Clinical trials: Neurological Diseases or Conditions
Pain, Weakness
Clinical Trial of CoQ10 for Mild-to-Moderate Statin-Associated Muscle Symptoms
This study will evaluate whether a dietary supplement, coenzyme Q10 (CoQ10), will improve muscle symptoms, such as muscle aches, pains, cramps, and/or weakness, which are experienced by some individuals who use statin medications.
- Conditions
- Pain, Weakness, Cramps, Myalgia or Myositis Nos
- Trial name
- NCT01032993
- Testing
- Coenzyme Q10
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Catherine Buettner
Arthritis, Arthralgia
Immune-Mediated Pathophysiology And Clinical Triage Program
Many people develop joint pain, stiffness and swelling due to their cancer treatment that targets the immune system. The severity of symptoms ranges from mild to debilitating and sometimes requires delaying or stopping cancer…
- Trial name
- IMPACT 2 (NCT04354649)
- Testing
- Hydroxychloroquine
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- AHS Cancer Control Alberta
Head and Neck Cancer, Mucositis
Doxepin Hydrochloride in Treating Oral Mucositis Pain in Patients With Head and Neck Cancer Undergoing Radiation Therapy With or Without Chemotherapy
RATIONALE: Doxepin hydrochloride may be an effective treatment for oral mucositis pain in patients undergoing radiation therapy with or without chemotherapy.
- Conditions
- Head and Neck Cancer, Mucositis, Oral Complications of Radiation Therapy, Pain
- Trial name
- NCT01156142
- Testing
- doxepin hydrochloride
- Where
- 120 sites in United States
- Volunteers
- 155 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Headache
Prednisolone in the Treatment of Withdrawal Headache in Probable Medication Overuse Headache
The purpose of this study is to determine whether prednisolone is more effective than placebo in the first six days after initiation of medication withdrawal therapy for a medication overuse headache.
- Trial name
- NCT00135122
- Testing
- prednisolone
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Sorlandet Hospital HF
Sciatica, Lumbosacral Radiculopathy
Mechanical Diagnosis and Treatment and/or Steroid Injections for Lumbar Radiculopathy
Aim 1: The primary aim of this study is to test the feasibility of Mechanical Diagnosis and Treatment (MDT) +/- transforaminal epidural steroid injections (TESI) on pain and disability in patients awaiting physiatry consult for…
- Conditions
- Sciatica, Lumbosacral Radiculopathy, Lumbar Disc Rupture
- Trial name
- NCT02951377
- Testing
- Exercise (MDT approach), Transforaminal epidural steroid injection (20mg dexamethasone 0.5cc lidocaine 2%)
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- University of Alberta
Stable or Unstable Angina Pectoris, Myocardial Ischemia
Efficiency of a New Therapy to Treat Stenosis of Coronary Vessels in Comparison With Two Already Admitted Therapies
The aim of the study is to examine the efficacy of Paclitaxel injection after a stent implantation in patients with stenosis in native coronary arteries to prevent restenosis in comparision with two admitted therapies.
- Trial name
- NCT00396929
- Testing
- local intracoronary dosis of Paclitaxel
- Where
- Germany
- Volunteers
- 204 people
- Sponsor
- University Hospital Tuebingen
Breast Cancer, Cancer Survivor
Quality of Life in African-American or Caucasian Female Breast Cancer Survivors
RATIONALE: Studying quality of life in cancer survivors may help determine the long-term effects of breast cancer and may help improve the quality of life for future cancer survivors.
- Conditions
- Breast Cancer, Cancer Survivor, Depression, Fatigue
- Trial name
- NCT00268502
- Testing
- study of socioeconomic and demographic variables, fatigue assessment and management, management of therapy complications
- Where
- United States
- Volunteers
- 195 people
- Sponsor
- Indiana University
Postoperative Pancreatic Fistula, Delayed Gastric Emptying
Pancreaticoduodenectomy With or Without Braun Enteroenterostomy: Comparison of Postoperative Pancreatic Fistula and Delayed Gastric Emptying
The investigators plan to perform a prospective randomized, head-to-head trial to test the hypothesis that the addition of Braun enteroenterostomy to standard pancreaticoduodenectomy (PD) reconstruction can decrease the rates of…
- Trial name
- NCT01481753
- Testing
- pancreaticoduodenectomy without Braun enteroenterostomy, Braun enteroenterostomy
- Where
- United States
- Volunteers
- 341 people
- Sponsor
- Johns Hopkins University
Abdominal Pain, Rectal Bloodloss
Head-to-head Comparison of Two Fecal Biomarkers to Screen Children for IBD
RATIONALE: A substantial proportion of children and teenagers with suspected inflammatory bowel disease (IBD) referred for endoscopy do not have the disease.
- Conditions
- Abdominal Pain, Rectal Bloodloss, Diarrhea, Inflammatory Bowel Disease
- Trial name
- CACATU (NCT02197780)
- Where
- 19 sites in Belgium, Netherlands
- Volunteers
- 355 people
- Sponsor
- University Medical Center Groningen
Pediatric ALL, Pediatric Anesthesia
Nalbuphine Versus Ketamine for Prevention of Emergence Agitation After Sevoflurane in Children Undergoing Tonsillectomy
The effect of low dose nalbuphine or ketamine in the prevention of emergence agitation after sevoflurane anesthesia in children undergoing tonsillectomy with or without adenoidectomy.
