Clinical trials: Neurological Injury
Spinal Cord Injuries or Similar Neurological Weakness
EKSO Trial: Powered Exoskeleton for Ambulation in Subjects With Spinal Cord Injury (SCI)
This study seeks to test the safety and efficacy of the Esko device in SCI population and in populations with similar neurological weakness to the SCI population.
- Trial name
- EKSO (NCT01701388)
- Testing
- Ekso exoskeleton
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injury, Neurological Conditions
Olfactory Cell Transplantation and Intensive Rehabilitation to Repair Chronic Spinal Cord Injury
This is a randomised, blinded and controlled Phase I trial to measure the safety, feasibility and efficacy of a combined cell transplantation and intensive rehabilitation intervention to treat spinal cord injury.
- Conditions
- Spinal Cord Injury, Neurological Conditions, Rehabilitation Exercise
- Trial name
- NCT07596563
- Testing
- Olfactory Ensheathing Cell, biological intervention, rehabilitation
- Volunteers
- 30 people
- Sponsor
- Dr Brent McMonagle
Spinal Cord Injuries, Neuropathic Pain
Neuropathic Pain and Operant Conditioning of Cutaneous Reflexes After SCI
The purpose of the second part of the study is to examine the effect of reflex training in the leg to decrease neuropathic pain.
- Conditions
- Spinal Cord Injuries, Neuropathic Pain, Neurological Injury, Pain
- Trial name
- NCT05492188
- Testing
- Operant Conditioning of Cutaneous Reflexes
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Medical University of South Carolina
Combat-Related Limb Injury, Nerve Block
Nerve Blocks or Combat Trauma: What Drives Peripheral Nerve Injury?
This study will examine nerve problems after combat-related injuries to the arms or legs. Some patients receive a peripheral nerve block, an injection of local anaesthetic near a nerve, to help control pain.
- Conditions
- Combat-Related Limb Injury, Nerve Block, Nerve Damage, Nerve Blocks
- Trial name
- NERVE-COMBAT (NCT07868133)
- Volunteers
- 1,000 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Neurological Disorders, Neuroscience
Advanced Space-time Resolved Techniques for Functional Neuroimaging at 7 Tesla MRI
In recent years, the in vivo study of the central nervous system has undergone significant advancement through the implementation of magnetic resonance imaging (MRI)-based neuroimaging techniques.
- Conditions
- Neurological Disorders, Neuroscience, Epilepsy, Brain Injuries, Focal
- Trial name
- AURORA (NCT07865546)
- Testing
- Functional neuroimaging
- Where
- Italy
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Imago 7 Fondazione di Ricerca onlus
Acute Neurological Injury, Acute Medical Conditions
Transcutaneous Auricular Vagus Enhanced Recovery in the NeuroICU
This study will demonstrate the impact of taVNS on reducing adverse events in NeuroICU patients, determine if taVNS reduces length of stay, and quantify the economic benefits of taVNS implementation in a broader neurocritical…
- Trial name
- TAVERN (NCT07219108)
- Testing
- Auricular Vagus Nerve Stimulation
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Washington University School of Medicine
Hand Injuries and Disorders, Neurological Conditions
3D Hand Orthosis Trial
In people with chronic hand conditions, hand orthoses are frequently prescribed to improve performance in activities of daily living (ADL).
- Conditions
- Hand Injuries and Disorders, Neurological Conditions, Neuromuscular Diseases (NMD), Musculoskeletal Conditions (e.g., Tendinitis, Capsulitis)
- Trial name
- NCT07633821
- Testing
- 3D-printed hand orthosis (intervention), Conventional hand orthosis (control)
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Mild Traumatic Brain Injury, Intracranial Lesions
TES HT100 Clinical Validation for Brain Injury Screening in Patients With Mild Head Trauma or Neurological Symptoms
The goal of this clinical study is to evaluate how accurately and safely the TES HT100 device can identify intracranial abnormalities in adult emergency department patients with mild head trauma or neurological symptoms that are…
- Conditions
- Mild Traumatic Brain Injury, Intracranial Lesions, Neurological Symptoms Not Related to Head Trauma
- Trial name
- TESCO (NCT07490418)
- Testing
- Temnographic Brain Screening Examination
- Where
- 3 sites in Italy, Poland
- Volunteers
- 850 people
- Sponsor
- B&B srl
Spinal Cord Injuries, Neurological Injury
Operant Conditioning of Spinal Reflexes Training System--Reflex Operant Down Conditioning
The purpose of this study is to validate the capacity of a reflex training system to change the size of the targeted reflex. For this, the researchers are recruiting 25 individuals with chronic incomplete SCI who have spasticity…
- Conditions
- Spinal Cord Injuries, Neurological Injury, Paralysis, Spasticity, Muscle
- Trial name
- NCT05094362
- Testing
- Spinal Reflex Operant Down Conditioning
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Medical University of South Carolina
Stroke, Parkinson Disease (PD)
Digital Patient Engagement in Technology-Supported Neurorehabilitation
The goal of this observational study is to investigate digital patient engagement and its psychosocial correlates and potential predictors among adults aged 18-85 years with neurological disorders who are undergoing…
- Conditions
- Stroke, Parkinson Disease (PD), Motor Neuron Disease, Spinal Cord Injury
- Trial name
- PSY-NeT-Engage (NCT07794072)
- Where
- 3 sites in Italy
- Volunteers
- 129 people
- Sponsor
- Catholic University, Italy
Ictus, Convalescence
Effectiveness of Laser Visual Feedback in Postural Control After a Stroke
Background: Stroke is one of the leading causes of acquired disability and frequently results in impairments in balance and postural control that affect functional independence.
