Clinical trials: Neurologic Complication
Postoperative Pain, Pain
Comparison of Analgesic Efficacy of Intrathecal Bupivacaine Versus Bupivacaine Plus Dexmedetomidine in Patients Undergoing Orthopedic Surgeries.
Clinical Trial Overview: Intrathecal Bupivacaine vs. Bupivacaine + Dexmedetomidine Primary Objective Duration of Analgesia:** To compare the mean duration of postoperative pain relief between hyperbaric bupivacaine alone versus…
- Conditions
- Postoperative Pain, Pain, Orthopaedic Surgery, Anesthesia, Spinal
- Trial name
- NCT07866508
- Testing
- Dexmedetomidine plus Hyperbaric Bupivacaine, Hyperbaric bupivacaine % 0.5
- Where
- Pakistan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sheikh Khalifa Bin Zayed Al Nahyan Combined Military Hospital Muzaffarabad
Postoperative Pain
The Role of Preoperative Melatonin in Reducing the Inhaled Isoflurane Requirements in Open Nephrectomy
Melatonin is a hormone that the pineal gland in the brain produces. Melatonin fulfills many functions in the body but it is mostly known for maintaining a circadian rhythm that is governed by the central circadian pacemaker…
- Trial name
- NCT04959825
- Testing
- Melatonin 5 mg, Sugar Coated Tablets
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Postoperative Pain
Comparison of Erector Spinae Plane Block With Thoracic Paravertebral Block for Video Assisted Thoracoscopic Surgery
Erector Spinae Plane Block (ESPB) is a newly described and effective interfascial plane block for thoracic and abdominal surgery. It was first described by Forero et al. in 2016, effectiveness being reported in four cases.
- Trial name
- NCT03538496
- Testing
- Bupivacaine Hcl 0.25% Inj
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ataturk University
Post Operative Pain, Distal Radius Fracture
Low Dose Dexamethasone for Distal Radius Fractures
The addition of the steroid dexamethasone to a single injection of local anesthetic has been shown to significantly prolong the duration of peripheral nerve blockade compared to local anesthetic alone.
- Trial name
- NCT05274113
- Testing
- Dexamethasone 4mg, Ropivacaine
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Sarcoma, Neuroblastoma
A Phase I Study of Pazopanib as a Single Agent for Children With Refractory Solid Tumors
Background: Pazopanib, a drug that inhibits the growth of new blood vessels in tumors, was recently approved by the Food and Drug Administration to treat advanced kidney cancer in adults.
- Conditions
- Sarcoma, Neuroblastoma, Wilms Tumor, Osteosarcoma
- Trial name
- NCT01130623
- Testing
- Pazopanib (GW786034)
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Late Complication From Skin Graft, Infection of Skin Donor Site
Clinical Study on Silk Sericin Wound Dressing for Split-thickness Skin Graft Donor Sites Treatment
1. Silk sericin wound dressing may reduce time for complete epithelialisation of split-thickness skin graft donor sites compared to Bactigras®. 2.
- Conditions
- Late Complication From Skin Graft, Infection of Skin Donor Site, Impaired Wound Healing, Pain, Intractable
- Trial name
- NCT01539980
- Testing
- Sericin scaffold
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Chulalongkorn University
Post-Operative Pain
Rectal Indomethacin Versus Intraperitoneal Lidocaine for Analgesia After Laparoscopic Cholecystectomy
Hospitals, Qena, Egypt in period between May 2020 to May 2021.eighty patients was scheduled to elective laparoscopic cholecystectomy , divided Into two groups randomly using closed envelop method.
- Trial name
- NCT04964180
- Testing
- Indomethacin suppository, Lidocaine 2% Injectable Solution
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- South Valley University
Carotid Artery Disease, Carotid Artery Stenoses
Perioperative Argon Inhalation to Improve Neurocognitive Recovery After Carotid Surgery
Currently, over 400,000 reconstructive surgeries on carotid arteries are performed annually worldwide, including carotid endarterectomy (CEA) and carotid stenting.
- Trial name
- NCT07200180
- Testing
- Аrgon-oxygen breathing mixture, Nitrogen-oxygen breathing mixture
- Where
- 2 sites in Russia
- Volunteers
- 100 people
- Sponsor
- Negovsky Reanimatology Research Institute
Renal Colic
Pramipexole and Morphine for Renal Colic
Opioid analgesics are among the most commonly prescribed class of medications in the US. While opioids may effectively control pain and other sensory disorders under acute conditions, the rates of misuse/abuse and accidental…
- Trial name
- NCT04160520
- Testing
- Pramipexole, Morphine
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- East Carolina University
Pain, Postoperative, Pain, Chronic
Pain and Impact of Chronic Pain on Function After Total Knee Replacements
After Institutional Review Board approval, adult patients scheduled for total knee arthroplasty (TKA) will be enrolled into the study after obtaining informed consent over a 24 month period.
