Clinical trials: Neurologic Disorder
Sleep Disorders, Cerebrovascular Disorders
Epidemiology of Sleep-Disordered Breathing in Adults
To characterize the natural history and biologic spectrum of sleep disordered breathing (SDB) and other sleep problems and disorders, and test hypotheses regarding the causes and consequences of SDB and other sleep problems and…
- Conditions
- Sleep Disorders, Cerebrovascular Disorders, Cardiovascular Disease, Neurologic Disorders
- Trial name
- NCT00005557
- Where
- United States
- Volunteers
- 1,545 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Parkinson's Disease, Tourette's Syndrome
Physiological Investigations of Movement Disorders
Background: Previous studies have given researchers information on how the brain controls movement, how people learn to make fine, skilled movements, and why some people have movement disorders.
- Conditions
- Parkinson's Disease, Tourette's Syndrome, Tic Disorders, Dystonia
- Trial name
- NCT01019343
- Testing
- Transcranial Direct Current Stimulation (tDCS), Eye-tracking Device, Pulsed vibrator
- Where
- United States
- Volunteers
- 1,273 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Stroke, Acute, Gait, Hemiplegic
Focused Intensive Repeated Stepping During Inpatient Rehabilitation Poststroke - A Quality Improvement Project
The purpose of this quality improvement project was first to monitor usual physical therapy care (types \& cardiovascular intensity of interventions and amount of stepping practice provided) and outcomes.
- Trial name
- FIRST-IN (NCT05393661)
- Testing
- inpatient physical therapy poststroke
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Indiana University
Gait Disorders, Neurologic, Atypical Parkinson Disease
Brain Activity During Complex Walking in People With Atypical Parkinsonian Syndromes
Every-day life means being part of a complex environment and performing complex tasks that usually involve a combination of motor and cognitive skills.
- Conditions
- Gait Disorders, Neurologic, Atypical Parkinson Disease, fNIRS, Aging
- Trial name
- NCT06906276
- Testing
- Assessment of brain activity with fNIRS and behavioural assessments (motor, motor-cognitive and cognitive) during three complex walking conditions.
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Karolinska Institutet
Leber Congenital Amaurosis 10, Blindness
Study to Evaluate Sepofarsen in Subjects With Leber Congenital Amaurosis (LCA) Type 10 (HYPERION)
The purpose of this double-masked, randomized, placebo-controlled, paired-eye study is to evaluate the efficacy, safety and tolerability of Sepofarsen in subjects with Leber Congenital Amaurosis (LCA) due to the c.2991+1655A>G…
- Conditions
- Leber Congenital Amaurosis 10, Blindness, Leber Congenital Amaurosis, Sensation Disorders
- Trial name
- HYPERION (NCT06891443)
- Testing
- sepofarsen
- Where
- 18 sites in United States, Australia and 8 more
- Volunteers
- 32 people
- Sponsor
- Laboratoires Thea
Multiple Sclerosis, Fibromyalgia
Evaluation of the Safety and Efficacy of a Full-Body Electrostimulation Garment for Individuals With Neurological and Neuromuscular Conditions That Cause Spasticity, Hyperreflexia, and Pain
The purpose of this study is to to explore the safety and efficacy of the EXOPULSE Mollii suit, a full-body electrostimulation suit, for individuals with neurological or neuromuscular conditions that cause spasticity…
- Conditions
- Multiple Sclerosis, Fibromyalgia, Neurologic Disorder, Neuromuscular Disorders
- Trial name
- NCT07132775
- Testing
- Active full-body stimulation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Shirley Ryan AbilityLab
Neurologic Disorders
Evaluation and Treatment of Neurosurgical Disorders
Objective: This protocol is designed to allow the Surgical Neurology Branch to evaluate and treat the neurosurgical disorders of protocol participants.
- Trial name
- NCT00060541
- Testing
- Laboratory tests, Radiological exams
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Stroke, Spinal Cord Injuries (SCI)
ZEPU-AI1 Gait Robot Training Study (ZEPUAI1RCT)
Walking problems caused by stroke, spinal cord injury, or orthopedic surgery are common and can seriously limit a person's independence.
- Conditions
- Stroke, Spinal Cord Injuries (SCI), Gait Disorders, Neurologic
- Trial name
- NCT07735676
- Testing
- ZEPU-AI1 Gait Training and Evaluation System, Standard-of-Care Rehabilitation (Individualized Rehabilitation and Exercise)
- Where
- Bangladesh
- Volunteers
- 51 people
- Sponsor
- Bangladesh Medical University
Stroke
Improving Measurement and Treatment of Post-stroke Neglect
This study examines how to best assess and treat post-stroke neglect. This study will examine the preliminary effects of an innovative intervention (repetitive task-specific practice + transcranial direct current stimulation) for…
- Trial name
- NCT03317860
- Testing
- Active direct current stimulation (tDCS)
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- VA Office of Research and Development
Neurologic Disorder, Traumatic Brain Injury
Effectiveness of Music Therapy on Level of Consciousness
It is known that even in patients with severe disorders of consciousness (DOC), the perception of known stimuli triggers emotional reactions that can be interpreted as an expression of a residual function of consciousness.
