Clinical trials: Neurologic Complications
Postoperative Delirium, Postoperative Cognitive Dysfunction
Modulating ApoE Signalling to Reduce Brain Inflammation, deLirium and postopErative Cognitive Dysfunction
This research study will evaluate the effectiveness and estimate the feasibility of administering an investigational drug called 'CN-105' (the study drug), to prevent postoperative cognitive decline, delirium (serious confusion)…
- Trial name
- MARBLE (NCT03802396)
- Testing
- CN-105
- Where
- United States
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Miles Berger, MD PhD
Post Operative Pain, Quality of Recovery After Mastectomy
Quality of Recovery From Mastectomy With and Without PECS Blocks
This is a prospective observational study. Investigators want to understand post-operative recovery for patients undergoing mastectomy at NorthShore University HealthSystem.
- Trial name
- NCT05795413
- Testing
- Mastectomy with PECS blocks, Liposomal bupivacaine
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Hip Fracture, Postoperative Pain
Fascia Iliaca vs Femoral Nerve Block in Hip Fracture Patients
Hip fractures are common orthopedic injuries, especially in older adults, and surgical repair such as hip arthroplasty is often required.
- Conditions
- Hip Fracture, Postoperative Pain, Peripheral Nerve Block, Femoral Nerve
- Trial name
- CPTH (NCT07597317)
- Testing
- Fascia Iliaca Compartment Block (FICB)
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- Central Park Teaching Hospital, Lahore
Postoperative Pain, NEBULIZATION
Effects of Different Drugs for Glottic Atomization on Postoperative Sore Throat After Thyroid Surgery
Postoperative sore throat is a common complication following tracheal intubation under general anesthesia for thyroidectomy. The special surgical position for thyroidectomy, as well as the physical and electrical stimulation from…
- Conditions
- Postoperative Pain, NEBULIZATION, Thyroid Surgery
- Trial name
- NCT07491991
- Testing
- Inhalation of budesonide combined with lidocaine, Inhalation of saline solution via nebulization
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Qianfoshan Hospital
Hemorrhoid
Subarachnoid or Infiltration for Hemorrhoidectomy
There will be compared the postoperative analgesic effect of infiltration or spinal block for hemorrhoidectomy
- Trial name
- NCT01927874
- Testing
- Infiltration, Spinal block, Bupivacaine
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of São Paulo
Bowel Diseases, Inflammatory, Bowel Surgery
Use of Dexmedetomidine to Improve Pain Control and Recovery After Laparocopic-Assisted Bowel Surgery in Adults
This study is testing whether continuing a medication called dexmedetomidine after surgery can improve quality of recovery for adults undergoing laparoscopic-assisted bowel surgery.
- Conditions
- Bowel Diseases, Inflammatory, Bowel Surgery, Laparoscopic Abdominal Surgeries
- Trial name
- PODEX (NCT07434310)
- Testing
- Dexmedetomidine infusion
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Dr. Naveed Siddiqui
Pain, Postoperative
An Open-Label Functionality, Safety and Efficacy Study in Patients Undergoing Elective Unilateral Knee Replacement
This study is being performed to evaluate the functionality of a device (Sufentanil NanoTab® PCA System) that has been developed for use by patients to self-administer the ARX-F01 pain medication (Sufentanil NanoTab 15 mcg) for…
- Trial name
- NCT00859313
- Testing
- Sufentanil NanoTab PCA System/15 mcg
- Where
- 3 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Talphera, Inc
Postoperative Pain, Hip Arthroplasty
Multihole or Epidural Catheter for Local Anesthetic in the Wound
Postoperative administration of local anesthetics is effective for postoperative pain management across surgical specialties but the optimal type of catheter (single, few or multiholed catheters) has not been determined.
- Trial name
- NCT00921908
- Testing
- 2 mBq radioactive technetium diluted in 20 mL saline
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- Hvidovre University Hospital
Pain, Postoperative
The Effect of Femoral Nerve Block on Opioid Requirements After Surgery for a Femur Fracture in Children
This study evaluates the effect of a femoral nerve block on opioid requirements following femoral fracture fixation with flexible nails in the paediatric population. This is a double blind, prospective randomized clinical trial.
- Trial name
- NCT00175591
- Testing
- Administration of a femoral nerve block (bupivacaine HCL)
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- University of British Columbia
Post-operative Delirium, Post-operative Cognitive Dysfunction
Risk Communication About Post-operative Delirium (POD) and Post-operative Cognitive Dysfunction (POCD)
The purpose of this study is to assess the awareness of post-operative delirium (POD) and post-operative cognitive dysfunction (POCD), their respective risk factors and effective preparation and treatment options in a…
- Trial name
- NCT03953313
- Where
- Germany
- Volunteers
- 223 people
- Sponsor
- Charite University, Berlin, Germany
Postoperative Pain
Non-invasive Assessment of Immediate Postoperative Analgesia Using Analgesia/Nociception Index (ANI)
The aim of this study is to evaluate the clinical performance on Analgesia/Nociception Index (ANI) in the assessment of immediate postoperative analgesia in PACU in adult patients undergoing general anesthesia.
