Clinical trials: Neurogenic Inflammation
Overactive Bladder, Painful Bladder Syndrome
Changes in Inflammatory and Contractile Protein Expression in Patients With Painful Bladder Syndrome/IC.
Interstitial cystitis (IC)/chronic pelvic pain syndrome (CPPS) is a clinical syndrome of pelvic pain and/or urinary urgency/frequency in absence of a specific cause such as bacterial infection or damage to the bladder.
- Conditions
- Overactive Bladder, Painful Bladder Syndrome, Chronic Pelvic Pain Syndrome, Cystitis, Interstitial
- Trial name
- NCT00775281
- Where
- Switzerland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Scarring Alopecia, Frontal Fibrosing Alopecia
Role of Neurogenic Inflammation and Topical 6% Gabapentin Therapy in Symptomatic Scarring Alopecia
This study will serve as a pilot study to determine the efficacy and safety of topical gabapentin in the treatment of symptomatic scarring alopecia.
- Conditions
- Scarring Alopecia, Frontal Fibrosing Alopecia, Lichen Planopilaris, Central Centrifugal Cicatricial Alopecia
- Trial name
- NCT03346668
- Testing
- Topical gabapentin
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Minnesota
Inflammatory Bowel Disease (IBD)
Biophysical Assessments of Acupuncture Points in Inflammatory Bowel Disease
Acupuncture points or acupoints are fundamental to the practice of acupuncture, yet their scientific basis remains unclear. According to traditional explanations of acupuncture, acupoints can become tender or more sensitive to…
- Trial name
- NCT07681895
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Trigeminal Neuralgia, Glossopharyngeal Neuralgia
Anti-CGRP for Inflammation and Pain Modulation in Small Fiber Neuropathy/Fibromyalgia
The investigators will treat patients (targeting enrollment of n=20) who suffer from trigeminal or glossopharyngeal nerve pain in the context of painful small fiber neuropathy.
- Trial name
- NCT04158752
- Testing
- Galcanezumab
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Duke University
Nervous System Malformations, Arthropathy, Neurogenic
Anakinra to Treat Patients With Neonatal Onset Multisystem Inflammatory Disease
This study will evaluate the safety and effectiveness of anakinra (Kineret) for treating patients with neonatal-onset multisystem inflammatory disease (NOMID), also known as chronic infantile neurological, cutaneous and…
- Conditions
- Nervous System Malformations, Arthropathy, Neurogenic, Urticaria, Papilledema
- Trial name
- NCT00069329
- Testing
- anakinra
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Inflammation, Pruritus
L-menthol as a Topical Counter-irritant to TRPA1-induced Neurogenic Inflammation and Pain
The aim of this study is to quantitatively characterize the effects of L-menthol as a topical counter-irritant on cutaneous pain and hyperalgesia provoked by topical application of the TRPA1-agonist trans-cinnamaldehyde (CA) in…
- Conditions
- Inflammation, Pruritus, Hyperalgesia
- Trial name
- NCT02653703
- Testing
- Topical L-menthol 40%, Vehicle, topical ethanol 96%
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Diabetes Mellitus, Polyneuropathies
Neurogenic Inflammation in Diabetes
Polyneuropathy is a complication of diabetes mellitus which leads to decreased sensation in arms and legs. This in turn can lead to the development of (infected) foot ulcers.
- Conditions
- Diabetes Mellitus, Polyneuropathies, Arthropathy, Neurogenic
- Trial name
- NCT01370837
- Testing
- Intracutaneous injection of Candida albicans antigen., Temperature measurement.
- Where
- Netherlands
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Occlusal Trauma, Orthodontic Appliance Complication
Importance of Neurogenic Inflammation in the Angiogenic Response of the Dental Pulp as a Defensive Response
This study measures SP, CGRP and VEGF expression in human dental pulp under occlusal trauma induced by occlusal interferences under moderate orthodontic forces or under a combination of occlusal trauma and moderate orthodontic…
- Trial name
- NCT03804034
- Testing
- Block of resin, Buccal tube, Bracket and 0.0017 × 0.025 in titanium molybdenum alloy wire
- Where
- Colombia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Institucion Universitaria Colegios de Colombia
Psoriasis
Excimer Light in Psoriasis
The aim of this study is to determine the standard tissue levels of SP and its receptor in lesional skin of psoriasis patients in both developing and stationary stages before and after excimer light therapy.
