Clinical trials: Neuroinflammation
PANS, Pediatric Acute-Onset Neuropsychiatric Syndrome
Biomarkers for Diagnosis and Treatment Response in Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS)
Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) is a complex neuropsychiatric disorder characterized by the abrupt onset of symptoms and currently diagnosed mainly on clinical criteria, as reliable diagnostic biomarkers…
- Trial name
- BIOMA-PANS (NCT07718958)
- Testing
- Psycodiagnostic evaluation, Polysomnography, 1H-NMR analysis
- Where
- 5 sites in Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Cagliari
Idiopathic Pulmonary Fibrosis (IPF), Idiopathic Pulmonary Fibrosis
PET Study of PIPE-791 in Healthy Volunteers and Volunteers With PrMS and IPF
This is a study of PIPE-791, an investigational study drug to treat progressive multiple sclerosis (MS) and idiopathic pulmonary fibrosis (IPF).
- Conditions
- Idiopathic Pulmonary Fibrosis (IPF), Idiopathic Pulmonary Fibrosis, Multiple Sclerosis, Multiple Sclerosis, MS
- Trial name
- NCT06683612
- Testing
- PIPE-791
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Contineum Therapeutics
Neuroinflammatory Response
Safety & PK of Single Doses of MT1980
MT1980 is being developed as a treatment for neuroinflammation (an inflammatory response in the brain and/or spinal cord). Much research has focused on the central role of neuroinflammation in the pathogenesis of many conditions…
- Trial name
- NCT05429840
- Testing
- MT1980
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Monument Therapeutics Limited
Perinatal Depression, Chronic Pain
CSF/Serum Biomarkers in Predicting PND/Persistent Pain After Cesarean
The aim is to investigate if inflammatory biomarkers in the blood and cerebrospinal fluid (CSF) are associated with the development of perinatal depression and/or persistent pain after cesarean delivery.
- Trial name
- NCT04271072
- Testing
- No intervention
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Duke University
Alzheimer Disease, Obesity
Alzheimer"s Imaging Biomarkers in Obesity
High body fat at midlife, as evidenced by overweight or obese body mass index (BMI), is increasingly understood as a risk factor for Alzheimer's disease.
- Conditions
- Alzheimer Disease, Obesity, Metabolic Disease
- Trial name
- NCT05077579
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Cyrus A Raji
Neuroinflammation, Stroke
Translocator Protein PET/CT in Various TSPO-Related Disease
To evaluate the potential usefulness of 18F-DPA714/FDPA positron emission tomography/computed tomography (PET/CT) for the diagnosis of primary and metastatic lesions in various TSPO-related disease patients.
- Conditions
- Neuroinflammation, Stroke, Neurodegenerative Diseases
- Trial name
- NCT06725719
- Testing
- 18F-DPA714/FDPA
- Where
- 3 sites in China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University
Alzheimer Disease, Early-Onset
Examining Neuroinflammation in AlzHeimer's
Alzheimer disease (AD) is a neurodegenerative disorder with a poorly understood pathology. It is an irreversible progressive brain disease that slowly deteriorates memory, thinking and behavior.
- Trial name
- ENHANCE (NCT03548883)
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- AdventHealth
Huntington Disease
Clinicopathological MRI and CSF Correlates in Huntington's Disease.
In this study the investigators will link brain iron levels obtained from quantitative susceptibility maps of HD patients with specific and well-known clinical CSF markers for iron accumulation, neurodegeneration and…
- Trial name
- NCT05534139
- Testing
- 7T MRI-scan, CSF collection via lumbar puncture, Blood withdrawal
- Where
- Netherlands
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Chronic Pain, Living Kidney Donor
The Effect of Quadratus Lumborum (QL) Block on the Incidence of Chronic Neuropathic Pain After Retroperitoneal Laparoscopic Donor Nephrectomy: A Study on Neuroinflammation and Neurophysiology
To analyze the relationship of anterior subcostal quadratus lumborum (QL) block compared with control block on the incidence of chronic neuropathic pain at three months post-laparoscopic retroperitoneal living kidney donor.
- Conditions
- Chronic Pain, Living Kidney Donor, Quadratus Lumborum Block, Laparoscopic Donor Nephrectomy
- Trial name
- NCT07037992
- Testing
- injection of local anesthesia solution, Injection of normal saline
- Where
- Indonesia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Obstructive Sleep Apnoea, Inflammation
Investigating the Neuropathology of Obstructive Sleep Apnoea
Our multi-disciplinary research group works closely with people who have obstructive sleep apnoea. This is a life-long illness that causes breathing to stop during sleep, which leads to low-oxygen in the blood.
