Clinical trials: Neuroimaging
Orthotopic Neobladder
The Supraspinal Control of Lower Urinary Tract Function in Patients With Orthotopic Sigmoid Neobladder.
Orthotopic sigmoid neobladder surgery is one of the ideal urinary diversion methods after radical cystectomy.In recent years, functional imaging studies have revealed brain regions related to urinary system function, but brain…
- Trial name
- NCT05558111
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Expectancy Versus Pharmacotherapy Effect of Adderall
Neuroimaging the Expectancy Versus Pharmacotherapy Effect of Adderall on Cognitive Performance
The purpose of this balanced-placebo design study is to pilot a larger study to further explore the current evidence that stimulant medications are not cognitive enhancers, despite this rampant belief in young adults.
- Trial name
- NCT03530631
- Testing
- Adderall
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Post-traumatic Stress Disorder (PTSD)
CB1 Receptor PET Imaging Reveals Gender Differences in PTSD
The objective of the proposed translational study is to test a model, based upon basic science studies, exploring multisystem impairments in PTSD including endocannabinoid (eCB) and glucocorticoids in the modulation of fear…
- Trial name
- NCT02237677
- Testing
- Positron emission tomography (PET) imaging
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Major Depression in Remission
Pharmaco-Neuroimaging Studies of Approach/Avoidance Behaviors and Post-Mortem Studies: Study 1.2 (Stress Manipulation)
This study investigates how remitted individuals with past major depressive disorder (MDD) make approach-avoidance decisions and which brain regions are implicated in such decisions.
- Trial name
- NCT04325529
- Testing
- Aversive stimuli
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Brain Aging
Milk Intervention Study for Brain Aging
The purpose of this study is to learn if increased dairy food consumption helps brain health in older adults by protecting nerve cells from damage.
- Trial name
- NCT02957422
- Testing
- 1% Milk, Control
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Healthy
tDCS of the Left dlPFC: Effects on Information Processing
This study investigates how a non-invasive form of brain stimulation, called transcranial direct current stimulation (tDCS), affects brain activity and information processing in younger and older adults.
- Trial name
- NCT07168031
- Testing
- Active Transcranial Direct Current Stimulation (tDCS)
- Where
- Switzerland
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- University of Bern
Parkinson's Disease
Investigating the Microstructural and Functional Alterations of Brain in Parkinson's Disease Patients
The objective of this protocol is to investigate the microstructural alterations and monoaminergic function in Parkinson's disease patients with impulse control disorders and cognitive impairment by multimodal MRI and 18F-DTBZ…
- Trial name
- NCT02599753
- Testing
- 18-FDTBZ
- Where
- Taiwan
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Major Depressive Disorder
Stress Dynamics and Familial Risk for Depression in Female Adolescents
Stress and a parental history of major depressive disorder (MDD) are among the strongest risk factors for future development of MDD.
- Trial name
- NCT06816329
- Testing
- Computer Task Manipulation
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Drug Abuse, Nicotine Dependence
Advanced Functional and Structural MRI Techniques for Neuropharmacological Imaging
Background: Functional and structural magnetic resonance imaging (MRI) techniques have allowed researchers to map and study how the brain works when at rest and when engaged in specific tasks.
- Trial name
- NCT01036581
- Testing
- MagPro X100 Magnetic Stimulator, Transcranial Rotating Magnetic Stimulator, Magnetom Prisma Fit 3T Scanner
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Fibromyalgia
A Brain Imaging Study of Tai Chi on Fibromyalgia
To accomplish our Specific Aims, we propose to conduct a two-session fMRI experiment in up to 30 patients with fibromyalgia (FM) and up to 30 healthy controls.
