Clinical trials: Neuromuscular Block
Muscle Relaxation
Deep NMB in Ambulatory Gynecological Laparoscopy
Gynecological laparoscopic surgery is commonly performed as an ambulatory basis for the aim of rapid discharge, reduce hospital stay with reduced costs and to improve postoperative QOR [1,2].
- Trial name
- NCT04105764
- Testing
- Rocuronium, Rocuronium bromide
- Where
- Kuwait
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Wahba bakhet
Neuromuscular Blockade
Pilot Study on the Pharmacodynamics of Sugammadex in Morbidly Obese Patients: Reversal of Deep Neuromuscular Blockade
Should the dose of sugammadex in morbid obese patients be calculated on the real body weight or the ideal body weight? To study the pharmacodynamics of sugammadex in morbidly obese patients by comparing 1 mg/kg IBW versus 1 mg/kg…
- Trial name
- MOS (NCT01855217)
- Testing
- Sugammadex
- Where
- Netherlands
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- St. Antonius Hospital
Neuromuscular Blocking Agents, Urinary Retention After Procedure
NMBA Reversal and Postoperative Urinary Retention
In this single-center retrospective cohort study of adult patients who underwent surgery under general anesthesia at Beth Israel Deaconess Medical Center between September 2016 and January 2024, the association between the choice…
- Conditions
- Neuromuscular Blocking Agents, Urinary Retention After Procedure, Urinary Retention Postoperative, Neuromuscular Blockade Reversal Agent
- Trial name
- NCT06948409
- Testing
- Choice of reversal agent (sugammadex or neostigmine [with muscaranic antagonist])
- Where
- United States
- Volunteers
- 70,000 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Drug Allergy, Neuromuscular Blockade
High Dimensional Analysis of Immune Cells in Pediatric Patients
The purpose of this study is to characterize immune cells using single-cell transcriptomic analysis in pediatric patients aged 2 to 18 years undergoing general anesthesia who are expected to receive Rocuronium, a non-depolarizing…
- Trial name
- NCT05820802
- Where
- South Korea
- Volunteers
- 294 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Femoral Nerve Disease
Femoral Nerve Block: Anatomical Insertion Point - A Prospective Randomised Double-Blind Controlled Trial
Nerve blocks are an effective way to control pain after surgery. There are two major nerves that provide sensation to the knee: the femoral nerve provides sensation to the front of the knee and sciatic nerve provides sensation to…
- Trial name
- FNB (NCT00732706)
- Testing
- Sartorius Muscle Twitch, Quadriceps Muscle Twitch
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Neuromuscular Blockade
Comparison of the TOFscan and the TetraGraph During Recovery of Neuromuscular Function
Assess the values of train-of-four ratios with the TetraGraph and thoses obtained with the TOFscan during recovery of neuromusculat function in surgical patients who have been administred rocuronium.
- Trial name
- DECURAR-EMG (NCT04816539)
- Testing
- TetraGraph
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Intracranial Hypertension
Comparison of the Effects of Deep and Moderate Neuromuscular Blockade on Optic Nerve Sheath Diameter
Increased intracranial pressure (IICP) is a common problem in traumatic brain injuries and many medical diseases. Early recognition of IICP can save lives.