- Conditions
- Pain, Postoperative, Pain, Chronic, Osteogenic Sarcoma, Knee Arthropathy
- Trial name
- NCT03032679
- Testing
- Non interventional study
- Where
- India
- Volunteers
- 139 people
- Sponsor
- Tata Memorial Centre
Postoperative Pain, Surgery
Local Anesthesia Versus Saline Serum in Surgical Incision of Colorectal or Hepatic Surgery
The purpose of this study is to determine whether a continuous infusion of local anesthesia with a catheter in the surgical wound reduces patient consumption of opiates by 30% in the 48-hour postoperative period following surgery…
- Conditions
- Postoperative Pain, Surgery, Postoperative Complications
- Trial name
- CATROP-2007 (NCT01075646)
- Testing
- ropivacaine, saline solution
- Where
- Spain
- Volunteers
- 225 people
- Sponsor
- Hospital Universitari de Bellvitge
Pain, Postoperative
Feasibility of TAP for XLIF Surgery
Key questions of this feasibility trial will be the feasibility of performing the TAP block in XLIF patients, screen for safety of the block and preliminary investigate the influence on pain control and quality of recovery.
- Trial name
- NCT05497908
- Testing
- TAP block via lateral approach, TAP block via posterior approach
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Jessa Hospital
Postpartum Recovery, Mother-infant Bonding
Labor Epidural Analgesia and Mother-Infant Bonding After Vaginal Delivery
This prospective observational cohort study aims to evaluate the association between postpartum recovery quality and mother-infant bonding in women undergoing vaginal delivery.
- Conditions
- Postpartum Recovery, Mother-infant Bonding, Labor Pain
- Trial name
- NCT07582289
- Testing
- Labor Epidural Analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Ataturk University
Postoperative Pain Management
Ultrasound-Guided Versus Laparoscopy-Guided Transversus Abdominis Plane Block for Postoperative Analgesia
This prospective, randomized, double-blind study aimed to compare the effects of ultrasound-guided versus laparoscopy-guided transversus abdominis plane(TAP) block on postoperative analgesia in patients undergoing laparoscopic…
- Trial name
- US-LTAP (NCT07352189)
- Testing
- Ultrasound-guided Transversus Abdominis Plane (US-TAP) Block, Laparoscopy-guided Transversus Abdominis Plane (LS-TAP) Block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Postoperative Delirium
Treatment of Postoperative Delirium With Continuous Theta Burst Stimulation
To determine whether continuous theta burst stimulation can cure postoperative delirium in senior patients.
- Trial name
- NCT05239897
- Testing
- Continuous theta burst stimulation (cTBS)
- Where
- China
- Volunteers
- 20 people
- Sponsor
- RenJi Hospital
Urinary Tract Infections, Spinal Cord Injuries
Gentamicin Bladder Instillations to Prevent Urinary Tract Infections in Patients With Spinal Cord Injury
A non-randomized study evaluating the efficacy of intravesical gentamicin on the occurrence rate of urinary tract infections and bladder complications in patients after spinal cord injury (SCI), and to assess its effectiveness in…
- Conditions
- Urinary Tract Infections, Spinal Cord Injuries, Spinal Cord Diseases, Neurogenic Bladder
- Trial name
- NCT03503513
- Testing
- Gentamicin Sulfate
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Michigan
Benign Prostatic Hyperplasia Postoperative Pain
Comparison of Magnesium Sulphate vs Tramadol as Adjuvants in Intrathecal Bupivacaine for Postoperative Pain in TURP Patients
The goal of this clinical trial is to determine whether adding magnesium sulfate or tramadol to intrathecal bupivacaine improves postoperative pain control and hemodynamic stability in adult male patients undergoing transurethral…
- Trial name
- NCT07113782
- Testing
- 1. Magnesium Sulphate 2. Tramadol
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Armed Forces Institute of Urology, Rawalpindi
Pain, Postoperative, Inguinal Hernia
Inguinal Hernia Operation and Postoperative Pain
Inguinal hernia is a common disease, which is treated surgically when symptomatic. Pain after open inguinal hernia surgery can affect the patient significantly and weaken their quality of life.
- Conditions
- Pain, Postoperative, Inguinal Hernia, Quality of Life
- Trial name
- NCT03734224
- Testing
- Adhesix mesh, Progrip mesh
- Where
- Finland
- Volunteers
- 270 people
- Sponsor
- Helsinki University Central Hospital
Acute Postoperative Pain
Prediction of Postoperative Pain by Measuring Nociception at the End of Surgery
There is a large variability of postoperative pain intensity and of the drug doses necessary to alleviate this pain. The investigators hypothesis is that a measurement of nociception at the end of surgery, using either the RIII…
- Trial name
- PREPOP (NCT01828424)
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Benno Rehberg-Klug
Pain, Postoperative, Adult
Longitudinal Assessment of Pain-Related Patient-Reported Outcomes After Surgery
Little is known about pain-related outcomes experienced by patients in the first few weeks after surgery, once they are discharged from hospital.
- Conditions
- Pain, Postoperative, Adult, Pain Measurement, Functional Status
- Trial name
- NCT05315596
- Where
- 16 sites in Germany, Mexico
- Volunteers
- 1,000 people
- Sponsor
- Jena University Hospital
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