- Conditions
- Neurologic Disorder, Traumatic Brain Injury, Disorder of Consciousness
- Trial name
- NCT04442971
- Testing
- Music Stimulation, Alternative Stimulation, No Auditory Stimulation
- Where
- Germany
- Volunteers
- 66 people
- Sponsor
- BDH-Klinik Hessisch Oldendorf
Neurologic Disorder, Disorder of Consciousness
Prognostic Factors to Regain Consciousness
The study aims to identify factors that predict the medium and long-term outcome of patients with disorders of consciousness (DOC) undergoing early neurological rehabilitation.
- Conditions
- Neurologic Disorder, Disorder of Consciousness, Traumatic Brain Injury, Stroke
- Trial name
- NCT04445649
- Testing
- Coma-Recovery-Scale-Revised (CRS-R)
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- BDH-Klinik Hessisch Oldendorf
Neurologic Disorder, Subarachnoid Hemorrhage, Aneurysmal
Hippocampal Volume and Memory Functions in Aneurysmal Subarachnoid Hemorrhage
Neuropsychological and functional long-term consequences of subarachnoid hemorrhages (SAH) represent a great challenge, since sometimes considerable cognitive deficits occur without evidence of substantial brain damage.
- Trial name
- NCT04449666
- Testing
- Neuropsychological assessment and structural MRI
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- BDH-Klinik Hessisch Oldendorf
Multiple Sclerosis, Gait Disorders, Neurologic
Gait Pattern and Its Relation to Cognition and VEP in Multiple Sclerosis
This cross-sectional study aims to assess the pattern of gait in patients with multiple sclerosis and to evaluate its relation to cognitive function, visual evoked potentials, and radiological findings.
- Trial name
- NCT07847086
- Volunteers
- 70 people
- Sponsor
- Assiut University
Neurologic Disorders, Spinal Cord Injury
Reliability and Validity of the PReFS
This study is testing the psychometric properties of a new tool to determine recommendations for pressure relief frequency in wheelchair users.
- Conditions
- Neurologic Disorders, Spinal Cord Injury, Stroke, Traumatic Brain Injury
- Trial name
- PReFS (NCT07280923)
- Testing
- Interview
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Baylor University
Neurologic Disorders, Autism
The Neurodevelopmental and Behavioral Phenotyping Screening Protocol
The purpose of this protocol is to allow for the careful evaluation of healthy volunteers and individuals with risk for psychiatric disorders or neurodevelopmental disorders, such as autism spectrum disorder for specific…
- Conditions
- Neurologic Disorders, Autism, Neurodegenerative Disease, Neurobehavioral Manifestation
- Trial name
- NCT00271622
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Intensive Care Unit, Mortality
Analysis of the Evolution of Mortality in an Intensive Care Unit
The intensive care units is of the main components of modern healthcare systems. Formally, its aim is to offer the critically ill health care fit to their needs; ensuring that this health care is appropriate, sustainable, ethical…
- Conditions
- Intensive Care Unit, Mortality, Epidemiology, Respiration, Artificial
- Trial name
- NCT05261607
- Where
- Spain
- Volunteers
- 27,463 people
- Sponsor
- Hospital Universitario Getafe
Mucopolysaccharidosis Type II, Metabolic Diseases
A Multi-cohort Study of Safety, Efficacy, PK and PD of GNR-055 in Patients With Mucopolysaccharidosis Type II
This is phase 2/3 study to evaluate the safety, pharmacokinetics, pharmacodynamics, and efficacy of the investigational product GNR-055 in MPS II (Hunter syndrome) patients of different age groups.
- Trial name
- NCT05208281
- Testing
- GNR-055 1.0-2.0-3.0 mg/kg, GNR-055 2.0 mg/kg, GNR-055 3.0 mg/kg
- Where
- 5 sites in Russia
- Volunteers
- 32 people
- Sponsor
- AO GENERIUM
Cognition, Parkinson's Disease
Dual-Task Balance and Gait Training Combined With Cognitive Training in Parkinson's Patients
The aim of the study is to examine the effects of a structured, cognitive dimension-specific cognitive training combined with dual-task balance and gait training on balance, gait, and cognition in individuals with Parkinson's…
- Conditions
- Cognition, Parkinson's Disease, Gait Disorders, Neurologic, Balance Disorders
- Trial name
- NCT07213232
- Testing
- Core Stability Training, Dual-Task Balance and Gait Training, Cognitive Training
- Where
- Turkey (Türkiye)
- Volunteers
- 14 people
- Sponsor
- Gazi University
Menopause, Gait, Unsteady
Effects of Strength Training on the Gait and Pelvic Floor in Menopausal Women
The overall objective will be to observe whether a strength and balance training intervention produces significant changes in the analysis of double stance phase movement during gait, the analysis of coxofemoral, tibial and…
- Conditions
- Menopause, Gait, Unsteady, Pelvic Floor Disorders
- Trial name
- NCT07824947
- Testing
- Strength training
- Where
- Spain
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Alcala
Parkinson Disease, Gait Disorders, Neurologic
Benefits of Different Exercise Types to Enhance Walking for PD
Background: Gait disturbance is one of the most common complaints from patients with Parkinson's disease (PD). It is well-established that people with PD have motor learning impairments.
- Trial name
- NCT04895787
- Testing
- Gait + aerobic exercise, Gait + resistance exercises, Gait + conventional physical therapy
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- National Taiwan University Hospital