Clinical trials: Neurological Diseases
Stable Angina, Unstable Angina, Silent Coronary Ischemia, Coronary Artery Disease
ISAR-DAPT (A Comparative Evaluation of Efficacy and Safety in the 3-Months DAPT Group vs. the 6-Months DAPT Group of Patients Treated With the Coroflex ISAR Stent; A Prospective, Multicenter, Randomized, Open-Label Clinical Trial)
This clinical trial studies patients treated with the Coroflex ISAR Stent for coronary artery disease in order for the objective of verifying the non-inferiority of results that among patients who were administered DAPT for 3…
- Trial name
- NCT02609698
- Testing
- Coroflex ISAR, 3 months DAPT, 6 months DAPT
- Where
- South Korea
- Volunteers
- 906 people
- Sponsor
- Ajou University School of Medicine
Muscular Dystrophies, Scapular Dyskinesis
Evaluation of a Textile Scapula Orthosis
Shoulder instability due to muscle weakness is a common problem in disorders of the upper extremities. During arm motion, the scapula acts as a dynamic base for the humeral head.
- Conditions
- Muscular Dystrophies, Scapular Dyskinesis, Muscular Dystrophy, Facioscapulohumeral, Muscle Weakness
- Trial name
- ScapOrthosis (NCT04154098)
- Testing
- Scapula orthosis assistance, Manual scapula assistance, No assistance
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 8 people
- Sponsor
- Swiss Federal Institute of Technology
Heart Failure
Evaluation of the Entresto Effect on Sympathic Nervous System in Patient With Heart Failure
The hyperactivation of the sympathetic nervous system is a feature of the heart failure and the determinants of disease progression and risk of sudden cardiac death.
- Trial name
- B2AN-SNS (NCT02787798)
- Testing
- valsartan/sacubitril 100 mg, valsartan/sacubitril 200 mg, Microneurography
- Where
- France
- Volunteers
- 4 people
- Sponsor
- University Hospital, Toulouse
Cardiac Surgery, Neural Injury
Cerebral Oximetry in Cardiac Surgery to Reduce Neurological Impairment and Hospital Length-of-stay
Cerebral oximetry using near-infrared spectroscopy (NIRS) has been shown to reduce the incidence of neurological dysfunction and hospital length-of-stay in adult cardiac surgery though not all studies agree.
- Conditions
- Cardiac Surgery, Neural Injury, Cerebral Ischemia
- Trial name
- NCT04463563
- Testing
- Physiological
- Volunteers
- 182 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Being Diagnosed With Primary Infertility, Having Had an Embryo Transfer for the First Time
Effects of Virtual Reality Glasses and Meditation Music on Anxiety, Pain, Vital Signs, Satisfaction and Pregnancy Outcomes in Embryo Transfer Procedure
The aim of this study is to determine the effects of virtual reality glasses (VRG) and meditation music on anxiety, pain, vital signs, satisfaction and pregnancy outcomes during the embryo transfer (ET) procedure.
- Trial name
- NCT06802692
- Testing
- VR glasses and meditation music group, Meditation music group
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people
- Sponsor
- Nuh Naci Yazgan University
Acute Pain, Urinary Retention
Incidence of Urinary Retention in Patients Undergoing Unilateral Total Knee Arthroplasty- Comparison Between Continuous Epidural Analgesia and Single Shot Femoral Nerve Block- a Randomized Controlled Study (UriKANE)
This study aims to compare the incidence of urinary retention and requirement of bladder catheterization in patients undergoing total knee arthroplasty while receiving either continuous epidural analgesia or single shot femoral…
- Conditions
- Acute Pain, Urinary Retention, Post Operative Pain
- Trial name
- UriKANE (NCT02689011)
- Testing
- Femoral Nerve Block, Epidural
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Aga Khan University
Chronic Pain Due to Injury, Acute Pain
Evaluating the Impact of Focused Muscle Contraction Therapy in Retire APF Players
This study will investigate the effects of an exercise intervention on retired American professional football (APF) players. A total of 20 retired APF players (≥ 18 years of age), who suffer from chronic pain, will be enrolled.
- Conditions
- Chronic Pain Due to Injury, Acute Pain, Depression, Brain Injuries
- Trial name
- GH-APF (NCT04822311)
- Testing
- Experimental: Investigate the effects of an exercise intervention on retired APF players
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Illinois Chicago
Postherpetic Neuralgia, Diabetic Polyneuropathies
Botulinum Toxin in Peripheral Neuropathic Pain
Pain due to peripheral nerve lesion remains extremely difficult to treat and current treatments have onl moderate efficacy and/or side effects.
- Conditions
- Postherpetic Neuralgia, Diabetic Polyneuropathies, Other Polyneuropathies
- Trial name
- NCT01251211
- Testing
- botulinum toxin type A
- Where
- 3 sites in Brazil, France
- Volunteers
- 66 people
- Sponsor
- Hospital Ambroise Paré Paris
Prostate Cancer, Neuropathy
a Vigibase Pharmacovigilance Study of ENzalutamide Drug-induced neurotoxicitY
Enzalutamide may lead to various adverse reactions. This study investigates reports of different neurological toxicities in the World Health Organization's (WHO) global database of individual safety case reports (VigiBase).
