Clinical trials: Neuromuscular Block, Recovery
Neuromuscular Blockade
Residual Block in Postoperative Anaesthetic Care Unit
The purpose of this study is to assess the incidence of residual block in patients arriving in the Post Anaesthetic Care Unit (PACU) following surgery, and in those who have received neuromuscular blocking drugs (muscle…
- Trial name
- NCT02930629
- Testing
- Train-of-Four (TOF) Watch
- Where
- Singapore
- Volunteers
- 400 people
- Sponsor
- Singapore General Hospital
Neuromuscular Blockade, Arthroplasty, Replacement, Hip
Reversal of Neuromuscular Blockade With Sugammadex or Usual Care in Hip Fracture Surgery or Joint (Hip/Knee) Replacement (P07038)
This study will assess the effect of reversal of neuromuscular blockade with sugammadex compared with reversal according to usual care (neostigmine or spontaneous reversal) on the incidence of post-surgical bleeding events and on…
- Conditions
- Neuromuscular Blockade, Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee, Blood Coagulation
- Trial name
- NCT01422304
- Testing
- Sugammadex, neostigmine and glycopyrrolate or atropine
- Volunteers
- 1,198 people
- Sponsor
- Merck Sharp & Dohme LLC
Neuromuscular Blockade
Comparison of TOFscan and TOF-Watch SX in Pediatric Neuromuscular Function Recovery
Comparison of TOFscan and TOF-Watch SX for monitoring of neuromuscular blockade function in children
- Trial name
- NCT03775603
- Testing
- TOFscan
- Where
- South Korea
- Volunteers
- 37 people
- Sponsor
- Seoul National University Hospital
Neuromuscular Residual Curarization
Comparison of the TOFScan and the WiTOF During Recovery of Neuromuscular Function
The purpose of this study is to compare two neuromuscular blockade monitors on recovery from an ATRACURIUM intra veinous injection for surgery. The TOFscan, a wired connected monitors and the WiTOF, a wireless connected monitor.
- Trial name
- NCT05231525
- Testing
- WiTOF, TOFscan
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Drop Foot
Does Blood Vessel Vasodilation, Caused by Focal Infiltration of Lidocaine Cause Temporary Nerve Functional Recovery for Patients with Common Peroneal Nerve Injury or Entrapment: Testing the 'Phoenix Sign' Effect Between Lidocaine (a Common Local Anesthetic) and Papaverine, a Know Vasodilator
The goal of this clinical trial is to compare lidocaine without epinephrine to papaverine a known vasodilatory agent, in creating improved motor strength in patients with drop foot involving an entrapment of the Common Peroneal…
- Trial name
- NCT06637046
- Testing
- Diagnostic procedures, Lidocaine HCl
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stephen Barrett
Stomach Cancer
The Effect of Deep Neuromuscular Block on the Perioperative Stress Response Reduction and Postoperative Recovery Enhancement in Robot-assisted Stomach Cancer Surgery
Stress reactions caused by surgical stimuli can cause sympathetic nervous system activation and increased stress hormones, such as catecholamines, inflammatory cytokines, and pituitary hormones, and insulin resistance.
- Trial name
- NCT03937440
- Testing
- Deep neuromuscular block with 'rocunium®', Moderate neuromuscular block with 'rocunium®'
- Where
- South Korea
- Volunteers
- 46 people
- Sponsor
- Yonsei University
Quality of Recovery, Postoperative Pain
Quality of Recovery Under Low or Standard Pneumoperitoneum Pressure
The use of low-pressure pneumoperitoneum seems to be able to reduce complications such as postoperative pain. However, the quality of evidence for most studies evaluating this relationship is considered low.
- Conditions
- Quality of Recovery, Postoperative Pain, Postoperative Nausea and Vomiting, Neuromuscular Blockade
- Trial name
- NCT05040022
- Testing
- Pneumoperitoneum pressure 10 mmHg, Pneumoperitoneum pressure 14 mmHg
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Pontificia Universidade Catolica de Sao Paulo
Neuromuscular Block
Effects of Intravenous Lidocaine Associated With Magnesium Sulfate on the Cisatracurium-Induced Neuromuscular Block
The magnesium sulfate and lidocaine have been increasingly used alone or in combination during anesthesia procedure to meet various objectives, such as reduction of pain, use of smaller anesthetic doses and stabilization of…
- Trial name
- NCT02483611
- Testing
- Magnesium Sulfate, Lidocaine, Isotonic Solution
- Volunteers
- 48 people
- Sponsor
- University of Sao Paulo
Acute Respiratory Distress Syndrome, Neuromyopathies
Effect of Randomization to Neuromuscular Blockade on Physical Functional Impairment and Recovery in ARDS
The proposed work will determine the effect of neuromuscular blockade on physical function and recovery in patients with ARDS. The investigators will conduct a prospective ancillary study at five PETAL clinical centers that will…
- Trial name
- PRIMROSE (NCT03038906)
- Where
- United States
- Volunteers
- 290 people
- Sponsor
- University of Washington
Anesthesia Recovery
"Low Dose Sugammadex Combined With Neostigmine and Glycopyrrolate Versus Full Dose Sugammadex for Reversal of Rocuronium-induced Neuromuscular Blockade: a Cost Saving Strategy"
Prospective Randomized non inferiority Trial involving adult patients undergoing elective surgery under general anesthesia.56 Patients will be enrolled in 2 groups : full dose sugammadex vs half dose sugammadex for reversal of…
- Trial name
- NCT02375217
- Testing
- Sugammadex, Neostigmine, glycopyrrolate
- Where
- Lebanon
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Residual Neuromuscular Block
Impact of Sugammadex Versus Neostigmine on Early Postoperative Pulmonary Function
Residual neuromuscular blockade (NMB) after general anesthesia increases the risk of postoperative respiratory complications (atelectasis, pneumonia, re-intubation) and delays pulmonary function recovery.
- Trial name
- NCT07309393
- Testing
- Sugammadex, Neostigmine
- Where
- 3 sites in China
- Volunteers
- 240 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Bariatric Surgery Candidate
The Impact of Moderate Versus Deep Neuromuscular Blockade on Enhanced Recovery After Bariatric Anesthesia
Most published articles suggest that deep neuromuscular blockade is required for bariatric surgery. However, the evidence for such practice is still inconclusive.
- Trial name
- NCT04466943
- Testing
- Neuromuscular transmission monitoring (NMT)
- Where
- Saudi Arabia
- Volunteers
- 110 people
- Sponsor
- King Saud University
Neuromuscular Blockade, Chronic Obstructive Pulmonary Disease
Comparison of Time to Extubation Using Sugammadex or Neostigmine
A prospective blinded randomized clinical trial to compare time to extubation using Sugammadex versus Neostigmine/glycopyrrolate as reversal agents after use of neuromuscular blockade agents in an outpatient bronchoscopy suite.
- Trial name
- NCT04606901
- Testing
- neostigmine/glycopyrrolate, sugammadex
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Temple University
Respiratory-Gated Imaging Techniques
Functional Respiratory Imaging After Neostigmine or Sugammadex
The use of neuromuscular blocking agents (NMBAs) is still associated with postoperative pulmonary complications. The investigators rely on acceleromyography (AMG) of a peripheral nerve/muscle to assess the patients' breathing…
- Trial name
- FRINeoS (NCT02284412)
- Testing
- Neostigmine, Sugammadex, Water for injection
- Where
- Belgium
- Volunteers
- 13 people
- Sponsor
- Onze Lieve Vrouw Hospital
Neuromuscular Blockade, Surgery
Effect of Neuromuscular Blockade on Operating Conditions and Overall Satisfaction During Spinal Surgery
The investigators aim to investigate operating conditions, postoperative recovery and overall satisfaction of surgeons between deep neuromuscular blockade (NMB) group and restricted NMB group during spinal surgery under general…
- Conditions
- Neuromuscular Blockade, Surgery, Anesthesia, Spinal Diseases
- Trial name
- NCT02724111
- Testing
- sufficient dose of rocuronium, sugammadex 10 min after position change
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Korea University Guro Hospital
Craniectomy, Sugammadex
Comparison of the Effects of Sugammadex and Neostigmine on Early Extubation, Intensive Care Unit Admission and Length of Stay, and Hospital Costs in Adult Cranial Surgery
The aim of this study was to retrospectively investigate the effects of sugammadex or neostigmine, which are routinely used after the completion of surgery to antagonize (reverse) neuromuscular blockade in adult patients…
- Conditions
- Craniectomy, Sugammadex, Extubation, Recovery After Neuromuscular Block
- Trial name
- NCT06987357
- Where
- Turkey (Türkiye)
- Volunteers
- 112 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Spine Surgery
Speed of Recovery of Reversal of Neuromuscular Blockade in Geriatric Patients Undergoing Spine Surgery
Spine surgery is one of the most common operative procedures in the United States. It is performed in the prone position (a patient laying on belly).
- Trial name
- NCT03112993
- Testing
- sugammadex, Neostigmine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Missouri-Columbia
Neuromuscular Blockade
Deep Neuromuscular Blockade During Robotic Radical Prostatectomy
Basic requirement for safe performance of the robotic intra-abdominal surgery is a calm and clear surgical field after the introduction of a capnoperitoneum. That can be enabled by a neuromuscular blockade.
- Trial name
- NCT02513693
- Testing
- Standard neuromuscular blockade, Deep neuromuscular blockade
- Where
- 2 sites in Czechia
- Volunteers
- 80 people
- Sponsor
- Palacky University
Neuromuscular Blockade, Neuromuscular Monitoring
A Comparison Between TOF Watch® SX and Tetragraph®
This observational study was designed to assess the agreement between the recently marketed electromyographic neuromuscular blockade monitor Tetragraph® (Senzime, Uppsala, Sweden) and the TOF Watch® SX (Organon Teknika B.V.…
- Trial name
- NCT04947306
- Testing
- Tetragraph® (Senzime, Uppsala, Sweden), TOF Watch® SX (Organon Teknika B.V., Boxtel, Holland)
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Neuromuscular Blocking Agents, Reversal of Neuromuscular Blockade
Recovery Times of Half Dose Sugammadex and Neostigmine for Rocuronium-induced Neuromuscular Blockade
In operating procedure with general anesthesia muscle relaxant is usually used to increase success rate of the operation and to give better outcome.
- Conditions
- Neuromuscular Blocking Agents, Reversal of Neuromuscular Blockade, Recovery Time
- Trial name
- NCT06794450
- Testing
- Sugammadex 1 mg/kg, Neostigmine + Atropine
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Universitas Padjadjaran