- Trial name
- INcOSA (NCT02967536)
- Where
- United Kingdom
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- King's College London
Multiple System Atrophy - Cerebellar Subtype (MSA-C), Multiple System Atrophy - Parkinsonian Subtype (MSA-P)
TSPO PET in the Evaluation of Neuroinflammation in Patients with Multiple System Atrophy
The aim of this study was to apply PET/MR techniques targeting TSPO to explore the temporal and spatial alterations characterizing neuroinflammation in MSA patients, and to assess its value as a biomarker for diagnostic typing…
- Trial name
- NCT06890390
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Min Zhao,MD
Fibromyalgia, Chronic Fatigue Syndrome
Assessment of Neuroinflammation in Central Inflammatory Disorders Using [F-18]DPA-714.
The primary objective of this study is to measure the concentration and the regional brain distribution of activated brain microglia/macrophages using the PET radiopharmaceutical [F-18]DPA-714 in individuals with chronic pain and…
- Conditions
- Fibromyalgia, Chronic Fatigue Syndrome, Multiple Sclerosis, Healthy
- Trial name
- NCT03759522
- Testing
- DPA-714 PET/MRI
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
SARS CoV-2 Post-Acute Sequelae
Positron Emission Tomography (PET) Imaging of Neuroinflammation in Patients With Neurological Dysfunction After Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV 2) Infection
This clinical imaging study will use the small molecule translocator protein (TSPO) ligand, Fluorodeoxyglucose(18F)-labeled DPA-714, to visualize and quantify neuroinflammation in individuals with post-acute sequelae of…
- Trial name
- NCT05656105
- Testing
- DPA-714 PET/MRI
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Alzheimer Disease
Impact of Microglial Activation on Synaptic Density in Alzheimer's Disease
This study aims to analyse, in vivo, the interplay between microglial activation and tau pathology in Alzheimer's disease (AD) using [18F]-DPA-714 and [18F]-Ro948 tracers by Position Emission Tomography (PET), and their…
- Trial name
- GliSyn (NCT05911178)
- Testing
- [11C]-UCB-J, [18F]-DPA-714, [18F]-RO-948
- Where
- 3 sites in France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Traumatic Brain Injury
Effects of Intravascular Administration of Mesenchymal Stromal Cells Derived from Wharton's Jelly of the Umbilical Cord on Systemic Immunomodulation and Neuroinflammation After Traumatic Brain Injury.
Traumatic brain injuries (TBI) are one of the leading causes of death and disability worldwide. These patients are burdened by physical, cognitive, and psychosocial deficits, leading to an important economic impact for society.
- Trial name
- TRAUMACELL (NCT06146062)
- Testing
- Mesenchymal Stromal Cells (MSC)
- Where
- 3 sites in France
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cognitive Change, Cytokine Levels
The Effect of Oral Use of Lyophilised Royal Jelly on Cognitive Functions and Immune System in Elderly Individuals
Dementia is a significant public health problem, affecting 47 million people worldwide in 2015, according to World Health Organization data. It is expected to increase to 75 million in 2030 and reach 132 million in 2050.
- Conditions
- Cognitive Change, Cytokine Levels, Neuroinflammation
- Trial name
- NCT06404203
- Testing
- Balparmak Apitera Royal Jelly Herbal Capsule Food Supplement 500 mg/day, Balparmak Apitera Royal Jelly Herbal Capsule Food Supplement 1000 mg/day, Balparmak Apitera Royal Jelly Herbal Capsule Food Supplement 1500 mg/day
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medipol University
Neuroinflammation, Autism Spectrum Disorder
Imaging - Clinical Evaluation of Altered Nervous System Drainage
The current study aims to evaluate the aspects of perfusion, fluid diffusivity in the interstitium and the T1 and T2 signal of the PVS and WMH.
- Trial name
- I-CLEANED (NCT06432023)
- Testing
- Magnetic resonance imaging
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Nervous System Disease, Immune System Disease
Detection and Characterization of Neurologic Manifestations of Inborn and Acquired Errors of Immunity
Background: Immune system and nervous system have significant interaction so that People with immunity diseases can have complications that affect the nervous system and people with some neurological disease may have defects in…
- Trial name
- NCT06169150
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Major Depressive Disorder
Biomarkers of Neuroinflammation and Anti-Inflammatory Treatments in Major Depressive Disorder
The purpose of this study is to determine if translocator protein total distribution volume (TSPO VT) is elevated in major depressive disorder that is not responding to medication and if adding minocycline can affect TSPO VT.
- Trial name
- NCT02362529
- Testing
- Minocycline, Celecoxib
- Where
- Canada
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Major Depression
Brain Inflammation in Major Depressive Disorder Background
Background: Studies have shown that inflammation plays an important role in depression. Brain inflammation may contribute to depression, and may make it more difficult to treat some kinds of depression with current therapies.
- Trial name
- NCT01851356
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)