Clinical trials: Neuroimaging, open to volunteers
Alzheimer Disease and Related Dementias, Cognition
Home-Based Brain Stimulation for Motoric Cognitive Risk Syndrome
The objective of this study is to determine the effects of a 6-month, home-based personalized transcranial direct current stimulation (tDCS) intervention targeting the left dorsolateral prefrontal cortex on cognitive function…
- Conditions
- Alzheimer Disease and Related Dementias, Cognition, Mobility Disability
- Trial name
- TDCS4MCR (NCT06821568)
- Testing
- Personalized Transcranial Direct Current Stimulation (tDCS)
- Where
- 2 sites in United States, Israel
- Volunteers
- 128 people
- Sponsor
- Hebrew SeniorLife
Multiple Sclerosis
Home-based Action Observation Treatment With Virtual-reality for Arm Rehabilitation in People With Multiple Sclerosis
Action Observation Treatment (AOT) is a rehabilitative strategy which has been proposed as a promising approach to improve motor performance in neurological conditions, including multiple sclerosis (MS).
- Trial name
- NCT05713890
- Testing
- Home-based Action Observation Treatment with virtual-reality for upper limb rehabilitation, Home-based landscape observation with virtual-reality for upper limb rehabilitation
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS San Raffaele
Inflammation, Stress
Mapping the Effect of (neuro)inflammation on Stress Sensitivity in the Brain of Healthy Men
The goal of this interventional study is to determine the effects of inflammation on stress responses in the brain of healthy men.
- Conditions
- Inflammation, Stress, Healthy Volunteer
- Trial name
- INFLAMES (NCT06620679)
- Testing
- Lipopolysaccharide (LPS)
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Hearing Loss
fNIRS in Pediatric Hearing Aids
Pilot phase. Monocentric, non-controlled, non-randomized, open-label study evaluating the capacity of the functional near-infrared functional neuroimaging (fNIRS) technique to translate temporal cortical activity in response to a…
- Trial name
- FNIRS (NCT04696835)
- Testing
- speech audiometry
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Lille
Prediabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Peanuts for Cardiometabolic, Brain, and Intestinal Health
The overall objective of this 14-month randomized crossover study is to seek evidence demonstrating that daily consumption of peanuts and peanut products improve cardiometabolic, cognitive, and intestinal health in a racially…
- Conditions
- Prediabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Cognition, Microvascular Function
- Trial name
- NCT06867198
- Testing
- Peanuts
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Georgia State University
Borderline Personality Disorder
Brain Signal Training to Enhance Affect Down-regulation
Individuals with Borderline Personality Disorder (BPD) experience intensive, instable negative emotions. Hyperactivity of the amygdala is assumed to drive exaggerated emotional responses in BPD.
- Trial name
- BrainSTEADy (NCT06626789)
- Testing
- Amygdala neurofeedback
- Where
- 6 sites in Germany
- Volunteers
- 164 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Autism Spectrum Disorder, Autism
Neuroimaging Predictors of Improvement to Pivotal Response Treatment (PRT) in Young Children With Autism
Autism spectrum disorder (ASD) is a very heterogeneous disorder with limited empirically validated behavioral and biological interventions.
- Trial name
- PRT-I (NCT03583684)
- Testing
- Pivotal Response Treatment Program (PRT-P)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Stanford University
Visual Field Defect, Stroke
Home-based Vision Rehabilitation Guided by Brain Imaging
The BRIGHT (Behavioral Rehabilitation Through Image-Guided Home-based Training) study aims to evaluate the effectiveness of image-guided, home-based perceptual training at improving visual performance in individuals with visual…
- Conditions
- Visual Field Defect, Stroke, Hemianopia Homonymous, Quadrantanopia
- Trial name
- BRIGHT (NCT07635329)
- Testing
- High-level perceptual learning-based training, Low-level perceptual learning-based training
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Georgetown University
Status Epilepticus
The STatus Epilepticus Prognosis Study
The goal of this study is to improve the prognosis of patients who present with Status Epilepticus (SE). In the first part of this study, the investigators aim to find better markers of good and poor outcomes of SE patients while…
- Trial name
- STEP (NCT06590883)
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Alcohol Use Disorder
Non-invasive Vagal Nerve Stimulation as Novel Treatment to Improve Functional Outcomes in Veterans With Alcohol Use Disorder
Alcohol use disorder (AUD) is a major health concern amongst Veterans as it causes functional impairments and decreased quality of life.
