Clinical trials: Neurologic Gait Disorder
Parkinson Disease
Pathways Mediating Impaired Postural Control in Parkinson's Disease
The purpose of this project is to use transcranial magnetic stimulation (TMS) to explore the state of excitability of corticocortical and corticofugal (cortex to spinal cord, cortex to brainstem to spinal cord) pathways that…
- Trial name
- NCT06464029
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Stroke Sequelae, Gait, Hemiplegic
ACTive Exoskeleton for Unilaterally-Assisted Locomotion (ACTUAL)
Walking difficulties are common symptoms after stroke, significantly reducing quality of life. Walking recovery is therefore one of the main priorities of rehabilitation.
- Trial name
- ACTUAL (NCT06061601)
- Testing
- Exoskeleton stroke group
- Where
- Italy
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Cerebral Palsy, Robotics
Can Robot-Assisted Gait Training In Addition To Conventional Rehabilitation Provide Better Outcomes In Children With Cerebral Palsy?
A total of 26 patients who were diagnosed with CP [diplegic, with Gross Motor Function Classification System (GMFCS) level of 2-5] and who regularly participated in a rehabilitation programme were included in the study after…
- Trial name
- NCT04781101
- Testing
- conventional therapy, RoboGait®
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Okan University
Parkinson Disease(PD)
AR Stimulation Effects on Gait, Anxiety, and Brain Connectivity in Parkinson's Disease
A project aims at addressing gait impairments and non-motor symptoms such as anxiety and stress in Parkinson's disease (PD) patients through a novel approach involving heart rate variability (HRV) feedback and Augmented Reality…
- Trial name
- NCT06367101
- Testing
- AR training with gait and HRV feedback
- Where
- Taiwan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Chang Gung University
Parkinson's Disease, Somatosensory Disorders
Somatosensory Dysfunction as the Underlying Mechanism of Upper Limbs Motor Blocks in People With Parkinson's Disease
Motor blocks during gait and upper limb movements (FOULs) are a disabling and common motor impairment in mild to severe stages of Parkinson's disease (PD).
- Trial name
- NCT02610257
- Testing
- Mechanical stimulus (vibration) applied on the forearm
- Where
- Belgium
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Stroke, Ideomotor Apraxia
Ideomotor Apraxia and Robotic Gait Rehabilitation Outcomes After Stroke
After a stroke, some people have difficulty planning and carrying out familiar movements. This difficulty is called ideomotor apraxia and cannot be explained by muscle weakness alone.
- Conditions
- Stroke, Ideomotor Apraxia, Hemiplegia
- Trial name
- NCT07881471
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Izmir City Hospital
Stroke, Hemiplegia
Task-Oriented Training Versus High-Intensity Gait Training in People With Chronic Stroke
The purpose of this study is to compare the effects of high-repetition task-oriented training and high-intensity gait training on walking capacity and functional mobility in individuals with chronic stroke.
- Conditions
- Stroke, Hemiplegia, Chronic Stroke
- Trial name
- NCT07725211
- Testing
- Neurodevelopmental Treatment, High-Repetition Task-Oriented Training, High-Intensity Gait Training
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Istanbul University - Cerrahpasa
Cerebral Palsy
Exoskeleton-assisted Physiotherapy for Children With Mobility Impairments
Non-ambulatory children with cerebral palsy (CP) and similar childhood-onset neuromotor conditions face many challenges to fulsome participation in everyday life.
- Trial name
- NCT05463211
- Testing
- Trexo Plus Pediatric Exoskeleton
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Parkinson Disease
The Influence of Manual and Verbal Guidance for Therapeutic Results in People With Parkinson's Disease
A prospective, single-blind, parallel-group, randomised trial was conducted in Sao Paulo, Brazil. Thrid eight People with Parkinson's Disease were recruited and randomly allocated in two groups: Experimental Group (EG), that…
- Trial name
- NCT03774225
- Testing
- Virtual Reality with Manual and Verbal Guidance, Virtual Reality with No Manual and Verbal Guidance, Physical Therapy
- Where
- 2 sites in Brazil
- Volunteers
- 49 people
- Sponsor
- University of Sao Paulo General Hospital
Myotonic Dystrophy Type 1, Falls
Fall Frequency and Factors Affecting Dynamic Balance in Patients With Myotonic Dystrophy Type 1
This cross-sectional observational study aims to determine the frequency of falls in patients with myotonic dystrophy type 1 and to identify factors affecting dynamic balance.
- Trial name
- NCT07493525
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Antalya Training and Research Hospital
Parkinson Disease
Combined Deep Brain Stimulation for Parkinson's Disease
Background: Deep brain stimulation (DBS) in the subthalamic nucleus (STN) is an approved treatment for Parkinson s disease. It stimulates a part of the brain that helps control symptoms like tremor, stiffness, and slow movements.
- Trial name
- NCT01485276
- Testing
- DBS Surgery
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
PD - Parkinson's Disease
PAS Balance Training for Parkinson Disease (PD)
Gait initiation (GI) difficulty is a common problem in individuals with Parkinson's disease (PD), often linked to impaired anticipatory postural adjustments (APA).
- Trial name
- NCT06598891
- Testing
- Weight shift training and APA feedback, Paired associative stimulation
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Chang Gung University
Stroke, Hemiplegic Gait
The Effects of Plantar Flexion Training in People With Chronic Stroke
This study consists of three phases that aim to develop an exercise intervention to promote maximal activation of ankle plantar flexors in the paretic lower extrimty (LE) in order to restore a more normalized gait pattern in…
- Trial name
- NCT03548090
- Testing
- Skateboard exercise at an incline angle of 0 degrees and 50% body weight, Skateboard exercise at an incline angle of 5 degrees and 50% body weight, Skateboard exercise at an incline angle determined to be optimal in phase 1 (either 0 or 5 degrees) and 75% body weight
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- The University of Texas Health Science Center, Houston
Multiple Sclerosis
Project FARMS: Fall Risk Reduction in Multiple Sclerosis
Over half of persons with multiple sclerosis (MS) report falling over a 6-month period and a majority of those who fall require medical attention for injuries.
- Trial name
- FARMS-1 (NCT01837017)
- Testing
- Home-based Exercise
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Illinois at Urbana-Champaign
Gait Disorders, Neurologic, Parkinson Disease
Individualization of Music-based Cueing During Gait in Parkinson's Disease.
Spatio-temporal correction of the step is a key component of gait rehabilitation in Parkinson's disease. Walking rehabilitation techniques using visual or auditory cueing of the cadence or step length have been tested to prevent…
- Trial name
- MUSIGAIT (NCT05585489)
- Testing
- Gait training with musical cue
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Henri Mondor University Hospital
Spinal Cord Injuries
Clinical Investigation on Feasibility and Usability of the ABLE Exoskeleton Device for Individuals With Spinal Cord Injury to Perform Skills for Home and Community Environments
The loss of the ability to walk and the associated restriction of mobility presents a major challenge to people with spinal cord injury in an everyday environment designed for pedestrians.
- Trial name
- NCT05643313
- Testing
- ABLE Exoskeleton
- Where
- 2 sites in Germany, Spain
- Volunteers
- 10 people
- Sponsor
- ABLE Human Motion S.L.
Parkinson Disease
Adaptive Deep Brain Stimulation for Freezing of Gait in Parkinson's Disease
The goal of this clinical trial is to learn if adaptive deep brain stimulation (DBS) can decrease or prevent freezing of gait in participants with Parkinson's disease.
- Trial name
- NCT06819020
- Testing
- Percept RC
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Doris Wang, MD, PhD
Parkinson Disease, Freezing of Gait Symptoms in Parkinson Disease
Pedunculopontine Nucleus Transcranial Ultrasound Stimulation as a Treatment of Freezing of Gait in Parkinson's Disease
This study is investigating the use of transcranial ultrasound stimulation (TUS) on the Pedunculopontine nucleus (PPN) in changing freezing of gait in people with Parkinson's disease.
- Trial name
- NCT07695233
- Testing
- Excitatory Stimulation, Inhibitory Stimulation
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Robert Chen
Parkinson's Disease
Effect of Deep Brain Stimulation on Gait of Patients With Parkinson's Disease Depending on Electrode Location in Subthalamic Area
Deep brain stimulation of STN (subthalamic nucleus) at high frequencies generally improved gait in parkinsonian patients. However, sometimes the investigators observed a gait aggravation either with using high voltage and high…
- Trial name
- NCT01782638
- Testing
- deep brain stimulation
- Where
- France
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Parkinson's Disease, Postural Instability
Anterior Foot Wedge With Neuromuscular Training for Balance in Parkinson's Disease
This study will test whether combining an anterior foot wedge with neuromuscular training can improve balance, gait, and muscle activity in people with Parkinson's disease.
- Conditions
- Parkinson's Disease, Postural Instability, Gait Disorder
- Trial name
- AFW-NT (NCT07334847)
- Testing
- Anterior foot wedge, Neuromuscular training
- Volunteers
- 30 people
- Sponsor
- MTI University
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