Clinical trials: Neuromuscular Block, Recovery
Peripheral Chemosensitivity
The Breath-2 Trial
This is a randomized, cross over, experimental trial in which carotid body function will be evaluated in 35 healthy subjects during partial muscle relaxation and after recovery from muscle relaxation
- Trial name
- NCT05149872
- Testing
- Muscle relaxation, Reversal
- Where
- Netherlands
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Postoperative Gastrointestinal Dysfunction (POGD), Postoperative Ileus
Neuromuscular Blocking Agents on Gastrointestinal Function Following Colorectal Surgery
This study is a clinical research project conducted at Xijing Hospital to compare the effects of two different neuromuscular blockade reversal strategies on the recovery of gastrointestinal (GI) function after colorectal surgery.
- Conditions
- Postoperative Gastrointestinal Dysfunction (POGD), Postoperative Ileus, Colorectal Surgery
- Trial name
- NCT07271875
- Testing
- Neostigmine + Atropine, Sugammadex
- Volunteers
- 560 people
- Sponsor
- Xijing Hospital
Neuromuscular Blockade, Pain
Recovery After Laparoscopic Hysterectomy With Deep Neuromuscular Blockade and Low Intra-abdominal Pressure
The purpose of this study on laparoscopic hysterectomy is to investigate postoperative pain. Patients are allocated to either deep neuromuscular blockade and low intra-abdominal pressure (8 mmHg) or moderate neuromuscular…
- Conditions
- Neuromuscular Blockade, Pain, Laparoscopy
- Trial name
- NCT01722097
- Testing
- Rocuronium
- Where
- Denmark
- Volunteers
- 110 people
- Sponsor
- Herlev Hospital
Breast Cancer, Nerve Block
Erector Spinae Block vs. Placebo Block Study
Regional anaesthesia combined with general anaesthesia has become common in the perioperative management of breast cancer surgery patients. Regional techniques have been recognised to provide excellent post-operative analgesia.
- Conditions
- Breast Cancer, Nerve Block, Regional Anesthesia, Neuromuscular Blockade
- Trial name
- NCT03978780
- Testing
- Erector spinae plane block
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Women's College Hospital
Postoperative Residual Neuromuscular Blockade
Electromyographic Monitoring and Postoperative Recovery
Residual neuromuscular blockade (weakness) is a common occurrence in the postanesthesia care unit when muscle relaxant drugs have been used in the operating room.
- Trial name
- NCT03891381
- Testing
- Tetragraph quantitative monitoring
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Muscle Relaxation
Deep NMB in Ambulatory Gynecological Laparoscopy
Gynecological laparoscopic surgery is commonly performed as an ambulatory basis for the aim of rapid discharge, reduce hospital stay with reduced costs and to improve postoperative QOR [1,2].
- Trial name
- NCT04105764
- Testing
- Rocuronium, Rocuronium bromide
- Where
- Kuwait
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Wahba bakhet
Postoperative Residual Curarisation, Postoperative Hypoxemia
Postoperative Residual Curarisation at Arrival in the Post-anesthesia Care Unit
Several studies have documented that neuromuscular block often persists in the postanesthesia care unit (PACU). Residual paralysis is associated with postoperative complications such as hypoxia, weakness, and respiratory failure.
- Conditions
- Postoperative Residual Curarisation, Postoperative Hypoxemia, Postoperative Airway Obstruction
- Trial name
- NCT01362647
- Testing
- neuromuscular transmission monitoring, Pulse oximetry measurement
- Where
- Belgium
- Volunteers
- 625 people
- Sponsor
- Onze Lieve Vrouw Hospital
Respiratory Muscles, Electromyography
Electromyographic Activity of the Respiratory Muscles During Neostigmine or Sugammadex Enhanced Recovery After Neuromuscular Blockade
It was recently shown that neostigmine reversal was associated with increased atelectasis and that high-dose neostigmine was associated with longer postoperative length of stay and with an increased incidence of pulmonary edema…
- Trial name
- REDNESII (NCT02403063)
- Testing
- Sugammadex, Neostigmine, Neostigmine-sugammadex
- Where
- Belgium
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Onze Lieve Vrouw Hospital
Neuromuscular Block, Dexamethasone, Neuromuscular Block, Recovery
Influence of a Single Dose Dexamethasone on the Time Course of Neuromuscular Blockade of Rocuronium
The aim of the present study is to compare the time course of a neuromuscular block in patients receiving dexamethasone 8 mg in order to reduce postoperative nausea or vomiting several hours before surgery with patients receiving…
- Trial name
- NCT01782820
- Where
- Germany
- Volunteers
- 108 people
- Sponsor
- Kreiskrankenhaus Dormagen
Post-operative Residual Curarization
Recovery of Muscle Function After Deep Neuromuscular Block by Means of Diaphragm Ultrasonography
Diaphragm ultrasonography as a diagnostic tool in order to demonstrate the superiority of Sugammadex vs. AChEI in facilitating post-operative neuromuscular recovery.
