Clinical trials: Neurodegenerative Disorders
Alzheimer s Disease
Terazosin And Metabolic Engagement in Alzheimer's Disease
The TAME-AD trial will be a randomized, double-blind, placebo-controlled Phase IIa clinical trial to evaluate the metabolic target engagement of terazosin for the treatment of Alzheimer's disease.
- Trial name
- TAME-AD (NCT07796308)
- Testing
- Terazosin (Hytrin)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Qiang Zhang
Parkinson
Effects of Deep Brain Stimulation for the Treatment of Parkinson's Disease
The purpose of this study is to assess the effects of unilateral deep brain stimulation on upper and lower extremity motor function in advanced Parkinson's disease patients.
- Trial name
- NCT00358189
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- US Department of Veterans Affairs
Constipation, Childhood Acute Lymphoblastic Leukemia
Comparison of Gastrointestinal Motility in Healthy Children and Children With Constipation
To gain a better understanding of the underlying dysmotility in constipation in children, we will use a novel minimal invasive method called 3D Transit.
- Conditions
- Constipation, Childhood Acute Lymphoblastic Leukemia, Neurofibromatosis 1, Chronic Constipation With Overflow
- Trial name
- NCT03981510
- Testing
- 3D-Transit
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Amyotrophic Lateral Sclerosis
Trial of Sodium Valproate in Amyotrophic Lateral Sclerosis
The purpose of this study is to determine whether the use of sodium valproate is effective in slowing the disease progression in Amyotrophic Lateral Sclerosis.
- Trial name
- NCT00136110
- Testing
- Sodium Valproate
- Where
- Netherlands
- Volunteers
- 165 people
- Sponsor
- UMC Utrecht
Parkinson Disease
Development and Research of an Individualized Intelligent Platform for Rehabilitaion in Parkinson's Disease
The present study aims to compare the clinical efficacy of intelligent POWER therapy, intelligent LSVT-BIG therapy, and the three exercise models currently in clinical use.
- Trial name
- NCT03212014
- Testing
- LSVT-BIG, POWER, Traditional rehabilitation
- Where
- Taiwan
- Volunteers
- 75 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Alzheimer Disease
Imaging Tau in Alzheimer's Disease and Normal Aging
This study is being done to learn about tau tangles in Alzheimer's disease. A type of positron emission tomography (PET) scan is used to measure the abnormal accumulation of protein called tau in the brain.
- Trial name
- NCT03373604
- Testing
- 18F-MK-6240, Lumbar Puncture (optional)
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Patrick Lao
Amyotrophic Lateral Sclerosis
Three Intermediate Expanded Access Protocols (EAP) CNMAu8.EAP01, CNMAu8.EAP02, and CNMAu8.EAP06 for ALS
The primary objective of the intermediate expanded access protocol is to provide access to the investigational product, CNM-Au8, to up to 300 people living with ALS (pALS).
- Trial name
- NCT05281484
- Testing
- CNM-Au8
- Where
- 16 sites in United States
- Sponsor
- Clene Nanomedicine
Tourette's Syndrome, Tourette Syndrome
Subthalamic Stimulation in Tourette's Syndrome
The main objective of this project is to evaluate the efficacy of subthalamic nucleus deep brain stimulation (STN DBS) in treating motor and phonic tics in medically refractory Tourette's syndrome (TS).
- Conditions
- Tourette's Syndrome, Tourette Syndrome, Gilles de la Tourette Syndrome, Tourette Disorder
- Trial name
- STN-DBSinTS (NCT02619084)
- Testing
- STN DBS
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Tourette Syndrome
A Study to Examine the Efficacy of a Therapeutic THX-110 for Tourette Syndrome
This study evaluates the efficacy and safety of THX-110 in the management of tics and other symptoms (e.g. rage attacks, anxiety, depression, sleep difficulties) in patients with Tourette syndrome.
- Trial name
- NCT03651726
- Testing
- THX-110 (dronabinol plus PEA)
- Where
- 2 sites in Germany
- Volunteers
- 60 people
- Sponsor
- Neurothera Labs Inc.
Parkinson Disease
A Trial of Fecal Microbiome Transplantation in Parkinson's Disease Patients
48 PD patients (age 35-75y; H\&Y 1-3) testing positive in a stool PD-dysbiosis test will be randomized in a 2:1 ratio to receive either donor FMT or their own stool through intracaecal infusion.
- Trial name
- NCT04854291
- Testing
- Administration of donor FMT
- Where
- 4 sites in Finland
- Volunteers
- 51 people
- Sponsor
- Helsinki University Central Hospital
PARKINSON DISEASE (Disorder), Aged 65 Years or Older
Multidimensional Assessment of Fatigability in Older Adults Living in Southern Switzerland and Elderly With Parkinson's Disease
With our study, the investigators aim to assess the impact of the fatigue experienced during daily life activities (tiredness) and whether there is a relationship with muscle fatigue during an exercise task.