- Trial name
- NCT05283876
- Testing
- Excimer light
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Burning Mouth Syndrome
Neurogenic Mechanisms in Burning Mouth Syndrome
Burning mouth syndrome (BMS) is characterized by a bilateral burning sensation in the anterior tongue, hard palate and lips in the absence of any clinical or laboratory findings.
- Trial name
- BMS17 (NCT00875537)
- Testing
- Capsaicin oral gel 0.025%, Capsaicin oral gel 0.01%
- Where
- Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Anesthesia, Surgery
Postoperative Neuroinflammation and Cognitive Dysfunction After Abdominal Surgery
The main purpose of this study is to assess the induction of neuroinflammation in brain regions of interest for learning and memory in adult patients undergoing urological surgery under general anesthesia
- Conditions
- Anesthesia, Surgery, Neurogenic Inflammation, Cognitive Disorders
- Trial name
- POPE (NCT01881646)
- Testing
- Positron emission tomography (PET) using [11C]PBR28
- Volunteers
- 8 people
- Sponsor
- Karolinska University Hospital
Neurogenic Inflammation, Dental Pulp Disease
Neuropeptide Y Regulates Neurogenic Pulp Inflammation
Objective. This study assessed the neuropeptide Y (NPY) expression in healthy human dental pulp following tooth bleaching with three in-office hydrogen peroxide-based systems: Opalescence Boost© (Ultradent Products, South Jordan…
- Trial name
- NCT06606236
- Testing
- H2O2 at 35% for 8 minutes, H2O2 at 40% for 20 minutes, H2O2 at 25% plus cold blue light for 15 minutes
- Where
- Colombia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Institucion Universitaria Colegios de Colombia
Fibromyalgia
Dynamic Contrast Enhanced (DCE)-MRI in Fibromyalgia
The primary objective of the current pilot study is to analyze MRI contrast-enhancement patterns in the hands of patients with fibromyalgia as compared to the findings in healthy controls.
- Trial name
- NCT01506817
- Testing
- Dynamic contrast-enhanced MRI of the hands
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Frederiksberg University Hospital
Post Nasal Drip
Capsaicin Cough Threshold in Chronic Cough Due to Postnasal Drip
This study is being done to find out why some people with mucus dripping down the back of their throat have a nagging cough while others do not cough.
- Trial name
- NCT00588627
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Mayo Clinic
Carpal Tunnel Syndrome, Neurogenic Inflammation
BotulInum Toxin Type A for Peripheral Neuropathic Pain in subjEcts With Carpal Tunnel Syndrome
The main purpose of the study is to assess the safety and efficacy of repeated administrations of BoNT-A in subjects with NP attributable to carpal tunnel syndrome (CTS) through a randomized, double-blind, placebo-controlled…
- Conditions
- Carpal Tunnel Syndrome, Neurogenic Inflammation, Pain, Drug Use
- Trial name
- INjECT (NCT05411900)
- Testing
- BoNT-A
- Where
- Italy
- Volunteers
- 164 people
- Sponsor
- Francesco Bono
Overactive Bladder
Clinical and Biochemical Evidence of Neurogenic Inflammation in Women With Urinary Urgency
The purpose of this study is to gain a better understanding of what causes urinary urgency in women by asking about different symptoms and measuring biomarker levels in their urine.
- Trial name
- NCT01933074
- Where
- United States
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Neurogenic Inflammation, Periimplant Diseases
Neurogenic Inflammation in Peri-implant and Periodontal Diseases
Regulatory effects of some neuropeptides substance-P (SP), neurokinin-A (NKA), calcitonin gene-linked peptide (CGRP) and neuropeptide-Y (NPY) )on inflammatory responses in periodontal disease has been described; however, the…
- Conditions
- Neurogenic Inflammation, Periimplant Diseases, Periodontal Diseases, Gingival Crevicular Fluid
- Trial name
- NCT03663140
- Testing
- gingival crevicular fluid (GCF) and peri-implant sulcular fluid(PISF) collection
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University