- Trial name
- NCT02698969
- Testing
- Sugammadex, Diaphragm Ultrasonography, Neostigmine
- Where
- Italy
- Volunteers
- 58 people
- Sponsor
- University of Florence
Neuromuscular Block
Can Adequacy of Anesthesia Depth and Quality of Recovery be Influenced by the Level of Neuromuscular Blockade?
The investigators hypothesize that an anesthetic protocol maintaining deep neuromuscular block throughout the entire surgical procedure followed by sugammadex reversal, would suppress EMG activity and result in improved…
- Trial name
- NCT02484651
- Testing
- Sugammadex, Rocuronium
- Where
- Portugal
- Volunteers
- 70 people
- Sponsor
- Centro Hospitalar do Porto
Postoperative Residual Curarization
Comparison of Train of Four, Tetanus 50 and 100 Hz Recovery After Rocuronium Block Reversed by Neostigmine
Despite neuromuscular transmission monitoring and pharmacological reversal allowing a train of four ratio recovery higher than 0.9, patients receiving neuromuscular blocking agent during general anesthesia have a high risk of…
- Trial name
- DECURATOF 2 (NCT05224648)
- Testing
- TOF scan train of four ratio monitoring, ITF device tetanus stimulation monitoring
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Poitiers University Hospital
Neuromuscular Block
Deep Neuromuscular Block and Sugammadex Versus Standard of Care on Quality of Recovery in Patient Undergo Elective Laparoscopic Cholecystectomy
Single center, prospective, randomized, single blinded, parallel group and controlled, assessor-blinded trial to compare the impact of Deep neuromuscular block and Sugammadex versus Standard of care on Quality of recovery in…
- Trial name
- NCT02648503
- Testing
- Deep neuromuscular block, Moderate neuromuscular block
- Where
- Vietnam
- Volunteers
- 120 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Bariatric Surgery Candidate
Neuromuscular Blockade: Outcome and Recovery for Laparoscopic Bariatric Surgery
The aim of the current observational study is to better assess the relationships between neuromuscular blockade and multiple surgical outcomes in patients undergoing elective laparoscopic bariatric surgery.
- Trial name
- NCT02300168
- Testing
- Sleeve gastrectomy
- Volunteers
- 50 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Residual Paralysis, Post Anesthesia, Postoperative Complications
Predicting Neuromuscular Recovery in Surgical Patients Using Machine Learning
Despite emerging efforts to decrease residual paralysis and postoperative complications with the use of quantitative neuromuscular monitoring and reversal agents their incidences remain high.
- Conditions
- Residual Paralysis, Post Anesthesia, Postoperative Complications, Neuromuscular Blockade, Quantitative Neuromuscular Monitoring
- Trial name
- PINES (NCT05471882)
- Where
- 2 sites in Germany
- Volunteers
- 240,000 people
- Sponsor
- University Hospital Ulm
Anesthesia, Surgery
Time Prediction for Complete Recovery From Neuromuscular Blockade After Visual Recovery With Double Burst Stimulation
The purpose is to calculate the time for an optimal recovery (T4/T1 > 0.9) from the moment when 2 responses to double burst stimulation are visually identical and this for 95% of patients.
- Trial name
- DBS PREDICTION (NCT02893436)
- Testing
- Surgery with tracheal intubation curarisation
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Central Hospital, Nancy, France
Anesthesia Recovery Period
Street Fitness in Surgical Patients Undergoing General Anesthesia After Reversal of Neuromuscular Blockade
Rationale: Recovery from outpatient anesthesia includes dissipation of anesthetics agents, normalization of physiological function, observation for medical or surgical complications, treatment of immediate side effects of…
- Trial name
- SFINX (NCT01453530)
- Testing
- Sugammadex, Neostigmine/Glycopyrrolate
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Neuromuscular Blockade
Neuromuscular Blockade During Transurethral Resection of Bladder Cancer
Transurethral resection of the bladder tumor (TURB) for bladder tumor excision is the mainstream treatment. However, the beneficial effects of sugammadex after general anesthesia for TURB have not been thoroughly evaluated.
- Trial name
- NCT03039543
- Testing
- Rocuronium, Sugammadex
- Where
- South Korea
- Volunteers
- 108 people
- Sponsor
- Seoul National University Bundang Hospital
Postoperative Residual Curarization, Residual Neuromuscular Block
Comparison Between Cisatracurium and Rocuronium in Terms of Recovery of the Muscular Strength in the Postoperative Phase After Surgery and General Anaesthesia
The purpose of this study is to determine the incidence of post-operative residual curarization in our patients and to determine if Cisatracurium and Rocuronium behave differently from each other in terms of residual curarization.
- Trial name
- NCT01651572
- Testing
- Cisatracurium, Rocuronium
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Azienda Ospedaliera di Padova
Anesthesia Recovery Period, Neuromuscular Blockade
The Dose of Sugammadex for Rapid Reversal of Profound Neuromuscular Block in Young and Elderly Patients
To find out the dose of sugammadex for recovery of the TOF ratio to 0.9 within 2 minutes from profound rocuronium-induced neuromuscular block in young and elderly adult patients.
- Trial name
- NCT01890057
- Testing
- Sugammadex
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Severance Hospital