Clinical trials: Neurodevelopmental Disorder
Phelan-McDermid Syndrome, Autism Spectrum Disorder
Mapping the Genotype, Phenotype, and Natural History of Phelan-McDermid Syndrome
The purpose of this study is to comprehensively characterize PMS using standardized medical, cognitive, and behavioral measures and to track the natural history of the syndrome using repeated longitudinal assessments.
- Conditions
- Phelan-McDermid Syndrome, Autism Spectrum Disorder, Intellectual Disability
- Trial name
- NCT02461420
- Where
- 5 sites in United States
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Parents, Stress
Telehealth Mindfulness-Based Music and Songwriting for Parents of Children With Intellectual/Developmental Disabilities
This is a pilot study of the feasibility and potential impact of a Mindfulness-Based Music and Songwriting program (delivered via telehealth) on stress and well-being in parents/caregivers of children with intellectual or…
- Conditions
- Parents, Stress, Developmental Disability, Intellectual Disability
- Trial name
- NCT04962659
- Testing
- Mindfulness-Based Music and Songwriting
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Attention Deficit Disorder With Hyperactivity
Psychological Effects of Tai Chi Training
The general purpose of this study is to examine the effect of tai chi training on cognitive function in young adults. The investigators will test subjects enrolled in a semester-long tai chi course along with control subjects.
- Trial name
- NCT01681082
- Testing
- Tai Chi training
- Where
- United States
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Craniosynostoses
Neurodevelopmental Outcomes in Craniosynostosis Repair
Context: Craniosynostosis is a common craniofacial abnormality which can be associated with various clinical syndromes. Though it has been established that children with craniosynostosis score lower on certain developmental…
- Trial name
- NCT04072783
- Testing
- MRI,DTI, functional MRI
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Cleft Lip and/or Palate, Speech Disorder
Neural Changes After Speech Therapy in Patients With Cleft Palate: A Brain Imaging Study
Cleft palate is one of the most common maxillofacial congenital malformations, which results in severe speech disorders. Compensatory articulation disorder, also known as non-oral articulation disorder (NOA), is considered as the…
- Conditions
- Cleft Lip and/or Palate, Speech Disorder, Speech Therapy, Brain
- Trial name
- fMRI-Speech-CP (NCT07330687)
- Testing
- Structured Speech Training for Decompensation
- Where
- China
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Shufan Zhao
Neurofibromatosis Type 1, Learning Disability
Interventions for Reading Disabilities in NF1
Neurofibromatosis Type 1 (NF1) is a common genetic disorder that is associated with a four times greater risk of learning disabilities, including reading disabilities, and a deficiency of neurofibromin - a protein important in a…
- Conditions
- Neurofibromatosis Type 1, Learning Disability, Reading Disability, NF1
- Trial name
- NCT02964884
- Testing
- Lovastatin, reading tutoring intervention
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Child Mental Disorder
The Effect of Animal-assisted Practice Applied to Hospitalised Children on Children's Anxiety, Fear, Psychological and Emotional Well-being
In the normal development stage, children become ill for various reasons and maybe hospitalised. Illnesses and hospitalization are major sources of stress for any growing child.
- Trial name
- NCT04775771
- Testing
- Animal Assisted Practice
- Where
- Turkey (Türkiye)
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Inonu University
Autism Spectrum Disorder
Structured Sensory-Based Occupational Therapy in Children With Autism
This controlled clinical study will investigate the effects of a 12-week structured sensory-based occupational therapy intervention on occupational performance, sensory processing, gross motor development, and eating behaviors in…
- Trial name
- NCT07789704
- Testing
- Structured Sensory-Based Occupational Therapy, Individualized Home Activity Program
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Emre DANSUK
ADHD
Internet-based Cognitive Behavioral Therapy for Adult Attention Deficit Hyperactivity Disorder
Attention deficit hyperactivity disorder (ADHD) is a disorder characterized by lack of attention, hyperactivity, and impulsivity.
- Trial name
- NCT05700539
- Testing
- Internet-based cognitive behavioral therapy
- Where
- Sweden
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Autism, Stress
5Minutes4Myself: A Wellness Program for Caregivers
This research study refines a wellness program designed for caregivers of autistic children called 5Minutes4Myself and further investigates its feasibility.
