Clinical trials: Neurologic Complication
Opioid Use, Pain, Postoperative
Optimizing Outpatient Anesthesia (OSPREy-Outpatient Surgery Pain Relief Enhancement)
The overall goal of this research is to improve perioperative pain treatment, decrease post-operative opioid consumption, diminish opioid related side effects, and reduce postop opioid prescribing (and hence opportunity for…
- Trial name
- OSPREy (NCT03726268)
- Testing
- Methadone, Fentanyl, Hydromorphone
- Where
- United States
- Volunteers
- 907 people
- Sponsor
- Duke University
Postoperative Cognitive Dysfunction
Cerebral Oximetry and Neurological Outcomes in Aortic Arch Surgery Patients
The investigators hypothesize that early intervention to optimize regional cerebral oxygenation detected by cerebral oximetry monitoring during deep hypothermic circulatory arrest (DHCA) for patients undergoing aortic surgery…
- Trial name
- NCT01149148
- Testing
- INVOS Somanetics Cerebral Oximeter
- Volunteers
- 25 people
- Sponsor
- University of Michigan
Cancer
Massage Therapy in Treating the Symptoms of Patients With Locally Advanced or Metastatic Cancer
RATIONALE: Massage therapy may help relieve symptoms associated with cancer. It is not yet known which type of massage therapy is more effective in treating the symptoms of patients with cancer.
- Trial name
- NCT00253708
- Testing
- management of therapy complications, massage therapy, pain therapy
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Beth Israel Deaconess Medical Center
Post-operative Pain
Uniport and Multiport Epidural Catheters in Post-surgical Patients
The investigators hypothesize that multi-port thoracic epidural catheters will provide superior pain relief when compared to uniport catheters for post-surgical patients.
- Trial name
- NCT02159560
- Testing
- Epidural catheter
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Beth Israel Deaconess Medical Center
Rotator Cuff Tear, Pain, Postoperative
Single Shot Liposomal Bupivicaine in Rotator Cuff Surgery
This document is a protocol for a human research study. This study is to be conducted according to United States standards of Good Clinical Practice in accordance with applicable Federal regulations and institutional research…
- Trial name
- NCT03822182
- Testing
- liposomal bupivicaine, Dexamethasone
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Indiana University
Infantile Refsum's Disease, Zellweger Syndrome
Compassionate Treatment of Patients With Inborn Errors of Bile Acid Metabolism With Cholic Acid
OBJECTIVES: I. To Evaluate the therapeutic efficacy of cholic acid during provision of compassionate treatment to patients with identified inborn errors of bile acid synthesis and metabolism II.
- Conditions
- Infantile Refsum's Disease, Zellweger Syndrome, Adrenoleukodystrophy, Peroxisomal Disorders
- Trial name
- NCT00007020
- Testing
- Cholic Acids
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Mirum Pharmaceuticals, Inc.
Deviated Nasal Septum
Septorhinoplasty Post-operative Pain Control With SPG Nerve Block
Maxillary nerve blocks have been shown to significantly reduce post-operative pain and analgesic intake during the 24-hour period following sinus surgery.
- Trial name
- NCT05667324
- Testing
- Ropivacaine, Dexamethasone
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Florida
Postoperative Pain, Postoperative Nausea and Vomiting
Effect of Steroids on Post-tonsillectomy Morbidities
This study aims to evaluate the effect of postoperative systemic rapid onset and short acting dexamethasone followed by a tapering dose of oral prednisolone on post-tonsillectomy morbidities.
- Trial name
- NCT02401529
- Testing
- IV dexamethasone, Oral prednisolone, Paracetamol
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- King Fahd General Hospital
Stem Cell Transplant Complications, Delirium
Feasibility of Prophylactic Haldol to Prevent Delirium in Cancer Patients
This research study proposes to conduct an open label, feasibility study administering prophylactic oral haldol to patients undergoing a hematopoietic stem cell transplant (HSCT).
- Trial name
- PHDC (NCT03489551)
- Testing
- Haldol
- Volunteers
- 17 people
- Sponsor
- Michelle Weckmann
Pain, Postoperative, Urethral Stricture
Efficacy of Opioid-limiting Pain Management Protocol in Men Undergoing Urethroplasty
The investigator's study aims to see if an enhanced recovery regimen of pain medications before and during surgery will decrease the use and risk of opioid pain medications as well as improve pain control in anterior…
- Trial name
- NCT03859024
- Testing
- Oxycodone, Acetaminophen, Gabapentin
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Alabama at Birmingham
Ultrasound Guided Rectus Sheath Block, Pain, Postoperative
Comparison Between Ultra Sound Guided Rectus Sheath Block and Field Block for Midline Hernia Repair
Randomized double blinded controlled clinical trial will be done with a total number of 75 patients will be divided into 3 groups.
