Clinical trials: Neurologic Signs
Sickle Cell Disease, Pain
Nitric Oxide and Sickle Cell Pain
Background: Sickle cell disease often causes crises, with episodes of pain. Many people with sickle cell disease also have pain between crises. Inflammation is an important part of sickle cell pain.
- Trial name
- NCT01393847
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- National Institute of Nursing Research (NINR)
Movement Disorders, Parkinson Disease
Abbott DBS Post-Market Study of Outcomes for Indications Over Time
The purpose of this international study is to evaluate long-term safety and effectiveness of Abbott deep brain stimulation (DBS) systems for all indications, including Parkinson's disease, essential tremor or other disabling…
- Conditions
- Movement Disorders, Parkinson Disease, Essential Tremor, Tremor
- Trial name
- ADROIT (NCT04071847)
- Testing
- Deep Brain Stimulation (DBS)
- Where
- 48 sites in United States, Australia and 7 more
- Volunteers
- 1,000 people
- Sponsor
- Abbott Medical Devices
Sleep, Alzheimer Disease
Sleep Trial to Prevent Alzheimer's Disease
The purpose of this study is to determine if treatment with the sleep aid suvorexant can decrease the rate of amyloid-β (Aβ) accumulation in the brain.
- Trial name
- SToP-AD (NCT04629547)
- Testing
- Suvorexant 20 mg
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Herpes Zoster Pain, Neuralgia, Postherpetic
High-Voltage Long-Duration Pulsed Radiofrequency Combined With Liposomal Bupivacaine Subcutaneous Block for Herpes Zoster-Associated Neuralgia
Research Objectives Background and Significance: Zoster-associated neuralgia (ZAN) refers to neuropathic pain experienced by herpes zoster (HZ) patients before, during, and after rash resolution, characterized by paroxysmal…
- Trial name
- NCT06959147
- Testing
- High-Voltage Long-Duration Pulsed Radiofrequency plus Liposomal Bupivacaine group, High-Voltage Long-Duration Pulsed Radiofrequency
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Shirong Tan
Emergence Delirium, Anesthesia
Turkish Version of The Pediatric Anesthesia Emergency Delirium
Emergence delirium (ED) is a mental disorder seen in children during recovery from general anesthesia. The Pediatric Anesthesia Emergence Delirium (PAED) scale is the only valid scale to assess ED in pediatric patients undergoing…
- Trial name
- PAED (NCT06931249)
- Testing
- The observational study
- Where
- Turkey (Türkiye)
- Volunteers
- 385 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Injuries, Spinal Cord, CVA (Cerebrovascular Accident)
Transitioning to a Valve-Gated Intrathecal Drug Delivery System (IDDS)
Comparing the efficacy of Intracthecal Baclofen dose between the Prometra II and Medtronic SynchroMed II for patients with spasticity and with current a current SyncroMed II pump needing replacement.
- Conditions
- Injuries, Spinal Cord, CVA (Cerebrovascular Accident), Traumatic Brain Injury, MS (Multiple Sclerosis)
- Trial name
- NCT04530955
- Testing
- Prometra II Programmable Pump - Flowonix Medical
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Culicchia Neurological Clinic
Gastroparesis
Clinical Management With SPM System and Validation of the SPM 5 Hour Cutoff in Patients With Symptoms of Gastroparesis
This protocol is designed to validate use of the SPM for diagnosis of delayed gastric emptying in patients with symptoms of gastroparesis and assess impact of a SmartPill study on patient management in the gastroparetic…
- Trial name
- NCT02022826
- Testing
- SmartPill Monitoring System
- Where
- 11 sites in United States
- Volunteers
- 167 people
- Sponsor
- Medtronic - MITG
Myasthenia Gravis (MG), Myasthenia Gravis, Generalized
AXIS MG Patient Registry
The goal of the AXIS Autoimmune Neurology Registry is to learn about the experiences of adults living with autoimmune neurological disorders, starting with myasthenia gravis (MG), over time.
- Conditions
- Myasthenia Gravis (MG), Myasthenia Gravis, Generalized, Myasthenia Gravis, Ocular, Myasthenia Gravis Crisis
- Trial name
- AXIS (NCT07761026)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Autoimmune Neurology Alliance
SCA38
Docosahexaenoic Acid (DHA) Replacement for Treatment in Spinocerebellar Ataxia 38
The project will study a therapeutic approach in Spinocerebellar Ataxia (SCA38) by DHA replacement. SCA38 is caused by missense mutations in the ELOVL5 (Elongation of very long chain fatty acids protein 5) gene.
- Trial name
- SCA38DHA (NCT03109626)
- Testing
- DHA
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Barbara Borroni
PARKINSON DISEASE (Disorder), Parkinson Disease (PD)
Cognitive-Based Balance Rehabilitation in Parkinson's Disease: Virtual Reality vs. Dual Task
This prospective, randomized, single-blind, controlled clinical trial aims to evaluate and compare the efficacy of cognitive-based balance rehabilitation delivered via immersive Virtual Reality (VR) versus traditional Dual-Task…
- Conditions
- PARKINSON DISEASE (Disorder), Parkinson Disease (PD), Parkinson s Disease, Postural Instability
- Trial name
- NCT07660978
- Testing
- Dual Task Training (DTT), Virtual Reality Training (VRT)
- Volunteers
- 34 people
- Sponsor
- Bezmialem Vakif University
Anxiety, Pain
Effect of the 4-7-8 Breathing Technique Before Central Venous Catheter Insertion
Purpose: This study aims to evaluate the effect of the 4-7-8 breathing technique applied before central venous catheter (CVC) insertion on patients' anxiety, pain, and vital signs.
- Conditions
- Anxiety, Pain, Vital Sign Evaluation, 4-7-8 Breathing Technique
- Trial name
- NCT07917585
- Testing
- 4-7-8 breathing technique
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mersin University
Akathisia
Akathisia in Post Operative Outpatients Surgery
The main objective of this study is to evaluate the incidence of akathisia with Droperidol, the prophylactic treatment of post operative nausea and vomiting, used at two different doses, versus control group (Ondansetron), in…
- Trial name
- NCT01942343
- Testing
- Droperidol 1,25 mg administration, Droperidol 0,625 mg administration, Odansetron 4 mg administration
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Strasbourg, France
Metatarsalgia
Physiotherapy for Chronic Metatarsalgia
The pilot study was conducted in the form of an open prospective single-arm observational study with 28 patients who received physiotherapy at the Spiraldynamik® Med Center in Zurich.
- Trial name
- NCT02578615
- Testing
- physiotherapy
- Volunteers
- 28 people
- Sponsor
- Spiraldynamik AG
Anterior Ischemic Optic Neuropathy
PDE5 Inhibitor Use and Non-arteritic Anterior Ischemic Optic Neuropathy (NAION)
The primary objective of this study is to determine whether the use of PDE5 inhibitors (vardenafil, sildenafil, or tadalafil) increases the risk for the development of NAION.
- Trial name
- NCT00867815
- Testing
- Diagnostic procedures
- Where
- 13 sites in United States, Australia and 1 more
- Volunteers
- 10 people
- Sponsor
- Bayer
Chronic Pain, Hemiplegic Shoulder Pain
StimRouter™ for Pain Management in Post-stroke Shoulder Pain
StimRouter Neuromodulation System includes an implanted lead which provides peripheral nerve stimulation for chronic pain. Post-stroke shoulder pain patients will be the focus of this study.
- Trial name
- PSSP (NCT03093935)
- Testing
- StimRouter Neuromodulation System
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Bioness Inc
Chronic Pain, Musculoskeletal Pain
Pain Neuroscience Education and Physical Exercise Program in Chronic Back Pain
This study evaluates the effects of a pain neuroscience education (PNE) and physical exercise (PE) program in patients with chronic back pain.
- Conditions
- Chronic Pain, Musculoskeletal Pain, Back Pain
- Trial name
- NCT03654235
- Testing
- Health Education, Physical exercise, Usual care in Primary Care Physiotherapy Units
- Where
- Spain
- Volunteers
- 170 people
- Sponsor
- Fundacion para la Investigacion y Formacion en Ciencias de la Salud
Neurodegenerative Diseases, Parkinson Disease
Saliva and Extracellular Vesicles for Neurodegenerative Diseases
Early diagnosis of Neurodegenerative diseases (NDDs) and accurate patient profiling are key goals needed to tailor prompt personalized therapeutic strategies that can significantly impact disease progression and patients' quality…
- Conditions
- Neurodegenerative Diseases, Parkinson Disease, Alzheimer Disease, Parkinsonism
- Trial name
- MINERVA (NCT06869135)
- Testing
- Saliva collection, longitudinal
- Where
- 5 sites in Italy
- Volunteers
- 242 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Intraventricular Neoplasm
Observational Pilot Study With TachoSil as a Ventricular Sealant
The working hypothesis in this study is that after entering the cerebral ventricular system the sealing with TachoSil is effective and safe.
- Trial name
- NCT05717335
- Testing
- TachoSil
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Germans Trias i Pujol Hospital
Postoperative Pain
ESP Block vs. Traditional Pain Management for ERAS
Patients undergoing thoracotomy, thoracoscopy or other surgical procedures involving the integrity of the chest wall are always in a special point of interest of both surgical and anesthesiological specialities.
- Trial name
- NCT04299035
- Testing
- Erector spinae plane block
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Soroka University Medical Center
Bruxism, Manual Theapy
Effects of Manual Therapy and Home Exercise in Bruxism
Objectives: This trial aimed to examine the effects of manual therapy and home exercise treatments on pain, sleep quality, stress level and quality of life in patients with bruxism.
- Conditions
- Bruxism, Manual Theapy, Exercise, Orofacial Pain
- Trial name
- NCT06610435
- Testing
- Manual Therapy, Home Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Ankara University
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