Disease
This project aims to longitudinally profile plasma-derived GDEVs and plasma biomarkers of neuroinflammation across three stages of the AD continuum (Subjective Cognitive Decline, Mild Cognitive Impairment, and Alzheimer's…
- Conditions
- Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease, Alzheimer's Disease Dementia, Alzheimer's Disease (AD)
- Trial name
- GLEVAD (NCT07803055)
- Testing
- blood sampling
- Where
- Italy
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Postoperative Neurocognitive Dysfunction, Postoperative Neurocognitive Disorder
The Role of Neuroinflammation on Neurocognitive Outcome in Cardiac Surgery
RATIONALE: Postoperative cognitive changes are common after cardiac surgery and can be categorised into three main types: postoperative delirium (POD), delayed neurocognitive recovery (DNCR) and postoperative neurocognitive…
- Conditions
- Postoperative Neurocognitive Dysfunction, Postoperative Neurocognitive Disorder, Cardiac Surgery, Major Surgery Under General Anesthesia
- Trial name
- INOCS (NCT07200726)
- Testing
- Observational study design - no intervention
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Ziekenhuis Oost-Limburg
Atrial Fibrillation
Preventing Stroke, Premature Death and Cognitive Decline in a Broader Community of Patients With Atrial Fibrillation
The DaRe2 approach (healthcare Data for pragmatic clinical Research in the NHS - primary 2 secondary) is designed to operationalise efficient, nationwide, primary care approaches for randomised trials embedded within the UK…
- Trial name
- DaRe2THINK (NCT04700826)
- Testing
- Direct Oral Anticoagulants
- Where
- United Kingdom
- Volunteers
- 3,000 people
- Sponsor
- University of Birmingham
Dementia of Alzheimer Type
Reducing African American's Alzheimer's Risk Through Exercise-Mild Cognitive Impairment (RAATE-MCI)
The RAATE-MCI proposal is designed to determine the effects of physical activity on risk factors for Alzheimer's Disease in older African American adults.
- Trial name
- RAATE-MCI (NCT04956549)
- Testing
- Physical activity program, Successful Aging
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Pennington Biomedical Research Center
Postoperative Delirium, Postoperative Cognitive Dysfunction
Development of a Prediction Model for Delirium After Cardiac Surgery Using a Novel Self-Administered Preoperative Cognitive Assessment Tool
This observational cohort study is designed to validate the CogCheck application as a risk prediction tool for postoperative delirium in patients undergoing cardiac surgery.
- Conditions
- Postoperative Delirium, Postoperative Cognitive Dysfunction, Cognitive Decline, Cognitive Impairment
- Trial name
- CogCheck-Valid (NCT03360838)
- Testing
- CogCheck
- Where
- Switzerland
- Volunteers
- 475 people
- Sponsor
- University Hospital, Basel, Switzerland
Prodromal Alzheimer's Disease, Mild Cognitive Impairment
The Digital Memory Notebook
Compensatory aids (e.g., alarms, calendars) play an important supporting role when completing everyday tasks (e.g., appointments, medication management), and there is a growing body of scientific work suggesting that compensatory…
- Conditions
- Prodromal Alzheimer's Disease, Mild Cognitive Impairment, Subjective Cognitive Complaints
- Trial name
- DMN (NCT04240665)
- Testing
- Digital Memory Notebook (DMN) Application
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Davis
Limbic Encephalitis With LGI1 Antibodies
Antibody-mediated LGI1 Encephalitis: Symptoms, Biomarkers, and Mechanisms of the Chronic Phase of the Disease
The encephalitis mediated by antibodies against Leucine-rich, glioma inactivated 1 protein (anti-LGI1 encephalitis) predominantly affects men (M:F, 6:4) and mostly older than 60 years.
- Trial name
- NCT06515106
- Testing
- Remote cognitive rehabilitation program
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Cognitive Deficit
Patient-Centered NeuroRehabilitation (PCN)
As individuals grow older, a number of factors can reduce our cognitive (or thinking) abilities such as "normal" aging, neurodegenerative diseases, and cardiovascular disease.
- Trial name
- PCN (NCT03036319)
- Testing
- Active tDCS, Cognitively based intervention, Active tACS
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Age-related Cognitive Decline
Acute Effects of THC in Older Adult
The primary objective of this study is to determine if increasing age confers greater vulnerability to the acute A) cognitive (e.g., memory, attention, psychomotor function), B) subjective (e.g., anxiogenic and rewarding…
- Trial name
- THC-Aging (NCT06948136)
- Testing
- Delta-9-THC Low Dose, Delta-9-THC Medium Dose
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yale University
Mild Cognitive Impairment (MCI), Opioid Use
Postsurgical Pain and Opioid Use in Older Adults: Effects of Mild Cognitive Impairment
Mild cognitive impairment (MCI) affects a substantial proportion of older adults undergoing major surgery and may alter pain processing, pain experience, and opioid use after surgery.
- Conditions
- Mild Cognitive Impairment (MCI), Opioid Use, Cognitive Dysfunction, Postoperative Pain
- Trial name
- NCT07885085
- Where
- United States
- Volunteers
- 552 people
- Sponsor
- Miklos Kertai
Mild Cognitive Impairment (MCI)
Mild Cognitive Impairment and Neuromodulation
This is a parallel, sham-controlled design of low-intensity focused ultrasound in patients with mild cognitive impairment (MCI). The study will evaluate safety, tolerability, and effects on cognitive function.
- Trial name
- MCI (NCT07691918)
- Testing
- Low intensity focused ultrasound
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Virginia Polytechnic Institute and State University
Obesity, Mild Cognitive Impairment
Improvement of Fish Oil in Obesity With Mild Cognitive Impairment
Eighty-eight patients with obesity with mild cognitive impairment（MCI） from the Multicenter Nutrition and Chronic Disease Cohort, who met the inclusion and exclusion criteria, were selected as study subjects and randomly divided…
- Trial name
- NCT06992726
- Testing
- Fish oil intervention
- Volunteers
- 88 people
- Sponsor
- Weiwei Ma
Mild Cognitive Impairment, Alzheimer Dementia (AD)
Closed-Loop Brain Stimulation as a Potential Intervention for Cognitive Decline
The goal of this clinical study is to investigate the effectiveness of non-invasive stimulation to enhance cognitive control abilities in older adults with and without cognitive impairment.
- Trial name
- NCT05907343
- Testing
- Closed-loop TBS, Open-loop TBS
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Bipolar Disorder (BD), Cognitive Impairment
TMS for Improving Cognitive Function in Bipolar Disorder
Bipolar disorder is a highly disabling psychiatric illness, and cognitive impairment is common in patients with bipolar depression as well as during remission, contributing substantially to functional disability and poorer…
- Trial name
- NCT07414147
- Testing
- Active Intermittent Theta Burst Stimulation, Online Cognitive Training
- Where
- China
- Volunteers
- 88 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Alzheimer Disease
Effect of CAFfeine on Cognition in Alzheimer's Disease
Sporadic Alzheimer's disease is a multifactorial illness arising a major medico-economic stakes for our aging societies. There is currently no curative treatment available.
- Trial name
- CAFCA (NCT04570085)
- Testing
- Caffeine
- Where
- 17 sites in France
- Volunteers
- 248 people
- Sponsor
- University Hospital, Lille
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Mild Cognitive Impairment, Cognitive Dysfunction
Effects of a Computerized Cognitive Stimulation Intervention Adapted to the Level of Cognitive Reserve
Normal ageing presents subtle cognitive changes that can be detected before meeting the criteria for Mild cognitive impairment (MCI).
- Trial name
- NCT06279325
- Testing
- Computerized cognitive stimulation program, Face-to-face training-explanatory session
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universidad de Zaragoza
Stroke, Cognitive Impairment
Tele-Rehabilitation vs Conventional Rehabilitation for Cognitive Improvement in Stroke Survivors.
This study aims to: Compare tele-rehabilitation and conventional rehabilitation for cognitive improvement after stroke. Evaluate changes in cognitive function using standardized assessment tools.
- Conditions
- Stroke, Cognitive Impairment, Post-Stroke Cognitive Impairment
- Trial name
- NCT07504276
- Testing
- Tele-rehabilitation, Conventional Rehabilitation
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Riphah International University
Gynecologic Cancer, Chemotherapy Effect
Improve Cancer-related Cognitive Impairment
Cancer-related cognitive impairment (CRCI), also known as "chemobrain," is the cognitive decline that negatively impacts the majority of cancer patients undergoing chemotherapy, radiation, and/or hormonal treatments.
- Conditions
- Gynecologic Cancer, Chemotherapy Effect, Chemo-brain, Cancer-related Cognitive Difficulties
- Trial name
- NCT05864274
- Testing
- Cognitive training application
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Major Depressive Disorder (MDD), Cognitive Dysfunction
Cognitive Rehabilitation for Veterans With MDD-related Cognitive Functioning Deficits
Individuals with depression often describe difficulties with memory, attention, concentration, and overall cognitive functioning, which can persist even after mood episodes get better, and can affect treatment and health…
- Trial name
- NCT06728774
- Testing
- Motivationally Enhanced Compensatory Cognitive Training for Major Depressive Disorder (ME-CCT-MDD), Goal-focused Supportive Contact
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Portland VA Medical Center
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