Clinical trials: Neurological Diseases
Thalassemia
Assessment of Pain in People With Thalassemia Who Are Treated With Regular Blood Transfusions
Thalassemia is an inherited blood disorder that can result in mild to severe anemia. Regular blood transfusions, which refresh the healthy red blood cell supply, are one treatment for thalassemia.
- Trial name
- NCT00872833
- Where
- 9 sites in United States, Canada
- Volunteers
- 32 people
- Sponsor
- Carelon Research
Quadriplegia/Tetraplegia
Development and Validation of a New Questionnaire for Caregivers to Assess Hip Pain in Quadriplegic Pediatric Patients: Non-Ambulatory Hip Pain Questionnaire
The goal of this clinical trial is twofold: 1. to develop a questionnaire for care givers to assess hip pain in quadriplegic pediatric patients who are not able to communicate it independently 2.
- Trial name
- NAHPq (NCT06798233)
- Testing
- Non-Ambulatory Hip Pain questionnaire
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Post-Acute Sequelae of SARS-CoV-2 (PASC) Infection
Efficacy, Safety, Tolerability of AXA1125 in Fatigue After COVID-19 Infection
This study will compare the effects of AXA1125, an orally active mixture of amino acids, compared to placebo, on improving muscle function (metabolism) following moderate exercise in subjects with fatigue-Predominant Post-Acute…
- Trial name
- NCT05152849
- Testing
- AXA1125
- Where
- United Kingdom
- Volunteers
- 41 people
- Sponsor
- Axcella Health, Inc
Pain, Sickle Cell Disease
Peer Support for Adolescents and Emerging Adults With Sickle Cell Pain
The study, known as the Peer suppoRt for adolescents and Emerging adults with Sickle cell pain: promoting ENgagement in Cognitive behavioral thErapy (PRESENCE), aims to determine the effectiveness of digital CBT in reducing pain…
- Trial name
- PRESENCE (NCT06374238)
- Testing
- CBT+ Health coach, CBT w/o Health Coach ( self-guided), Usual Care
- Where
- 14 sites in United States
- Volunteers
- 390 people
- Sponsor
- University of Pittsburgh
Pain, Surgery
(TAP) Block vs. Systemic Lidocaine: Effects on Recovery
It has been demonstrated that female patients have poor quality of surgical recovery compared to male patients. Increased sensitivity to pain and increased susceptibility to postoperative nausea and vomiting have been attributed…
- Trial name
- TAP (NCT02053558)
- Testing
- Systemic lidocaine, TAP BLOCK with ropivacaine
- Sponsor
- Northwestern University
Healthy Subjects
First-in-man Study of Single and Multiple Ascending Doses of a New Drug for Neurological Disorders
The primary purpose of this first-in-man study is to investigate whether a new drug for neurological disorders is safe and well-tolerated when administered orally to healthy adults
- Trial name
- NCT02702648
- Testing
- AC-082
- Where
- Germany
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Idorsia Pharmaceuticals Ltd.
Stable Angina, Ischemic Heart Disease
Drug Coated Balloon for Side Branch Treatment vs. Conventional Approach in True Bifurcation Coronary Disease: PRO-DAVID
Bifurcation lesions (BL) on coronary arteries account for 15-20 % of all performed percutaneous coronary interventions (PCI). Preferred approach for treatment of most bifurcation lesions is the stepwise provisional stent strategy…
- Conditions
- Stable Angina, Ischemic Heart Disease, Coronary Artery Disease, Unstable Angina
- Trial name
- PRO-DAVID (NCT04403048)
- Testing
- Provisional DCB approach PCI procedure, Standard provisional approach PCI procedure
- Volunteers
- 800 people
- Sponsor
- Clinical Hospital Center Rijeka
Postoperative Pain After a Total Knee Arthroplasty
Post-operative Analgesic Effect of Oral Nefopam
Primary knee arthroplasty by total prosthesis is a painful surgery, performed on patients with advanced gonarthrosis (stage III), thus already presenting hyperalgesia and hyperalgesia and allodynia.
- Trial name
- NefPO (NCT04576078)
- Testing
- Oral nefopam
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
Hemorrhoid Pain
Post Hemorrhoidectomy Anorectal Pain
This is a quality assurance trial to evaluate the effectiveness of guided breathing exercises on reducing the symptoms of hemorrhoidal disease in colorectal surgery patients.
- Trial name
- NCT03240185
- Testing
- deep breathing exercises
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Diabetic Polyneuropathy, Sleep Hygiene
The Effect of Sleep Hygiene Education on Sleep Quality and Quality of Life in Patients With Painful Diabetic Polyneuropathy
This randomized controlled study was designed to the effect of sleep hygiene education on sleep quality and quality of life in patients with painful diabetic polyneuropathy The study was conducted between January 2025 and January…
- Conditions
- Diabetic Polyneuropathy, Sleep Hygiene, Pain
- Trial name
- NCT07646743
- Testing
- sleep hygiene education, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Trakya University
Constipation - Functional, Abdominal Pain (AP)
Co-Development and Validation of Colonic Symptom Pictograms for Young People
Severe constipation affects 10% of children, often leading to significant physical and emotional distress. While constipation is commonly associated with impaired bowel movements, it is fundamentally linked to abnormalities in…
- Conditions
- Constipation - Functional, Abdominal Pain (AP), Nausea and Vomitting, Bloating
- Trial name
- NCT07337343
- Testing
- Pictogram comprehension and validation
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Auckland, New Zealand
Depression, Involutional, Major Depresssion
Rapid Antidepressant Effects of Yohimbine in Major Depression
This study examines if Yohimbine, when given during the sleep cycle, will improve symptoms of depression within a matter of hours.
- Trial name
- NCT00078715
- Testing
- Yohimbine hydrochloride
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- National Institute of Mental Health (NIMH)
STEMI, NSTEMI
Evaluation of Safety and Efficacy of Two Ticagrelor-based De-escalation Antiplatelet Strategies in Acute Coronary Syndrome
The ELECTRA-SIRIO 2 study is a randomized, multicenter, double-blind, investigator-initiated clinical trial aimed to evaluate safety and efficacy of two ticagrelor-based de-escalation antiplatelet strategies in patients with…
- Conditions
- STEMI, NSTEMI, Unstable Angina
- Trial name
- ELECTRA-SIRIO (NCT04718025)
- Testing
- Ticagrelor 90mg, Ticagrelor 60mg, Aspirin
- Where
- Poland
- Volunteers
- 4,500 people
- Sponsor
- Collegium Medicum w Bydgoszczy
Therapeutic Touch
The Effect of Therapeutic Touch on Agitation, Pain, and Cortisol Levels in Intensive Care Patients
Intensive care units (ICU) are special clinical areas where advanced monitoring and treatment of patients with life-threatening organ failure or those at risk of developing organ failure are carried out, with high technological…
- Trial name
- NCT07061340
- Testing
- Therapeutic Touch
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Firat University
Usher Syndromes
Safety and Efficacy of NPI-001 Tablets for RP Associated With Usher Syndrome
This study will examine the safety and efficacy of NPI-001 Tablets as compared to placebo for 24 months in subjects with vision loss due to RP associated with Usher syndrome.
- Trial name
- SLO RP (NCT04355689)
- Testing
- NPI-001
- Where
- 4 sites in Australia
- Volunteers
- 49 people
- Sponsor
- Nacuity Pharmaceuticals, Inc.
Migraine Without Aura, Headache
Effect of Sumatriptan on Levcromakalim-Induced Symptoms in Individuals With Migraine
The study aims to explore the effects of Sumatriptan on Levcromakalim-induced migraine in individuals with migraine without aura.
- Trial name
- SLIM (NCT05211050)
- Testing
- Levcromakalim, Sumatriptan, Saline
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- Danish Headache Center
Syncope, Cryptogenic Stroke
BIO|STREAM.ICM France
The main objective of the BIO│STREAM.ICM France submodule is to provide clinical evidence from patients in France on safety and efficacy of the BIOMONITOR system
- Trial name
- NCT04206774
- Where
- 3 sites in France
- Volunteers
- 92 people
- Sponsor
- Biotronik SE & Co. KG
Neuropathic Pain, Infections
Determining Cost of Explant of Neurmodulation Device Due to Infection
Spinal cord stimulation (SCS) is a medical device inserted beside the spine to treat nerve pain. When the device becomes infected (which happens 4 % of the time) it needs to be taken out and put back in again at a later date.
- Conditions
- Neuropathic Pain, Infections, Device Related Sepsis, Chronic Pain
- Trial name
- NCT05735574
- Testing
- IPG infections
- Volunteers
- 18 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Diabetic Neuropathy Peripheral, Neuropathic Pain
Peripheral Analgesia in Painful Diabetic Neuropathy
Chronic obliterative arteriopathy of the inferior limbs is a frequent condition observed in diabetics. The later stages induce pain at rest and trophic disorders (ulcer, gangrene) that lead to chronic limb ischemia.
- Conditions
- Diabetic Neuropathy Peripheral, Neuropathic Pain, Diabetic Foot Infection
- Trial name
- DIALOXY (NCT03354806)
- Testing
- Continuous peripheral nerve blocks, Analgesic treatment
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Critical Illness, Sedation
Analgosedative adjuncT keTAmine Infusion iN Mechanically vENTilated ICU Patients
The purpose of this study is to investigate the efficacy and safety of a low dose ketamine infusion used in combination of standard of care in critically ill patients to test whether ketamine can help to shorten the time of being…
- Conditions
- Critical Illness, Sedation, Mechanical Ventilation
- Trial name
- ATTAINMENT (NCT04075006)
- Testing
- Ketamine
- Where
- Saudi Arabia
- Volunteers
- 84 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
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