- Trial name
- NCT03225313
- Testing
- Bupivacaine Hydrochloride 0.5% Injection Solution_#4, Normal Saline Flush, 0.9% Injectable Solution_#5
- Where
- Egypt
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Theodor Bilharz Research Institute
Head and Neck Cancer, Mucositis
Doxepin Hydrochloride in Treating Oral Mucositis Pain in Patients With Head and Neck Cancer Undergoing Radiation Therapy With or Without Chemotherapy
RATIONALE: Doxepin hydrochloride may be an effective treatment for oral mucositis pain in patients undergoing radiation therapy with or without chemotherapy.
- Conditions
- Head and Neck Cancer, Mucositis, Oral Complications of Radiation Therapy, Pain
- Trial name
- NCT01156142
- Testing
- doxepin hydrochloride
- Where
- 120 sites in United States
- Volunteers
- 155 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Postoperative Pain, Surgery
Local Anesthesia Versus Saline Serum in Surgical Incision of Colorectal or Hepatic Surgery
The purpose of this study is to determine whether a continuous infusion of local anesthesia with a catheter in the surgical wound reduces patient consumption of opiates by 30% in the 48-hour postoperative period following surgery…
- Conditions
- Postoperative Pain, Surgery, Postoperative Complications
- Trial name
- CATROP-2007 (NCT01075646)
- Testing
- ropivacaine, saline solution
- Where
- Spain
- Volunteers
- 225 people
- Sponsor
- Hospital Universitari de Bellvitge
Gynecologic Cancer, Post-operative Pain
Transversus Abdominis Plane Blocks for Patients Undergoing Robotic Gynecologic Oncology Surgery
This study is a single-center, randomized, placebo-controlled, double-blind clinical trial. The purpose of this study is to evaluate the impact of pre-operative transverses abdominis plane (TAP) blocks on post-operative analgesia…
- Trial name
- NCT01444924
- Testing
- Bupivicaine
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Wisconsin, Madison
Postoperative Nausea and Vomiting, Pain, Postoperative
Guanfacine for PONV and Pain After Sinus Surgery
Postoperative nausea and vomiting (PONV) and pain are the most common causes of Post Anesthesia Care Unit (PACU) discharge delay, with untreated PONV occurring in 20-30% of post-surgical patients.
- Trial name
- NCT02882854
- Testing
- Guanfacine
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Vanderbilt University Medical Center
Postoperative Pain
Percutaneous Peripheral Nerve Stimulation (Neuromodulation) for Postoperative Analgesia
The moderate-to-severe pain many patients experience following orthopedic surgery is often treated with opioids, which are associated with side effects such as nausea/vomiting, sedation, and respiratory depression (and a risk of…
- Trial name
- NCT02898103
- Testing
- Percutaneous peripheral nerve stimulation
- Where
- 3 sites in United States
- Volunteers
- 7 people
- Sponsor
- University of California, San Diego
Emergence Agitation, Pain
Emergence Agitation and Pain Scores in Pediatrics When Comparing Single-modal vs Multi-modal Analgesia for ENT Surgery
The purpose of this study is to compare the incidence of EA in pediatric patients undergoing minor ENT surgery under Sevoflurane and compare opioid-only based intra-operative analgesia to multi-modal analgesia consisting of…
- Trial name
- NCT03062488
- Testing
- IV acetaminophen, Fentanyl, PO acetaminophen
- Where
- United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Hypertriglyceridemia, Diabetic Neuropathy
Lovaza® and Microvascular Function in Type 2 Diabetes
The objective of this study is to determine the efficacy of 6 months of 4 g/day oral Lovaza® on endothelial-dependent and heat-induced vasodilation in type 2 diabetics with neuropathy and elevated triglyceride levels.
- Trial name
- NCT00931879
- Testing
- omega-3-ethyl esters
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Eastern Virginia Medical School
Pain, Postoperative
An Open-Label Safety Study Of DIC075V (Intravenous Diclofenac Sodium) In Patients With Acute Post-Operative Pain
This is an open-label, multiple-dose, safety study of DIC075V in patients with acute post-operative pain following abdominal or orthopedic surgery.
- Trial name
- NCT00726388
- Testing
- DIC075V (intravenous diclofenac sodium)
- Where
- 46 sites in United States
- Volunteers
- 1,050 people
- Sponsor
- Pfizer
Painful Diabetic Neuropathy
A Trial to Assess the Efficacy and Safety of 400mg/Day Lacosamide in Subjects With Painful Diabetic Neuropathy
The purpose of this trial is to assess whether 400mg/day of lacosamide is effective in reducing pain caused by distal diabetic neuropathy.
- Trial name
- NCT00350103
- Testing
- SPM 929
- Where
- Germany
- Volunteers
- 551 people
- Sponsor
- UCB Pharma
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