Clinical trials: Neurodevelopmental Disorder
Children With Autism Spectrum Disorder, Typical Developed Children
Investigating Handwriting Characteristics and Underlying Factor in Children With Autism Spectrum Disorder
The mechanism of the motor problem in children with autism spectrum disorder (ASD) in handwriting has been investigated in the following three aspects, including collecting dynamic handwriting performance, exploring the related…
- Trial name
- NCT06228885
- Testing
- handwriting experiment and motor ability test
- Where
- Taiwan
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Developmental Disorders
Risk of Recurrence of de Novo Mutations: Research and Quantification of Paternal Germinal Mosaicism by the Combined Use of Genomic Tools
1. Inclusion of 5 families Inclusions will be made by the clinical genetics department of the Rouen University Hospital (monocentric study) and will correspond to trios of parents + child with unexplained developmental…
- Trial name
- RRMUT (NCT04564235)
- Testing
- genome-wide analyses, Search for de novo mutations in paternal sperm samples
- Where
- France
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Autism Spectrum Disorder
Training Early Social Language in Autism
The aim of the study is to determine whether a targeted behavioral intervention can lead to both changes in early communication skills and in neural responses in toddlers and preschoolers with autism.
- Trial name
- TESLA (NCT03427138)
- Testing
- Jasper, Parent Education
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Autism Spectrum Disorder
Transcranial Magnetic Stimulation on Neural and Behavioral Facets of Social Cognition in Autism Spectrum Disorder
This study will evaluate the effects of repetitive Transcranial Magnetic Stimulation (rTMS) on neural and behavioral facets of social cognition in Autism Spectrum Disorder (ASD).
- Trial name
- TMSinASD (NCT04242355)
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Yale University
Neurofibromatosis 1
Antioxidant Therapy With N-acetylcysteine for Children With Neurofibromatosis Type 1
Children with neurofibromatosis type 1 (NF1) commonly suffer from the effects of cognitive, behavioral, and motor impairments. At present, there is no specific treatment for this NF1 complication.
- Trial name
- DoDNAC (NCT04481048)
- Testing
- N-Acetyl cysteine
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Attention Deficit Disorder With Hyperactivity (ADHD)
Dual Task and Attention Deficit and Hyperactivity Disorder
When motor control deficits, sensory-perceptual deficits, and deficits in attention allocation and executive functions, often seen in ADHD, are accompanied by impairments in attentional allocation and executive function, further…
- Trial name
- NCT07150078
- Testing
- test
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gaziantep Islam Science and Technology University
Autism Spectrum Disorder, Complication of Prematurity
Correlation of CXCR4 Expression in Premature Infants With a Diagnosis of Autism at 24 Months
Preterm children are at increased risk for autism spectrum disorders, with an estimated rate of 10%. In the US, about 1 in 8 pregnancies ends with a premature birth.
- Trial name
- ASD-CXCR4 (NCT01686685)
- Where
- Israel
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Heathly Subjects Susceptible to SARS-CoV-2 Infection
Microbiome-Based Risk Prediction of SARS-CoV-2 in Children and Families (PREDICOL)
The goal of this observational cohort study is to evaluate the association between gut microbiota composition, dietary patterns, lifestyle-related factors, and neurodevelopmental outcomes, as well as susceptibility to SARS-CoV-2…
- Trial name
- PREDICOL (NCT07717008)
- Where
- Spain
- Volunteers
- 932 people, healthy volunteers welcome
- Sponsor
- Spanish National Research Council
Neurodevelopmental Disorders, Attention Deficit Hyperactivity Disorder
Validity of Neurocognitive Assessment Methods in Childhood ADHD
The aim of the study is to examine the prospective validity of neurocognitive functions and emotional factors in schoolchildren with ADHD and a control group of typically developing schoolchildren at baseline and after three…
- Trial name
- NCT04201509
- Where
- Sweden
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Region Skane
Autism Spectrum Disorder
Fit Families Program: Fundamental Motor Skill Intervention in Children With Autism Spectrum Disorders and Their Parents
The investigators aim to identify the effect of a 12-week fundamental motor skills (FMS) (e.g., throwing, catching, running) intervention on the active participation in physical recreation activities and a variety of other…
- Trial name
- NCT04612647
- Testing
- 12-week FMS Intervention, Physical Activities & Activity Booklets
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Attention Deficit Hyperactivity Disorder, Autism Spectrum Disorder
Brain Activity Flow Patterns Analysis Using Evoked Response Potentials in Youth With ADHD, Bipolar Disorder, or Autism Spectrum Disorders: A Preliminary Study
The study aims to evaluate whether or not an EEG (a type of brain scan) is useful in diagnosing youth with either ADHD, BPD, ASD.
