Clinical trials: Neurological Manifestations
Pain
Chronic Lumbosacral Radiculopathy: Impact of an Analgesic Dietary Intervention on Pain & Function
The goal of this proposed research is to assess the preliminary efficacy of dietary interventions that change dietary fats in improving clinical outcomes related to lumbar radicular pain.
- Trial name
- LRPD (NCT02531711)
- Testing
- Diet A, Diet B
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of North Carolina, Chapel Hill
Voice Disorders
Effectiveness of Two Therapeutic Approaches in Female Teachers With Voice Disorders
The study compares two different approaches of voice therapy. Vocal Functional Exercises (Stemple,1997) and Voice Amplification using a portable amplifier (Tsi Supervoz II - Tecnisystem do Brasil TSI 1210).
- Trial name
- NCT01196611
- Testing
- Voice Amplification, Function Voice Exercises
- Where
- Brazil
- Volunteers
- 162 people
- Sponsor
- Federal University of São Paulo
Mechanical Low Back Pain
Prescriptive Mobilization Versus a Pragmatic Mobilization
This study is designed to compare the outcomes of two types of manual therapy techniques on patients with low back pain. Both immediate- and long-term outcomes will be examined.
- Trial name
- NCT01940744
- Testing
- Prescriptive Mobilization, Pragmatic Mobilization
- Where
- 3 sites in United States
- Volunteers
- 46 people
- Sponsor
- Walsh University
Amnestic Mild Cognitive Impairment, Alzheimer's Disease
The Study of Nasal Insulin in the Fight Against Forgetfulness (SNIFF)
An urgent need exists to find effective treatments for Alzheimer's disease (AD) that can arrest or reverse the disease at its earliest stages.
- Trial name
- NCT01767909
- Testing
- Insulin (Humulin® R U-100)
- Where
- 25 sites in United States
- Volunteers
- 240 people
- Sponsor
- University of Southern California
Reflex, Ankle, Decreased
The Reflex Mechanism Underlying Neuromuscular Effects Of The Whole Body Vibration
This study was conducted to determine whether the spinal reflex mechanism underlying the neuromuscular effects of whole body vibration (WBV) is tonic vibration reflex.
- Trial name
- WBV-IRM (NCT04516798)
- Testing
- vibration
- Where
- Turkey (Türkiye)
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Vision Disorders
Modification in Cortical Activation in Pseudophakic Patients With Visual Difficulties After a Multifocal Implantation
This study will highlight differences in cortical activation between asymptomatic and symptomatic patients.
- Trial name
- PlainteIMF (NCT02529098)
- Testing
- fMRI
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Elderly, Sarcopenia
Early Detection of Disability and Health Promotion for Community-dwelling Elderly
This study evaluates the effects of exercise intervention on muscle strength and walking speed for the community-dwelling elderly.
- Trial name
- NCT03607136
- Testing
- exercise training
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Buddhist Tzu Chi General Hospital
Parkinson Disease, Ataxia
Validation of Bulbicam for Parkinson- and Ataxia-patients
Aim is to investigate repeatability and stability of four Neurological-related Bulbicam tests in patients suffering Parkinson (PD),Ataxia (AT) and matched healthy control (HC).
- Trial name
- NCT05680571
- Testing
- BulbiCam
- Where
- Norway
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Meddoc
Kidney Calculi
Paravertebral Block Versus Epidural Anesthesia for Percutaneous Nephrolithotomy
This prospective, randomized study is aimed to assess the efficacy and safety of paravertebral block compared to epidural anesthesia for percutaneous nephrolithotomy.
- Trial name
- PVB (NCT03018899)
- Testing
- paravertebral block, epidural anesthesia
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Huazhong University of Science and Technology
Rett Syndrome, RTT
Efficacy and Safety of Cannabidiol Oral Solution (GWP42003-P, CBD-OS) in Patients With Rett Syndrome
To evaluate the efficacy of cannabidiol oral solution (GWP42003-P, CBD-OS) in reducing symptom severity when compared with placebo, in participants with Rett syndrome.
- Trial name
- ARCH (NCT03848832)
- Testing
- GWP42003-P
- Where
- 26 sites in United States, Italy and 2 more
- Volunteers
- 29 people
- Sponsor
- Jazz Pharmaceuticals
Acquired Brain Injury, Stroke
Computerized Attention Training for Individuals With Acquired Brain Injury
Problems with attention are a common and debilitating consequence of brain injury. Studies show that poor attention is the number one predictor of poor cognitive functioning one year post-injury.