- Trial name
- NCT06399653
- Testing
- Cervical transcutaneous vagus nerve stimulation (active comparator)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- VA Office of Research and Development
Treatment Resistant Depression
PCS in Severe Treatment Resistant Depression
This research study is designed to test if electrical stimulation of the surface of the brain in the frontal region will help treat depressive symptoms.
- Trial name
- NCT04124341
- Testing
- Prefrontal Cortical Stimulation (PCS)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Minnesota
Mild Traumatic Brain Injury, Pediatric Traumatic Brain Injury
Kids Injury Detection Study Using the i-STAT
KIDS-STAT is a prospective study evaluating whether a rapid blood test measuring the brain injury biomarkers GFAP and UCH-L1 using the i-STAT Alinity system can help identify children with mild traumatic brain injury who do not…
- Conditions
- Mild Traumatic Brain Injury, Pediatric Traumatic Brain Injury, Head Trauma
- Trial name
- KIDS-STAT (NCT07835919)
- Testing
- i-STAT TBI Cartridge with the i-STAT Alinity System
- Volunteers
- 700 people
- Sponsor
- Children's Healthcare of Atlanta
Cannabis Use Disorder, Cannabis Use Disorders
Effect of Semaglutide on Cannabis Use in Adults With Cannabis Use Disorder
The HASHTAG Study is investigating whether the medicine semaglutide can help adults with cannabis use disorder (CUD) reduce their cannabis use. Participants will be randomly assigned to receive either semaglutide or a placebo.
- Conditions
- Cannabis Use Disorder, Cannabis Use Disorders, Cannabis Abuse, Cannabis Dependence
- Trial name
- HASHTAG (NCT07523633)
- Testing
- semaglutide
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Anders Fink-Jensen, MD, DMSci
Multiple Sclerosis
Investigating the Utility of Demyelination Tracer [18F]3F4AP in Controls and Multiple Sclerosis Subjects
Our overall objective is to obtain an initial assessment of the potential value of using [18F]3F4AP for imaging demyelinating diseases such as multiple sclerosis: Aim 1) Assess the safety of [18F]3F4AP in healthy volunteers and…
- Trial name
- NCT04699747
- Testing
- F-18 3F4AP
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Creatine, Exercise
Creatine and Resistance Training in Older Adults With Mild Cognitive Impairment
The goal of this 26-week trial is to learn if creatine supplementation and resistance training (i.e., weightlifting; exercise that increases muscle mass), alone and together, impact cognition, brain health, and physical function…
- Conditions
- Creatine, Exercise, Mild Cognitive Impairment (MCI)
- Trial name
- NCT06948149
- Testing
- Creatine monohydrate, Resistance training
- Where
- Canada
- Volunteers
- 140 people
- Sponsor
- Western University, Canada
Pollution; Exposure, Neurodevelopmental Disorders
Air Pollution and Development in the Boricua Youth Study
This study seeks to understand the relationship between prenatal maternal air pollution exposure and offspring risk for ADHD and examine two potential -modifiable- mechanisms: prenatal maternal inflammation and offspring sleep…
- Trial name
- NCT05368493
- Testing
- MRI task
- Where
- 2 sites in United States, Puerto Rico
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Low Back Pain, Mechanical
Radiofrequency Denervation and Brain Imaging
The goal of this observational study is to learn about changes in brain and its activity of following radiofrequency denervation treatment for chronic low back pain.
- Trial name
- NCT05641948
- Testing
- MRI scan
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Aberdeen