Clinical trials: Neurological Complications
Postoperative Pain
Effect of Manual Glide Path Establishment on Endodontic Postoperative Pain
All patients will be treated in a single session approach regardless of the group. All molars will be anesthetized either through infiltration in case of maxillary molars or inferior alveolar nerve block in case of mandibular…
- Trial name
- NCT05206214
- Testing
- Manual glide path, Mechanical glide path
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pain, Postoperative, Orthognathic Surgery
Personalization of Opioid Prescription Following Orthognathic Surgery
This study aims to investigate pain management and satisfaction following orthognathic surgery, which is a type of surgery that corrects jaw and facial bone issues.
- Conditions
- Pain, Postoperative, Orthognathic Surgery, Opioid Use, Patient Satisfaction
- Trial name
- NCT05708521
- Testing
- Personalization of dose and frequency and instituting a tapering protocol of hydromorphone post-orthognathic surgery, Standardized dose and frequency of hydromorphone with no tapering post-orthognathic surgery
- Where
- Canada
- Volunteers
- 201 people
- Sponsor
- Nova Scotia Health Authority
Surgical Blood Loss, Postoperative Pain
PVI vs ESP Block for Reducing Bleeding and Postoperative Pain in Lumbar Fusion Surgery.
This randomized controlled trial compares periarticular vasoconstrictor infiltration (PVI) versus erector spinae plane block (ESP) to reduce bleeding and postoperative pain in adults undergoing lumbar fusion surgery (up to 3…
- Conditions
- Surgical Blood Loss, Postoperative Pain, Lumbar Spinal Fusion Surgery
- Trial name
- NCT07550114
- Testing
- Periarticular vasoconstrictor infiltration (PVI), Erector Spinae Block (ESP)
- Where
- 2 sites in Spain
- Volunteers
- 62 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Post Operative Pain
Comparative Study Between Dexmedetomidine and Fentanyl as Adjuvants to Bupivacaine
Combined femoral and sciatic nerve block provides surgical anesthesia with better cardiorespiratory stability as compared to the spinal anesthesia blockade which has side effects of hypotension, bradycardia, meningitis, post…
- Trial name
- NCT06864416
- Testing
- dexmedetomidine as adjuvant to bupivacaine, Fentanyl as adjuvant to bupivacaine
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Ain Shams University
Cesarean Section, Cesarean Delivery
Pain Management After Cesarean Section - A Before-and-After Cohort Study
Inadequate pain relief remains a challenge after Cesarean section (CS) and may significantly impair postoperative recovery. A recent Danish single-center study (n=100) revealed that 66% of elective CS patients experienced severe…
- Conditions
- Cesarean Section, Cesarean Delivery, Pain Management, Pain Management in Postoperative Care
- Trial name
- NCT06813638
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Nordsjaellands Hospital
Lower Extremity, Nerve Block
Bupivacaine-Lidocaine vs Bupivacaine for Ultrasound-Guided Popliteal Sciatic Nerve Block
This prospective, randomized, double-blind clinical trial aims to compare the efficacy of two local anesthetic regimens for ultrasound-guided popliteal sciatic nerve block in adult patients undergoing elective distal lower…
- Conditions
- Lower Extremity, Nerve Block, Pain, Postoperative, Pain, Nerve
- Trial name
- PSSNB-BL (NCT07550348)
- Testing
- Bupivacaine-Lidocaine Combination, Bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ataturk University
Autism Spectrum Disorder, Complication of Prematurity
Correlation of CXCR4 Expression in Premature Infants With a Diagnosis of Autism at 24 Months
Preterm children are at increased risk for autism spectrum disorders, with an estimated rate of 10%. In the US, about 1 in 8 pregnancies ends with a premature birth.
- Trial name
- ASD-CXCR4 (NCT01686685)
- Where
- Israel
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Chronic Pain, Pelvic Pain
Virtual Reality During Ultrasound Examination of Women With Endometriosis
To evaluate the effectiveness of VR as a distraction technique in the management of acute pain and anxiety during ultrasound exam in patients with endometriosis in the outpatient setting.
- Conditions
- Chronic Pain, Pelvic Pain, Endometriosis
- Trial name
- NCT04711408
- Testing
- SootheVR: AppliedVR, Los Angeles, California a head-mounted displa
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Diabetic Retinopathy, Sickle Cell Trait
Diabetic Retinopathy and Sickle Trait
To more clearly ascertain the relationship between ocular manifestations of sickle cell disease and diabetes, specifically; whether the presence of sickle cell trait exacerbates the disease progression of diabetic retinopathy.
- Trial name
- NCT00720317
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Medical University of South Carolina
Postoperative Pain
The Prevention of Postoperative Epidural Catheter Migration: a Comparison of Three Types of Dressing
Three types of dressing will be compared to prevent postoperative epidural catheter migration. Patients will be randomised to have a Tegaderm dressing, an Epi-fix dressing or a Lockit-Plus dressing to secure the epidural catheter…
- Trial name
- NCT00764283
- Testing
- Tegaderm dressing, Epi-Fix dressing, Lockit-Plus
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- University Ghent
Spinal Cord Injuries (SCI), Neurogenic Lower Urinary Tract Dysfunction
Radio-frequency (RF) Bladder Monitor
The goal of this pilot feasibility study is to evaluate a wearable microwave (MW)-based bladder monitoring system in adult volunteers and those with spinal cord injury (SCI) who use self-catheterization for bladder management.
