Clinical trials: Neurocognitive Function of Elderly Patients
Cognition Disorders in Old Age, Cognitive and Behavioral Impairment
Evaluation of the Effect of L-Arginine on the Cognitive Function in Geriatric Patients
This study aims to evaluate the effect of L-arginine supplementation on cognitive function in geriatric patients. Eligible participants will receive either L-arginine (6 grams once daily) or placebo, and their cognitive…
- Trial name
- NCT07338682
- Testing
- L-Arginine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- German University in Cairo
Geriatric Assessment, Health Services for the Aged
Geriatric-CO-mAnagement for Cardiology Patients in the Hospital
The primary objective of the evaluation study is to determine if geriatric co-management is superior to standard of care in preventing functional decline in older patients admitted for acute heart disease or Transcatheter Aortic…
- Conditions
- Geriatric Assessment, Health Services for the Aged, Cardiovascular Diseases, Activities of Daily Living
- Trial name
- G-COACH (NCT02890927)
- Testing
- Cardio-geriatric co-management
- Where
- Belgium
- Volunteers
- 454 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Alzheimer's Disease, Dementia
Nutritional Programme for Dementia Elderly Patient
The main objective of this study is the improvement of the quality of life and state of health of elderly people with cognitive deterioration and their families through a weight loss prevention programme.
- Trial name
- NCT00479843
- Testing
- Nutritional programme
- Where
- Spain
- Volunteers
- 946 people
- Sponsor
- Société des Produits Nestlé (SPN)
Cognitive Dysfunction
Ketamine vs Midazolam on Cognitive Function in Elderly in Elective Surgery Three-Months Postoperatively (ketaminvsMDZ)
Deterioration of posoperative cognitive function (DCPO) is an intermediate state between normal cognitive aging and dementia, defined as a cognitive alteration greater than expected for the patient's age and educational level…
- Trial name
- ketaminvsMDZ (NCT04134052)
- Testing
- ketamine sedation versus midazolam sedation
- Where
- Mexico
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Universidad de Colima
Community-dwelling Older Adults, Neurocognitive Function of Elderly Patients
Modified Otago Exercise Program on Neurocognitive Level and Balance Parameters
This study examined the effect of an eight-week modified Otago Exercise Program on neurocognitive level and balance parameters in community-dwelling older adults.
- Conditions
- Community-dwelling Older Adults, Neurocognitive Function of Elderly Patients, Functional Mobility, Fall Prevention in Healthy Aging
- Trial name
- NCT07831174
- Testing
- Otago Exercise, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 87 people
- Sponsor
- Alanya Alaaddin Keykubat University
Delirium - Postoperative
Effect of Dexmedetomidine Dosage on Postoperative Delirium in Geriatric Orthopedic Surgery
This study evaluates the dose-response relationship of Dexmedetomidine (DEX) in reducing the incidence and severity of postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) in elderly patients.
- Trial name
- NCT07443085
- Testing
- Dexmedetomidine (Low dose), Dexmedetomidine (High dose), Fentanyl
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Benha University
Thoracic Anesthesia, Geriatric Anesthesia
The Effect of Single Lung Ventilation Duration and Intraoperative Brain Oxygenation on Cognitive Function and Postoperative Pain in Geriatric Patients
One lung ventilation (OLV) is commonly used in thoracic surgery. Although the lack of ventilation of the lung in the surgical area (independent lung) during OLV redirects pulmonary blood flow to the dependent lung, shunt…
- Conditions
- Thoracic Anesthesia, Geriatric Anesthesia, One Lung Ventillation (OLV), POCD - Postoperative Cognitive Dysfunction
- Trial name
- NCT07339124
- Testing
- Cognitive Remediation, Pain Medicine
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital
Cerebral Small Vessel Disease, Postoperative Cognitive Function
VR Training to Improve Postoperative Cognitive Function in Elderly Patients With Cerebral Small Vessel Disease Undergoing Non-Cardiac Surgery
This clinical study aims to investigate whether virtual reality (VR)-based cognitive training can help improve postoperative cognitive function in elderly non-cardiac surgery patients with pre-existing cerebral small vessel…
- Trial name
- NCT07370844
- Testing
- Virtual reality cognitive function training, Virtual scene intervention
- Where
- 3 sites in China
- Volunteers
- 240 people
- Sponsor
- Peking University Third Hospital
Postoperative Delirium, Elderly Patients
The Effects of Subanesthetic S-ketamine on Postoperative Delirium and Cognitive Function in the Elderly Undergoing Non-cardiac Thoracic Surgery
Postoperative delirium (POD) is a common and distressing complication after thoracic surgery. S-ketamine has neuroprotective properties as a dissociative anesthetic.
- Trial name
- SKED (NCT05242692)
- Testing
- S-ketamine, Dexmedetomidine
- Where
- China
- Volunteers
- 520 people
- Sponsor
- Affiliated Cancer Hospital & Institute of Guangzhou Medical University
Malnutrition, Falling
Identification of Risk Patients in Emergency Medical Services
Background: Inadequate nutrition has been associated with growing risk of falling and impaired ability in elderly patients. Falling is a significant threat to the health of the elderly.