- Conditions
- Ictus, Convalescence, Rehabilitation by Recovery of Function, Rehabilitation Frail Elderly Subjects
- Trial name
- FV-CP (NCT07811843)
- Testing
- Intervention
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Parc Sanitari Pere Virgili
Neuro ICU, Sub Arachnoid Hemorrhage
Comparison of Ultrasound Cerebral Perfusion Imaging With Routine Perfusion CT
The primary goal of neurocritical care is to prevent secondary brain injury, which worsens neurological outcomes. Because clinical monitoring is often insufficient due to the patient's condition and medical treatments, multimodal…
- Conditions
- Neuro ICU, Sub Arachnoid Hemorrhage, Neurological Complication, Cerebral Ischemia
- Trial name
- SCULPT (NCT07324421)
- Testing
- Ultrasound contrast agent (Contrast-enhanced ultrasound)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Resolve Stroke
All-cause Mortality, Quality of Life
PRophylaxis Against Early VENTilator-associated Infections in Acute Brain Injury
This research is about whether treatment with a commonly used antibiotic can prevent infections in airway and lungs and improves the chance of surviving, if it is given soon after patients commence mechanical ventilation when…
- Conditions
- All-cause Mortality, Quality of Life, Disability, Intellectual, Neurological Disorder
- Trial name
- PREVENT-NEURO (NCT06819592)
- Testing
- Ceftriaxone 2g diluted in >200ml 0.9%sodium chloride
- Where
- 29 sites in Australia, Canada and 1 more
- Volunteers
- 3,300 people
- Sponsor
- The George Institute
Neurologic Disorders, Nervous System Diseases
Neurologic Stem Cell Treatment Study
This is a human clinical study involving the isolation of autologous bone marrow derived stem cells (BMSC) and transfer to the vascular system and inferior 1/3 of the nasal passages in order to determine if such a treatment will…
- Conditions
- Neurologic Disorders, Nervous System Diseases, Neurodegenerative Diseases, Neurological Disorders
- Trial name
- NEST (NCT02795052)
- Testing
- Intravenous and Intranasal BMSC
- Where
- 3 sites in United States, United Arab Emirates
- Volunteers
- 500 people
- Sponsor
- MD Stem Cells
Acute Neurological Injury, Emotional Distress
Building Resiliency in Dyads of Patients With an ANI Admitted to the Neuro-ICU and Their Informal Caregivers
The purpose of the present investigation is to test the efficacy of a brief (6 sessions) dyadic (patient and caregiver together) intervention to prevent chronic emotional distress in at risk dyads admitted to a Neuroscience…
- Trial name
- NCT05157880
- Testing
- Recovering Together
- Where
- United States
- Volunteers
- 388 people
- Sponsor
- Massachusetts General Hospital
Covid19, Neurological Manifestations
Study of Morphological, Spectral and Metabolic Manifestations of Neurological Complications in Covid-19 Patients
Viral pandemics, such as HIV and SARS-Cov-V1, have shown that they can lead to acute and / or delayed neurological complications.
- Conditions
- Covid19, Neurological Manifestations, Brain Damage
- Trial name
- NSpectroCovid (NCT04546737)
- Testing
- Magnetic Resonance Spectroscopy (MRS).
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Neurological Injury
Response of the Cardiac Autonomic Control System After Oxygen Therapy 100% in Hyperbaric Environment
The purpose of this study is to examine changes in cardiac autonomic nerve system function in patients receiving Hyperbaric oxygen therapy .
- Trial name
- NCT07537452
- Where
- Israel
- Volunteers
- 17 people
- Sponsor
- Assaf-Harofeh Medical Center
Healthy Volunteers, Spinal Cord Injury
Chronic Transcutaneous Stimulation to Promote Motor Function and Recovery in Individuals With Paralysis or Paresis
This is an early feasibility trial to determine whether transcutaneous neuromuscular electrical stimulation, with or without transcutaneous spinal cord stimulation, using an investigational neurostimulation device improves…
- Conditions
- Healthy Volunteers, Spinal Cord Injury, Stroke, Paralysis
- Trial name
- NCT04755699
- Testing
- Transcutaneous Electrical Stimulation
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Spinal Cord Injuries, Neuropathic Pain
Transcranial Magnetic Stimulation Therapy in Neuropathic Painful Spinal Cord Injury Patients
The aim of our study is to investigate the effect of high-frequency Repetitive Transcranial Magnetic Stimulation(rTMS) therapy applied to the dorsolateral PFC (DLPFC) area on neuropathic pain in patients with spinal cord injury.
- Conditions
- Spinal Cord Injuries, Neuropathic Pain, Neurological Diseases or Conditions
- Trial name
- NCT05645003
- Testing
- High-frequency real-time rTMS protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Afyonkarahisar Health Sciences University
Neurological Disorder, Multiple Sclerosis
Metaverse Applications in Clinical Neurorehabiliation: Device Feasibility
The main objective of the TERSICORE project is the development of a new advanced set of exergames in the Metaverse that can be used in all clinical and home rehabilitation devices to improve the cognitive therapy of neurological…
- Conditions
- Neurological Disorder, Multiple Sclerosis, Parkinson Disease, Stroke
- Trial name
- TERSICORE XRM (NCT07456475)
- Testing
- Cognitive rehabilitation with TERSICORE digital platform
- Where
- Italy
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Istituto per la Ricerca e l'Innovazione Biomedica