- Conditions
- Acquired Brain Injury, Stroke, Hemispatial Neglect
- Trial name
- NCT01641432
- Testing
- Tonic and Phasic Attention Training, Active Comparator
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Posit Science Corporation
Loss of Consciousness
Remimazolam Bolus for General Anesthesia
It is important to estimate the adequate dose of remimazolam intravenous bolus injection to induce the loss of consciousness. We will determine the ED50 and ED95 of remimazolam intravenous bolus on the loss of consciousness in…
- Trial name
- NCT04901871
- Testing
- 0.02 mg/kg, age<65, 0.07 mg/kg, age<65, 0.12 mg/kg, age<65
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Gangnam Severance Hospital
Cognition, Parkinson's Disease
Dual-Task Balance and Gait Training Combined With Cognitive Training in Parkinson's Patients
The aim of the study is to examine the effects of a structured, cognitive dimension-specific cognitive training combined with dual-task balance and gait training on balance, gait, and cognition in individuals with Parkinson's…
- Conditions
- Cognition, Parkinson's Disease, Gait Disorders, Neurologic, Balance Disorders
- Trial name
- NCT07213232
- Testing
- Core Stability Training, Dual-Task Balance and Gait Training, Cognitive Training
- Where
- Turkey (Türkiye)
- Volunteers
- 14 people
- Sponsor
- Gazi University
Dizziness, Equilibrium; Disorder, Labyrinth
Posturography-assisted Vestibular Retraining for Stable Unilateral Vestibular Deficit
People that have difficulty with balance have a higher risk of falling and reduced quality of life. Some individuals can learn to compensate using their vision, their sense of where their limbs are in space, and balance organs…
- Conditions
- Dizziness, Equilibrium; Disorder, Labyrinth, Inner Ear Injury, Inner Ear Disease
- Trial name
- NCT05115032
- Testing
- Vestibular retraining with dynamic posturography, At-home rehabilitation exercises
- Where
- Canada
- Volunteers
- 37 people
- Sponsor
- Eytan A. David
Counterpulsation, Angina Pectoris
Effectiveness of ECP Therapy in Stable Angina Pectoris Patients
External Counterpulsation (ECP) is a non-invasive therapy using pressured cuff that is performed on patients with refractory stable angina pectoris to relieve symptoms and increase quality of life.
- Trial name
- NCT04873687
- Testing
- External Counter Pulsation (ECP) therapy
- Where
- Indonesia
- Volunteers
- 84 people
- Sponsor
- Universitas Padjadjaran
Hyposmia, Anosmia
Theophylline Nasal Spray for PD-Related Hyposmia and Anosmia
The goal of this study is to learn if intranasal theophylline (CYR-064) improves sense of smell in participants with hyposmia or anosmia related to the onset of Parkinson's Disease.
- Trial name
- NCT06498687
- Testing
- CYR-064
- Sponsor
- University of Nebraska
Back Pain, Low Back Pain
Tapentadol Prolonged Release (PR) Versus Oxycodone/Naloxone Prolonged Release in Severe Chronic Low Back Pain With a Neuropathic Component.
This was a clinical effectiveness trial designed to compare the effectiveness, safety, and tolerability of treatment with tapentadol prolonged release with that of oxycodone/naloxone prolonged release in non-opioid pre-treated…
- Conditions
- Back Pain, Low Back Pain, Neuropathic Pain
- Trial name
- NCT01838616
- Testing
- Tapentadol Prolonged Release, Oxycodone/Naloxone Prolonged Release
- Where
- 50 sites in Austria, Germany and 2 more
- Volunteers
- 367 people
- Sponsor
- Grünenthal GmbH
Obesity, Sarcopenia
Biological Effects of Weight Loss In Older, Obese Women
Obesity and sedentary lifestyle are associated with physical impairments and biological changes in older adults. Weight loss combined with exercise may reduce inflammation and may improve physical functioning in older adults who…
- Trial name
- WL+E (NCT01032733)
- Testing
- Lifestyle Counseling, Educational Control
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Florida
Altered Taste
TQ-PAL Development and Validation
Taste problems are common among patients with advanced cancer. These symptoms can affect the pleasure of eating and drinking, reduce dietary intake, cause low mood, and a lower quality of life.
- Trial name
- NCT06588933
- Testing
- completion of a questionnaire
- Where
- Ireland
- Volunteers
- 200 people
- Sponsor
- Prof Andrew Davies
Low Back Pain
The Right Intervention for the Right Patient
Complicated and expensive interventions are used to treat unspecific low back pain and the intervention is not always targeted the patients specific problems.It is therefore not surprising that a large fraction of unspecific low…
- Trial name
- NCT00459433
- Testing
- Biopsychosocial intervention
- Where
- Denmark
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The Back Research Center, Denmark