- Conditions
- Malnutrition, Falling, Cognitive Impairment
- Trial name
- NCT03759314
- Testing
- Observation
- Where
- Finland
- Volunteers
- 500 people
- Sponsor
- Helsinki University Central Hospital
Postoperative Cognitive Dysfunction
LINC01844 as a Diagnostic Biomarker for POCD in Elderly Patients
Postoperative cognitive dysfunction (POCD) is a common complication after surgery that is associated with more adverse events and death.
- Trial name
- NCT06387836
- Testing
- Isoflurane 0.8 MAC, Desflurane 0.8MAC
- Where
- China
- Volunteers
- 85 people
- Sponsor
- Shanghai Zhongshan Hospital
Cognitive Function Abnormal, Anesthesia
Perioperative Changes of Cerebrovascular Autoregulation and Association With Cognitive Function
Cerebral blood flow is tightly regulated to ensure constant cerebral perfusion independently from systemic blood pressure fluctuations.
- Conditions
- Cognitive Function Abnormal, Anesthesia, Surgery
- Trial name
- NCT04101006
- Where
- Germany
- Volunteers
- 78 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Neurocognitive Function of Elderly Patients
Effect of Lidocaine Infusion Versus Dexmedemidine Infusion on the Neurocognitive Function of Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography(ERCP).
dexmedetomidine infusion or lidocaine infusion starting before induction of intravenous general anesthesia and continue as infusion intraoperative can reduce postoperative cognitive dysfunction incidence (primary outcome)…
- Trial name
- NCT07497009
- Testing
- Dexmedetomidine, lidocaine, normal saline
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Benha University
Postoperative Cognitive Dysfunction
Evaluation of the Effect of Preoperative Intravenous Amantadine Sulfate on the Postoperative Early Cognitive Functions in a Elderly Patient With Laparoscopic Radical Prostatectomy
Evaluation of the effect of preoperative intravenous administration of amantadine sulfate on the prevention of the development of early cognitive dysfunction in elderly patients undergoing laparoscopic radical prostatectomy
- Trial name
- NCT03988010
- Testing
- Amantadine Sulfate
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- TC Erciyes University
Anesthesia, Cognitive Dysfunction
Evaluation of Cognitive Functions by Cerebral Pulse Oximetry
General and Spinal Anesthesia can be used in geriatric patients in orthopedic surgery. Post-op cognitive dysfunction can be seen in orthopedic surgeries in this group of patients.
- Trial name
- NCT03827083
- Testing
- cerebral pulse oximetry
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tepecik Training and Research Hospital
Gynecologic Cancer, Frailty
Cognitive and Physical Frailty as Predictors of Decision Satisfaction in Geriatric Gynecologic Oncology
This prospective observational study aims to evaluate the association between preoperative cognitive function, measured by the Montreal Cognitive Assessment (MoCA), and physical frailty, assessed using the Clinical Frailty Scale…
- Conditions
- Gynecologic Cancer, Frailty, Cognitive Impairment, Geriatric Oncology
- Trial name
- GYNCOGFRAIL (NCT07085000)
- Testing
- No Intervention - Observational Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Izmir City Hospital
Quality of Life, Surgery
Determination of the Effect of Puzzle Use in Elderly Patients
The aim of this study is to determine the effects of the use of a simple, reliable and cost-effective puzzle on post-operative cognitive function changes, postoperative recovery, and quality of life using questionnaires and…
- Conditions
- Quality of Life, Surgery, Postoperative Confusion, Cognitive Dysfunction
- Trial name
- NCT05796830
- Testing
- Puzzle application
- Volunteers
- healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Anesthesia, Hip Fractures
Anesthesia and Perioperative Neurocognitive Disorders in the Elderly Patients Undergoing Hip Fracture Surgery Platform Trial (ANDES Platform Trial)
The ANDES Platform Trial is a pragmatic, multicenter, adaptive randomized controlled platform trial in patients aged 65 years or older undergoing surgery for hip fracture.
- Conditions
- Anesthesia, Hip Fractures, Dementia, Cognitive Impairment
- Trial name
- ANDES platform (NCT06452147)
- Testing
- Nerve block, Standard anesthesia care, Bupivacaine liposome
- Where
- 13 sites in China
- Volunteers
- 1,860 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Surgery--Complications
Effect of Multimodal Postoperative Rehabilitation on Functional and Cognitive Decline
Older adults, especially those with frailty, have a higher risk for complications, functional and cognitive decline after urgent surgery.
- Trial name
- NCT05290532
- Testing
- Individualized exercise training
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- Hospital of Navarra
Perioperative Care
Improvement of Perioperative Care of Elderly Patients
The focus of this study is the development of a perioperative treatment concept for elderly patients, based on individual necessities and risk factors, aiming to improve patient outcome.
- Trial name
- PeriAge (NCT03325413)
- Testing
- Systematic inclusion of family members, Preoperative information, Physical and breathing exercises
- Where
- Germany
- Volunteers
- 310 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf