Clinical trials: Neurological Complications
Postoperative Pain, Video-Assisted Thoracoscopic Surgery
US-Guided ESPB Versus TPVB on Acute and Chronic Pain After VATS
Postoperative acute and chronic pain is frequently observed in patients undergoing video assisted thoracoscopic surgery (VATS). This prolongs the discharge time of patients and increases the frequency of postoperative pulmonary…
- Conditions
- Postoperative Pain, Video-Assisted Thoracoscopic Surgery, Thoracic Paravertebral Block, Erector Spinae Plane Block
- Trial name
- NCT04964401
- Testing
- Thoracic paravertebral block vs Erector spinae plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Atatürk Chest Diseases and Chest Surgery Training and Research Hospital
Nervous System, Diabetic Kidney Disease
Mechanisms of Diabetic Kidney Disease in American Indians
Background: An ongoing study is looking at American Indians who have kidney problems caused by type 2 diabetes. Kidney disease due to type 2 diabetes is a major problem in American Indians.
- Conditions
- Nervous System, Diabetic Kidney Disease, Diabetes Mellitus, Type 2
- Trial name
- NCT01878045
- Where
- United States
- Volunteers
- 141 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Analgesia, Pain Management
Ultrasound-Guided Recto-Intercostal Fascial Plane Block in Laparoscopic Cholecystectomy
The aim of the study is to reduce postoperative pain by performing rectointercostal block in L/S cholecystectomy surgeries. Main goal is to provide well managed post-operative analgesia.
- Conditions
- Analgesia, Pain Management, Pain, Acute Post-Operative
- Trial name
- NCT07745972
- Testing
- Rectointercostal facial plane block using bupivacaine 0.25%
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istinye University
Pain, Postoperative
Prediction of Pain in Total Hip Arthroplasty
In this consecutive, prospective cohort study the investigators evaluate if preoperative pain response upon heat stimulation is predictive for acute and subacute postoperative pain after total hip arthroplasty.
- Trial name
- NCT01324375
- Testing
- heat pain test (Modular Sensory Analyzer, Somedic AB, Horby, Sweden).
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Hvidovre University Hospital
Acute Pain, Postoperative Pain
Study of QL Analgesic Response and Extent
A total of 14-18 healthy volunteers will be included. There will be three different procedure days, separated by at least one week. On each visit, the subjects will receive a QL block, according to the randomization process.
- Conditions
- Acute Pain, Postoperative Pain, Regional Anesthesia Block
- Trial name
- SQUARE (NCT07566312)
- Testing
- Quadratus Lumborum with 1.5% Lidocaine
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Duke University
Postoperative Pain
Genetic Predictors of Analgesic Efficacy of Propranolol for Treating Postoperative Pain
This study is a randomized, double-blind, placebo controlled clinical trial. The main purpose of this study is to determine if postsurgical pain ratings are improved with treatment with oral Propranolol, and if the effectiveness…
- Trial name
- PRO_GENE_POP (NCT02511483)
- Testing
- Propranolol PO, IV-PCA morphine, Quantitative Sensory Testing (QST)
- Where
- 2 sites in Canada
- Volunteers
- 10 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Chronic Pain, Postsurgical Pain
Safety, Tolerability, Effectiveness, and Pharmacokinetic Data in Opioid-experienced Children
The purpose of this study was to assess the safety and pharmacokinetics (single- and multiple-dose) of oxymorphone ER for the relief of moderate to severe pain in pediatric participants ages 7 - ≤17 years old requiring a…
- Trial name
- NCT04681027
- Testing
- Oxymorphone hydrochloride (HCl)
- Where
- 5 sites in United States
- Volunteers
- 15 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Pain, Post-operative
Evaluation of N1539 Following Abdominoplasty Surgery
The primary objective of this study is to evaluate the analgesic efficacy of N1539 in subjects with acute moderate to severe pain following abdominoplasty surgery.
- Trial name
- NCT02678286
- Testing
- N1539
- Where
- 4 sites in United States
- Volunteers
- 219 people
- Sponsor
- Baudax Bio
Inguinal Hernia
A Multi-site Trial Comparing Lichtensteins Operation and Prolene Hernia System in Inguinal HErnia Repair
Patients with a primary unilateral inguinal hernia are randomized to Lichtenstein's operation or Prolene Hernia System to repair their groin hernia. Follow up for three years with a total number of 4 clinical examinations.
- Trial name
- NCT00184483
- Testing
- Lichtenstein's operation, Prolene Hernia System
- Where
- Norway
- Volunteers
- 405 people
- Sponsor
- Norwegian University of Science and Technology
Hemodialysis, Renal Failure , Chronic
Comparative Study Between Leg Massage and Vibration on Cramps and Comfort for Patients Undergoing Hemodialysis
This planned randomized controlled trial will enroll 164 patients undergoing hemodialysis to compare the effectiveness of leg massage versus vibration therapy on muscle cramps and patient comfort.
- Trial name
- NCT07777354
- Testing
- massage, vibration
- Volunteers
- 160 people
- Sponsor
- University of Baghdad
Abdominal Obesity, Postoperative Pain
Transversus Abdominis Plan Block Versus Rectus Sheath Block
The investigator aims to compare the analgesic efficacy of Transversus Abdominis Plan Block and Rectus Sheath Block which are used to prevent intraoperative and postoperative pain and reduce the use of opioid in abdominoplasty…
- Conditions
- Abdominal Obesity, Postoperative Pain, Postoperative Complications
- Trial name
- NCT06897345
- Testing
- transversus abdominis plane block, rectus sheat block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Chronic Kidney Diseases, Post Operative Pain
Methadone Pharmacokinetics in End-stage Renal Disease
The goal of this observational study is to describe the influence of renal function on the pharmacokinetics of methadone used through an intravenous patient-controlled analgesia (IV-PCA) pump for the management of acute…
- Conditions
- Chronic Kidney Diseases, Post Operative Pain, Pain, Acute
- Trial name
- MCKD (NCT06056245)
- Testing
- Preoperative step, Intraoperative, Post-operative
- Where
- Chile
- Volunteers
- 20 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Postoperative Dental Pain, Pulp Disease, Dental
Effect of Different Apical Actions on Local Inflammatory Mediators and Pain
The goal of this clinical trial is to determine patients' the inflammation and pain response to different apical actions used in rotary instrumentation during root canal shaping process.
- Conditions
- Postoperative Dental Pain, Pulp Disease, Dental, Pulpitis - Irreversible
- Trial name
- NCT06760312
- Testing
- Root canal shaping with Continuous Rotation, Root canal shaping with Apical Reverse, Root canal shaping is conducted with Apical slow-down kinematic.
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Total Knee Arthroplasty
Compression Bandage in Local Infiltration Analgesia Afte Total Knee Arthroplasty
purpose: to determine wether a compression bandage prolongs analgesia of local infiltration analgesia after total knee arthroplasty
- Trial name
- NCT00485212
- Testing
- compression bandage
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Hvidovre University Hospital
Obesity
Pain Control in Bariatric Patients: EXPAREL(R) vs. the On-Q(R) Pain Ball
This study was conducted to compare the effectiveness of two local pain control methods in bariatric patients by assessing the amount of postoperative pain and amount of postoperative pain medications needed.
- Trial name
- NCT02142829
- Testing
- EXPAREL, On-Q Pain Ball
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Postoperative Cognitive Dysfunction, Cognitive Impairment
Cognitive Changes After Major Joint Replacement - Full Trial (Cognigram 2)
Patients assume that cognitive performance rapidly returns to baseline after anesthesia and surgery. Several studies have shown that one week after major non-cardiac surgery about 27% of patients have postoperative cognitive…
- Conditions
- Postoperative Cognitive Dysfunction, Cognitive Impairment, Mild Cognitive Impairment, Delirium
- Trial name
- NCT03147937
- Testing
- Cognitive Testing
- Where
- Canada
- Volunteers
- 505 people
- Sponsor
- Dr. Stephen Choi
Prematurity
Effect of Osteopathic Manipulative Treatment on Pain in Preterms
Osteopathic manipulative treatment (OMT) has been used to treat term and preterm newborns. Recent studies demonstrated the effectiveness of OMT in reducing length of stay and costs (Cerritelli, 2013) as well as the likelihood of…
- Trial name
- NCT02146677
- Testing
- Osteopathic manipulative treatment, Usual care
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- European Institute for Evidence Based Osteopathic Medicine
Nerve Block
Pectoral Nerve Block and Serratus Posterior Superior Intercostal Plane Block in Breast Cancer Surgery
This randomized clinical trial aims to evaluate and compare the analgesic efficacy of the Pectoral Nerve Block (PECS II) and the Serratus Posterior Superior Intercostal Plane (SPSIP) Block in patients undergoing breast cancer…
- Trial name
- NCT07001657
- Testing
- SPSIP Block, PECS II Block
- Where
- Turkey (Türkiye)
- Volunteers
- 118 people
- Sponsor
- Antalya Training and Research Hospital
Pain, Postoperative
Dexmedetomidine for Improved Pain Relief and Recovery in Spine Surgery
Chronic low back pain (CLBP) is a prevalent condition causing significant pain, disability, and reduced quality of life. While various treatments like exercise, NSAIDs, and spinal manipulation are recommended, their effectiveness…
- Trial name
- NCT06685081
- Testing
- Dexmedetomidine, lidocaine and triamcinolone
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Menoufia University
Post Operative Pain, Erector Spinae Plane Block
The Effect of Local Anesthetic Infiltration or Erector Spina Plan Block on Stress Hormone Response
Laparoscopic cholecystectomy is one of the most common operations in abdominal surgery. Effective analgesia in the postoperative period; It is of great importance in terms of acceleration of recovery, prevention of atelectasis…
- Conditions
- Post Operative Pain, Erector Spinae Plane Block, Inguinal Hernia
- Trial name
- NCT05717530
- Testing
- wound site local anesthesic infiltration, Erector spina plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital