Clinical trials: Neuroimaging
Mild Concussion, Healthy Volunteers
A New Generation of Magnetoencephalographs for High Speed Functional Brain Imaging
The goal is to perform a first evaluation of the capabilities of a new generation of non-invasive magnetoencephalography whole head device using optically pumped magnetometers using Helium 4 as the sensitive element (OPM He4) to…
- Trial name
- DEMAGUS (NCT06244472)
- Testing
- Experiment 1: visual and auditory attention task, Experiment 2: language production and rest tasks, Experiment 3: visuo-motor task
- Where
- 2 sites in France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Mild Cognitive Impairment, Alzheimer's Disease
Korea Alzheimer's Disease Neuroimaging Initiative
PRIMARY OBJECTIVES -Establish a registry for Alzheimer's disease (AD) and subcortical ischemic vascular dementia (SIVD) STUDY DESIGN -This is a non-randomized, natural history, observational, registry study.
- Conditions
- Mild Cognitive Impairment, Alzheimer's Disease, Subcortical Vascular Dementia
- Trial name
- K-ADNI (NCT01979419)
- Where
- South Korea
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Korean Alzheimers' Disease Neuroimaing Intitiative
Healthy Volunteers
A Brain Imaging Study to Assess the Binding of MSP-2020 to Serotonin 5-HT2A Receptors in Healthy Male Adults
This study is to see how well MSP-2020 attaches to specific targets in the brain called serotonin type 2A receptors (5-HT2AR). This study will also look at how much of the study drug (and its metabolite) is in the blood and how…
- Trial name
- NCT07329621
- Testing
- MSP-2020
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Amphetamine-Related Disorders
Functional Brain Imaging in Recreational Users of Ecstasy
Recreational use of "ecstasy" (MDMA; 3,4-methylenedioxymethamphetamine) is associated with long-lasting effects on metabolism in the human brain.
- Trial name
- NCT00254306
- Where
- Israel
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Major Depressive Disorder
Neuroimaging Studies of Reward Processing in Depression
This study investigates stress-related signaling of glutamate and dopamine within the reward-processing circuit in Major Depressive Disorder (MDD), and whether they can be used to predict depressive symptoms in the future.
- Trial name
- NCT03026036
- Testing
- PET Scan with Raclopride
- Where
- United States
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Development, Child, Executive Functions
Orchestra in Class, a Novel Booster for Executive Functions and Brain Development in Young Primary School Children
How to optimally stimulate the developing brain is still unclear. Executive functions (EF) exhibited substantially stronger far transfer effects in children who learned to play a musical instrument than in children who acquired…
- Conditions
- Development, Child, Executive Functions, Interventions, Music
- Trial name
- ORBIT (NCT05912270)
- Testing
- Orchestra in Class
- Where
- Switzerland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- School of Health Sciences Geneva
Parkinson Disease
LRRK2 Mutation and Parkinson's Disease
The Leucine-Rich Repeat Kinase 2 (LRRK2) is implicated in autosomal dominant Parkinson's disease (PKD). An inhibitor for the leucine-rich repeat kinase 2 (LRRK2) is in pre-clinical development for potential use in treating…
- Trial name
- NCT01424475
- Testing
- Healthy, PKD Patients
- Where
- United Kingdom
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Alzheimer Disease
Renji Alzheimer's Disease Neuroimaging Cohort Study
This study focuses on the population of Alzheimer disease (AD). Based on Aβ(A)-Tau(T)-Vascular(V)-Neurodegeneration(N) (ATV(N))-AD evaluation system of NIA-AA Association, it can accurately diagnose and predict early AD.
- Trial name
- NCT05433363
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Cerebrovascular Disorders, Brain Lesions
Neuropsychological and Brain Medical Imaging Study in Patients With Brain Damage
Two groups of subjects will be constitute: (i) patients with circumscribed brain injury (including stroke, vascular malformations, tumor or circumscribed infectious lesions) or degenerative disorders and selective cognitive…
- Conditions
- Cerebrovascular Disorders, Brain Lesions, Degenerative Diseases, Developmental Pathology
- Trial name
- CORAC (NCT01849549)
- Testing
- Neuropsychological testing, MRI
- Where
- France
- Volunteers
- 346 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Obesity
A Translational Understanding of Obesity-Related Phenotypes Using Brain Imaging and Manipulation
This study will examine a potential relationship between family history of obesity, that is whether people with at least one parent who had obesity in adulthood compared to people with two parents who did not have obesity in…
- Trial name
- OPBIM (NCT06353464)
- Testing
- Ensure and Water
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Drexel University
Anesthesia, Pain
Ketamine and Propofol NeuroImaging
This is a multi-visit which will collect MRI (pictures of the brain) and EEG (brain waves) data to determine changes in brain connectivity and brain activity for memory formation and pain perception while receiving the…
- Trial name
- KAPNI (NCT07294092)
- Testing
- Propofol, Ketamine, Peripheral Nerve Stimulation
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Keith M Vogt
Schizophrenia, Bipolar Disorder
Brain Network Mechanisms of Cognitive Impairments in Major Psychiatric Disorders and Their Clinical Applications
Previous and our studies have shown that cognitive impairments are core symptoms of three major psychiatric disorders-schizophrenia, bipolar disorder, and major depressive disorder, and are associated with underlying brain…
- Conditions
- Schizophrenia, Bipolar Disorder, Major Depressive Disorder (MDD)
- Trial name
- NCT07444463
- Testing
- repetitive transcranial magnetic stimulation (rTMS)
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Central South University
GABAergic System
Association Between Serum and Neuroimaging Measurements of the GABAergic System
The goal of this study is to better understand the relationship between peripheral and central nervous system measurements of the gamma-aminobutyric acid (GABA) system in otherwise healthy individuals.
- Trial name
- NCT06464172
- Testing
- Acute Oral gamma-aminobutyric acid (Natural Health Product in Canada)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Francois Corbin
Familial Alcoholism Vulnerability
Functional Neuroimaging of Alcoholism Vulnerability: Probing Glutamate and Reward, Using the mGluR5 Inhibitor Mavoglurant
The purpose of this study is to evaluate the role of Mavoglurant in clarifying the neurobiology of alcoholism risk. This is a one-site, randomized, within subjects, counterbalanced double-blind study of a single dose (200mg) of…
- Trial name
- NCT05203965
- Testing
- Mavoglurant (AFQ056)
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Yale University
Bipolar Disorder, Bipolar I Disorder
Using Neuroplasticity-Based Computerized Training to Improve Emotion Regulation in Bipolar Disorder (BRAINS)
The goal of this study is to evaluate the feasibility and potential benefit of a behavioral intervention designed to improve emotion regulation in individuals with bipolar disorder.
- Conditions
- Bipolar Disorder, Bipolar I Disorder, Bipolar Affective Disorder, Bipolar Disorder I
- Trial name
- BRAINS (NCT05683431)
- Testing
- Cognitive Control of Emotion (CCE) Training
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Brain Imaging
tFUS Imaging & LIFU
This study is investigating a new method of brain imaging - transcranial functional ultrasound (tFUS). We are comparing the imaging capabilities with functional magnetic resonance imaging (fMRI).
- Trial name
- NCT07222865
- Testing
- Feasibility of imaging using tFUS
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Parkinson's Disease
Clinical, Molecular and by Neuroimaging of LRRK2 Mutations
Besides Parkinson's disease (PD), it exists rare parkinsonian syndromes clinically close to PD and that correspond to Mendelian entities.
- Trial name
- LRRK2 (NCT01085227)
- Where
- 2 sites in France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Post-traumatic Stress Disorder (PTSD), Trauma
Kappa Opioid Receptor Imaging in Post-traumatic Stress Disorder (PTSD)
This study uses positron emission tomography (PET) imaging to measure kappa opioid receptors (KOR) in the brains of individuals with and without post-traumatic stress disorder (PTSD).
- Trial name
- NCT02237703
- Testing
- Positron emission tomography (PET) imaging
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Bipolar Disorder
The Bipolar Illness Onset Study (the BIO Study)
This longitudinal study aims to identify 1) a composite blood-based biomarker, 2) a composite electronic Smartphone-based biomarker and 3) a neurocognitive signature for bipolar disorder
- Trial name
- BIO (NCT02888262)
- Where
- Denmark
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Functional Magnetic Resonance Imaging
A Study of Two Methodologies for Measuring Blood Flow in the Brain in Response to Non-Drug Stimuli (P08085/MK-0000-180)
This study will identify a dose of ferumoxytol that can reliably detect changes in blood flow/volume in response to non-drug stimuli.
- Trial name
- NCT01244282
- Testing
- fMRI with sensory stimulation
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC