Clinical trials: Neurologic Gait Disorder
Parkinson Disease
Optimizing Vibrational Therapy to Improve Gait and Balance in Parkinson's Disease
The purpose of this research study is to test the safety, tolerability, and the effect of vibration (delivered by an experimental device called PDVibe2) on freezing of gait (FOG) in persons with Parkinson's disease (PD).
- Trial name
- NCT03883217
- Testing
- Vibration Session, No vibration session
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Virginia Commonwealth University
Cerebral Palsy
Relationships Between OLST, GMFM and Pedobarographic Values in CP
The primary aim of this study was to investigate the relationship between the One Leg-Standing Test (OLST) and the Gross Motor Function Measurement (GMFM) and stance phase stability during gait in Unilateral Cerebral Palsy (UCP).
- Trial name
- NCT04273204
- Testing
- one leg standing test, gross motor function measurement, pedobarographic measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Istanbul Kültür University
Multiple Sclerosis, Multiple Sclerosis, Secondary Progressive
Development of Camera Based Gait Quality Measure for Persons With Multiple Sclerosis
The purpose of this study is to develop a measurement of walking quality, called Gait Deviation Index (GDI) for people with Multiple Sclerosis (MS).
- Conditions
- Multiple Sclerosis, Multiple Sclerosis, Secondary Progressive, Multiple Sclerosis Relapse, Multiple Sclerosis, Relapsing-Remitting
- Trial name
- MS-GDI (NCT06516458)
- Testing
- Camera Based Kinematic Analysis
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Shirley Ryan AbilityLab
PARKINSON DISEASE (Disorder)
Effectiveness of a Home-Based Exercise Program Supported by Self-Management Education in People With Parkinson Disease
This randomized, assessor-blinded clinical trial evaluates whether a structured self-management education and home exercise program improves balance, walking capacity, fall-related concerns, upper-extremity dexterity, and quality…
- Trial name
- NCT07817862
- Testing
- Self-Management Education and Home Exercise Program, Parkinson Disease Educational Booklet
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Istanbul University
Parkinson Disease
Intensive Running Exercise Improves Parkinson's Motor and Non-motor Symptoms
High quality clinical trial and meta-analysis have demonstrated short term, and to a lesser extent, long term benefits in various outcome measures.
- Trial name
- NCT03974529
- Testing
- Intensive running, Physiotherapy
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Chinese University of Hong Kong
Spinal Muscular Atrophy Type 3, Duchenne Muscular Dystrophy (DMD)
Establishing Walking-related Digital Biomarkers in Rare Childhood Onset Progressive Neuromuscular Disorders
The purpose of this research is (1) to identify disease specific walking-related digital biomarkers of disease severity, and (2) monitor longitudinal changes in natural environments, for extended periods of time, in DMD and SMA.
- Trial name
- NCT06839469
- Where
- 3 sites in United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Columbia University
Neurodegenerative Diseases, Parkinson Disease
Neurodegenerative Diseases Progression Markers (MARKERS-NDD)
MARKERS-NDD is a prospective, observational, longitudinal study, which aims to collect data from patients affected by neurodegenerative diseases (NDD) followed longitudinally for routine examinations performed as part of normal…
- Conditions
- Neurodegenerative Diseases, Parkinson Disease, Synucleinopathies, Lewy Body Disease
- Trial name
- MARKERS-NDD (NCT06596746)
- Testing
- Observation
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- Casa di Cura San Raffaele Cassino
Tuberous Sclerosis, STXBP1 Encephalopathy With Epilepsy
Gait in Rare Diseases
The aim of this pilot study is to explore whether the knowledge and experience gained during the T-GaiD project (Treatment of Gait Disorders in Dravet Syndrome - NCT03857451) can be transferred to other populations with similar…
- Trial name
- GAGA (NCT05161494)
- Where
- Belgium
- Volunteers
- 41 people
- Sponsor
- Universiteit Antwerpen
CVA, Gait, Hemiplegic
Robotic Exoskeleton Assisted Gait Post Stroke
The current investigation takes advantage of both a progressive and adaptive assist-as-needed massed practice and time-sensitive neuroplasticity through exoskeleton assisted walking in order to induce greater recovery-oriented…
- Trial name
- RE-Assist (NCT04309305)
- Testing
- EksoGT™, Ekso Bionics, Berkley, CA, USA, Standard of Care, No Intervention
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Fall Injury, Walking, Difficulty
Attentional Focus Instructions and Conscious Movement Processing in Older Adults
This study aims to provide a novel scientific contribution through addressing critical knowledge gaps, examining the effects of attentional focus instructions on real-time (state) conscious movement processing propensity, gait…
- Conditions
- Fall Injury, Walking, Difficulty, Gait, Unsteady
- Trial name
- NCT05411536
- Testing
- Walking trials
- Where
- China
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Stroke Patients
Virtual Reality-Based Rehabilitation After Stroke: A Randomized Controlled Trial
To determine the added value of integrating virtual reality therapy (VRT) based balance training into conventional therapy (CT) for improving balance and gait in subacute stroke patients, and to evaluate the usability and patient…
- Trial name
- NCT07409116
- Testing
- Standard Conventional Rehabilitation, Virtual Reality Rehabilitation Program
- Where
- Belgium
- Volunteers
- 34 people
- Sponsor
- Erasme University Hospital
Ataxia, Cerebellar, Ataxia - Genetic Diagnosis - Unknown
Efficacy of tDCS in Degenerative Ataxia
Degenerative cerebellar ataxias are a group of rare diseases that cause gradual damage to the cerebellum, the part of the brain that controls balance and coordination.
- Conditions
- Ataxia, Cerebellar, Ataxia - Genetic Diagnosis - Unknown, Ataxia, Spinocerebellar, Ataxias, Hereditary
- Trial name
- NCT07250321
- Testing
- transcranial direct current stimulation
- Where
- Italy
- Volunteers
- 16 people
- Sponsor
- University of Cagliari
Stroke, Chronic Stroke
Analysis Acceleration/Deceleration Distance Gait Speed Tests in Stroke Survivors
Introduction: Gait speed is currently used to predict the future functional status of the patient or to evaluate the improvements produced by different neurorehabilitation treatments.
- Trial name
- Walk-test (NCT05679011)
- Testing
- 4 and 6 meters walking test
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Universitat Internacional de Catalunya
Parkinson Disease
Smart Home-based Technology to Promote Functional Mobility Among Individuals With Parkinson's Disease
Many patients with Parkinson's disease suffer of gait disorder termed as "freezing of gait" (FOG). non-pharmacological approach such as applying external cues is effective in mitigating FOG events.
- Trial name
- NCT05211687
- Testing
- Smart-home for freezing of gait
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- University of Haifa
Multiple Sclerosis, Foot Drop
Walking With FES or AFO in People With MS With Foot Drop
This investigation consists of two parallel groups of participants who will follow the same protocol. The aim of the study is to investigate the effects of using Functional Electrical Stimulation/Ankle Foot Orthosis (AFO) or…
- Trial name
- NCT01977287
- Testing
- Functional Electrical Stimulation, Ankle Foot Orthosis
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- Queen Margaret University
Stroke, Hemiplegia
Asymmetrical Gait Training After Pediatric Stroke
The purposes of this pilot research study are 1. To begin to test if two different types of physical therapy might have different results in children and adolescents who have had a prior stroke, and 2.
- Trial name
- NCT01827436
- Testing
- Conventional physical therapy, Asymmetrical gait training
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Children's Hospital of Philadelphia
Lower Limb Spasticity
Trial to Test the Effectiveness of Vibrotactile Stimulation for Lower Limb Spasticity
The goal of this clinical trial is to find out if Vibrotactile Stimulation (VTS) can help improve mobility and reduce spasticity (muscle stiffness) in people with lower limb spasticity.
- Trial name
- NCT07447934
- Testing
- Vibrotactile Stimulation (Static Use), Vibrotactile Stimulation (Dynamic Use), Vibrotactile Stimulation (Neurophysiological Mechanism)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Weill Medical College of Cornell University
Stroke
Development and Evaluation of a Novel Portable Robotic Gait Rehabilitation in Chronic Stroke
The aims of this study is to test the training effects of the robotic walker. This study will compare the effectiveness of 2 different types of gait training protocols in chronic stroke patients, 1) conventional gait training…
- Trial name
- NCT03444688
- Testing
- Conventional Gait Training, Gait rehabilitation with walker
- Where
- Singapore
- Volunteers
- 100 people
- Sponsor
- National University Hospital, Singapore
Parkinson's Disease
Effect of Lower Extremity Ankle Foot Orthoses in Parkinson's Disease
The purpose of this study is to investigate the impact of a specifically designed ankle foot orthosis (AFO, hinged, with Tamarack joint and adjustable check strap) on the spatial and temporal gait parameters, electromyography…
- Trial name
- NCT01798927
- Testing
- Ankle foot orthosis
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Texas Southwestern Medical Center
Spinal Cord Injuries (SCI)
RTsMS and Body Weight-support Treadmill Training After Incomplete Spinal Cord Injury
The aim of this study is to assess the feasibility of combining rTsMS with BWSTT for gait and sensorimotor recovery in individuals with incomplete spinal cord injury.
- Trial name
- NCT06886308
- Testing
- Repetitive trans-spinal magnetic stimulation
- Where
- Brazil
- Volunteers
- 6 people
- Sponsor
- Universidade Federal de Pernambuco
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