Clinical trials: Neurological Condition
Pain
Hydrocodone For Pain Control in First Trimester Surgical Abortion
The purpose of this study is to determine whether preoperatively administered hydrocodone/acetaminophen (HC/APAP) reduces pain during a first trimester surgical abortion.
- Trial name
- NCT01330459
- Testing
- Hydrocodone/acetaminophen, Ibuprofen, Lorazepam
- Where
- 2 sites in United States
- Volunteers
- 121 people
- Sponsor
- Elizabeth Micks
Pain, Fever
Medication Education for Dosing Safety
Acetaminophen and ibuprofen are two of the most commonly used medication products among children <12 years old, and these medications are frequently prescribed for patients leaving the emergency department (ED), but previous…
- Trial name
- MEDS (NCT03223246)
- Testing
- Additional teaching
- Where
- United States
- Volunteers
- 149 people
- Sponsor
- Massachusetts General Hospital
Rett Syndrome, RTT
A Long-term Safety Study of Cannabidiol Oral Solution (GWP42003-P, CBD-OS) in Patients With Rett Syndrome
This study will be conducted to evaluate the long-term safety of cannabidiol oral solution (GWP42003-P, CBD-OS) in participants with Rett syndrome.
- Trial name
- NCT04252586
- Testing
- GWP42003-P
- Where
- 31 sites in United States, Australia and 4 more
- Volunteers
- 21 people
- Sponsor
- Jazz Pharmaceuticals
Status Epilepticus
Randomized Therapy In Status Epilepticus
This study evaluated the effectiveness and safety of an investigational product (IP), intravenous (IV) ganaxolone, to treat participants with status epilepticus (SE).
- Trial name
- RAISE (NCT04391569)
- Testing
- Ganaxolone
- Where
- 74 sites in United States, Australia and 1 more
- Volunteers
- 100 people
- Sponsor
- Marinus Pharmaceuticals
Renal Disease, Sleep Disorders
Light for Renal Transplant Recipients Having a Sleep-Wake Dysregulation
Sleep-wake dysregulation is a disturbance in the roughly 24-hour cycle of the circadian rhythm. Well known disorders presenting a sleep-wake dysregulation are seasonal affective disorder, jet lag and shift work.
- Trial name
- SleepTx-1 (NCT01256983)
- Testing
- Bright Light Therapy, Wait-list intervention
- Volunteers
- 30 people
- Sponsor
- University of Basel
Drug-resistant Epilepsy, Focal-Onset Seizures
Study to Test the Efficacy and Safety of Padsevonil as Adjunctive Treatment of Focal-onset Seizures in Adults With Drug-resistant Epilepsy
The purpose of the study is to characterize the dose-response relationship with respect to efficacy of Padsevonil administered concomitantly with up to 3 anti-epileptic drugs (AEDs) for treatment of observable focal-onset…
- Trial name
- ARISE (NCT03373383)
- Testing
- Padsevonil
- Where
- 148 sites in United States, Australia and 17 more
- Volunteers
- 411 people
- Sponsor
- UCB Biopharma S.P.R.L.
Narcotic Consumption, Pain
Motorized Continuous Cold Therapy Versus Standard Post-op Icing Protocol for Two Foot and Ankle Procedures
This study will compares differences in pain level, narcotic consumption, wound healing, patient satisfaction in patients randomized to the Iceman® cold pack therapy system (djOrtho, Inc) versus those who use ice.
- Conditions
- Narcotic Consumption, Pain, Wound Healing, Patient Satisfaction
- Trial name
- NCT00950183
- Testing
- Iceman® Cold Therapy unit (djOrtho), Ice
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- OrthoCarolina Research Institute, Inc.
Stroke, Brain Ischemia
Use of Dexmedetomidine in Acute Stroke and Cerebral Vasospasm Interventions
Dexmedetomidine is a unique sedative medication able to provide sedation without causing respiratory depression and maintaining neurological functions.
- Conditions
- Stroke, Brain Ischemia, Vasospasm, Intracranial, Hemorrhage, Intracranial
- Trial name
- NCT01845441
- Testing
- Dexmedetomidine, Fentanyl, Midazolam
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University Hospitals Cleveland Medical Center
Urinary Bladder, Neurogenic
Open-label Long-term Extension Study of Fesoterodine in Japanese Subjects With Neurogenic Detrusor Overactivity.
The purpose of this study is to investigate the safety and tolerability of fesoterodine following once daily long-term treatment in Japanese pediatric neurogenic detrusor overactivity (NDO) subjects.
- Trial name
- NCT02501928
- Testing
- Fesoterodine PR 4 mg, Fesoterodine PR 8 mg, Fesoterodine BIC 2 mg
- Where
- 7 sites in Japan
- Volunteers
- 12 people
- Sponsor
- Pfizer
Hearing Loss, Language Impairment
Retrieval Practice for Word Learning for Deaf and Hard of Hearing Children
This study is designed to advance the promising yet underutilized research on retrieval practice by evaluating the effectiveness and efficiency of two key retrieval practice features (feedback and spacing).
- Trial name
- NCT05512000
- Testing
- Feedback with massed trials, Feedback with spaced trials, No feedback with massed trials
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Vanderbilt University Medical Center
Pain
Nebulized Sub-dissociative Dose Ketamine for Treating Pain
The investigators previous research study comparing the efficacy of intravenous ketamine to morphine showed ketamine to provide equivalent relief of moderate to severe acute pain in emergency department patients.
- Trial name
- NCT03909607
- Testing
- Ketamine 0.75 mg/kg, Ketamine 1.0 mg/kg, Ketamine 1.5 mg/kg
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Antonios Likourezos
Voice Disorders
Vocal Warm-up and Respiratory Muscle Training
The purpose of this study is to verify the effects of two speech-pathology interventions: vocal warm-up and respiratory training in teachers who work in a public school of the city of Salvador-Bahia, with or without complaints of…
- Trial name
- NCT02102399
- Testing
- Vocal Warm-up, Respiratory Muscle Training
- Where
- Brazil
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Federal University of Bahia
Dementia, Aggression
Preventing Aggression in Veterans With Dementia
This study tests whether education about memory and pain might help to prevent aggression in persons with dementia who have pain.
- Conditions
- Dementia, Aggression, Pain
- Trial name
- PAVeD (NCT01325714)
- Testing
- PAVeD Intervention, Enhanced Usual Care
- Where
- United States
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Hypofibrinogenemia, Afibrinogenemia
Human Fibrinogen Concentrate in Pediatric Cardiac Surgery
The goal of the study is to determine whether the use of Human Fibrinogen Concentrate (RiaSTAP) will decrease blood loss and the need for component blood therapy in neonates and infants undergoing cardiopulmonary bypass.
- Conditions
- Hypofibrinogenemia, Afibrinogenemia, Bleeding Disorders
- Trial name
- RiaSTAP (NCT02822599)
- Testing
- RiaStAP, Saline
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Nicklaus Children's Hospital f/k/a Miami Children's Hospital
Cocaine-Related Disorders, Anhedonia
Targeting Anhedonia in Cocaine Use Disorder
The purpose of this study is to examine anhedonia as a potential moderator of treatment outcomes for Cocaine Use Disorder (CUD).
- Trial name
- NCT02773212
- Testing
- d-amphetamine, Contingency management
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Illinois Chicago
Schizophrenia
A Randomized, Open-Label, Multi-Center Study To Evaluate The Efficacy And Safety Of Intramuscular Ziprasidone In Patients With Agitation
This local registration study is to confirm the hypothesis of the efficacy, tolerability and safety of ziprasidone IM (intramuscular) in the Chinese population with agitation in schizophrenia
- Trial name
- NCT00723606
- Testing
- Intramuscular ziprasidone mesylate, Intramuscular haloperidol
- Where
- 9 sites in China
- Volunteers
- 376 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Dysmenorrhea, Menstrual Pain
Non-Steroidal Anti-Inflammatory Drug (NSAID) Response and Central Sensitization of Pain in Women With Dysmenorrhea
Menstrual pain is the most common gynecological complaint and the leading cause of school and work absences in reproductive-age girls and women.
- Conditions
- Dysmenorrhea, Menstrual Pain, Non-steroidal Anti-inflammatory Drug
- Trial name
- NCT05900336
- Testing
- Sodium Naproxen
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Chronic Low Back Pain, Degenerative Disc Disease
Opioid Treatment for Chronic Low Back Pain and the Impact of Mood Symptoms
Opioids are frequently prescribed for chronic low back pain (CLBP). Psychiatric illness, such as high levels of depression and anxiety symptoms, is a common co-occurrence in chronic pain patients (and is termed comorbid negative…
- Conditions
- Chronic Low Back Pain, Degenerative Disc Disease, Depression, Anxiety
- Trial name
- NCT01502644
- Testing
- Oxycodone, Morphine
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Brigham and Women's Hospital
Hyperalgesia
Study on the Development of Opioid Induced Hyperalgesia (OIH) After Exposure to Alfentanil
The purpose of this study was to follow a person's response to experimental pain after multiple consecutive exposures to alfentanil or diphenhydramine to see if the person can tolerate the pain more, less, or the same at the end…
- Trial name
- 0813 (NCT00991809)
- Testing
- Alfentanil, Diphenhydramine
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Postoperative Pain
Dexamethasone for Post Cesarean Delivery Analgesia
The purpose of this study is to assess the effectiveness intravenous (IV) dexamethasone when used as part of a multimodal regimen to manage post cesarean delivery pain.
- Trial name
- NCT01868633
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Iowa
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