- Trial name
- NCT05176119
- Testing
- Nalbuphine Injection, Ketamine, Saline
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Entropion
The Effect of Preoperative Ketamine on the Emergence Characteristics in Children Undergoing Entropion Surgery
The investigators evaluate extubation time and recovery profiles in children undergoing entropion surgery.
- Trial name
- NCT02916407
- Testing
- Sevoflurane, Desflurane
- Where
- South Korea
- Volunteers
- 56 people
- Sponsor
- Inje University
Combat-Related Limb Injury, Nerve Block
Nerve Blocks or Combat Trauma: What Drives Peripheral Nerve Injury?
This study will examine nerve problems after combat-related injuries to the arms or legs. Some patients receive a peripheral nerve block, an injection of local anaesthetic near a nerve, to help control pain.
- Conditions
- Combat-Related Limb Injury, Nerve Block, Nerve Damage, Nerve Blocks
- Trial name
- NERVE-COMBAT (NCT07868133)
- Volunteers
- 1,000 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Endometriosis and Dysmenorrhea
Drug Use Investigation (DUI) of YazFlex for Endometriosis-associated Pelvic Pain and/or Dysmenorrhea
This study is a Japanese post-marketing surveillance (PMS) which is required by the regulatory authorities. General objective of PMS is to confirm the clinical usefulness, especially the safety profile of a drug under the routine…
- Trial name
- NCT03126747
- Testing
- BAY86-5300_YAZ-Flex
- Where
- Japan
- Volunteers
- 715 people
- Sponsor
- Bayer
Epilepsy With Simple or Complex Partial Onset Seizures
Safety and Efficacy of Eslicarbazepine Acetate Monotherapy in Subjects With Partial Epilepsy Not Well Controlled by Current Antiepileptic Drugs
This is an 18-week, double-blind, multicenter study with gradual conversion from previous antiepileptic therapy to eslicarbazepine acetate monotherapy in subjects with partial epilepsy.
- Trial name
- NCT00866775
- Testing
- Eslicarbazepine acetate
- Where
- 106 sites in United States, Canada
- Volunteers
- 193 people
- Sponsor
- Sumitomo Pharma America, Inc.
Traumatic and/or Non-traumatic Brain Injury
Assessing Special Features of Impaired Gait After Acquired Brain Injury With an Instrumented Treadmill
Hemiparetic gait following acquired brain injury (ABI) is grossly characterized by decreased speed of walking, increased stance time on the unaffected side, and decreased stance time on the affected side.These abnormalities are…
- Trial name
- NCT01413321
- Where
- Israel
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Spasticity
ETREAT Study on Effectiveness of Botulinum Toxin Type A Injections to Treat Post-stroke Upper and/or Lower Limb Spasticity
The objective of this study is to evaluate the effectiveness of BoNT-A on functional improvement in patients with post-stroke upper and/or lower limb spasticity in the early stage of spasticity development, according to routine…
- Trial name
- ETREAT (NCT02275312)
- Where
- 17 sites in Spain
- Volunteers
- 110 people
- Sponsor
- Ipsen
Hand Injuries/Disease Requiring Surgery to the Hand
A Study Investigating Ways to Make Local Anaesthetic Hand Surgery Less Painful - Reducing Tourniquet Associated Pain
Hand surgery requires a reduced blood flow to the hand during the operation, which is achieved using a tourniquet (tightly inflated circumferential cuff) around the upper arm. However this tourniquet is painful.
- Trial name
- ReTAP (NCT01611064)
- Testing
- Oxygen, Medical air
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Pain, Activities of Daily Living
A Double-blind, Randomized, Parallel Group, Fase III Comparative Study With Rose Hip Powder Powder and Placebo Given to Patients With Mild to Moderate Osteoarthritis in the Knee or/and Hip
The trial is an investigator-initiated, double-blind, randomized, placebo-controlled phase III study. After the patient has receiving information about the study and after given written informed consent, the patient will be…
- Conditions
- Pain, Activities of Daily Living, Quality of Life
- Trial name
- NCT01459939
- Testing
- Rose-hip powder capsules
- Where
- Denmark
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hyben Vital ApS
Drug Resistant Epilepsy, Epilepsy
A Safety, Tolerability, and Preliminary Efficacy of Low-intensity Focused Ultrasound Neuromodulation in Patients With Drug-resistant Epilepsy
This will be a prospective, open-label, single-arm, multi-center, pilot study to evaluate the safety, tolerability, and preliminary efficacy of low-intensity focused ultrasound (LIFU) neuromodulation using NaviFUS System in…
- Conditions
- Drug Resistant Epilepsy, Epilepsy, Seizures, Focal, Seizure
- Trial name
- NCT06388707
- Testing
- NaviFUS System
- Where
- 3 sites in United States
- Volunteers
- 8 people
- Sponsor
- NaviFUS Corporation
Neurological Diseases or Conditions
Measuring Single Neuron Activity in the Brain
The SUNAN (Single Unit Neurophysiological Architecture of the Neocortex) study aims to understand how individual brain cells called neurons interact and communicate, and how the neurons can be affected in neurological disease.
- Trial name
- SUNAN (NCT06763471)
- Testing
- Neuropixels recording intraoperatively during planned neurosurgery
- Volunteers
- 50 people
- Sponsor
- University College, London