- Conditions
- Spinal Cord Injuries (SCI), Neurogenic Lower Urinary Tract Dysfunction, Neurogenic Bladder (NB)
- Trial name
- NCT07639541
- Testing
- Wearable microwave Bladder Monitoring System
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Endometriosis, Pelvic Pain
Cannabidiol for the Treatment of Pelvic Pain in Endometriosis (DREAMLAND)
The objective of this work is to conduct a randomized, double-blind, placebo-controlled clinical trial to assess the efficacy and safety of cannabis extract in women with endometriosis who have already undergone hormonal…
- Trial name
- DREAMLAND (NCT05670353)
- Testing
- Cannabis Derivatives, Hormonal Contraceptive Agents
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Sao Paulo
Postoperative Pain
Combination of Duloxetine and Pregabalin to Improve Postoperative Pain
Postoperative pain is mediated by different mechanisms at multiple neural sites. Thus, multimodal analgesics can reduce the postoperative pain.
- Trial name
- NCT04862845
- Testing
- Duloxetine and Pregabalin, pregabalin
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Cairo University
Diabetes Mellitus, Type 2, Polyneuropathy Diabetes
24-hour Blood Pressure Dynamics and Autonomic Adrenergic Regulation in Type 2 Diabetics
Autonomic neuropathy is a common complication of type 2 diabetes mellitus. Symptoms from cardiovascular autonomic neuropathy include, dizziness, orthostatic hypotension and insufficient heart rate and blood pressure (BP)…
- Conditions
- Diabetes Mellitus, Type 2, Polyneuropathy Diabetes, Autonomic Neuropathy, Diabetic Neuropathies
- Trial name
- NCT04208295
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Agitation, Emergence
Efficacy of Dexmedetomidine vs Midazolam for Early Extubation in Critically Ill Agitated Patients Undergoing Weaning
Comparison of effect of dexmedetomidine and midazolam in icu patients who put on mechanical ventilation and show agitation on weaning.Selection of better agent minimises the drug related side effects like respiratory depression…
- Trial name
- NCT05264077
- Testing
- Dexmedetomidine Hydrochloride
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Sheikh Zayed Medical College
Constipation, Pain, Postoperative
Opioid Induced Bowel Dysfunction in Patients Undergoing Cesarean Section
Constipation is common in pregnant women. Surgery, anaesthesia and opioid analgesics may further impair bowel function. The aim of the present study was to evaluate if oxycodone-naloxone combination compared to oxycodone reduced…
- Trial name
- oksisektio (NCT02571881)
- Testing
- Caesarean section, Oxycodone, oxycodone-naloxone
- Where
- Finland
- Volunteers
- 57 people
- Sponsor
- Kuopio University Hospital
Inguinal Hernia
The Effect of Systemic Lidocaine Infusion to Postoperative Pain and Quality of Recovery After Laparoscopic Hernia Repair in Children
Systemic lidocaine administration may improve postoperative pain and recovery after laparoscopic inguinal hernia repair in pediatric patients
- Trial name
- NCT02007330
- Testing
- Systemic intravenous lidocaine infusion, Normal saline infusion
- Where
- South Korea
- Volunteers
- 66 people
- Sponsor
- Yonsei University
Post Operative Trauma, Acute Pain
The Use of Ultrasound to Measure Depth of Thoracic Epidural Space
The purpose of the study is to evaluate the use of ultrasound scanning of the thoracic spine to define the point of insertion and the depth of the epidural space compared to the blind technique.
- Trial name
- NCT01172730
- Testing
- Ultrasound scanning
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Massachusetts, Worcester
Coronary Artery Bypass, Anesthesia, Conduction
Effect of Transversus Thoracic Muscle Plane Block (TTMP) on Analgesia
In this prospective and controlled study, the investigators investigated the effect of transversus thoracic muscle plane block (TTMP) on analgesia in patients who undergo coronary artery bypass graft (CABG) surgery with median…
- Conditions
- Coronary Artery Bypass, Anesthesia, Conduction, Nerve Block, Pain, Postoperative
- Trial name
- NCT06601530
- Testing
- Transversus Thoracic Muscle Plane Block, Tramadol
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Istanbul University - Cerrahpasa
Analgesia, Postoperative Pain, Acute
Effects of Pericapsular Nerve Group Block on Postoperative Recovery for Total Hip Arthroplasty
The hypothesis of this study is that patients who undergo PENG block in before Total Hip Artroplasthy (THA) surgery with spinal anesthesia will have reduced postoperative pain scores, less need for opioid analgesics and earlier…
- Trial name
- NCT06183528
- Testing
- Pericapsular Nerve Group (PENG) Block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Umraniye Education and Research Hospital