Clinical trials: Neurodevelopmental Disability
Trauma, Psychological, Learning Disability
Narrative Exposure Therapy for Adults With an Intellectual Disability
The goal of this naturalistic single case series design is to investigate if an adapted Narrative Exposure Therapy protocol can be effective, is feasible, and acceptable for adults with a mile learning disability.
- Conditions
- Trauma, Psychological, Learning Disability, PTSD, Intellectual Disability, Mild
- Trial name
- NCT06934109
- Testing
- Narrative Exposure Therapy (NET)
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- University of Nottingham
Intellectual Disability, Mild to Moderate
Cooking Classes for Young Adults With ID
The purpose of this study is to examine the feasibility and initial efficacy of a healthy lifestyles intervention for the prevention of weight gain and the promotion of basic life skills related to improving health in transition…
- Trial name
- ChefBoyID (NCT05385016)
- Testing
- Cooking Skills, Physical Activity
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Kansas Medical Center
Autism Spectrum Disorder (ASD), Intellectual Disability
Verbal Intent and Gaze Cues on Action Prediction in ASD
A 2×2×3 mixed design (intent word × object type × group: TD, ASD, ID) was used. Age-matched children watched videos and judged which object a model would pick; their choices and eye movements were recorded.
- Trial name
- NCT07597694
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Intellectual Disability
New Skills - No Scores Research Study
The purpose of this study is to test the feasibility of a physical literacy and food literacy intervention for children with Intellectual Disabilities ages 12-16 years.
- Trial name
- NCT04254666
- Testing
- Physical Literacy & Food Literacy Intervention.
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Massachusetts, Worcester
Neurodevelopmental Abnormality
Two Year Developmental Follow-up for PREMOD2 Trial (Premature Infants Receiving Milking or Delayed Cord Clamping)
An extension of the PREMOD2 trial, the PREMOD2 Follow-Up trial will evaluate the neurodevelopmental outcomes at 22-26 months corrected age of preterm children who received UCM or DCC.
- Trial name
- PREMOD2FU (NCT03476980)
- Testing
- Randomized to Umbilical Cord Milking at birth, Randomized to Delayed Cord Clamping at birth
- Where
- 18 sites in United States, Canada and 2 more
- Volunteers
- 1,200 people
- Sponsor
- Sharp HealthCare
Fragile X Syndrome, FXS
A 2-Period Crossover Study of BPN14770 in Adults Males With Fragile X Syndrome
This is a single-center, randomized, double-blind, 2-period crossover study to explore the effects of BPN14770 on cognitive function and behavior in subjects with Fragile X Syndrome.
- Conditions
- Fragile X Syndrome, FXS, Fra(X) Syndrome
- Trial name
- NCT03569631
- Testing
- BPN14770
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Tetra Discovery Partners
Malnutrition, Developmental Disabilities
Promoting Physical Growth and Positive Development in Severely Stunted Guatemalan Children
This study seeks to evaluate the impact of an intensive home-based education intervention targeting severely stunted Guatemalan children for catch up growth and improved development.
- Trial name
- NCT02509936
- Testing
- Home-based nutrition education, Standard-of-care nutrition support
- Where
- Guatemala
- Volunteers
- 324 people
- Sponsor
- Wuqu' Kawoq, Maya Health Alliance
Rett Syndrome, Tourette Syndrome
The Role of Probiotics PS128 in Movement Disorders
Pediatric movement disorders comprise of a large number of different neurological diseases including Rett syndrome (RTT) and Tourette syndrome.
- Conditions
- Rett Syndrome, Tourette Syndrome, Tic Disorders
- Trial name
- NCT03259971
- Testing
- Probiotic-Lactobacillus plantarum PS128
- Where
- Taiwan
- Volunteers
- 500 people
- Sponsor
- National Taiwan University Hospital
Autism Spectrum Disorder, Intellectual Disability
Expert Guiding Technology to Help Individuals With Developmental Challenges Build Life and Vocational Skills
Clinical trials will evaluate the efficacy of expert guiding technology to support instructors to better help individuals with developmental challenges due to ASD and ID learn life and vocational skills.
- Trial name
- NCT04518358
- Testing
- Use of Expert Guiding Technology (GAINS) to Improve Live and Vocational Skills for Individuals with Developmental Challenges
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- John T. Nosek
Congenital Hypothyroidism
Clinical and Genetic Analysis in Congenital Hypothyroidism Due to Thyroid Dysgenesis.
Congenital hypothyroidism (CH) is a rare disease that affects 1 in 3500 newborn. This condition is detected consistently since the late 1970s in France, which has led to early care and a significant improvement in prognosis and…
- Trial name
- HYPOTYGEN (NCT01916018)
- Testing
- Clinical and radiologic exams and blood samples
- Where
- France
- Volunteers
- 558 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Relation, Mother-Child, Family Conflict
Children's Learning Centers Group FNI
The purpose of this study is to compare the effects of Family Nurture Intervention in a mother-child group setting with a Standard Children's Learning Center (CLC) Program for preschool-aged children (ages 2-4.5).
