Clinical trials: Neurologic Complications
Pain, Postoperative
Safety and Efficacy Study of KAI-1678 to Treat Subjects With Postoperative Pain
The purpose of this study is to determine whether KAI-1678 is effective in the treatment of postoperative pain following total hip or total knee replacement.
- Trial name
- NCT01015235
- Testing
- KAI-1678, Ketorolac Tromethamine
- Where
- New Zealand
- Volunteers
- 90 people
- Sponsor
- KAI Pharmaceuticals
Renal Cell Carcinoma, Brain Metastasis
Study of Lenvatinib Plus Pembrolizumab in IO Refractory mRCC Patients With Brain Metastases
This is a multi-center, open-label phase II study evaluating the efficacy and safety of pembrolizumab in combination with lenvatinib in patients with renal cell carcinoma (RCC) and brain metastasis who were previously treated…
- Trial name
- NCT07011849
- Testing
- Pembrolizumab, Lenvatinib
- Sponsor
- M.D. Anderson Cancer Center
Pain, Postoperative
Hand and Engine-driven Techniques for Endodontic Retreatment
Numerous instrumentation techniques have been suggested for the nonsurgical retreatment of teeth with primary failure of endodontic therapy in laboratory studies.
- Trial name
- NCT03743233
- Testing
- Hand file, Reciprocating
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Federal University of Pelotas
Interstitial Cystitis
Relationship of Interstitial Cystitis to Vulvodynia
This study is important in urologic nursing since many patients have interstitial cystitis (IC), a condition of frequency, urgency and pain affecting more than 1 million women in the United States.
- Trial name
- NCT00546858
- Testing
- Physical Examination
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Corewell Health East
Hyperalgesia
Opioid-induced Hyperalgesia After Remifentanil Infusion
Remifentanil is a rapid-acting opioid which has been widely used in pain treatment during surgery for the last 15 years 1. Remifentanil is rapidly eliminated (minutes) from the body after end of infusion, and this makes it easily…
- Trial name
- NCT01702389
- Testing
- Remifentanil
- Where
- Norway
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Assessment, Self, Muscle Atrophy
Correlation of Muscle Ultrasound Measures (2D and 3D) With Biphotonic X-ray Absorptiometry in Oldest Old Patients.
The sarcopenia diagnosis is based on the muscle mass and on impaired physical performance. The emerging field of ultrasound assessment of muscle mass in older patients is based on 2d parameters with prediction equations for…
- Conditions
- Assessment, Self, Muscle Atrophy, Ultrasound Therapy; Complications, Aging
- Trial name
- DIASEM (NCT04753450)
- Testing
- No intervention
- Where
- France
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Endometriosis, Dysmenorrhea
Effect of Propolis Administration for Dysmenorrhea in Endometriosis Patient With Levonorgestrel Implant Therapy
The goal of this clinical trial is to investigate the effect of propolis administration on dysmenorrhea in endometriosis patient.
- Trial name
- NCT05770297
- Testing
- Propolis
- Where
- Indonesia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Pain, Chronic Postsurgical, Knee Osteoarthritis
Central Sensitization in Total Knee Arthroplasty Patients with Persistent Pain
Persistent post-surgical pain is a significant adverse effect after total knee arthroplasty, present in around 20% of the patients. Central sensitization may contribute to developing and maintaining pain.
- Conditions
- Pain, Chronic Postsurgical, Knee Osteoarthritis, Sensitization, Central
- Trial name
- NCT05575310
- Testing
- Total Knee Arthroplasty
- Where
- Spain
- Volunteers
- 117 people
- Sponsor
- University of Barcelona
Postoperative Pain
The Median Effective Dose (ED50) of Paracetamol and Morphine : A Study of Interaction Study
The aim of our study is to define the median effective analgesic doses (ED50) of paracetamol, morphine, and their combination and determination the nature of their interaction administered IV for postoperative pain after moderate…
- Trial name
- NCT01366313
- Testing
- Paracetamol, Morphine, Paracetamol- Morphine
- Where
- Saudi Arabia
- Volunteers
- 90 people
- Sponsor
- Procare Riaya Hospital
Cervical Cancer, Endometrial Cancer
Amifostine in Treating Women With Ovarian, Peritoneal, Cervical, Fallopian Tube, Uterine, or Endometrial Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Chemoprotective drugs, such as amifostine, may protect normal cells from the side effects of chemotherapy.
- Conditions
- Cervical Cancer, Endometrial Cancer, Fallopian Tube Cancer, Neurotoxicity
- Trial name
- NCT00003624
- Testing
- amifostine trihydrate, cisplatin, paclitaxel
- Where
- 8 sites in United States
- Sponsor
- Gynecologic Oncology Group
Chronic Kidney Disease, Pain, Procedural
Comparing Mirror and Music for Dialysis Needle Pain
Inserting needles into the vascular access (fistula) is a major source of pain and anxiety for many hemodialysis patients. This study compared two simple, non-drug techniques to reduce this pain: listening to music and looking…
- Conditions
- Chronic Kidney Disease, Pain, Procedural, Arteriovenous Fistula
- Trial name
- MIRROR-MUSIC (NCT07320859)
- Testing
- Mirror Therapy (Visual Illusion Therapy), Music Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Izmir Kavram Vocational School
Diabetic Polyneuropathy
Peripheral Nerve Stimulation in Diabetic Patients
The prevalence of diabetes mellitus (DM) in industrialized countries is estimated to be about 7.3% and its incidence has been growing in recent years.