- Conditions
- Attention Deficit Hyperactivity Disorder, Autism Spectrum Disorder, Bipolar Disorder
- Trial name
- NCT01506232
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Autistic Disorder
Comparison of Applied Behavioral Analysis (ABA) Versus ABA and Risperidone
Hypotheses: 1. Preschool children with autism spectrum disorders (ASDs) who undergo ABA treatment only will demonstrate significantly better outcomes compared to an age and severity matched control group without ABA treatment. 2.
- Trial name
- NCT00374764
- Testing
- Risperidone, ABA
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Pollution; Exposure, Neurodevelopmental Disorders
Air Pollution and Development in the Boricua Youth Study
This study seeks to understand the relationship between prenatal maternal air pollution exposure and offspring risk for ADHD and examine two potential -modifiable- mechanisms: prenatal maternal inflammation and offspring sleep…
- Trial name
- NCT05368493
- Testing
- MRI task
- Where
- 2 sites in United States, Puerto Rico
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Sport Injury, Attention-deficit/Hyperactivity Disorder
Effects of Subconcussive Head Impacts on Neural Integrity and Function in ADHD
The purpose of this study is to examine the acute neural responses to subconcussive head impacts in individuals with Attention-deficit/hyperactivity disorder (ADHD).
- Trial name
- NCT04880304
- Testing
- Soccer Heading
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Indiana University
ADHD
Proton Magnetic Spectroscopy in Children and Adolescents With ADHD Before and After Treatment With OROS Methylphenidate
This will be an open label study using daily does of up to 126mg/day of Concerta in the treatment of children and adolescents, ages 12-17, who meet DSM-IV criteria for ADHD.
- Trial name
- NCT00593112
- Testing
- OROS methylphenidate, No intervention
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Neurodevelopmental Disorders
Developmental Origins of Mental Health Disorders
Common mental disorders (CMD) such as Depression, contributes significantly to the global burden of disease. Fetal exposure to adverse intrauterine environment mediated by life course factors can enhance risk of non-communicable…
- Trial name
- NCT03096028
- Testing
- maternal vitamin B12 folate level during pregnancy
- Where
- India
- Volunteers
- 386 people, healthy volunteers welcome
- Sponsor
- Kem Hospital, Pune, India
Down Syndrome, Intellectual Disability
Parents as the Primary Sexuality Educators for Their Young Adults With Down Syndrome
By integrating sexuality and disability literatures, theories, and research methodologies, this study aims to: 1) contribute to the limited knowledge professionals have of parents as the primary sexuality educators; 2) create a…
- Conditions
- Down Syndrome, Intellectual Disability, Sexuality, Parent-Child Relations
- Trial name
- NCT03135236
- Testing
- Parent training
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Autism Spectrum Disorder
Treatment Planning for ABA Employing Auxiliary Tools V2+ (TREAAT2+)
Technology enhancement in Applied Behavior Analysis (ABA) treatment planning may increase confidence, efficiency, consistency, and satisfaction for Board Certified Behavior Analysts (BCBAs) which, in turn, can provide for better…
- Trial name
- TREAAT2+ (NCT06204536)
- Testing
- Tech-enabled ABA treatment planning
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Montera Health Texas LLC
Neurodevelopmental Disorders
Validation of the French Translation of the SOSI-M
The aim of this study is to validate the French version of the SOSI-M test on healthy children as well as on children with neurodevelopmental disorders (NDDs).
- Trial name
- NCT07353112
- Testing
- Administration of the French translation of the SOSI-M test.
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Haute Ecole Ilya Prigogine
Depression, Anxiety
BEhavioral Health Stratified Treatment (BEST) Study for Youth With Intellectual and/or Developmental Disabilities (IDD)
Many youth with disabilities and their families receive "care coordination services" from a state Maternal and Child Health Bureau (MCHB) agency.
- Conditions
- Depression, Anxiety, Transition
- Trial name
- BEST (NCT05520983)
- Testing
- Adapted Teens Achieving Mastery over Stress (TEAMS) Treatment, Adapted Teens Achieving Mastery over Stress (TEAMS) Prevention, Adapted Competent Adulthood Transition with Cognitive-behavioral & Interpersonal Training (CATCH-IT)
- Where
- United States
- Volunteers
- 780 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
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