Clinical trials: Neurological Condition
Postural Orthostatic Tachycardia Syndrome (POTS)
The Renin-Aldosterone Axis in Postural Tachycardia Syndrome
The purpose of this study is to determine the role of the renin-angiotensin-aldosterone in the pathophysiology of postural tachycardia syndrome, and to provide an insight about the disease process in this disorder.
- Trial name
- NCT00962949
- Testing
- Angiotensin II
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Fibromyalgia
Neurotropin Treatment of Fibromyalgia
This study will examine the safety and effectiveness of the experimental drug, neurotropin, for preventing or easing pain associated with fibromyalgia.
- Trial name
- NCT00366535
- Testing
- Neurotropin
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- National Institute of Nursing Research (NINR)
Chronic Pain
CoverEdge Algorithm Programming Study
This is a prospective, on-label, multi-center, non-randomized, exploratory, single-arm study to characterize the effects of programming features of the Boston Scientific Precision Spectra™ Spinal Cord Stimulator (SCS) System…
- Trial name
- NCT02492880
- Testing
- Precision Spectra™ SCS system programming features
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Boston Scientific Corporation
Partial Seizures
A Study to Assess the Efficacy and Safety of Adjunctive Zonisamide in Paediatric Partial Onset Seizures (CATZ Extension Study)
The purpose of this study is to assess the long-term safety and efficacy of zonisamide used as an adjunctive treatment in pediatric subjects treated with 1 or 2 other anti-epileptic drugs (AEDs).
- Trial name
- NCT01136954
- Testing
- Zonisamide
- Where
- Italy
- Volunteers
- 144 people
- Sponsor
- Eisai Limited
Postoperative Pain
Evaluating Transcutaneous Electrical Nerve Stimulation for Postoperative Pain After Video-Assisted Thoracotomy Surgery
We propose to evaluate the use of Transcutaneous Electrical Nerve Stimulation (TENS) in patients having undergone Video-Assisted Thoracotomy Surgery (VATS) with the aim to determine if: Nurses will be able to apply TENS…
- Trial name
- NCT01046695
- Testing
- TENS Unit
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Mayo Clinic
Mitochondrial Diseases, Drug Resistant Epilepsy
A Study to Evaluate Efficacy and Safety of Vatiquinone for Treating Mitochondrial Disease in Participants With Refractory Epilepsy
This is a parallel-arm, double-blind, placebo-controlled study with a screening phase that includes a 28-day run-in phase to establish baseline seizure frequency, followed by a 24-week, randomized, placebo-controlled phase.
- Conditions
- Mitochondrial Diseases, Drug Resistant Epilepsy, Leigh Disease, Leigh Syndrome
- Trial name
- MIT-E (NCT04378075)
- Testing
- Vatiquinone
- Where
- 27 sites in United States, Canada and 7 more
- Volunteers
- 68 people
- Sponsor
- PTC Therapeutics
Low Back Pain
Study Evaluating Dexketoprofen Trometamol/Tramadol Hydrochloride Analgesic Efficacy in Acute Low Back Pain
A randomized, double-blind, study to evaluate the analgesic efficacy and safety of Dexketoprofen trometamol and Tramadol hydrochloride combination versus placebo on moderate to severe acute pain in patients with acute low back…
- Trial name
- Dante (NCT05170841)
- Testing
- Dexketoprofen Trometamol 25 mg/Tramadol Hydrochloride 75 mg, Tramadol Hydrochloride 100 mg
- Where
- Italy
- Volunteers
- 538 people
- Sponsor
- Menarini International Operations Luxembourg SA
POSTOPERATIVE PAIN
Comparative Study of Two Different Techniques to Perform TAP-blocks
The TAP is a space between the muscle layers of the abdominal wall that houses nerves supplying the abdominal skin. Injecting the local anesthetic ropivacaine into this space will block these nerves and prevent pain following…
- Trial name
- Surgical-TAP (NCT02571439)
- Testing
- Surgical TAP block, Conventional TAP block, 0.5% ropivacaine
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Maimonides Medical Center
Pain
Efficacy And Safety Of Parecoxib 40mg vs. Ketoprofen 100mg In The Management Of Acute Renal Colic
This is a multicenter, randomized, double blind, double dummy, comparative, active-controlled trial designed to assess the analgesic activity and safety of intravenous doses of parecoxib 40 mg relative to intravenous doses of…
- Trial name
- NAP (NCT00553605)
- Testing
- Ketoprofen 100mg, Parecoxib 40mg
- Where
- 17 sites in Brazil, Chile and 4 more
- Volunteers
- 340 people
- Sponsor
- Pfizer
Sensorineural Hearing Loss, Autoimmune Inner Ear Disease
A Clinical Trial of Anakinra for Steroid-Resistant Autoimmune Inner Ear Disease
The purpose of this study is to determine if Anakinra (an interleukin-1 receptor antagonist) can improve hearing thresholds in those patients with Autoimmune Inner Ear Disease (AIED) that did not respond to oral steroid therapy…
- Trial name
- NCT01267994
- Testing
- Anakinra
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Andrea Vambutas
Medication-Induced Dyskinesia
Study to Assess the Safety, Tolerability and Preliminary Efficacy of NLX-112 Versus Placebo in L-dopa-induced Dyskinesia
This is a double-blind, randomized, placebo-controlled Phase 2a study evaluating the safety, tolerability, and preliminary efficacy of up to 2 mg/day (1 mg BID) of NLX-112 versus placebo in patients with moderate to severe L-DOPA…
- Trial name
- NCT05148884
- Testing
- NLX-112
- Where
- 5 sites in Sweden
- Volunteers
- 27 people
- Sponsor
- Neurolixis SAS
Agitation
Acupuncture to Improve Comfort of Children on a Ventilator in the Intensive Care Unit
The purpose of this study is to determine whether acupuncture is effective at improving comfort in children on a ventilator in the intensive care unit.