- Trial name
- NCT01488474
- Testing
- peripheral nerve stimulation
- Where
- Austria
- Volunteers
- 124 people
- Sponsor
- Medical University of Graz
Chronic Pelvic Pain, Interstitial Cystitis
Effect of Repetitive Transcranial Direct Current Stimulation (tDCS) on Chronic Pelvic Pain
We will rigorously test whether modulation of the motor cortex by transcranial direct current stimulation (tDCS) is an effective treatment for patients with chronic pelvic pain through the following specific aims: A) The primary…
- Conditions
- Chronic Pelvic Pain, Interstitial Cystitis, Post Traumatic Stress Disorder, Fibromyalgia
- Trial name
- NCT00554320
- Testing
- tDCS
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Summa Health System
Painful Diabetic Neuropathy
Comparison of 10 kHz SCS Combined With CMM to CMM Alone in the Treatment of Neuropathic Limb Pain
This post-market study is being conducted to document comparative safety, clinical effectiveness, and cost-effectiveness of the addition of HF10™ therapy to CMM compared with CMM alone in subjects with chronic, intractable…
- Trial name
- SENZA-PDN (NCT03228420)
- Testing
- Senza HF10 Therapy, CMM
- Where
- 4 sites in United States
- Volunteers
- 430 people
- Sponsor
- Nevro Corp
Anesthesia, General Anesthesia
Efficacy of Opioid-free Anesthesia in Reducing Postoperative Respiratory Depression in Children Undergoing Tonsillectomy
The objective of this trial is to determine whether an opioid-free general anesthetic (OFA) technique utilizing ketamine, dexmedetomidine, lidocaine, and gabapentin can help reduce postoperative respiratory depression in the…
- Conditions
- Anesthesia, General Anesthesia, Analgesics, Opioid, Postoperative Complications
- Trial name
- NCT02987985
- Testing
- Acetaminophen, gabapentin, Acetaminophen, Ketamine , Lidocaine , Dexmedetomidine
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Saskatchewan
Skin Graft Complications, Pain Management
The Rule of Bupivacaine Hydrochloride in Skin Graft Donor Site
Split Thickness Skin Graft is frequently utilized for reconstructing skin loss of various causes. Unfortunately, the donor site of the STSG has an unavoidable, annoying post-operative pain
- Trial name
- NCT06766474
- Testing
- Bupivacain
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Minia University
Surgery, Postoperative Cognitive Dysfunction
Five Years Follow-up of Neurological Outcome After Minimally Invasive Cardiac Surgery
A monocenter observational study will be started to investigate postoperative cognitive dysfunction 5 years after minimally invasive cardiac surgery.
- Trial name
- FUNOMICS (NCT05330260)
- Testing
- neurocognitive test battery
- Where
- Belgium
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Jessa Hospital
Immediate Severe Postoperative Pain, Perioperative Hemodynamic
GOAL-Directed ANalgesia (GOALDAN)
The primary purpose of GOALDAN study is to demonstrate the superiority of a targeted perioperative analgesic strategy by the ANI over the usual practice on the incidence of immediate postoperative pain.
- Trial name
- GOALDAN (NCT03618082)
- Testing
- Anesthesic agent guided by ANI (Interventional Group), Administration of the lowest effective concentration of desflurane (Interventional Group)
- Where
- France
- Volunteers
- 380 people
- Sponsor
- University Hospital, Clermont-Ferrand
Lumbar Disc Herniation, Lumbar Discogenic Pain
Comparing General Anesthesia, General Anesthesia With ESP Block or TLIP Block in Patients Undergoing Lumbar Surgeries
The regional methods of anesthesia for the neurosurgical operations of the spine and spinal cord reducing the needs for opioids intra operatively and reducing pain in the postoperative period, decrease the numbers of failed back…
- Conditions
- Lumbar Disc Herniation, Lumbar Discogenic Pain, Lumbar Spinal Stenosis, Failed Back Surgery Syndrome
- Trial name
- NCT05447780
- Testing
- regional anesthesia
- Where
- Ukraine
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Anesthesia Research Group UA
Postoperative Pain
The Effect of Intravenous Lidocaine on Pain After Tonsillectomy
This prospective randomized study aims to evaluate the effectiveness of intravenous lidocaine injection on the relief of pain in patients undergoing tonsillectomy.
- Trial name
- NCT01291979
- Testing
- Intravenous lidocaine injection, Intravenous normal saline injection
- Where
- South Korea
- Volunteers
- 62 people
- Sponsor
- Chung-Ang University Hospital
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