Clinical trials: Neuromuscular Block
Muscle Relaxation
Deep vs Moderate Neuromuscular Blockade in Day Case Laparoscopic Cholecystectomy.
Laparoscopic cholecystectomy (LC) is commonly performed on ambulatory basis as a result of its ability to improve postoperative quality of recovery (QOR) and significantly reduce hospital stay .
- Trial name
- NCT03881423
- Testing
- Rocuronium Bromide
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Wahba bakhet
Healthy
Phase I Clinical Trial to Evaluate the Safety, Pharmacokinetics and Efficacy of CW002
The purpose of this study is to test the safety and efficacy of an investigational neuromuscular blocking agent called CW002 and to document its effects on healthy adult volunteers.
- Trial name
- CW002 (NCT01338935)
- Testing
- CW 002
- Where
- United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Neuromuscular Blockade
Effect of Magnesium Sulphate on Neostigmine
The purpose of this study is to evaluate the effect of magnesium sulphate on neostigmine-induced reversal of neuromuscular block by rocuronium
- Trial name
- NCT03020706
- Testing
- Magnesium Sulfate, Injectable
- Where
- South Korea
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Gachon University Gil Medical Center
Residual Neuromuscular Block
Neostigmine Reversal And Neuromuscular Recovery
Patients undergoing surgery often receive paralytic agents (or neuromuscular blocking agents (NMBAs)) to facilitate the procedure. At the end of surgery, the effects NMBAs are reversed with a drug called neostigmine.
- Trial name
- NCT02433808
- Testing
- Neostigmine Group, No Neostigmine group
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Neuromuscular Blockade
The Effect of Magnesium Sulphate on the Time Course of Rocuronium Induced Neuromuscular Block
The aim of this study is to investigate whether an optimized pre-treatment with intravenous magnesium enhances the speed of onset of a standard intubation dose of rocuronium.
- Trial name
- MagRoc (NCT00405977)
- Testing
- Physiologic saline, Magnesium sulphate
- Where
- Switzerland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Obese Patients, Laparoscopic Colorectal Surgery
Pharmacodynamics of Injection of Cisatracurium Base on Lean Body Mass Pattern to Maintain Deep Neuromuscular Blockade in Obese Patients
To observe the pharmacodynamics of intravenous injection of cisatracurium to maintain deep neuromuscular blockade in obese patients with lean body mass in laparoscopic colorectal surgery
- Trial name
- NCT05391958
- Testing
- base on Lean Body Mass Pattern, base on Actual Body Weight, obese patients
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The First Hospital of Qinhuangdao
Anesthesia, Pregnancy Related
Upper vs Lower Extremity BP in Spinal Cesarean Using ClearSight
This is a single-center, prospective observational study in patients undergoing cesarean delivery under spinal or combined spinal-epidural anesthesia.
- Conditions
- Anesthesia, Pregnancy Related, Blockades Neuromuscular
- Trial name
- NCT07685730
- Testing
- ClearSight
- Where
- United States
- Volunteers
- 327 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Residual Neuromuscular Blockade, Curarization, Postoperative Residual
Validation of the REPS Prediction Tool
Neuromuscular blocking agents' (NMBA) use during surgery is associated with postoperative respiratory complications and increased risk of readmission to the hospital following ambulatory surgery.
- Conditions
- Residual Neuromuscular Blockade, Curarization, Postoperative Residual, Postoperative Respiratory Complication
- Trial name
- NCT03585400
- Testing
- Observational Study
- Where
- United States
- Volunteers
- 101,510 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Muscle Weakness, Muscle Damage
Acute Physiological Responses to Twice Daily Blood Flow Restriction Training
The Academic Department of Military Rehabilitation (ADMR) is currently conducting a pan-defence, randomised control trial (RCT) investigating the utility of twice daily blood flow restriction training in UK military personnel…
- Trial name
- NCT06334224
- Testing
- Low load resistance training with blood flow restriction, Low load resistance training
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Defence Medical Rehabilitation Centre, UK
Electromyography, Neuromuscular Monitoring
Neurostimulation and Electromyographs Assessment of th TetraGraph in Healthy (Volunteers
TetraGraph is a newly developed EMG-based (electromyograph), quantitative, battery-powered neuromuscular monitoring system intended for daily clinical use.
- Trial name
- NEAT-2 (NCT02630576)
- Testing
- Neuromuscular stimulation
- Where
- Hungary
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Debrecen
Postoperative Residual Neuromuscular Blockade
Electromyographic Monitoring and Postoperative Recovery
Residual neuromuscular blockade (weakness) is a common occurrence in the postanesthesia care unit when muscle relaxant drugs have been used in the operating room.