- Conditions
- Prostate Cancer, Neuropathy, Epilepsy, Encephalopathy
- Trial name
- VENDY (NCT04290611)
- Testing
- Enzalutamide
- Where
- France
- Volunteers
- 500,000 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Pancreatitis, Chronic, Abdominal Pain
Δ9-THC (Namisol®) in Chronic Pancreatitis Patients Suffering From Persistent Abdominal Pain
Abdominal pain resulting from chronic pancreatitis (CP) is often recurrent, intense and long-lasting, and is extremely difficult to treat.
- Conditions
- Pancreatitis, Chronic, Abdominal Pain, Chronic Pain
- Trial name
- NCT01551511
- Testing
- Tetrahydrocannabinol
- Where
- Netherlands
- Volunteers
- 29 people
- Sponsor
- Radboud University Medical Center
Septic Shock
Interest of Plasma microRNAs
ICU acquired muscle weakness (IAMW) is a common disease that is associated with high morbidity and mortality. Patients with septic shock are particularly at risk.
- Trial name
- µARN (NCT02464371)
- Testing
- kinetic of microRNAs
- Where
- 2 sites in France
- Volunteers
- 58 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
PTSD, Chronic Pain
Mindful Yoga Therapy for Veterans With PTSD and Pain
The primary objective of the current study is to establish the safety and acceptability of Mindful Yoga Therapy as an adjunctive treatment for Posttraumatic Stress Disorder (PTSD) and chronic pain among OEF/OIF/OND Veterans.
- Trial name
- NCT01957371
- Testing
- Mindful Yoga Therapy
- Where
- United States
- Sponsor
- VA Connecticut Healthcare System
Postoperative Delirium, Postoperative Cognitive Dysfunction
Intraoperative Infusion of Methylene Blue for Prevention of Postoperative Delirium and Cognitive Dysfunction in Elderly Patients Undergoing Major Elective Noncardiac Surgery
Postoperative neurocognitive impairments often occur in elderly patients undergoing anesthesia and non-cardiac surgery, including postoperative delirium (POD) and postoperative cognitive dysfunction (POCD).
- Trial name
- NCT04341844
- Testing
- Methylene Blue
- Where
- China
- Volunteers
- 248 people
- Sponsor
- Fudan University
Stroke, Upper-limb Paresis
Automatic Versus Intentional Movement Exercises to Enhance Arm Functions After Stroke
Many patients retain upper-limb motor impairment following stroke. Most conventional rehabilitation techniques are aimed to improve motor intentional movement by repeated exercises.
- Trial name
- AUTOTAB (NCT01565044)
- Testing
- motor training
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Hospices Civils de Lyon
Cognitive Impairment
PAMNEU - Memory in Neurology
Memory in Neurology project (PAMNEU) aims to map the distribution and severity of cognitive impairment in patients of outpatient neurologic offices across the geographical area of the Czech Republic.
- Trial name
- NCT06154564
- Where
- Czechia
- Volunteers
- 600 people
- Sponsor
- Charles University, Czech Republic
Ataxia
RFC1 Natural History Study
This international, multi-center, multi-modal and prospective observational study aims to determine the phenotypic spectrum and the natural progression of the RFC1 repeat expansion disease, and to seek and validate digital…
- Trial name
- RFC1-NHS (NCT05177809)
- Testing
- Clinical rating scale to measure ataxia disease severity and progression
- Where
- 10 sites in Australia, Brazil and 5 more
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Prof. Dr. Matthis Synofzik
Angina Pectoris, Left Ventricular Wall Motion Abnormalities
Intraprocedural Determination of Myocardial Vitality Using 2 Different Imaging Methods
The investigators will compare myocard vitality diagnostics using 2D-Strain echography and MRI.
- Trial name
- NCT01934699
- Testing
- Cardiac ultrasound, MRI scanner
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- RWTH Aachen University
Prader-Willi Syndrome
Cortisol Activity in Patients With Prader-Willi Syndrome and Healthy Controls
The purpose of the study is to find out if people with Prader-Willi syndrome have a difference in the protein which changes inactive cortisone to the active stress hormone cortisol.
- Trial name
- NCT00932932
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Pain, Osteoarthritis
Psychosocial Factors a Prognostic Study of Pain in Patients With CMC Osteoarthritis
In this clinical trial, females with a diagnosis of thumb CMC OA, will be recruited. The primary outcome of potential risk factors of osteoarthritis, pain and function will be measured using the demographic data, visual analog…
- Trial name
- CMC (NCT03821298)
- Testing
- Standard of Care Hand Therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Gannon University
Alzheimer Disease
Assessment of Sleep Disturbance in Alzheimer Disease
The purpose of this study is to study circadian rhythms, or daily cycles of sleep, wake, and activity. The investigators hope to learn how disturbed sleep in Alzheimer's Disease relates to changes in activity cycles, and how…
- Trial name
- NCT00831298
- Testing
- Analysis of sleep disturbance
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
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