Clinical trials: Neuroinflammatory Disorders
Neuropsychiatric Disorders, Neuroinflammatory Disorders
A Longitudinal Natural History Study of Immune Biomarkers in Neuropsychiatric Illness
Background: Some brain or mental health conditions may be caused when a person s immune system attacks their own body. These are called immunologic neuropsychiatric disorders.
- Conditions
- Neuropsychiatric Disorders, Neuroinflammatory Disorders, Post-Infectious Neuropsychiatric Disorders
- Trial name
- NCT07877246
- Where
- 3 sites in United States
- Volunteers
- 5,000 people
- Sponsor
- National Institute of Mental Health (NIMH)
Parkinson Disease 6, Early-Onset, Parkinson Disease (Autosomal Recessive, Early Onset) 7, Human
Hereditary Parkinson s Disease Natural History Protocol
Background: Parkinson s disease is a disease of the nervous system that affects movement. People usually get it in their 70s or 80s. Early onset Parkinson s disease (EOPD) begins before the age of 50.
- Conditions
- Parkinson Disease 6, Early-Onset, Parkinson Disease (Autosomal Recessive, Early Onset) 7, Human, Parkinson Disease Autosomal Recessive, Early Onset, Parkinson Disease, Autosomal Recessive Early-Onset, Digenic, Pink1/Dj1
- Trial name
- NCT02511015
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Depressive Disorder, Post-Acute COVID-19 Syndrome
IMPACT-D+: Immune-Modulating and Psychometric Effects of Accelerated TMS in Depression Plus Comorbid Post-COVID-19 Condition
This is a monocentric, randomized pilot study conducted at the Max Planck Institute of Psychiatry, Munich. The study investigates the effects of two different intermittent theta-burst stimulation (iTBS) schedules on biological…
- Trial name
- IMPACT-D+ (NCT07197138)
- Testing
- Intermittent theta-burst stimulation (iTBS) using PowerMAG 100 ppTMS
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- Max-Planck-Institute of Psychiatry
Impacted Third Molar, Postoperative Pain
Kynurenic Acid and Serotonin as Perioperative Neuroinflammatory Biomarkers in Sequential Third Molar Surgery
A prospective cohort of 40 consecutive patients with bilateral impacted mandibular third molars underwent two sequential surgical extractions separated by a two-week interval.
- Conditions
- Impacted Third Molar, Postoperative Pain, Neuroinflammation, Anxiety
- Trial name
- KYNA-3M (NCT07644065)
- Testing
- Ibuprofen, Ibuprofen + Gabapentin
- Where
- Bulgaria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Plovdiv Medical University
Traumatic Brain Injury (TBI) Patients, Post Concussive Symptoms
Hyperbaric Oxygen Therapy for Veterans With TBI and PCS: A Biomarker Study
The goal of this study is to examine changes in blood biomarkers following hyperbaric oxygen therapy (HBOT) in military veterans with traumatic brain injury and persistent post-concussive symptoms.
- Conditions
- Traumatic Brain Injury (TBI) Patients, Post Concussive Symptoms, PTSD
- Trial name
- NCT07849465
- Testing
- Hyperbaric Oxygen Therapy (HBOT)
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Summit Hyperbarics and Wellness
Down Syndrome Regression Disorder (DSRD), Down Syndrome (Trisomy 21)
An Open-Label Phase II Feasibility Study for the Use of Ublituximab in Adults With Down Syndrome Regression Disorder
The goal of this clinical trial is to evaluate whether the monoclonal antibody ublituximab can treat Down Syndrome Regression Disorder (DSRD) by assessing its safety, tolerability, and preliminary efficacy in affected…
- Conditions
- Down Syndrome Regression Disorder (DSRD), Down Syndrome (Trisomy 21), Neuroinflammatory / Neuropsychiatric Disorder
- Trial name
- NCT07812181
- Testing
- Ublituximab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Jonathan Santoro
Schizoaffective Disorder
LRFN5 and OLFM4 in Schizoaffective Disorder
Schizoaffective disorder (SAD) is a chronic psychiatric condition characterized by psychotic and mood symptoms. Emerging evidence suggests that Leucine-Rich Repeat and Fibronectin Type-III Domain-Containing Protein 5 (LRFN5) and…
- Trial name
- NCT07447960
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Elazığ Mental Health and Diseases Hospital
Autism Spectrum Disorder, Autism Spectrum Disorders
Prednisone in Adults With an Immune-Mediated Subtype of Autism Spectrum Disorder
The goal of this clinical trial is to learn how prednisone affects adults with autism spectrum disorder (ASD). It will also learn about the safety of prednisone.
- Conditions
- Autism Spectrum Disorder, Autism Spectrum Disorders, Autistic Disorder, Autism
- Trial name
- PREDICT (NCT06934915)
- Testing
- Prednisone
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Christopher John McDougle, M.D.
PANS, Pediatric Acute-Onset Neuropsychiatric Syndrome
Biomarkers for Diagnosis and Treatment Response in Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS)
Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) is a complex neuropsychiatric disorder characterized by the abrupt onset of symptoms and currently diagnosed mainly on clinical criteria, as reliable diagnostic biomarkers…
- Trial name
- BIOMA-PANS (NCT07718958)
- Testing
- Psycodiagnostic evaluation, Polysomnography, 1H-NMR analysis
- Where
- 5 sites in Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Cagliari
Intracerebral Hemorrhage
A Study to Evaluate the Safety, Tolerability and the Effects of Ixodes Ricinus-Contact Phase Inhibitor (Ir-CPI) in Adult Patients With Spontaneous Intracerebral Haemorrhage
The purpose of the study is to provide a first assessment of safety, tolerability and efficacy of Ir-CPI, administered on top of standard-of-care, on secondary brain injury in patients with spontaneous intracerebral haemorrhage.
- Trial name
- BIRCH (NCT05970224)
- Testing
- Ir-CPI
- Where
- 8 sites in Belgium
- Volunteers
- 23 people
- Sponsor
- Bioxodes S.A.
Attention Deficit Hyperactivity Disorder
Effectiveness of Neuroplasticity-Targeted Supplements on Neuroinflammatory Markers, ADHD Symptom Severity, and Clinical Scores in Children
This randomized controlled trial will evaluate the effectiveness of neuroplasticity-targeted supplements on neuroinflammatory markers and ADHD symptoms in children aged 6 to 12 years diagnosed with Attention Deficit Hyperactivity…
- Trial name
- NCT07665658
- Testing
- Inulin, Probiotic, Omega-3 Fatty Acids
- Where
- Pakistan
- Volunteers
- 68 people
- Sponsor
- Khyber Medical University Peshawar
Carotid Artery Disease, Carotid Artery Stenoses
Perioperative Argon Inhalation to Improve Neurocognitive Recovery After Carotid Surgery
Currently, over 400,000 reconstructive surgeries on carotid arteries are performed annually worldwide, including carotid endarterectomy (CEA) and carotid stenting.
- Trial name
- NCT07200180
- Testing
- Аrgon-oxygen breathing mixture, Nitrogen-oxygen breathing mixture
- Where
- 2 sites in Russia
- Volunteers
- 100 people
- Sponsor
- Negovsky Reanimatology Research Institute
Major Depressive Disorder (MDD), Treatment Resistant Depression (TRD)
Accelerated iTBS for Major Depression
Major depressive disorder (MDD) is a common and disabling psychiatric condition, and many patients do not achieve adequate response to standard antidepressant treatments.
- Trial name
- AIM-D (NCT07603804)
- Testing
- Accelerated Intermittent Theta Burst Stimulation (iTBS)
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Istanbul University - Cerrahpasa
Sickle Cell Disease, Cognitive Impairment
Minocycline In Neurocognitive Outcomes - Sickle Cell Disease
Sickle cell disease (SCD) is a common, inherited blood disorder that primarily affects people of African Ancestry. It has a lot of complications including neurological complications.
- Conditions
- Sickle Cell Disease, Cognitive Impairment, Cognitive Decline, Cognitive Change
- Trial name
- MINO-SCD (NCT05605366)
- Testing
- Minocycline
- Volunteers
- 30 people
- Sponsor
- University of Cincinnati
Major Depressive Disorder, Neuroinflammation
The Effect of Celecoxib on Neuroinflammation in MDD
Major depressive disorder (MDD) affects an estimated 350 million people worldwide and is a leading contributor to global disease burden.
- Trial name
- NCT04814355
- Testing
- Celecoxib 400 mg
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Stony Brook University
Parkinson Disease, Parkinsonian Disorders
Study of Axial and Cognitive Symptoms and Biomarkers of Neurodegeneration in Brain-first and Body-first PD
This observational study aims to systematically characterize a cohort of patients with early-stage Parkinson's disease (PD) attending the Movement Disorders Center of AUSL-IRCCS Reggio Emilia, Italy.
- Conditions
- Parkinson Disease, Parkinsonian Disorders, Brain Disease, Basal Ganglia Diseases
- Trial name
- BRABOAXPD (NCT07187843)
- Testing
- Clinical assessments, Phenotypic classification
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Treatment Resistant Depression
Minocycline as Adjunctive Treatment for Treatment Resistant Depression
Major depressive disorder (MDD) is a leading cause of disability worldwide. Up to 50% of patients experience treatment resistant depression (TRD), which accounts for a vast majority of disease burden.
- Trial name
- MINDEP2 (NCT03947827)
- Testing
- Minocycline
- Where
- Canada
- Volunteers
- 76 people
- Sponsor
- Centre for Addiction and Mental Health
Attention Deficit Disorder With Hyperactivity (ADHD)
The Effect Of Methylphenıdate Treatment On Neuroınflammatıon Levels In Chıldren Wıth Attentıon Defıcıt Hyperactıvıty Dısorder
The aim of this study was to investigate the effect of treatment of ADHD with methylphenidate on neuroinflammation by examining the levels of Interleukin-6 (IL-6), S100B, Claudin-5 in serum samples of patients who were diagnosed…
- Trial name
- NCT07041333
- Where
- Turkey (Türkiye)
- Volunteers
- 57 people
- Sponsor
- Enes Faruk ALTUNKILIÇ
Anesthesia, Neuroinflammation
Neuroinflammatory Biomarkers After General Anesthesia: A Comparison Study
This prospective, observational study investigates the impact of repeated general anesthesia exposure on neuroinflammatory biomarkers and neurotrophic factors.
- Conditions
- Anesthesia, Neuroinflammation, Cognitive Disorders
- Trial name
- NCT07388160
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Health Sciences Balikesir Hospital Eduation and Research
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative