Clinical trials: Neurological; Disorder, Nervous System
Delirium, Intensive Care Unit Delirium
PREdiction of DELIRium in Medical ICU Patients
In intensive care unit (ICU) patients, the ability to predict delirium may help reduce its incidence, duration, and severity. The PREdiction of DELIRium in ICU (PRE-DELIRIC) model was recently developed for this purpose.
- Trial name
- NCT04218461
- Testing
- PRE-DELIRIC model
- Where
- Turkey (Türkiye)
- Volunteers
- 172 people
- Sponsor
- Istanbul Demiroglu Bilim University
Myopathy
SAPhIRE Statin Adverse Drug Reaction
To find out the pharmacokinetic and genetic risk factors involved in muscular side effects (myalgia) associated with statin therapy.
- Trial name
- STATIN (NCT03042286)
- Where
- Singapore
- Volunteers
- 1,500 people
- Sponsor
- National Heart Centre Singapore
Stroke, Hemiparesis
Vibrotactile Feedback to Improve Walking After Stroke
Stroke survivors often walk more slowly and may have difficulty producing the movements needed to walk efficiently. This study will evaluate whether vibrotactile feedback, delivered through small wearable devices that provide…
- Trial name
- NCT07831642
- Testing
- Vibrotactile Feedback System
- Volunteers
- 32 people
- Sponsor
- Geisinger Clinic
Pain, Analgesia
Non-Pharmacologic Interventions to Relief Pain in Healthy Newborns Submitted to Vaccination to Hepatitis B
Acute procedural pain in neonates may be alleviated by non-pharmacological procedures. This study objective is to test the efficacy regarding pain attenuation of 3 interventions (skin-to-skin contact versus glucose 25% versus…
- Trial name
- NCT00713986
- Testing
- Water 2mL PO 2 minutes prior to intra-muscular injection, skin-to-skin contact, Glucose 25% 2 mL PO 2 minutes prior to injection
- Volunteers
- 640 people
- Sponsor
- Federal University of São Paulo
Laparoscopic Cholecystectomy
ERAS (Enhanced Recovery After Surgery) and Multimodal Analgesia in Laparoscopic Cholecystectomy
This clinical study aims to evaluate the effects of multimodal analgesia management administered within an ERAS (Enhanced Recovery After Surgery) protocol on postoperative pain, length of hospital stay, early complications, and…
- Trial name
- ERAS (NCT06885086)
- Testing
- Control group - 1, Observation group -2
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Hearing Loss
Lyric4 Outcomes Evaluation
The goal of this clinical investigation is to obtain feedback on Lyric4 device updates within a cohort of experienced adult Lyric hearing instrument users.
- Trial name
- NCT06169683
- Testing
- Lyric4
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- Sonova AG
Cognitive Symptoms
Chemotherapy-Induced Cognitive Impairment
The investigators overall research hypothesis is that systemic chemotherapy induces structural changes in the white matter of the brain as demonstrated with Diffusion Tensor Imaging (DTI) and functional changes in well-defined…
- Trial name
- CICI (NCT01578083)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Jay F. Piccirillo, MD
Breast Cancer Early Stage Breast Cancer (Stage 1-3), Breast Neoplasm Malignant Female
Supervised Exercise During Neoadjuvant Chemotherapy for Breast Cancer
The goal of this clinical trial is to learn whether supervised exercise is practical and safe for women receiving chemotherapy before surgery for breast cancer.
- Trial name
- NCT07764341
- Testing
- Supervised exercise
- Where
- Bahrain
- Volunteers
- 80 people
- Sponsor
- King Hamad University Hospital, Bahrain
Sleep Initiation and Maintenance Disorder; Elderly, Mental Disorder
A Long-Term Safety Study of Org 50081 (Esmirtazapine) in Elderly Outpatients With Chronic Primary Insomnia (176005/P05697/MK-8265-001)
The current study is a 52-week safety study in elderly outpatients with chronic primary insomnia randomized to treatment with 1.5 mg or 3.0 mg of esmirtazapine (Org 50081, SCH 900265, MK-8265) to investigate the safety and…
- Conditions
- Sleep Initiation and Maintenance Disorder; Elderly, Mental Disorder, Dyssomnias, Sleep Disorders
- Trial name
- Jade (NCT00561574)
- Testing
- Esmirtazapine
- Volunteers
- 259 people
- Sponsor
- Merck Sharp & Dohme LLC
Covid19, Muscle Loss
The Impact of Covid-19 on Skeletal Muscle
With the recent worldwide outbreak of the COVID-19 infection and the huge impact it has had upon lives in the UK, it is key to increase knowledge on the impact of the virus on the body.
- Conditions
- Covid19, Muscle Loss, Mitochondrial Alteration
- Trial name
- NCT04756674
- Testing
- No intervetion will be used
- Where
- United Kingdom
- Sponsor
- University of Nottingham
Epilepsy, Functional Neurological Disorder
EXercise-induced PhysioLogical Adaptations In Neurological Disorders
The goal of this study is to investigate how a one-time exercise session influences different parameters of brain function in people with neurological diseases compared to healthy volunteers.
- Conditions
- Epilepsy, Functional Neurological Disorder, Mild Cognitive Impairment, Dementia
- Trial name
- EXPLAIN (NCT07883720)
- Testing
- Acute Exercise
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Temporomandibular Joint Disorders
Low Level Laser Therapy in the Treatment of Temporomandibular Joint Disorders (TMJDs) Related Pain
The Low Level Laser Therapy (LLLT) has been recently introduced with success in the management of the pain associated to this condition.
- Trial name
- NCT03119324
- Testing
- B-Cure® diode laser, Nimesulide Ratiopharm® and Flexiban®
- Volunteers
- 90 people
- Sponsor
- University of Roma La Sapienza
Delirium
Early Diagnosis and Treatment Standardization of Delirium
1. Observe the characteristics of delirium patients, searching for early diagnostic methods or finding risk factors 2. Design a guideline for delirium, diagnosis or treatment
- Trial name
- NCT03199859
- Where
- South Korea
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Pain, Postoperative
Transversus Abdominis Plane Block in Iliac Crest harvest-is it Beneficial?
The purpose of this study is to determine whether a supplemental Transversus Abdominis Plane block administered intraoperatively improves the postoperative parameters in patients undergoing Alveolar bone grafting with iliac crest…
- Trial name
- NCT02997124
- Testing
- local infiltration and TAP block, local infiltration only
- Volunteers
- 143 people
- Sponsor
- Jubilee Mission Medical College and Research Institute
Tetraplegia, Guillain-Barre Syndrome
Brain Computer Interface for Communication in ICU: a Feasibility Study
The main objective of this study is to evaluate the usability of a system to assist verbal communication based on BCI system using the P300 wave in patients with tetraplegia who can no longer communicate because of severe engine…
- Trial name
- RoBIK-1 (NCT01005524)
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Versailles
Neonatal Seizures
Levetiracetam Treatment of Neonatal Seizures: Safety and Efficacy Phase II Study
LEVNEONAT is a multicentre French clinical trials with the aim to develop new treatment strategies for the treatment of neonatal seizures using Levetiracetam.
- Trial name
- LEVNEONAT-1 (NCT02229123)
- Testing
- Intravenous Levetiracetam
- Where
- 8 sites in France
- Volunteers
- 18 people
- Sponsor
- University Hospital, Tours
Insomnia, Aging
Efficacy of CBT-I With Adjuvant Melatonin in Older Adults Chronic Insomnia
This study tests the efficacy of cognitive behavioural therapy for insomnia (CBT-I) with or without adjunct melatonin in older adults with insomnia.
- Conditions
- Insomnia, Aging, Sleep Disorders
- Trial name
- SOAM (NCT07695246)
- Testing
- Cognitive behavioural therapy for insomnia, Melatonin 3 mg immediate-release, Psychoeducation
- Where
- Hong Kong
- Volunteers
- 183 people
- Sponsor
- The University of Hong Kong
Cancer-related Problem/Condition, Neurotoxicity
Electrical Stimulation Pain Therapy in Treating Chronic Pain and Numbness Caused By Chemotherapy in Patients With Cancer
RATIONALE: Electrical stimulation pain therapy may help relieve chronic pain and numbness caused by chemotherapy. PURPOSE: This pilot trial studies electrical stimulation pain therapy in treating chronic pain and numbness caused…
- Conditions
- Cancer-related Problem/Condition, Neurotoxicity, Pain, Peripheral Neuropathy
- Trial name
- NCT01196442
- Testing
- electrical stimulation pain therapy, questionnaire administration
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Virginia Commonwealth University
Lumbar Disc Herniation, Lumbar Radiculopathy
Selective Nerve Root Block Versus Sham to Reduce Surgery for Lumbar Disc Herniation
The SELDISC trial will investigate whether a selective nerve root block can reduce the need for surgery in adults with a herniated disc in the lower back.
- Conditions
- Lumbar Disc Herniation, Lumbar Radiculopathy, Lumbar Disc Herniation With Radiculopathy
- Trial name
- SELDISC (NCT07895589)
- Testing
- Selective Nerve Root Block
- Where
- 2 sites in Sweden
- Volunteers
- 262 people
- Sponsor
- Karolinska Institutet
ATRIAL FIBRILLATION, Syncope
BioMonitor Master Study
The BioMonitor is an implantable cardiac monitor used to automatically detect and record episodes of arrhythmia in patients with bradycardia, tachycardia, asystole and atrial fibrillation.
- Trial name
- BioMonitor (NCT01725568)
- Testing
- BioMonitor
- Where
- Germany
- Volunteers
- 152 people
- Sponsor
- Biotronik SE & Co. KG
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