- Trial name
- NCT03891381
- Testing
- Tetragraph quantitative monitoring
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Neuromuscular Blockade
Transmucular Quadratus Lumborum Block: Potential Quadriceps Muscle Weakness
The aim of this study is to examine whether the administration of the TQL block cause motor block of the lumbar plexus and thereby quadriceps muscle weakness.
- Trial name
- NCT05023343
- Testing
- Ropivacaine, Quadriceps muscle strength, Timed Up and Go
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Zealand University Hospital
Postherpetic Neuralgia
Ultrasound-Guided Thoracic Paravertebral Block With Steroid and Local Anesthetic for Acute Herpes Zoster: Effects on Pain Control and Prevention of Postherpetic Neuralgia
Background: Acute herpes zoster causes severe neuropathic pain and may progress to postherpetic neuralgia (PHN). This study aims to evaluate ultrasound-guided thoracic paravertebral block with local anesthetic and steroid in…
- Trial name
- NCT07349680
- Testing
- Valacyclovir + Paracetamol (Acetaminophen) + Gabapentin (standard medical therapy), Ultrasound-guided thoracic paravertebral block (TPVB) with bupivacaine 0.25% + methylprednisolone 40 mg
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Muscular Dystrophy, Duchenne
Safety Study of BLS-M22 in Healthy Volunteers
BLS-M22 is being developed as an anti-myostatin agent for the treatment of Duchenne Muscular Dystrophy (Muscular Dystrophy). A total of 37 subjects participated in this study to confirm the safety of BLS-M22.
- Trial name
- NCT03789734
- Testing
- BLS-M22
- Where
- South Korea
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- BioLeaders Corporation
Chronic Venous Disease, Venous Insufficiency
Venous Insufficiency and Neuromuscular Stimulation
The investigators will be evaluating the immediate and longer term effect of treatment with a medical device on the symptoms of chronic venous disease.
- Conditions
- Chronic Venous Disease, Venous Insufficiency, Deep Venous Obstruction
- Trial name
- VeINS (NCT02137499)
- Testing
- geko device
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Imperial College London
MELAS Syndrome, Mitochondrial Respiratory Chain Deficiencies
Safety, Tolerability and Pharmacokinetic Study of KL1333 in Healthy Male Volunteers
The purpose of this First In Human study is to investigate the safety and tolerability of KL1333 after a single oral dose and to investigate the pharmacokinetic characteristics of KL1333 after a single oral dose.
- Trial name
- NCT03056209
- Testing
- KL1333 25 mg, KL1333 50 mg, KL1333 100 mg
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yungjin Pharm. Co., Ltd.
Gastrointestinal Cancer, Sarcopenia
Sarcopenia and Neuromuscular Block in Gastrointestinal Cancer Surgery
This prospective observational study aims to evaluate the effects of sarcopenia on intraoperative neuromuscular block (NMB) in patients undergoing gastrointestinal cancer surgery.
- Conditions
- Gastrointestinal Cancer, Sarcopenia, Neuromuscular Blockade
- Trial name
- NCT07003061
- Testing
- Standard Anesthesia Management
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Cholecystitis, Inguinal Hernia, Direct
No Need for Neuromuscular Blockade in Daycase Laparoscopic Surgery
This study analyse the need for neuromuscular blockade in consecutive routine laparoscopic procedures without standard use of neuromuscular blockade in an ambulatory laparoscopic surgery setting and analyse specific reasons for…
- Conditions
- Cholecystitis, Inguinal Hernia, Direct, Umbilical Hernia
- Trial name
- NCT02782832
- Volunteers
- 1,245 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Meralgia Paresthetica
Comparing Ways to Freeze the Nerve That Provides Thigh Sensation
Background The sensation on the outside of portion of our thighs is provided by a nerve called the lateral femoral cutaneous nerve (LFCN).
- Trial name
- NCT02577510
- Testing
- Nerve Injection- Nerve Stimulator, Nerve Injection - Ultrasound
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Canadian Forces Health Services Centre Ottawa
Brain Tumors
Effect of Sugammadex for Reversal of Rocuronium-induced Neuromuscular Block on Perioperative Management of Awake Craniotomy
Effect of sugammadex for reversal of rocuronium-induced neuromuscular block on Perioperative Management of awake Craniotomy
- Trial name
- NCT05202899
- Testing
- sugammadex
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command