- Trial name
- NCT01857219
- Testing
- Tai chi
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Psychiatric Illness, Healthy
Effects of GLYX-13 on Learning and Memory in Healthy Individuals and Those With Psychiatric Illness
The present study proposes to evaluate the potential cognitive enhancing effects of GLYX-13, an NMDAR partial agonist, among a group of healthy adults and those with psychiatric illness on a series of functional magnetic…
- Trial name
- NCT01844726
- Testing
- GLYX-13
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Cognitive Abilities, Performance
EEG-Guided Binaural Beat Audio to Reduce Performance-Related Stress and Improve Cognition
Performance-related stress can impair sustained attention, inhibitory control, and memory. This randomized, double-blinded, sham-controlled parallel-arm trial evaluates whether a 30-minute EEG-guided binaural beat audio…
- Conditions
- Cognitive Abilities, Performance, Stress, Cognitive Performance
- Trial name
- NCT07407426
- Testing
- EEG-guided binaural beat audio, Non-binaural audio intervention
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Dementia
The Sunnybrook Dementia Study
The prospect of disease-modifying therapies in the pipeline for Alzheimer's Disease (AD) has intensified efforts to use brain imaging more effectively for diagnosis and monitoring of dementing illnesses.
- Trial name
- SDS (NCT01800214)
- Where
- Canada
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Fetal Alcohol Spectrum Disorders
Improving Self Regulation in Children With Fetal Alcohol Syndrome Spectrum Disorders: A Neuroplastic Intervention
This study on children with fetal alcohol spectrum disorder (FASD) aims to (i) characterize their self-regulation deficits, a process important for controlling emotions and behavior, (ii) describe brain structure and function…
- Trial name
- NCT02457676
- Testing
- Alert Program for Self-Regulation
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Focal Dystonia
Electrophysiological and Neuroimaging Correlates of the Effect of Zolpidem in Patients With Focal Dystonia
To study electrophysiological and imaging correlations of the clinical effectiveness of zolpidem in task-specific dystonia and to elucidate mechanisms underlying its therapeutic effects, patients with focal dystonia will be…
- Trial name
- NCT04692285
- Testing
- Zolpidem
- Where
- 2 sites in Serbia, Slovenia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Alzheimer's Disease
A Study of 18F-AV-45 in Alzheimer's Disease (AD) and Healthy Volunteers
This study will test if two AV-45 PET scans up to 4 weeks apart in AD subjects and healthy volunteers provide the same results. The study will also test two different AV-45 injection methods in a small subgroup of enrolled AD…
- Trial name
- NCT01565343
- Testing
- florbetapir F 18
- Where
- 4 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Avid Radiopharmaceuticals
Inhalant Use Disorder
Brain Imaging Studies of the Effect of Inhalant Use Disorder
Inhalants substance misuse is an important public health problem whose prevalence is approximately 1% in the general population and 7% among high school students in Mexico.
- Trial name
- NCT02188914
- Testing
- Positron emission tomography scan, Magnetic resonance imaging
- Where
- Mexico
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Miguel Ángel Mendoza Meléndez
Healthy
Imaging of Cannabinoid Receptors Using New Radioactive Tracer
This study will test a new radioactive tracer, [(11)C]MePPEP, for use in positron emission tomography (PET) imaging. The tracer is used to visualize cannabinoid receptors, proteins in the brain that mediate a variety of natural…
- Trial name
- NCT00450021
- Testing
- [(11)C] MePPEP
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Friedreich Ataxia
A Natural History Study to TRACK Brain and Spinal Cord Changes in Individuals with Friedreich Ataxia (TRACK-FA)
This is a natural history study prospectively investigating neuroimaging markers of disease progression in children and adults with Friedreich ataxia (FA). There will be three assessment periods (baseline, 12 and 24 months).
- Trial name
- (TRACK-FA) (NCT04349514)
- Testing
- Natural history
- Where
- 7 sites in United States, Australia and 3 more
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Monash University
Alzheimer Dementia, Posttraumatic Stress Disorder
Risk Prediction for Alzheimer Dementia With Brain Imaging and Genetics
The purpose of this study is to learn about how trauma, posttraumatic stress disorder (PTSD), and mild traumatic brain injury that can occur during deployment affect the brain.
- Conditions
- Alzheimer Dementia, Posttraumatic Stress Disorder, Traumatic Brain Injury
- Trial name
- NCT03641768
- Testing
- MRI, PET, 18F-Florbetapir
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Duke University