Clinical trials: Neurological Condition
Hearing Loss, Sensorineural, Hearing Loss, Bilateral
Iowa/Nucleus 10/10 mm and Nucleus Freedom Feasibility Study
The purpose of this study is to evaluate whether the Iowa/Nucleus 10/10 mm in one ear, in conjunction with a Nucleus Freedom implant in the other ear can provide useful binaural hearing in pediatric subjects who have bilateral…
- Trial name
- NCT00594061
- Testing
- Iowa/Nucleus 10/10 mm and Freedom Cochlear Implantation
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Bruce J Gantz
Bipolar I Disorder, Acute Mania
A Trial to Evaluate the Safety and Tolerability of Brexpiprazole in the Treatment of Participants With Bipolar I Disorder.
This study evaluated the safety and evaluate the safety and tolerability of open-label brexpiprazole (2 - 4 mg/day, with a starting dose of 2 mg/day) for the treatment of adult subjects with bipolar I disorder.
- Trial name
- NCT03287869
- Testing
- Brexpiprazole
- Where
- 73 sites in United States, Bulgaria and 4 more
- Volunteers
- 381 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Delirium
The Prevention of Delirium and Complications Associated With Surgical Treatments Multi Center Clinical Trial
Delirium is a medical term or condition that includes a temporary inability to focus attention and to think clearly. Delirium occurs commonly (10% to 70%) in patients older than 60 undergoing large surgeries.
- Trial name
- PODCAST (NCT01690988)
- Testing
- Ketamine (0.5 mg/kg), Ketamine (1 mg/kg)
- Where
- United States
- Volunteers
- 746 people
- Sponsor
- Washington University School of Medicine
Muscle Cramp, Ache
7T Magnetic Resonance Spectroscopy and Skeletal Muscle Biopsy Findings in Statin Associated Adverse Muscle Events
Over 40 million Americans take statins to reduce their risk of atherosclerotic cardiovascular disease (ASCVD). Unfortunately, 10 to 20% stop taking them due to statin-associated muscle symptoms (e.g.
- Conditions
- Muscle Cramp, Ache, Weakness, Muscle, Statin Adverse Reaction
- Trial name
- NCT04507373
- Testing
- Simvastatin 40mg
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Texas Southwestern Medical Center
Osteoarthritis, Knee, Pain
A Phase 2 Clinical Trial Examining the Effects on Osteoarthritic Knee Pain of CGS-200-1, CGS-200-5 and Vehicle Control
This is a multi-center, randomized, double-blind clinical trial to examine the comparative effects on OAKP of CGS-200-1 (1% Capsaicin content) (N=40), CGS-200-5 (5% Capsaicin content) (N=40), and CGS-200 Vehicle (no Capsaicin)…
- Trial name
- NCT03528369
- Testing
- CGS-200-1, CGS-200-5, CGS-200 Vehicle
- Where
- 6 sites in United States
- Volunteers
- 122 people
- Sponsor
- Propella Therapeutics
Pain
Use of Dexmedetomidine for Deep Sedation in Patients Undergoing Outpatient Hysteroscopic Surgery
Patients undergoing deep sedation for outpatient procedures typically receive a combination of benzodiazepines, propofol, and opioids.
- Trial name
- NCT01337739
- Testing
- Active Comparator
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Northwestern University
Abdominoplasty
Study to Evaluate Botulinum Neurotoxin Serotype E (EB-001) in Reducing Musculoskeletal Pain in Abdominoplasty
To determine the safety and efficacy of single intra-operative treatment of Botulinum Neurotoxin Serotype E (EB-001) intramuscular (IM) injections into the Rectus Abdominus (RA) in participants undergoing abdominoplasty.
- Trial name
- NCT03429556
- Testing
- Botulinum Neurotoxin Serotype E
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- Allergan
Tinnitus
Effect of the Erchonia® HLS™ for the Relief of Tinnitus Symptoms
This study is to see if applying red low-level laser light can help to reduce tinnitus symptoms
- Trial name
- NCT05091060
- Testing
- Erchonia HLS
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Erchonia Corporation
Hearing Loss
Implantation With the Nucleus CI532 Cochlear Implant in Adults
The aim of this study is to investigate the clinical benefit for patients implanted with the Nucleus® CI532 cochlear implant. The Nucleus® CI532 has a pre-curved, perimodiolar array, the EA32, which is introduced into the cochlea…
- Trial name
- NCT02677220
- Testing
- CI532 cochlear implant
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Cochlear
Chronic Pain
Comparative Effectiveness Trial of Communication Strategies in the Management of Chronic Pain
Investigators will compare Clinical Decision Support (CDS) versus Patient Education and Activation Tools (PEATs) in patients prescribed long-term or multiple opioids to measure outcomes that are important to patients.
- Trial name
- NCT03301623
- Testing
- Clinical Decision Support, Patient Education and Activation Tools
- Where
- United States
- Volunteers
- 983 people
- Sponsor
- Cedars-Sinai Medical Center
Aphasia
Brain Stimulation and Aphasia Treatment
The purpose of this study is to assess the changes in language processing of patients with chronic, post-stroke aphasia following the application of brain stimulation.
- Trial name
- tDCS (NCT01686373)
- Testing
- Activa Dose II Real tDCS
- Where
- 2 sites in United States
- Volunteers
- 74 people
- Sponsor
- University of South Carolina
Miscarriage
Virtual Reality in MVA for Miscarriage
We are investigating the use of a virtual reality programme to reduce pain and anxiety experienced during manual vacuum aspiration.
- Trial name
- NCT04466956
- Testing
- Virtual reality
- Where
- 2 sites in United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Barts & The London NHS Trust
Stroke, Neurologic Disorder
Evaluation of Bioness Integrated Therapy System (BITS) Touch Screen Technology to Improve Field Awareness
The Bioness Integrated Therapy System (BITS) (Bioness Inc. Valencia, CA) Touch Screen is an FDA approved device comprised of an interactive touchscreen and diverse program options to challenge patients through the use of visual…
- Conditions
- Stroke, Neurologic Disorder, Traumatic Brain Injury, Acquired Brain Injury
- Trial name
- NCT04930822
- Testing
- Table Top Visual Intervention, Bioness Integrated Therapy System Visual Intervention
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Gaylord Hospital, Inc
Stroke, Cerebrovascular Accident (CVA)
The Role of Trans-spinal Direct Current Stimulation (tsDCS) in Treating Patients With Hand Spasticity After Stroke
The purpose of this study is to evaluate if 5 consecutive sessions of PathMaker anodal DoubleStim treatment, which combines non-invasive stimulation of the spinal cord (tsDCS- trans-spinal direct current stimulation) and of the…
- Conditions
- Stroke, Cerebrovascular Accident (CVA), Hemiparesis, Spasticity as Sequela of Stroke
- Trial name
- NCT03080454
- Testing
- anodal Doublestim
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Northwell Health
Postural Orthostatic Tachycardia Syndrome, Chronic Orthostatic Intolerance
Using Mirabegron to Increase BP in Patients With POTS
This is a pilot dose-finding study to test the hypothesis that mirabegron increases systolic blood pressure (BP), prevents syncope/presyncope, and improves the quality of life (QOL), functional capacity, chest pain, and…
- Conditions
- Postural Orthostatic Tachycardia Syndrome, Chronic Orthostatic Intolerance, Syncope
- Trial name
- RAISE-BP (NCT06133075)
- Testing
- Mirabegron 50 MG, Mirabegron 25 MG
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cedars-Sinai Medical Center
Mania
Neurochemical Effects of Omega-3 Fatty Acids in Adolescents at Risk for Mania
The purpose of this study is to see if taking a substance called omega-3 fatty acids is effective, safe, and well-tolerated for treating adolescents with major depressive disorder (also called simply "depression" or "clinical…
- Trial name
- R34 (NCT00917501)
- Testing
- OMega 3
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Epilepsy, Seizure Disorders
External Trigeminal Nerve Stimulation for Epilepsy
This study investigates a new therapy for epilepsy called Trigeminal Nerve Stimulation (TNS). TNS involves external electrical stimulation of sensory nerve located above the eyes and over the forehead.
- Trial name
- NCT01159431
- Testing
- Trigeminal Nerve Stimulation
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Olive View-UCLA Education & Research Institute
Post Acute Sequelae Covid-19 Hyposmia
Directed Topical Drug Delivery for Treatment for PASC Hyposmia
This is a phase II randomized, double-blinded, placebo-controlled study to evaluate the efficacy of topical intranasal treatment of beclomethasone vs. placebo for improved olfactory function.
- Trial name
- NCT05970731
- Testing
- Beclomethasone, Microsponge
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Duke University
Advanced Parkinson's Disease
Levodopa-Carbidopa Intestinal Gel Open-Label Study in Advanced Parkinson's Disease
The primary objective of this study will be to provide further evidence of the long-term safety and tolerability of levodopa-carbidopa intestinal gel (Duodopa®) over 12-months in participants with advanced Parkinson's disease…
- Trial name
- NCT00335153
- Testing
- Levodopa-carbidopa intestinal gel, CADD-Legacy® 1400 ambulatory infusion pump, PEG tube
- Where
- 83 sites in United States, Australia and 14 more
- Volunteers
- 354 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Hunter Syndrome
A Safety and Dose Ranging Study of Idursulfase (Intrathecal) Administration Via an Intrathecal Drug Delivery Device in Pediatric Patients With Hunter Syndrome Who Have Central Nervous System Involvement and Are Receiving Treatment With Elaprase®
Elaprase (idursulfase), a large molecular protein, is not expected to cross the blood brain barrier at therapeutic levels when administered intravenously.
- Trial name
- NCT00920647
- Testing
- Control, Idursulfase IT (1 mg), Idursulfase IT (10 mg)
- Where
- 3 sites in United States, United Kingdom
- Volunteers
- 16 people
- Sponsor
- Shire
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