- Trial name
- NCT01848158
- Testing
- acupuncture
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Seattle Children's Hospital
Bipolar I Disorder, Schizophrenia
Study in Adolescents With Schizophrenia or Bipolar Disorder
Open-label safety study of oral olanzapine treatment in adolescents, aged 13 to 17 years, with bipolar I disorder (manic or mixed episodes) or schizophrenia.
- Trial name
- NCT00982020
- Testing
- Olanzapine, Standard behavioral weight intervention, Intense behavioral weight intervention
- Where
- 14 sites in United States, Poland and 2 more
- Volunteers
- 203 people
- Sponsor
- Eli Lilly and Company
Tinnitus
A CBT-based Internet Intervention for Adults With Tinnitus in the United Kingdom
The purpose of this study is to determine the feasibility and effectiveness of a CBT-based internet intervention for adults with tinnitus in the United Kingdom
- Trial name
- NCT02370810
- Testing
- CBT-based internet-intervention for tinnitus
- Where
- United Kingdom
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Anglia Ruskin University
Acute Pain
A Phase 2 Study to Evaluate Analgesic Effect of IV CR845 For Pain Following Bunionectomy Surgery
This is a single-center, randomized, double blind, placebo controlled, parallel group proof of concept study to evaluate the analgesic efficacy as well as the safety, tolerability and pharmacokinetic profile of CR845 in patients…
- Trial name
- NCT01789476
- Testing
- CR845
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Cara Therapeutics, Inc.
Williams Syndrome, Anxiety
Buspirone Treatment of Anxiety in Williams Syndrome
The purpose of this study is to do a preliminary assessment of whether buspirone is effective, safe, and tolerable in the treatment of anxiety in children, adolescents, and adults with Williams syndrome.
- Trial name
- NCT04807517
- Testing
- Buspirone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Fever After Vaccination, Fever
Safety of Simultaneous mRNA COVID-19 Vaccine With Other Childhood Vaccines in Young Children
This is a prospective, randomized, open-label clinical trial to evaluate the safety of COVID-19 vaccination and other routine childhood vaccines given simultaneously at Visit 1, as compared to sequential vaccination of COVID-19…
- Conditions
- Fever After Vaccination, Fever, Seizures Fever
- Trial name
- NCT06038617
- Testing
- mRNA COVID-19 Vaccine, Routine Childhood Vaccinations
- Where
- 5 sites in United States
- Volunteers
- 347 people, healthy volunteers welcome
- Sponsor
- Duke University
Ataxia Telangiectasia
N-Acetyl-L-Leucine for Ataxia-Telangiectasia (A-T)
This is a multinational, multicenter, open-label, rater-blinded prospective Phase II study which will assess the safety and efficacy of N-Acetyl-L-Leucine (IB1001) for the treatment of Ataxia-Telangiectasia (A-T).
- Trial name
- NCT03759678
- Testing
- IB1001
- Where
- 4 sites in United States, Germany and 2 more
- Volunteers
- 17 people
- Sponsor
- IntraBio Inc
Postoperative Delirium, PD
Cognitive Protection - Dexmedetomidine and Cognitive Reserve
This is a pilot study to evaluate the effect of dexmedetomidine in the prevention of delirium in non-cardiac surgical patients. The preliminary data regarding the effect of dexmedetomidine on delirium comes from a study underway…
- Conditions
- Postoperative Delirium, PD, Postoperative Cognitive Dysfunction, POCD
- Trial name
- NCT00455143
- Testing
- Precedex (Dexmedetomidine)
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cancer, Pain
ACCESS (Access for Cancer Caregivers for Education and Support for Shared Decision Making)
The project will test the effect of educating and supporting family caregivers of hospice cancer patients on their active participation in shared decision making in the plan of care for their patients.
- Trial name
- ACCESS (NCT02929108)
- Testing
- Facebook, ACCESS
- Where
- 3 sites in United States
- Volunteers
- 489 people
- Sponsor
- Washington University School of Medicine
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.