- Trial name
- MBLONDE (NCT04211064)
- Testing
- Ultrasonographic measurement of optic nerve sheath diameter, Deep neuromuscular block, Moderate neuromuscular block
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Magnesium Sulfate, Neuromuscular Blockade
Effect of Pre-treatment With Magnesium Sulfate on the Duration of Deep Neuromuscular Blockade With Rocuronium
It is a prospective, comparative, randomized, double-blind clinical trial whose hypothesis is that pre-treatment with magnesium sulfate, due to its action at the neuromuscular junction,potentiate the duration of deep…
- Conditions
- Magnesium Sulfate, Neuromuscular Blockade, Rocuronium, Deep Neuromuscular Blockade
- Trial name
- NCT02989272
- Testing
- Sulfate, Magnesium, saline group
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospital Federal de Bonsucesso
Neuromuscular Blockade
Interaction of Volatile Anesthetics With Magnesium
Magnesium and volatiles anesthetics both have an effect on the neuromuscular transmission. The primary objective of the study is to quantify the effect of a perfusion of intravenous magnesium on neuromuscular transmission…
- Trial name
- Volmag (NCT05261516)
- Testing
- Magnesium Sulfate
- Where
- Switzerland
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Christoph Czarnetzki
Nerve Block, Pain, Postoperative
Pudendal Nerve Block in Vaginal Surgery
The objective of this this randomized controlled study is to determine whether a pudendal nerve block at the time of vaginal surgery is associated with improved postoperative pain control and decrease opioid consumption compared…
- Conditions
- Nerve Block, Pain, Postoperative, Pelvic Floor Disorders, Pelvic Organ Prolapse
- Trial name
- NCT04198714
- Testing
- Pudendal block
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- MetroHealth Medical Center
Pain Syndrome, Pain, Intractable
Determination of Longus Colli Muscle Thickness by Ultrasonography
This study aims to assess the longus colli muscle thickness by ultrasonography in order to guide stellate ganglion blocks
- Conditions
- Pain Syndrome, Pain, Intractable, Complex Regional Pain Syndromes, Hyperhidrosis
- Trial name
- NCT05108103
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Muscle Relaxants
Fade Upon TOF Stimulation Induced by Succinylcholine
Muscle relaxants are medications used during surgery to facilitate surgical access. The effect of the muscle relaxant medications is measured by stimulation a motor nerve and measuring the force of the resultant muscle…
- Trial name
- NCT02425449
- Testing
- Succinylcholine
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Toledo Health Science Campus
Neuromuscular Blockade
Comparison of Neuromuscular Recovery at the Hand and Foot
Gold standard for neuromuscular blockade evaluation is accelerometry in three dimensions at the thumb. There are many times that measurement at the hand can be falsely under-estimated intraoperatively secondary to constriction of…
- Trial name
- NCT06236763
- Testing
- TOFscan foot
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Neuromuscular Blockade
Electromyographic Assessment of the TetraGraph in Normal Volunteers
There is an urgent need for an easy-to-use and accurate quantitative neuromuscular monitor in the clinical setting. The aim of this clinical investigation is to examine a prototype of a quantitative monitoring instrument that…
- Trial name
- NCT02912039
- Testing
- TetraGraph, TOF Watch
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Reversal of Neuromuscular Blockade
A Single Ascending Dose of HRS-2162 in Healthy Subjects
The study is being conducted to evaluate the safety and tolerability of HRS-2162 injection in a single dose in healthy subjects, as well as the characteristics of PK/PD
- Trial name
- NCT07195604
- Testing
- HRS-2162
- Where
- China
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Critical Illness Polyneuropathy, Critical Illness Myopathy
Evaluation of the NeuroMuscular Junction Using the Single Fiber Electromyography and Reliability of Train-Of-Four in Critically Ill Patients.
Patients suffering from critical illnesses who are admitted to the Intensive Care Unit (ICU) are often affected by multiple organ failure.
- Conditions
- Critical Illness Polyneuropathy, Critical Illness Myopathy, Weakness Due to Disease, Neuromuscular Blockade
- Trial name
- NCT03893058
- Where
- Italy
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Gynecologic Disease, Neuromuscular Blockade
Moderate vs Deep Neuromuscular Block in Lower Pressure Pneumoperitoneum
The investigators hypothesized that deep neuromuscular block compare to moderate neuromuscular block would reduce the rate of increasing intraabdominal pressure and operation can be completely done in lower pressure…
- Trial name
- NCT05689957
- Testing
- Deep neuromuscular block using intravenous rocuronium induction at 1.2mg/kg and maintainance of 8-12mcg/kg/min for deep neuromuscular block
- Where
- Malaysia
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Observation of Neuromuscular Block
Train of Four Motor Point Stimulation and Monitoring
The assessment of neuromuscular blockage is common practice in the operating room, in which such agents are employed. Still today, the use of simple hand held stimulators and visual monitoring of these responses are the norm.
- Trial name
- NCT02591108
- Testing
- Neuromuscular Block Aid, Standard of Care: Microstim Plus
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Minnesota
Nerve Block, Neuromuscular Blockade
Dosage of Mepivacaine in Ultrasound Axillary Block
The use of ultrasonography as an adjunct to regional anesthesia has significantly increased in recent years. Brachial plexus blockade by an axillary approach is amenable to the use of ultrasound guidance.
- Conditions
- Nerve Block, Neuromuscular Blockade, Anesthesia
- Trial name
- NCT01485653
- Testing
- Mepivacaine
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Wayne State University