- Conditions
- Relation, Mother-Child, Family Conflict, Emotional Disturbances, Behavior Problem
- Trial name
- NCT03908268
- Testing
- Family Nurture Intervention (FNI), Standard Children's Learning Center (CLC) Program
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Columbia University
Rett Syndrome
A Safety Study of NNZ-2566 in Pediatric Rett Syndrome
The purpose of this study is to determine whether NNZ-2566 is safe and well tolerated in the treatment of Rett syndrome in children and adolescents.
- Trial name
- NCT02715115
- Testing
- NNZ-2566
- Where
- 12 sites in United States
- Volunteers
- 82 people
- Sponsor
- Neuren Pharmaceuticals Limited
Epilepsy, Insomnia
Trial of Melatonin to Improve Sleep in Children With Epilepsy and Neurodevelopmental Disabilities
The purpose of the study is to evaluate the safety and efficacy of oral melatonin in improving sleep continuity in children with epilepsy and neurodevelopmental delay who have chronic insomnia by comparing Fast Release Melatonin…
- Conditions
- Epilepsy, Insomnia, Developmental Disability
- Trial name
- NCT01161108
- Testing
- Fast Release Melatonin (FR MLT), Timed Release Melatonin (TR MLT)
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- The Hospital for Sick Children
Dyslexia, Visual Attention Span Deficit
Visual Attention Span Mobilisation for Dyslexia
The aim of the study is to evaluate the efficiency of the medical device MAEVAD in improving the reading skills of children with dyslexia.
- Trial name
- NCT05201235
- Testing
- MAEVAD, DeCaLigne
- Where
- 55 sites in France
- Volunteers
- 74 people
- Sponsor
- Humans Matter
Epilepsy, Intracranial Tumors
Magnetoencephalography in Children
This study is a single-center observational clinical study, which evaluates the diagnostic value of magnetoencephalography (MEG) in the diagnosis of neurodevelopmental diseases in children, such as the localization of epileptic…
- Conditions
- Epilepsy, Intracranial Tumors, Cerebrovascular Disease, Autism
- Trial name
- NCT06668519
- Testing
- Magnetoencephalography
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Children's Hospital of Fudan University
Dyslexia, Acquired, Brain Injuries
Therapy for Reading Problems in Adults After Brain Injury
Adults who sustain brain damage due to stroke, head injury, or traumatic surgery may develop difficulty reading. This study examines the effectiveness of behavior-based programs to improve reading ability in these individuals.
- Conditions
- Dyslexia, Acquired, Brain Injuries, Cerebrovascular Accident
- Trial name
- NCT00064805
- Testing
- Cognitive Therapy to Improve Reading
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Sleep Disorders
Efficacy and Safety of Circadin® in the Treatment of Sleep Disturbances in Children With Neurodevelopment Disabilities
The purpose of this study is to establish the efficacy and safety of Circadin in children with neurodevelopmental disorders and to determine the dose, this randomized, placebo-controlled study is planned to evaluate the efficacy…
- Trial name
- NCT01906866
- Testing
- Circadin 2/5/10 mg
- Where
- 28 sites in United States, Finland and 3 more
- Volunteers
- 125 people
- Sponsor
- Neurim Pharmaceuticals Ltd.
Aphasia, Stroke
Brain-based Understanding of Individual Language Differences After Stroke
Strokes often cause a loss of communication ability, referred to as aphasia, as well as cognitive difficulties. Each stroke survivor has a unique pattern of strengths and weaknesses in communication and cognition, and a unique…
- Conditions
- Aphasia, Stroke, Alexia
- Trial name
- BUILD (NCT04991519)
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Disruptive Behavior, Developmental Disability
Behavioral Parent Training to Address Early Childhood Disruptive Behavior Using the DOCS Parenting Programs
DOCS Parenting offers group-delivered behavioral parent training interventions for caregivers of children ages 0-12 years.
- Conditions
- Disruptive Behavior, Developmental Disability, Developmental Delay (Disorder), Behavior Problem of Childhood
- Trial name
- DOCS parenting (NCT07505381)
- Testing
- DOCS Parenting: Early Years, DOCS Parenting: School Years
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Intellectual Disabilities, Depression
Behavioural Activation and Severe Learning Disabilities
Research shows that people with severe learning disabilities get depressed at least as often as the wider population. Psychological therapies are recommended to treat depression, and some of these have been adapted for those…
- Trial name
- NCT06851741
- Testing
- Behavioural Activation for depression (BeatIt2)
- Volunteers
- 50 people
- Sponsor
- NHS Greater Glasgow and Clyde
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