Clinical trials: Neurologic Dysfunction
Gait Disorders, Neurologic, Gait Disorders in Old Age
ExerG: Video Game-based Physical Cognitive Training for Patients: a Usability Study
Video game-based training programs, in the following referred to as "exergames" are an innovative digital training approach to simultaneously train physical and cognitive functions and increase training motivation for various…
- Conditions
- Gait Disorders, Neurologic, Gait Disorders in Old Age, Gait Disorder, Sensorimotor, Balance; Distorted
- Trial name
- ExerGetic (NCT05967078)
- Testing
- ExerG
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Frank Behrendt
Post-Acute COVID-19 Syndrome, Cognitive Impairment
Safety, Efficacy, and Dosing of VIX001 in Patients With Neurological Symptoms of Post Acute COVID-19 Syndrome (PACS).
The study, identified as VIX001-PACS-01, is a Phase 1, open-label, dose-escalation trial evaluating the safety, tolerability, preliminary efficacy, and dose effect of VIX001, an amniotic fluid product, in patients with Post-Acute…
- Conditions
- Post-Acute COVID-19 Syndrome, Cognitive Impairment, Neurological Complication
- Trial name
- NCT05947617
- Testing
- VIX001
- Volunteers
- 9 people
- Sponsor
- Neobiosis, LLC
Post COVID-19, Cognitive Dysfunction
Multimodal Investigation of Post COVID-19 in Females
The purpose of this study is to investigate the effects of transcutaneous vagus nerve stimulation (t-VNS) on Long Covid symptoms in females and to identify factors influencing susceptibility and recovery-particularly in the…
- Trial name
- NCT05225220
- Testing
- Parasym Device (of Parasym Ltd, UK) using Transcutaneous Vagus Nerve Stimulation (t-VNS)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Cerebral Palsy, Motor Dysfunction
Evaluating the Therapeutic Effect of Scalp Acupuncture Treatment for Motor Dysfunction in Children With Cerebral Palsy
The investigators design a Multi-center randomized, control study to evaluate the therapeutic effect of the scalp acupuncture treatment for motor dysfunction in children with cerebral palsy by using the following outcomes: motor…
- Conditions
- Cerebral Palsy, Motor Dysfunction, Acupuncture
- Trial name
- NCT03921281
- Testing
- scalp acupuncture treatment, Rehabilitation Treatment
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Children's Hospital of Fudan University
Gulf War Illness, Chronic Fatigue
Coenzyme Q10 Phase III Trial in Gulf War Illness
The primary objective of this clinical trial is to determine if treatment with ubiquinol, a form of coenzyme Q10, improves the physical function of men and women Veterans suffering from Gulf War Illness (GWI).
- Conditions
- Gulf War Illness, Chronic Fatigue, Ubiquinol, Coenzyme Q10
- Trial name
- NCT02865460
- Testing
- Ubiquinol
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- VA Office of Research and Development
Parkinson Disease, Biomarkers
Intensive Multidisciplinary Rehabilitation and Biomarkers in Parkinson's Disease
Parkinson's disease (PD) is a progressive neurological disorder characterized by motor and non-motor symptoms such as rigidity, bradykinesia, resting tremor, cognitive and autonomic dysfunctions, gait and balance difficulties.
- Conditions
- Parkinson Disease, Biomarkers, Rehabilitation Outcome, Gait Disorders, Neurologic
- Trial name
- NCT05452655
- Testing
- Multidisciplinary Intensive Rehabilitation, Muscle-stretching and active mobilization exercises
- Where
- Italy
- Volunteers
- 72 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Autoimmune Diseases, Cardiovascular Disorders
Mesenchymal Stem Cells for the Treatment of Various Chronic and Acute Conditions
This multi-arm, multi-site study investigates the safety, tolerability, and efficacy of stem cell therapy for the treatment of various acute and chronic conditions.
- Conditions
- Autoimmune Diseases, Cardiovascular Disorders, Diabetes Complications, Integumentary Disease
- Trial name
- NCT04684602
- Testing
- PrimePro™/ PrimeMSK™
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Thomas Advanced Medical LLC
Growth Failure, Atopy
The PREWEAN Study. Weaning of Preterm Infants During the First Year of Life.
In this Austrian observational study preterm infants born with a birth weight <1500 g and a gestational age <32 weeks will be investigated at the neonatal outpatient clinic.
- Conditions
- Growth Failure, Atopy, Adiposity, Cognitive Impairment
- Trial name
- PREWEAN (NCT02936219)
- Where
- Austria
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Upper Extremity Dysfunction, Gait, Unsteady
The Effect of Improvement in Function on Foot Pressure, Balance and Gait in Children With Upper Extremity Affected
It has been shown that movements of the upper extremity during walking are associated with lower extremity mobility. For example, when walking at a slow pace, the swing frequency of the arms is 2: 1 compared to the legs, while…
- Conditions
- Upper Extremity Dysfunction, Gait, Unsteady, Juvenile Idiopathic Arthritis, Balance
- Trial name
- NCT04671524
- Testing
- Exercise protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Stroke, Motor Dysfunction
Hyperbaric Oxygen and Manipulative Therapies to Regain Function Post Stroke
To study safety, feasibility and outcomes of combining osteopathic manipulative therapies with hyperbaric oxygen therapy in reducing the functional deficits in stroke survivors in subacute and chronic phases post ischemic stroke.
- Conditions
- Stroke, Motor Dysfunction, Chronic Stroke, Ischemic Stroke
- Trial name
- HBOT/OMT (NCT03352232)
- Testing
- HBOT and OMT
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Abington Memorial Hospital
Bilirubin-induced Neurologic Dysfunction, Hyperbilirubinemia
Bilirubin Binding Capacity to Assess Bilirubin Load in Preterm Infants
Most preterm newborns are managed by phototherapy to reverse hyperbilirubinemia with the intent to prevent bilirubin neurotoxicity.
- Conditions
- Bilirubin-induced Neurologic Dysfunction, Hyperbilirubinemia, Kernicterus, Infant, Premature
- Trial name
- NCT02691156
- Testing
- Bilirubin Binding Capacity, End-tidal Carbon Monoxide, Carboxyhemoglobin
- Where
- United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Stanford University
Depression, Delirium
Cognitive Recovery After Electroconvulsive Therapy and General Anesthesia
This study is geared toward characterizing the recovery of brain activity and cognitive function following treatments of electroconvulsive therapy and ketamine general anesthesia.
- Conditions
- Depression, Delirium, Seizures, Cognitive Disorders
- Trial name
- RCC2 (NCT02761330)
- Testing
- Ketamine, Electroconvulsive Therapy
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Washington University School of Medicine
Myelomeningocele, Neurogenic Bladder
Efficacy of Contrast Enhanced Voiding Urosonography for Urodynamic Studies
The investigators will assess the feasibility of replacing fluoroscopy/iodinated contrast with ultrasound/sulfur hexafluoride lipid-type A microspheres during routine urodynamic studies.
- Conditions
- Myelomeningocele, Neurogenic Bladder, Tethered Cord Syndrome, Bladder, Neurogenic
- Trial name
- NCT04738539
- Testing
- Contrast Enhanced Voiding Urosonography with Urodynamic Testing, Urodynamic Testing
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Out-Of-Hospital Cardiac Arrest, Myocardial Infarction
Factors Associated With CPC 1-2 in 110 Patients Admitted in French ICU for a Myocardial Infarction Complicated by an OHCA.
This study evaluate the association of some in-ICU factors with the neurological prognosis of patients admitted for an out-of-hospital cardiac arrest due to a myocardial infarction.
- Conditions
- Out-Of-Hospital Cardiac Arrest, Myocardial Infarction, Coma, Outcome, Fatal
- Trial name
- ACR-MI (NCT04584463)
- Volunteers
- 110 people
- Sponsor
- Central Hospital, Nancy, France
Ischemic Stroke, Neurological Injury
Omega 3 and Ischemic Stroke; Fish Oil as an Option
In this trial, The investigators are going to investigate the improvement of neurological functions and infarced area of the brain in ischemic stroke patients after ingestion of omega 3 products that have high concentrations of…
- Conditions
- Ischemic Stroke, Neurological Injury, Stroke, Acute, Inflammatory Response
- Trial name
- OmegaStroke (NCT04386525)
- Testing
- Omega-3 fish oil
- Volunteers
- 60 people
- Sponsor
- King Fahad Medical City
Repetitive Transcranial Magnetic Stimulation, Transcranial Direct Current Stimulation
Efficacy of rTMS and tDCS as Adjunctive Rehabilitation for Cerebrovascular Disease-related Gait Dysfunction
This study was a prospective, randomized, single-blind, parallel-controlled, multicenter clinical study to evaluate the efficacy and safety of repetitive transcranial magnetic stimulation and transcranial direct current…
- Conditions
- Repetitive Transcranial Magnetic Stimulation, Transcranial Direct Current Stimulation, Cerebrovascular Disease, Gait Dysfunction, Neurologic
- Trial name
- NCT04282538
- Testing
- Active rTMS, Active tDCS, Walking training
- Where
- 6 sites in China
- Volunteers
- 100 people
- Sponsor
- zsneurology
Measurement Properties of 5iTUG, Physical Disability
Evaluation of the Measurement Properties of a 5 Time Repeated Instrumented Timed Up and Go (5iTUG)
In order to tailor interventions, objective assessments of physical function is needed. A limitation of several of today's clinical assessments is that they require too much time and/or space.
- Conditions
- Measurement Properties of 5iTUG, Physical Disability, Balance, Cognitive Impairment
- Trial name
- 5iTUG (NCT03769220)
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Robert Bosch Gesellschaft für Medizinische Forschung mbH (RBMF)
Post-stroke Patients With Motor and Sensory Dysfunction
Clinical Observation on the Treatment of Motor and Sensory Dysfunction After Stroke With Ruyizhenbao Pill
Many years of clinical practice experience has found that Ruyi treasure pill can be used to treat nerve meridian injury caused by cerebrovascular disease, but in the end, the clinical efficacy is still lacking systematic clinical…
- Trial name
- NCT04029701
- Testing
- Ruyizhenbao Pill
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Guangzhou University of Traditional Chinese Medicine
Multiple Sclerosis, Gait Disorders, Neurologic
Measurement and Training of Dual-Task of Gait in Persons With Multiple Sclerosis
The purpose of this study is to determine the utility of a performance measure for the dual-task of gait and considering people with multiple sclerosis have both cognitive and motor problems, the secondary aim of this study is to…
- Conditions
- Multiple Sclerosis, Gait Disorders, Neurologic, Cognitive Impairment
- Trial name
- MS (NCT03536299)
- Testing
- Dual-task gait, Single-task gait
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Texas Woman's University
Orthopedic Disorder, Neurologic Disorder
Safety and Clinical Outcomes With Amniotic and Umbilical Cord Tissue Therapy for Numerous Medical Conditions
To determine the safety and efficacy of Amniotic and Umbilical Cord Tissue for the treatment of the following condition categories: Orthopedic, Neurologic, Urologic, Autoimmune, Renal, Cardiac and Pulmonary Conditions.
- Conditions
- Orthopedic Disorder, Neurologic Disorder, Urologic Diseases, Erectile Dysfunction
- Trial name
- NCT03899298
- Testing
- Amniotic and Umbilical Cord Tissue Procedure
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- R3 Stem Cell