- Trial name
- NCT01633320
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Hôpital Edouard Herriot
Vulvodynia, Chronic Pain
Multidisciplinary Treatment of Chronic Vulvar Pain
Vulvodynia (i.e. chronic vulvar pain without identifiable cause) is a heterogeneous clinical entity with a complex multifactorial causation.
- Trial name
- NCT03640624
- Testing
- Multidisciplinary treatment, Treatment as usual
- Where
- Norway
- Volunteers
- 106 people
- Sponsor
- Norwegian University of Science and Technology
Stress, Emotional, Spinal; Puncture, Complications, Headache
Acute Mental Stress During Lumbar Puncture
This study explores lumbar puncture operators stress associated with their performance of the procedure, across three experience levels: Experts, Intermediates, and Novices.
- Conditions
- Stress, Emotional, Spinal; Puncture, Complications, Headache, Lumbar Puncture
- Trial name
- NCT03192423
- Where
- 3 sites in Denmark
- Volunteers
- 50 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Coronary Heart Disease, Anemia
The Role of Concomitant Diseases in Postoperative Complications Risk Stratification.
Study is conducted to assess the prevalence and structure of comorbidity among patients undergoing abdominal surgery and produce the stratification of the risk of postoperative complications by identifying independent predictors…
- Conditions
- Coronary Heart Disease, Anemia, Bronchial Asthma, Stroke
- Trial name
- STOPRISK (NCT03945968)
- Where
- 38 sites in Russia
- Volunteers
- 16,000 people
- Sponsor
- Russian Federation of Anesthesiologists and Reanimatologists
Hemorrhoidectomy, Hemorrhoids Third Degree
Comparison Study: Ligasure Versus Conventional Hemorrhoidectomy in III and IV Degree Hemorrhoids.
A comparison study was performed between Ligasure and Milligan morgan hemorrhoidectomy to find out the outcome between these two techniques in 3rd and 4th degree hemorrhoids.This advance vessel sealing device is used to seal the…
- Conditions
- Hemorrhoidectomy, Hemorrhoids Third Degree, Hemorrhoids Fourth Degree, Operative Time
- Trial name
- NCT03848468
- Testing
- Hemorrhoidectomy
- Where
- Pakistan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Services Hospital, Lahore
Symptomatic Irreversible Pulpitis (SIP), Post Operative Pain After Root Canal Therapy
Effects of Irrigation Activation and Obturation Techniques on Pain After Root Canal Treatment
This randomized controlled clinical trial aimed to compare postoperative pain and analgesic use following single-visit root canal treatment performed using different final irrigation activation and root canal obturation…
- Trial name
- NCT07882368
- Testing
- Conventional Needle Irrigation, Sonic Irrigation Activation, Cold Lateral Condensation
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Biruni University
Chronic Pain, Endometriosis
Return to Work in Patients With Chronic Pain
This study aims to evaluate whether a vocational behaviour change ability programme has any additional effect on return to work compared with return to work coordination only in persons with chronic pain.
- Trial name
- UWORKin (NCT03827174)
- Testing
- Return To Work Coordination, Behaviour Change Ability Program
- Where
- Sweden
- Volunteers
- 8 people
- Sponsor
- Uppsala University
Spinal Disease, Anesthesia
Influence of Lidocaine Infusion on Motor Evoked Potential Thresholds
The purpose of this study is to determine the effect of lidocaine infusion on intraoperative neuromonitoring in patients undergoing spine surgery.
- Conditions
- Spinal Disease, Anesthesia, Post Operative Pain
- Trial name
- NCT06792474
- Testing
- Lidocaine in Saline, Normal saline
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Pain, Postoperative
Efficacy of Bupivacain Local Infiltration for the Management of Pain During Cesarean Section
This study aims to evaluate the effect of local administration of bupivacain in the cesarean section incision for postoperative pain control, using the visual analogue pain scale (VAS) and assessing the need for rescue analgesia…
- Trial name
- NCT05404490
- Testing
- Bupivacain
- Where
- Panama
- Volunteers
- 202 people
- Sponsor
- Saint Thomas Hospital, Panama
Parkinson Disease
DESENSITIZE-PD: Intestinal Levodopa + Entacapone Therapy (Lecigon®) to Support Dopaminergic Desensitization in PD
20 patients with idiopathic Parkinson's disease, who are planned to undergo intestinal L-Dopa + entacapone (Lecigon®) treatment will be included into this observational single-armed study.
- Trial name
- NCT05579379
- Volunteers
- 20 people
- Sponsor
- University Hospital Tuebingen
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