- Conditions
- Autism, Stress, Autism Spectrum Disorder
- Trial name
- NCT03771001
- Testing
- Motivational Interviewing coaching and habit-building app
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Autism Spectrum Disorder
REward SYSTem in Autism Spectrum Disorder and Addictive Disorder
An MRI Study in Subjects with Autism Spectrum Disorder and Subjects with Food Addictive Disorder compared to healthy volunteers.
- Trial name
- RESYSTAA (NCT05391113)
- Testing
- MRI, EEG
- Where
- 3 sites in France
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Autism, Autism Disorder
Role of the Gut Vascular Barrier and Microbiota in Autism Spectrum Disorders
Recent research links gut microbiota alterations to Autism Spectrum Disorders (ASD), a neurobiological condition with multifactorial bases.
- Conditions
- Autism, Autism Disorder, Autism Spectrum Disorder (ASD)
- Trial name
- DSA/GVB (NCT07450443)
- Testing
- PostbiotiX Comfort®, Control
- Where
- 2 sites in Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Stroke-induced Aphasia
Overcoming Learned Non-Use in Chronic Aphasia
In this study the investigators are examining the effectiveness of intensive speech therapy in chronic moderate-to-severe stroke-induced aphasia under two conditions - responses "constrained" or unconstrained to speech.
- Trial name
- NCT02012374
- Testing
- Intensive Language Action Therapy
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Amherst
Developmental Disability
Benefits of Coding Training on Young Adults With Developmental Disabilities
The purpose of the present study is to develop and evaluate the Technology Early Career Preparation Intervention (TECH-Prep) program with African American high school students with developmental disabilities.
- Trial name
- NCT05132491
- Testing
- TECH-Prep Intervention
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Autism Spectrum Disorder
Study of the Genetic Factors Involved in Autism and Related Disorders
The main objective of the study is to define, for Autism Spectrum Disorder, the extent of genetic variation in synaptic pathways that may be targeted for therapeutic development.
- Trial name
- Gene&autism (NCT04727489)
- Testing
- DNA from subjects will be stored in the biobank of our study.
- Where
- 6 sites in France
- Volunteers
- 3,800 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Intellectual Disability, Quality of Life
The Effect of Gardening Activities on the Quality of Life of Students With Mild Intellectual Disability
This study will be conducted to determine the effect of gardening activities applied to mildly intellectually disabled secondary school students on their quality of life and to examine their views on these activities in depth.
- Trial name
- NCT07504874
- Testing
- Horticultural activity
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ordu University
Developmental Delay (Disorder)
Promoting Playfulness
Health inequalities, social isolation, and family adversity impact a child's development. Play is the context for child development in all areas.
- Trial name
- NCT06625255
- Testing
- Parent Education - Promoting Playfulness
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Florida Gulf Coast University
Autism Spectrum Disorder
Emergence of Generative Language
The purpose of this study is to investigate the effects of several applied behavior teaching procedures on the use of multi-word utterances by children with autism.
- Trial name
- NCT02555241
- Testing
- Mand Training, Matrix, Stimulus Equivalence Training
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Emory University
Mental Disorder, Child
MISC-CBO to Improve the Mental Health of OVC in South Africa
The goal of this cluster randomized control clinical trial is to evaluate the effectiveness of the Mediational Intervention for Sensitizing Caregivers for Community-based Organizations (MISC-CBO) in reducing mental health…
- Trial name
- NCT05943132
- Testing
- Mediational Intervention for Sensitizing Caregivers (MISC), Treatment as Usual
- Where
- South Africa
- Volunteers
- 792 people, healthy volunteers welcome
- Sponsor
- University of Houston
Major Depressive Disorder, Anxiety Disorder
The Relationship Between Emotion Regulation and Psychiatric Disorder in Youth
According to the increasing worldwide prevalence rate of psychiatric disorders in youth, the mental health of youth is becoming more and more important.
- Conditions
- Major Depressive Disorder, Anxiety Disorder, Attention Deficit Hyperactivity Disorder (ADHD), Adjustment Disorder
- Trial name
- NCT06271954
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
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