- Trial name
- LifeLike (NCT07485218)
- Where
- 5 sites in Italy, Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Applied Sciences and Arts of Southern Switzerland
Amyotrophic Lateral Sclerosis (ALS)
Placebo Controlled Study of ONO2506PO in the Presence of Riluzole in Patients With Amyotrophic Lateral Sclerosis (ALS)
The purpose of this study is to determine if oral treatment with ONO-2506PO in patients diagnosed with ALS, who have had onset of muscle weakness within 14 months of randomization, could lead to the slowing of decline in…
- Trial name
- NCT00403104
- Testing
- ONO-2506PO
- Where
- 26 sites in Austria, Belgium and 6 more
- Volunteers
- 420 people
- Sponsor
- Ono Pharmaceutical Co., Ltd.
Chronic Disease, Fall Patients
Nature-based Therapy Program for Parkinson's Disease (PARC)
The goal of this clinical trial is to learn if a nature-based program has positive effects on the physical and psychosocial health in a group of participants with Parkinson's disease.
- Conditions
- Chronic Disease, Fall Patients, Aging Problems, Parkinson Disease
- Trial name
- PARC (NCT06452043)
- Testing
- PARC program
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- Université du Québec à Chicoutimi
Parkinson Disease, Cognitive Dysfunction
A Study to Evaluate the Safety and Tolerability of SAGE-718 in Participants With Parkinson's Disease Mild Cognitive Impairment (PD-MCI)
The primary purpose of this two-part study was to evaluate the safety and tolerability of SAGE-718 and its effects on cognitive, neuropsychiatric, and motor symptoms in participants with Parkinson's disease mild cognitive…
- Trial name
- NCT04476017
- Testing
- SAGE-718
- Where
- 4 sites in United States
- Volunteers
- 18 people
- Sponsor
- Supernus Pharmaceuticals, Inc.
Alzheimer's Disease, Dementia
Specific Interventions for Agitation in Alzheimer's Disease
This study is aimed at investigating specific pharmacological interventions in the treatment of the disruptive, agitated behavior associated with Alzheimer's patients.
- Trial name
- NCT00018291
- Testing
- Risperidone, Gabapentin
- Where
- United States
- Sponsor
- US Department of Veterans Affairs
Muscular Atrophy, Spinal
A Study to Learn About the Safety and Effects of Salanersen (BIIB115) When Given to Babies With Spinal Muscular Atrophy (SMA) Who Were Previously Treated With Onasemnogene Abeparvovec
In this study, researchers will learn more about the safety and effects of BIIB115, also known as salanersen. Specifically, researchers will learn more about how salanersen works in babies who have already been treated with…
- Trial name
- STELLAR-2 (NCT07444450)
- Testing
- Salanersen
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Biogen
Alzheimer Disease
Oral Enteral Nutrition Feeding in Alzheimer's Patients
This is a prospective multicenter study with Alzheimer's patients with dysphagia. Patients enrolled are randomly divided equally into the observation group and the control group.
- Trial name
- NCT06301750
- Testing
- Conventional Care, Intermittent Oral-esophageal Tube Feeding, Nasogastric tube
- Volunteers
- 80 people
- Sponsor
- Muhammad
Mild Cognitive Impairment, Alzheimer Disease
Epilepsy in Alzheimer's Disease: Effect on Disease Progression
This is a long-term, prospective, interventional study to investigate the role and prevalence of subclinical epileptiform activity in the hippocampus in patients with mild cognitive impairment (MCI) due to Alzheimer's disease…
- Trial name
- EADP (NCT04131491)
- Testing
- Lumbar puncture
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Juvenile Neuronal Ceroid Lipofuscinosis (CLN3), Batten Disease
Investigations of Juvenile Neuronal Ceroid Lipofuscinosis
Background: CLN3, or Batten disease, is a genetic disorder. This deadly disease leads to decline of brain and nervous system functions. Symptoms of CLN3 typically occur between 4 and 7 years of age.
- Trial name
- NCT03307304
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Parkinson's Disease
Comparison of IPX054 and Immediate-Release Carbidopa-Levodopa in Patients With Parkinson's Disease
The purpose of this study is to compare the clinical efficacy of IPX054 to immediate-release carbidopa-levodopa in subjects with Parkinson's disease.
- Trial name
- NCT00253084
- Testing
- IPX054 200 mg, CD-LD IR
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Impax Laboratories, LLC